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1. 发明申请

US20060073584A1 Chemical analyzing apparatus 审中-公开
标题翻译：化学分析仪
公开(公告)号：US20060073584A1
公开(公告)日：2006-04-06
申请号：US11239231
申请日：2005-09-30
申请人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Hirotoshi Ishimaru , Nobuyuki Maki , Toshiaki Yokobayashi , Michihiro Saito , Taisaku Seino
发明人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Hirotoshi Ishimaru , Nobuyuki Maki , Toshiaki Yokobayashi , Michihiro Saito , Taisaku Seino
IPC分类号： C12M1/34
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502723 , B01L3/502753 , B01L2200/10 , B01L2200/16 , B01L2300/0654 , B01L2300/0816 , B01L2300/1822 , B01L2300/1844 , B01L2400/0406 , B01L2400/0409 , G01N2035/00356 , G01N2035/00495
摘要： A chemical analyzing apparatus accommodates therein a structure for retaining a sample and reagents. A detecting mechanism detects the sample after reaction with a reagent. After or during extraction of a biological substance from the sample in the structure, a temperature of a fluid in a space around the structure is controlled to a value which is suitable for enzyme.
摘要翻译：化学分析装置中容纳有用于保持样品和试剂的结构。检测机构在与试剂反应后检测样品。在从结构中的样品中提取生物物质之后或之后，结构周围空间中的流体的温度被控制为适合于酶的值。

2. 发明授权

US07678576B2 Chemical analysis apparatus and chemical analysis cartridge 有权
标题翻译：化学分析装置和化学分析盒
公开(公告)号：US07678576B2
公开(公告)日：2010-03-16
申请号：US11319680
申请日：2005-12-29
申请人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
发明人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
IPC分类号： G01N35/00 , B01F15/02
CPC分类号： B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1816 , B01L2400/0409 , B01L2400/0442 , B01L2400/0475 , G01N21/0332 , G01N21/07 , G01N21/645 , G01N2021/0325 , G01N2035/00148 , G01N2035/00495 , G01N2035/00534 , Y10T436/111666
摘要： The invention provides a chemical analysis apparatus which easily agitates and warms up. A chemical analysis apparatus has a motor, a retaining disc which can be rotated by the motor, a plurality of inspection cartridges which are arranged on the retaining disc, a punching machine for punching the inspection cartridges, a warming apparatus and a detection apparatus. The inspection cartridge includes a container formed by a concave portion and a base plate having a flow path. A cover covering the container and the flow path is installed to the base plate. A liquid solution is moved to the container in an outer peripheral side with respect to a rotation axis from the container in an inner peripheral side with respect to the rotation axis via the flow path, by utilizing a centrifugal force generated on the basis of the rotation of the retaining disc. The inspection cartridge is provided with an agitating means for agitating the liquid solution within the container and a warming means for warming up the liquid solution within the container.
摘要翻译：本发明提供一种容易搅动和加热的化学分析装置。化学分析装置具有电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查筒，冲压检查筒的冲孔机，加温装置和检测装置。检查筒包括由凹部形成的容器和具有流路的基板。覆盖容器和流路的盖子安装在基板上。通过利用基于旋转产生的离心力，液体溶液在相对于旋转轴线的旋转轴线的相对于旋转轴线的内周侧的外周侧经由流路被移动到容器的保持盘。检查筒设置有用于搅拌容器内的液体溶液的搅拌装置和用于预热容器内的液体溶液的加温装置。

3. 发明申请

US20060159586A1 Chemical analysis apparatus and chemical analysis cartridge 有权
标题翻译：化学分析仪和化学分析盒
公开(公告)号：US20060159586A1
公开(公告)日：2006-07-20
申请号：US11319680
申请日：2005-12-29
申请人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
发明人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
IPC分类号： G01N31/22
CPC分类号： B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1816 , B01L2400/0409 , B01L2400/0442 , B01L2400/0475 , G01N21/0332 , G01N21/07 , G01N21/645 , G01N2021/0325 , G01N2035/00148 , G01N2035/00495 , G01N2035/00534 , Y10T436/111666
摘要： The invention provides a chemical analysis apparatus which easily agitates and warms up. A chemical analysis apparatus has a motor, a retaining disc which can be rotated by the motor, a plurality of inspection cartridges which are arranged on the retaining disc, a punching machine for punching the inspection cartridges, a warming apparatus and a detection apparatus. The inspection cartridge includes a container formed by a concave portion and a base plate having a flow path. A cover covering the container and the flow path is installed to the base plate. A liquid solution is moved to the container in an outer peripheral side with respect to a rotation axis from the container in an inner peripheral side with respect to the rotation axis via the flow path, by utilizing a centrifugal force generated on the basis of the rotation of the retaining disc. The inspection cartridge is provided with an agitating means for agitating the liquid solution within the container and a warming means for warming up the liquid solution within the container.
摘要翻译：本发明提供一种容易搅动和加热的化学分析装置。化学分析装置具有电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查筒，冲压检查筒的冲孔机，加温装置和检测装置。检查筒包括由凹部形成的容器和具有流路的基板。覆盖容器和流路的盖子安装在基板上。通过利用基于旋转产生的离心力，液体溶液在相对于旋转轴线的旋转轴线的相对于旋转轴线的内周侧的外周侧经由流路被移动到容器的保持盘。检查筒设置有用于搅拌容器内的液体溶液的搅拌装置和用于预热容器内的液体溶液的加温装置。

