专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08043836B2 Process for producing amino acid derivative from hydroxyimino acid 失效
标题翻译：从羟肟酸生产氨基酸衍生物的方法
公开(公告)号：US08043836B2
公开(公告)日：2011-10-25
申请号：US11576421
申请日：2005-09-29
申请人： Masakazu Sugiyama , Kunihiko Watanabe , Tadashi Takemoto , Kenichi Mori
发明人： Masakazu Sugiyama , Kunihiko Watanabe , Tadashi Takemoto , Kenichi Mori
IPC分类号： C12P1/00 , C12P13/04 , C12P13/22 , C12P17/10 , C07D209/18
CPC分类号： C12P13/227 , C12P13/04 , C12R1/01 , C12R1/185 , C12R1/19
摘要： The present invention is to provide an industrially advantageous method for producing an amino acid derivative. Provided is a method for producing an amino acid derivative including contacting a microorganism and/or an enzyme with a hydroxyimino acid represented by the following general formula (I): wherein R1 represents an optionally substituted predetermined hydrocarbon group; R2 represents a C1 to C3 alkyl group or a hydrogen atom; and n is 0 or 1, to produce an amino acid derivative represented by the following general formula (III): wherein R1 and n have the same meanings as those of R1 and n in the general formula (I), wherein the microorganism and/or the enzyme is capable of catalyzing the reaction.
摘要翻译：本发明提供一种工业上有利的氨基酸衍生物的制备方法。本发明提供一种生产氨基酸衍生物的方法，其包括使微生物和/或酶与由以下通式（I）表示的肟基酸接触：其中R1表示任选取代的预定烃基; R2表示C1〜C3烷基或氢原子; 和n为0或1，以产生由以下通式（III）表示的氨基酸衍生物：其中R 1和n与通式（I）中的R 1和n的含义相同，其中微生物和/ 或者酶能够催化反应。

2. 发明申请

US20110189738A1 PROCESS FOR PRODUCING GLUTAMATE DERIVATIVES 审中-公开
标题翻译：生产谷氨酸衍生物的方法
公开(公告)号：US20110189738A1
公开(公告)日：2011-08-04
申请号：US13044618
申请日：2011-03-10
申请人： Masakazu SUGIYAMA , Kunihiko WATANABE , Nao FUNAKOSHI , Yusuke AMINO , Shigeru KAWAHARA , Tadashi TAKEMOTO
发明人： Masakazu SUGIYAMA , Kunihiko WATANABE , Nao FUNAKOSHI , Yusuke AMINO , Shigeru KAWAHARA , Tadashi TAKEMOTO
IPC分类号： C12P13/04
CPC分类号： C12P17/10 , C12N9/88 , C12P7/50 , C12P13/04 , C12P13/14
摘要： The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same.
摘要翻译：本发明涉及通过在式（2）的存在下将式（1）的取代的α-酮酸转化为式（2）的谷氨酸衍生物而有效地制备谷氨酸衍生物（包括其盐）如莫纳甜的方法催化其转化。

3. 发明申请

US20100323411A1 PROCESS OF PRODUCING GLUTAMATE DERIVATIVES 失效
标题翻译：生产谷氨酸衍生物的方法
公开(公告)号：US20100323411A1
公开(公告)日：2010-12-23
申请号：US12853844
申请日：2010-08-10
申请人： MASAKAZU SUGIYAMA , KUNIHIKO WATANABE , NAO FUNAKOSHI , YUSUKE AMINO , SHIGERU KAWAHARA , TADASHI TAKEMOTO
发明人： MASAKAZU SUGIYAMA , KUNIHIKO WATANABE , NAO FUNAKOSHI , YUSUKE AMINO , SHIGERU KAWAHARA , TADASHI TAKEMOTO
IPC分类号： C12P17/10
CPC分类号： C12P17/10 , C12N9/88 , C12P7/50 , C12P13/04 , C12P13/14
摘要： The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same.
摘要翻译：本发明涉及通过在式（2）的存在下将式（1）的取代的α-酮酸转化为式（2）的谷氨酸衍生物而有效地制备谷氨酸衍生物（包括其盐）如莫纳甜的方法催化其转化。

