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1. 发明申请

US20090259052A1 PROCESSES OF PRODUCING GLUTAMIC ACID COMPOUNDS AND PRODUCTION INTERMEDIATES THEREFORE AND NOVEL INTERMEDIATE FOR THE PROCESSES 有权
标题翻译：生产谷氨酸化合物的方法和生产过程中的中间体和中间体
公开(公告)号：US20090259052A1
公开(公告)日：2009-10-15
申请号：US12490024
申请日：2009-06-23
申请人： Shigeru KAWAHARA , Yusuke AMINO , Kenichi MORI , Nao FUNAKOSHI , Tadashi TAKEMOTO
发明人： Shigeru KAWAHARA , Yusuke AMINO , Kenichi MORI , Nao FUNAKOSHI , Tadashi TAKEMOTO
IPC分类号： C07D209/18 , C07C51/00
CPC分类号： C07D209/20 , A23L2/60 , A23L27/30 , A23L27/32 , C07C51/38 , C07C229/24 , C07C229/36 , C07D209/08 , C07D209/18 , C07C59/347
摘要： The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products.
摘要翻译：本发明涉及制备谷氨酸化合物的方法，例如莫纳甜，其可用作例如甜味剂或药物产品的生产中间体。

2. 发明申请

US20110189738A1 PROCESS FOR PRODUCING GLUTAMATE DERIVATIVES 审中-公开
标题翻译：生产谷氨酸衍生物的方法
公开(公告)号：US20110189738A1
公开(公告)日：2011-08-04
申请号：US13044618
申请日：2011-03-10
申请人： Masakazu SUGIYAMA , Kunihiko WATANABE , Nao FUNAKOSHI , Yusuke AMINO , Shigeru KAWAHARA , Tadashi TAKEMOTO
发明人： Masakazu SUGIYAMA , Kunihiko WATANABE , Nao FUNAKOSHI , Yusuke AMINO , Shigeru KAWAHARA , Tadashi TAKEMOTO
IPC分类号： C12P13/04
CPC分类号： C12P17/10 , C12N9/88 , C12P7/50 , C12P13/04 , C12P13/14
摘要： The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same.
摘要翻译：本发明涉及通过在式（2）的存在下将式（1）的取代的α-酮酸转化为式（2）的谷氨酸衍生物而有效地制备谷氨酸衍生物（包括其盐）如莫纳甜的方法催化其转化。

3. 发明申请

US20120295004A1 CRYSTALS OF NON-NATURAL-TYPE STEREOISOMER SALT OF MONATIN AND USE THEREOF 审中-公开
标题翻译：非天然类型立体异构体盐的晶体及其用途
公开(公告)号：US20120295004A1
公开(公告)日：2012-11-22
申请号：US13558870
申请日：2012-07-26
申请人： Yusuke AMINO , Kazuko Yuzawa , Kenichi Mori , Tadashi Takemoto
发明人： Yusuke AMINO , Kazuko Yuzawa , Kenichi Mori , Tadashi Takemoto
IPC分类号： A23L1/236 , A23L2/60 , C07D209/20
CPC分类号： C07D209/20 , A23L2/60 , A23L27/30 , A23L27/32
摘要： The present invention provides salt crystals of non-natural stereoisomer forms of monatin and to the use thereof.
摘要翻译：本发明提供了莫纳甜的非天然立体异构形式的盐晶体及其用途。

4. 发明申请

US20110189368A1 CRYSTALS OF NON-NATURAL-TYPE STEREOISOMER SALT OF MONATIN AND USE THEREOF 审中-公开
标题翻译：非天然类型立体异构体盐的晶体及其用途
公开(公告)号：US20110189368A1
公开(公告)日：2011-08-04
申请号：US13081024
申请日：2011-04-06
申请人： Yusuke AMINO , Kazuko YUZAWA , Kenichi MORI , Tadashi TAKEMOTO
发明人： Yusuke AMINO , Kazuko YUZAWA , Kenichi MORI , Tadashi TAKEMOTO
IPC分类号： A23L1/236 , C07D209/20 , A23L2/60
CPC分类号： C07D209/20 , A23L2/60 , A23L27/30 , A23L27/32
摘要： The present invention provides salt crystals of non-natural stereoisomer forms of monatin and to the use thereof.
摘要翻译：本发明提供了莫纳甜的非天然立体异构形式的盐晶体及其用途。