4. 发明申请

US20060159588A1 Chemical analysis device and chemical analysis cartridge 审中-公开
标题翻译：化学分析装置和化学分析盒
公开(公告)号：US20060159588A1
公开(公告)日：2006-07-20
申请号：US11319159
申请日：2005-12-28
申请人： Noriyo Nishijima , Yoshihiro Nagaoka , Toshiaki Yokobayashi , Michihiro Saito , Nobuyuki Maki , Satoshi Takahashi
发明人： Noriyo Nishijima , Yoshihiro Nagaoka , Toshiaki Yokobayashi , Michihiro Saito , Nobuyuki Maki , Satoshi Takahashi
IPC分类号： G01N9/30
CPC分类号： B01L3/502753 , B01L3/502723 , B01L3/502738 , B01L7/00 , B01L2200/10 , B01L2200/16 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/0694
摘要： A chemical analysis device has a motor, a holder disk to be rotated by the motor, a plurality of inspection cartridges, a penetrator for penetrating the inspection cartridges, a heater and a detector. The inspection cartridge has a substrate including containers formed as recesses and a flow path, and a cover is mounted on the substrate to cover the containers and flow path. By a centrifugal force generated by a rotation of the holder disk, a liquid is moved through the flow path from the container at a radially inner side with respect to a rotational axis to the container at a radially outer side with respect to the rotational axis.
摘要翻译：化学分析装置具有电动机，由电动机旋转的保持盘，多个检查筒，穿透检查筒的穿透器，加热器和检测器。检查盒具有包括形成为凹部和流路的容器的基板，并且在基板上安装盖以覆盖容器和流路。通过由保持盘旋转产生的离心力，使液体相对于旋转轴在径向外侧从相对于旋转轴的径向内侧的容器移动通过容器。

5. 发明申请

US20060245972A1 Chemical analyzer and cartridge for chemical analyzer 审中-公开
标题翻译：化学分析仪和化学分析仪盒
公开(公告)号：US20060245972A1
公开(公告)日：2006-11-02
申请号：US11411159
申请日：2006-04-26
申请人： Yasuo Osone , Michihiro Saito , Hiroki Ihara , Noriyo Nishijima , Yoshihiro Nagaoka , Naruo Watanabe , Shigeyuki Sasaki , Nobuyuki Maki
发明人： Yasuo Osone , Michihiro Saito , Hiroki Ihara , Noriyo Nishijima , Yoshihiro Nagaoka , Naruo Watanabe , Shigeyuki Sasaki , Nobuyuki Maki
IPC分类号： G01N35/00
CPC分类号： B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/16 , B01L2300/021 , B01L2300/041 , B01L2300/0672 , B01L2300/0816 , B01L2400/0409 , B01L2400/0677 , B01L2400/0683 , G01N21/07 , G01N35/00069 , G01N2035/00495
摘要： A chemical analyzer has a rotatable holding disk, test cartridges disposed thereon, and a detector. The test cartridge includes a base plate having vessels and flow channels. The base plate is covered with a cover for covering the vessels and flow channels. The holding disk is rotated to generate centrifugal force, causing a fluid to be moved from one vessel at the inner peripheral side with respect to a rotation axis of the holding disk to another vessel at the outer peripheral side with respect to the rotation axis via the flow channel. In the test cartridge, at least one reagent port is formed in the base plate, and a closed vessel containing a reagent is placed in the reagent port. The closed vessel is a microcapsule, a plastic closed vessel, or a screw-in closed vessel, for example.
摘要翻译：化学分析仪具有可旋转的保持盘，设置在其上的测试盒和检测器。测试盒包括具有容器和流动通道的基板。基板覆盖有用于覆盖容器和流动通道的盖。保持盘旋转以产生离心力，使得流体相对于保持盘的旋转轴线从内周侧的一个容器移动到相对于旋转轴的外周侧的另一个容器流通道。在测试盒中，在底板中形成至少一个试剂口，并且将含有试剂的密闭容器放置在试剂口中。密封容器例如是微胶囊，塑料密封容器或螺旋式密闭容器。