4. 发明授权

US07795296B2 Crystals of non-natural-type stereoisomer salt of monatin and use thereof 有权
标题翻译：莫纳甜的非天然型立体异构体盐的晶体及其用途
公开(公告)号：US07795296B2
公开(公告)日：2010-09-14
申请号：US10856756
申请日：2004-06-01
申请人： Yusuke Amino , Kazuko Yuzawa , Kenichi Mori , Tadashi Takemoto
发明人： Yusuke Amino , Kazuko Yuzawa , Kenichi Mori , Tadashi Takemoto
IPC分类号： A61K31/40 , C07D209/18
CPC分类号： C07D209/20 , A23L2/60 , A23L27/30 , A23L27/32
摘要： The present invention provides salt crystals of non-natural stereoisomer forms of monatin and to the use thereof.
摘要翻译：本发明提供了莫纳甜的非天然立体异构形式的盐晶体及其用途。

5. 发明授权

US07297800B2 Process of producing glutamate derivatives 失效
标题翻译：生产谷氨酸衍生物的方法
公开(公告)号：US07297800B2
公开(公告)日：2007-11-20
申请号：US10876468
申请日：2004-06-28
申请人： Masakazu Sugiyama , Kunihiko Watanabe , Nao Funakoshi , Yusuke Amino , Shigeru Kawahara , Tadashi Takemoto
发明人： Masakazu Sugiyama , Kunihiko Watanabe , Nao Funakoshi , Yusuke Amino , Shigeru Kawahara , Tadashi Takemoto
IPC分类号： C07D209/00 , C12P17/00
CPC分类号： C12P17/10 , C12N9/88 , C12P7/50 , C12P13/04 , C12P13/14
摘要： The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same
摘要翻译：本发明涉及通过在式（2）的存在下将式（1）的取代的α-酮酸转化为式（2）的谷氨酸衍生物而有效地生产谷氨酸衍生物（包括其盐）的莫纳甜的方法催化其转化

6. 发明授权

US07141263B2 Process for producing cinnamaldehyde derivatives, use thereof and the like 有权
标题翻译：制备肉桂醛衍生物的方法及其用途等
公开(公告)号：US07141263B2
公开(公告)日：2006-11-28
申请号：US11154658
申请日：2005-06-17
申请人： Kenichi Mori , Shinji Fujita , Nao Funakoshi , Tadashi Takemoto
发明人： Kenichi Mori , Shinji Fujita , Nao Funakoshi , Tadashi Takemoto
IPC分类号： A23L1/236 , C07C229/00
CPC分类号： C07C45/62 , C07C45/73 , C07C45/74 , C07C47/277 , C07K5/06113 , C07C47/27
摘要： A process for conveniently and efficiently producing a highly pure cinnamaldehyde derivative, for example, (2E)-(3-hydroxy-4-methoxy)cinnamaldehyde, which comprises reacting a benzaldehyde derivative, such as isovanillin and the like, with acetaldehyde in the presence of an alkali, in particular preferably, dropping acetaldehyde little by little thereto in an aqueous solution at a low temperature for the reaction thereof. The cinnamaldehyde derivative thus obtained is selectively reduced to produce 3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl)propionaldehyde. Further, through a reductive alkylation reaction of the compound thus produced with an aspartame, N-[N-[3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl)propyl]-L-aspartyl]-L-phenylalanine 1-methyl ester, which is useful as a sweetener having a high sweetening potency, can be industrially and efficiently produced. The processes therefor are also provided.
摘要翻译：方便有效地制备高纯度肉桂醛衍生物的方法，例如（2E） - （3-羟基-4-甲氧基）肉桂醛，其包括使苯甲醛衍生物如异喹啉腈等与乙醛在存在下反应的碱，特别优选在低温下在水溶液中逐滴滴加乙醛进行反应。由此得到的肉桂醛衍生物被选择性地还原以产生3-（3-羟基-4-取代的（与甲氧基等）苯基）丙醛。此外，通过如此制备的化合物与天冬甜素的还原烷基化反应，N- [N- [3-（3-羟基-4-取代的（与甲氧基等）苯基）丙基] -L-天冬氨酰基] - 作为具有高甜味效力的甜味剂可用的L-苯丙氨酸1-甲酯可以在工业上有效地生产。还提供了其工艺。

7. 发明授权

US07064219B2 Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes 失效
公开(公告)号：US07064219B2
公开(公告)日：2006-06-20
申请号：US10872573
申请日：2004-06-22
申请人： Shigeru Kawahara , Yusuke Amino , Kenichi Mori , Nao Funakoshi , Tadashi Takemoto
发明人： Shigeru Kawahara , Yusuke Amino , Kenichi Mori , Nao Funakoshi , Tadashi Takemoto
IPC分类号： C07D209/18
CPC分类号： C07D209/20 , A23L2/60 , A23L27/30 , A23L27/32 , C07C51/38 , C07C229/24 , C07C229/36 , C07D209/08 , C07D209/18 , C07C59/347
摘要： The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products.