5. 发明申请

US20100010234A1 PROCESS FOR MANUFACTURING A GLUTAMIC ACID DERIVATIVE AND A PYROGLUTAMIC ACID DERIVATIVE AND A NOVEL INTERMEDIATE IN THE MANUFACTURE THEREOF 失效
标题翻译：制造谷氨酸衍生物和吡咯烷酸衍生物的方法及其制备中的新型中间体
公开(公告)号：US20100010234A1
公开(公告)日：2010-01-14
申请号：US12500135
申请日：2009-07-09
申请人： Yusuke AMINO
发明人： Yusuke AMINO
IPC分类号： C07D403/06 , C07D207/26 , C07F7/02
CPC分类号： C07D207/28 , C07C229/36 , Y02P20/55
摘要： Glutamic acid derivatives, in particular monatin, may be conveniently prepared by alkylating a 4-protected hydroxyl pyroglutamic acid derivative with an alkylating agent to prepare a 4-protected hydroxyl-4-alkylglutamic acid derivative, followed by the steps of hydrolysis and deprotection. The 4-protected hydroxyl pyroglutamic acid derivative is easy to produce from hydroxyproline. The 4-protected hydroxyl pyroglutamic acid derivative is particularly suitable for use in the efficient manufacture of monatin of high optical purity, since it can be alkylated selectively at the 4-position and stereoselectively and after its alkylation, it can easily be converted to a glutamic acid derivative.
摘要翻译：谷氨酸衍生物，特别是莫纳甜，可以通过用烷基化剂烷基化4-保护的羟基焦谷氨酸衍生物以制备4-保护的羟基-4-烷基谷氨酸衍生物，然后进行水解和脱保护的步骤，可以方便地制备。 4-保护的羟基焦谷氨酸衍生物很容易由羟脯氨酸生成。 4-保护的羟基焦谷氨酸衍生物特别适用于有效制备高光学纯度的莫纳甜，因为它可以在4-位选择性地立体选择性烷基化，烷基化后可容易地转化为谷氨酸酸衍生物。

6. 发明申请

US20100152291A1 PRODUCTION METHOD OF CAPSINOID BY DEHYDRATING CONDENSATION, STABILIZING METHOD OF CAPSINOID, AND CAPSINOID COMPOSITION 审中-公开
标题翻译：通过脱水凝结，卡泊霉素稳定化方法和卡皮苷组合物制备胶囊蛋白的生产方法
公开(公告)号：US20100152291A1
公开(公告)日：2010-06-17
申请号：US12711629
申请日：2010-02-24
申请人： Yusuke AMINO , Wataru Kurosawa , Takashi Nakano , Kazuko Hirasawa
发明人： Yusuke AMINO , Wataru Kurosawa , Takashi Nakano , Kazuko Hirasawa
IPC分类号： A61K31/23 , C12P7/64 , A61P3/00
CPC分类号： C07C67/62 , C12P7/62 , C12P7/6418 , C12P7/6436 , C07C69/28
摘要： Capsinoids of formula (3) may be conveniently prepared in a high yield, in a short time, without using a dehydrating agent by esterification of a fatty acid of formula (1) with a hydroxymethylphenol of formula (2) using an enzyme without a solvent or in a low-polar solvent. Addition of a fatty acid represented by formula (4) is effective for stabilizing the ester compound of formula (3). wherein each symbol is as defined in the specification.
摘要翻译：式（3）的类胡萝卜素可以在短时间内以高产率方便地制备，而不使用脱水剂，通过使用不含溶剂的酶将式（1）的脂肪酸与式（2）的羟甲基苯酚酯化或在低极性溶剂中。由式（4）表示的脂肪酸的加入对于稳定式（3）的酯化合物是有效的。其中每个符号如说明书中所定义。