6. 发明申请

US20070025876A1 Chemical analysis device and chemical analysis cartridge 审中-公开
标题翻译：化学分析装置和化学分析盒
公开(公告)号：US20070025876A1
公开(公告)日：2007-02-01
申请号：US11493751
申请日：2006-07-27
申请人： Noriyo Nishijima , Yoshihiro Nagaoka , Shigeyuki Sasaki , Michihiro Saito , Satoshi Takahashi
发明人： Noriyo Nishijima , Yoshihiro Nagaoka , Shigeyuki Sasaki , Michihiro Saito , Satoshi Takahashi
IPC分类号： G01N35/00
CPC分类号： G01N35/00029 , B01L3/502715 , B01L3/50273 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/0409 , B01L2400/0487 , G01N1/40 , G01N21/07 , G01N33/4875 , G01N2035/00148 , G01N2035/00257 , G01N2035/00504
摘要： An analysis cartridge for use in a chemical analysis device comprises a reagent cartridge having a plurality of reagent containers formed therein to be able to contain reagents, and a reaction cartridge connected to the reagent cartridge and having a reaction container formed therein. The reagent cartridge and the reaction cartridge are each made up of a base plate and a cover covering recesses formed in a surface of the base plate. Channels for interconnecting the plurality of reagent containers and the reaction container are formed in the reagent cartridge and the reaction cartridge. The channels are formed inside the base plates of the reagent cartridge and the reaction cartridge in their connected portions. The structure of the analysis cartridge for mixing and reacting a specimen and reagents can be simplified.
摘要翻译：用于化学分析装置的分析盒包括：试剂盒，其具有形成在其中的多个试剂容器以能够容纳试剂;以及反应盒，连接到试剂盒并具有形成在其中的反应容器。试剂盒和反应盒各自由基板和形成在基板的表面中的盖覆盖凹部构成。用于互连多个试剂容器和反应容器的通道形成在试剂盒和反应盒中。通道形成在试剂盒的基板和反应盒的连接部分内。可以简化用于混合和反应样品和试剂的分析盒的结构。

7. 发明申请

US20060153735A1 Chemical analysis apparatus and chemical analysis cartridge 有权
标题翻译：化学分析仪和化学分析盒
公开(公告)号：US20060153735A1
公开(公告)日：2006-07-13
申请号：US11319977
申请日：2005-12-29
申请人： Yoshihiro Nagaoka , Nobuyuki Maki , Noriyo Nishijima , Michihiro Saito , Hiroki Ihara
发明人： Yoshihiro Nagaoka , Nobuyuki Maki , Noriyo Nishijima , Michihiro Saito , Hiroki Ihara
IPC分类号： G01N31/22 , G01N35/00
CPC分类号： G01N21/07 , G01N35/025 , G01N2035/00148 , G01N2035/00495 , Y10T436/11 , Y10T436/111666 , Y10T436/25
摘要： A chemical analysis apparatus comprises a motor, a holding disk that can be rotated by the motor, a plurality of examination cartridges arranged on the holding disk, a perforator that perforates the examination cartridges, a heating device, and a detection device. The examination cartridge comprises a substrate including a vessel and a flow channel, which are defined by recesses, and a cover that covers the vessel and the flow channel. A centrifugal force generated by rotation of the holding disk is made use of to move a solution from a vessel on an inner peripheral side relative to an axis of rotation to a vessel on an outer peripheral side relative to the axis of rotation through the flow channel.
摘要翻译：化学分析装置包括电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查盒，对检查筒进行穿孔的穿孔器，加热装置和检测装置。检查筒包括由凹部限定的容器和流路的基板和覆盖容器和流路的盖。通过保持盘的旋转而产生的离心力用于将溶液从相对于旋转轴线的内周侧的容器移动到通过流动通道相对于旋转轴线的外周侧上的容器。

8. 发明授权

US07727472B2 Chemical analysis apparatus and chemical analysis cartridge 有权
标题翻译：化学分析仪和化学分析盒
公开(公告)号：US07727472B2
公开(公告)日：2010-06-01
申请号：US11319977
申请日：2005-12-29
申请人： Yoshihiro Nagaoka , Nobuyuki Maki , Noriyo Nishijima , Michihiro Saito , Hiroki Ihara
发明人： Yoshihiro Nagaoka , Nobuyuki Maki , Noriyo Nishijima , Michihiro Saito , Hiroki Ihara
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： G01N21/07 , G01N35/025 , G01N2035/00148 , G01N2035/00495 , Y10T436/11 , Y10T436/111666 , Y10T436/25
摘要： A chemical analysis apparatus comprises a motor, a holding disk that can be rotated by the motor, a plurality of examination cartridges arranged on the holding disk, a perforator that perforates the examination cartridges, a heating device, and a detection device. The examination cartridge comprises a substrate including a vessel and a flow channel, which are defined by recesses, and a cover that covers the vessel and the flow channel. A centrifugal force generated by rotation of the holding disk is made use of to move a solution from a vessel on an inner peripheral side relative to an axis of rotation to a vessel on an outer peripheral side relative to the axis of rotation through the flow channel.
摘要翻译：化学分析装置包括电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查盒，对检查筒进行穿孔的穿孔器，加热装置和检测装置。检查筒包括由凹部限定的容器和流路的基板和覆盖容器和流路的盖。通过保持盘的旋转而产生的离心力用于将溶液从相对于旋转轴线的内周侧的容器移动到通过流动通道相对于旋转轴线的外周侧上的容器。