8. 发明申请

US20060074249A1 Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes 失效
标题翻译：因此生产谷氨酸化合物和生产中间体的过程和新工艺的中间体
公开(公告)号：US20060074249A1
公开(公告)日：2006-04-06
申请号：US11283943
申请日：2005-11-22
申请人： Shigeru Kawahara , Yusuke Amino , Kenichi Mori , Nao Funakoshi , Tadashi Takemoto
发明人： Shigeru Kawahara , Yusuke Amino , Kenichi Mori , Nao Funakoshi , Tadashi Takemoto
IPC分类号： C07D209/18 , C07C229/22
CPC分类号： C07D209/20 , A23L2/60 , A23L27/30 , A23L27/32 , C07C51/38 , C07C229/24 , C07C229/36 , C07D209/08 , C07D209/18 , C07C59/347
摘要： The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products.
摘要翻译：本发明涉及制备谷氨酸化合物的方法，例如莫纳甜，其可用作例如甜味剂或药物产品的生产中间体。

9. 发明申请

US20060014819A1 Crystal of (2R,4R)-monatin potassium salt and sweetener composition containing same 失效
公开(公告)号：US20060014819A1
公开(公告)日：2006-01-19
申请号：US11180622
申请日：2005-07-14
申请人： Ken-ichi Mori , Eriko Ono , Tadashi Takemoto
发明人： Ken-ichi Mori , Eriko Ono , Tadashi Takemoto
IPC分类号： A61K31/405 , C07D209/18
CPC分类号： C07D209/20
摘要： Crystals of (2R,4R)-monatin potassium salt which exhibit an X-ray powder diffraction pattern having characteristic peaks at diffraction angles 2θ of 5.5°, 7.2°, 8.1°, 8.9°, and 16.3°, by powder X-ray diffraction (Cu—Kα radiation), are superior in sweetness, preservation stability, solubility, and color stability.

10. 发明授权

US06965055B2 Process for producing cinnamaldehyde derivatives, use thereof and the like 有权
标题翻译：制备肉桂醛衍生物的方法及其用途等
公开(公告)号：US06965055B2
公开(公告)日：2005-11-15
申请号：US10295997
申请日：2002-11-18
申请人： Kenichi Mori , Shinji Fujita , Nao Funakoshi , Tadashi Takemoto
发明人： Kenichi Mori , Shinji Fujita , Nao Funakoshi , Tadashi Takemoto
IPC分类号： A23L27/30 , C07C45/62 , C07C45/73 , C07C45/74 , C07C47/277 , C07K5/072 , C07K5/075 , C07C45/72
CPC分类号： C07C45/62 , C07C45/73 , C07C45/74 , C07C47/277 , C07K5/06113 , C07C47/27
摘要： A process for conveniently and efficiently producing a highly pure cinnamaldehyde derivative, for example, (2E)-(3-hydroxy-4-methoxy)cinnamaldehyde, which comprises reacting a benzaldehyde derivative, such as isovanillin and the like, with acetaldehyde in the presence of an alkali, in particular preferably, dropping acetaldehyde little by little thereto in an aqueous solution at a low temperature for the reaction thereof. The cinnamaldehyde derivative thus obtained is selectively reduced to produce 3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl) propionaldehyde. Further, through a reductive alkylation reaction of the compound thus produced with an aspartame, N-[N-[3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl) propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester, which is useful as a sweetener having a high sweetening potency, can be industrially and efficiently produced. The processes therefor are also provided.
摘要翻译：方便有效地制备高纯度肉桂醛衍生物的方法，例如（2E） - （3-羟基-4-甲氧基）肉桂醛，其包括使苯甲醛衍生物如异喹啉腈等与乙醛在存在下反应的碱，特别优选在低温下在水溶液中逐滴滴加乙醛进行反应。由此得到的肉桂醛衍生物被选择性地还原以产生3-（3-羟基-4-取代的（与甲氧基等）苯基）丙醛。此外，通过如此制备的化合物与天冬甜素的还原性烷基化反应，N- [N- [3-（3-羟基-4-取代的（与甲氧基等）苯基）丙基] -L-α-天冬氨酰基 ] -L-苯丙氨酸1-甲酯，其可用作具有高甜味效力的甜味剂，可以在工业上有效地制备。还提供了其工艺。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式