7. 发明申请

US20080182894A1 METHOD OF PROVIDING PREPARATION FOR TOPICAL APPLICATION AND SUPPLEMENT MEETING CLIENT'S NEEDS 审中-公开
标题翻译：提供局部应用准备和补充会议客户需求的方法
公开(公告)号：US20080182894A1
公开(公告)日：2008-07-31
申请号：US12020791
申请日：2008-01-28
申请人： Yoshinobu TAKINO , Koichiro SAGAWA , Yusuke AMINO
发明人： Yoshinobu TAKINO , Koichiro SAGAWA , Yusuke AMINO
IPC分类号： A61K31/335 , A61K31/198 , G06F19/00 , A61K31/165
CPC分类号： A61K8/678 , A23L33/30 , A61K8/0212 , A61K8/97 , A61Q7/00 , A61Q19/00 , A61Q19/08
摘要： The present invention provides a method of efficiently providing, to a client, a preparation for topical application and a supplement suitable for the client. This method entails inputting the part desired by the client to be improved and an improvement effect desired for the part into a system, which will determine the composition of nutritional components of a preparation for topical application and a supplement that are suitable for the improvement effect desired for the part to be improved by referring to a database, in which compositions of nutritional components of supplements are registered in advance.
摘要翻译：本发明提供了一种向客户有效地提供用于局部应用的准备物和适合于客户的补充剂的方法。该方法需要输入要改进的客户期望的部分和将部分所需的改进效果进入系统，这将确定用于局部应用的制剂的营养成分的组成以及适合于所需改善效果的补充剂通过参照其中预先登记补充剂的营养成分的组成的数据库来改进该部分。

8. 发明申请

US20120070395A1 NOVEL AMIDE DERIVATIVE AND WHITENING AGENT 审中-公开
标题翻译：新颖的衍生和白色代理
公开(公告)号：US20120070395A1
公开(公告)日：2012-03-22
申请号：US13240358
申请日：2011-09-22
申请人： Yusuke AMINO , Yoshinobu TAKINO , Satoru OHASHI , Fumie OKURA , Megumi KANEKO
发明人： Yusuke AMINO , Yoshinobu TAKINO , Satoru OHASHI , Fumie OKURA , Megumi KANEKO
IPC分类号： A61K8/49 , A61Q19/02 , C07C235/34 , C07D209/14 , C07D405/12
CPC分类号： A61K8/492 , A61K8/42 , A61K8/49 , A61K31/4045 , A61Q19/02 , C07C235/34 , C07D209/14 , C07D209/20 , C07D209/32 , C07D405/12
摘要： Compound represented by formula (I): wherein the symbols are as defined in the description, and salts thereof, are useful as skin whitening agents.
摘要翻译：由式（I）表示的化合物：其中符号如说明书中所定义，及其盐可用作皮肤增白剂。