9. 发明申请

US20090016931A1 CHEMICAL ANALYSIS DEVICE 审中-公开
标题翻译：化学分析装置
公开(公告)号：US20090016931A1
公开(公告)日：2009-01-15
申请号：US12169968
申请日：2008-07-09
申请人： Taisaku Seino , Hiroshi Umetsu , Michihiro Saito , Takayuki Kanda , Kumiko Hattori
发明人： Taisaku Seino , Hiroshi Umetsu , Michihiro Saito , Takayuki Kanda , Kumiko Hattori
IPC分类号： G01N35/10 , B01L3/02
CPC分类号： G01N35/10 , B01L3/502 , G01N2035/103 , G01N2035/1051 , G01N2035/1062
摘要： A chemical analysis device capable of suppressing deterioration of analysis and test accuracy while avoiding contamination by residual samples or reagents and having no complicated configuration is constructed.A pipetting unit is equipped with a syringe, plunger, and needle unit in which a carrier for capturing nucleic acid and a detection cell is mounted on the needle unit. A pipetting unit drive system is configured so that the pipetting unit is detachable. After the detection cell is removed from the pipetting unit and fixed to a nucleic acid amplification detection unit, a suction/dispensing operation of samples/reagents is performed by the pipetting unit and components to be measured are captured by the carrier. Captured components are measured after being dispensed into the detection cell fixed to the nucleic acid amplification detection unit. Then, the detection cell is taken out from the nucleic acid amplification detection unit while mounted on the pipetting unit and the whole pipetting unit is removed from the pipetting unit drive system.
摘要翻译：能够抑制分析和测试精度恶化的化学分析装置，同时避免残留的样品或试剂的污染并且没有复杂的结构。移液单元配备有注射器，柱塞和针单元，其中用于捕获核酸的载体和检测单元安装在针单元上。移液单元驱动系统被构造成使得移液单元可拆卸。在从移液单元取出检测单元并固定在核酸扩增检测单元上之后，通过移液单元进行样品/试剂的抽吸/分注操作，由载体捕获要测量的成分。在分配到固定在核酸扩增检测单元上的检测单元之后，测量捕获的成分。然后，在安装在移液单元上的情况下，从核酸扩增检测单元取出检测单元，从移液单元驱动系统中取出整个移液单元。

10. 发明申请

US20110293473A1 AUTOMATIC ANALYZER 有权
标题翻译：自动分析仪
公开(公告)号：US20110293473A1
公开(公告)日：2011-12-01
申请号：US13145346
申请日：2009-12-14
申请人： Michihiro Saito
发明人： Michihiro Saito
IPC分类号： G01N21/76
CPC分类号： G01N21/6428 , G01N2021/6439 , G01N2035/0097
摘要： An analytic method uses a labeled antigen, labeled antibody, tracer, etc. in which a radio isotope, fluorescent dye, luminescent dye, enzyme, etc. is bonded to an antibody or an antigen bonded to a protein as an object of analysis for performing an assay of a trace amount of a substance such as a hormone, tumor marker, infective pathogen marker, infective antibody, etc., for blood, serum, plasma, or body fluid as a sample or specimen. The analysis is enabled at high sensitivity, with less generation of noises and at low background. When an assay is performed based on the antigen-antibody reaction for a sample in an analytic method by fluorometry or luminometry, detection or measurement of non-specific fluorescence or luminescence such as interference light is eliminated or removed effectively irrespective of the property of the sample or the level of the concentration of substances contained in the sample.
摘要翻译：分析方法使用标记的抗原，标记的抗体，示踪剂等，其中放射性同位素，荧光染料，发光染料，酶等与抗体或与蛋白质结合的抗原结合作为分析对象进行作为样品或样品的血液，血清，血浆或体液的微量物质如激素，肿瘤标志物，感染性病原体标志物，感染性抗体等的测定。该分析能够在高灵敏度下实现，噪声产生较少，背景较差。当通过荧光测定或发光测定法在分析方法中基于样品的抗原 - 抗体反应进行测定时，检测或测量非特异性荧光或发光如干涉光，无论样品的性质如何，均可有效地消除或去除或样品中所含物质的浓度水平。

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