9. 发明申请

US20090203774A1 SUBSTITUTED BENZYL ESTER DERIVATIVE AND USE THEREOF 有权
标题翻译：取代苄基酯衍生物及其用途
公开(公告)号：US20090203774A1
公开(公告)日：2009-08-13
申请号：US12345249
申请日：2008-12-29
申请人： Yusuke AMINO , Yoshinobu Takino
发明人： Yusuke AMINO , Yoshinobu Takino
IPC分类号： A23L1/30 , A61K31/357 , A61K31/225 , C07D317/44 , C07C53/00 , C07C57/00
CPC分类号： C07D317/54 , A23L33/10 , A61K8/37 , A61K8/4973 , A61Q19/00 , C07C69/24 , C07C69/28 , C07C69/533 , C12P7/62
摘要： The present invention relates to a pharmaceutical composition, a food composition or a cosmetic composition, containing one or more kinds of a compound represented by the following formula (I′) wherein R1 is a hydrogen atom, a hydroxyl group, a methoxy group or an ethoxy group, R2 is a hydroxyl group, a methoxy group or an acetoxy group, or R1 and R2 in combination optionally form a methylenedioxy group, R is represented by the following formula wherein Y is an ethylene group or a vinylene group, m and n are each an integer of 0 to 7, which satisfy m+n=2 to 8, and R3 and R4 are each independently a hydrogen atom, a methyl group or an ethyl group, provided that, (1) when R1 is a methoxy group, then R2 is not a hydroxyl group; and (2) when R1 is a hydroxyl group, then R2 is not a hydroxyl group and an acetoxy group. According to the present invention, a stable capsinoid derivative is provided, and a pharmaceutical composition, a food composition, a cosmetic composition and the like containing the derivative as an active ingredient can be provided.
摘要翻译：本发明涉及含有一种或多种下式（I'）表示的化合物的药物组合物，食品组合物或化妆品组合物，其中R1是氢原子，羟基，甲氧基或乙氧基，R2是羟基，甲氧基或乙酰氧基，或者R1和R2组合任选地形成亚甲二氧基，R由下式表示，其中Y是亚乙基或亚乙烯基，m和n 各自为0〜7的整数，其满足m + n = 2〜8，R3和R4各自独立地为氢原子，甲基或乙基，条件是：（1）当R1为甲氧基，则R2不是羟基; 和（2）当R1是羟基时，R2不是羟基和乙酰氧基。根据本发明，提供稳定的类毒素衍生物，并且可以提供含有该衍生物作为有效成分的药物组合物，食品组合物，化妆品组合物等。

10. 发明申请

US20090170942A1 ESTER DERIVATIVE AND USE THEREOF 有权
标题翻译：雌激素衍生物及其用途
公开(公告)号：US20090170942A1
公开(公告)日：2009-07-02
申请号：US12237142
申请日：2008-09-24
申请人： Yusuke AMINO , Yoshinobu Takino
发明人： Yusuke AMINO , Yoshinobu Takino
IPC分类号： A61K31/23 , C07C53/00 , A61P7/00
CPC分类号： C07C69/28 , A23L33/10 , A61K8/37 , A61Q19/00 , C07C69/533 , C07C69/734
摘要： A compound represented by the following formula (I′) wherein X1 is a methylene group, an ethylene group, a trimethylene group or a vinylene group, X2 is a divalent group represented by the following formula A or B, Y is an ethylene group or a vinylene group, m and n are each an integer of 0 to 7, which satisfy m+n=0 to 8, R1 and R2 are each independently a hydrogen atom, a methyl group or an ethyl group, provided that when X1 is a methylene group, then X2 is not a divalent group represented by the formula A, and when X1 is a vinylene group, then X2 is not a divalent group represented by the formula A. The compound is a stable capsinoid derivative, and is useful as an active ingredient of an external blood circulation enhancer or a cosmetic composition, a pharmaceutical composition, or a food composition.
摘要翻译：由下式（I'）表示的化合物，其中X1是亚甲基，亚乙基，三亚甲基或亚乙烯基，X2是由下式A或B表示的二价基团，Y是亚乙基或亚乙烯基，m和n各自为0〜7的整数，其满足m + n = 0〜8，R1和R2各自独立地为氢原子，甲基或乙基，条件是当X1为亚甲基，则X2不是由式A表示的二价基团，当X1是亚乙烯基时，X2不是由式A表示的二价基团。化合物是稳定的类毒素衍生物，可用作外部血液循环增强剂或化妆品组合物的活性成分，药物组合物或食品组合物。

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