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1. 发明授权

US10369570B2 Microfluidic device with droplet pre-charge on input 有权
公开(公告)号：US10369570B2
公开(公告)日：2019-08-06
申请号：US15661609
申请日：2017-07-27
申请人： Sharp Life Science (EU) Limited , SHARP KABUSHIKI KAISHA
发明人： Benjamin James Hadwen , Sinéad Matthews , Lesley Anne Parry-Jones , Adam Robinson , Tomohiro Kosaka , Takeshi Hara , Tomoko Teranishi
IPC分类号： B01L3/00 , B01L3/02
摘要： An EWOD device includes opposing substrates defining a gap and each including an insulating surface facing the gap. Array elements include electrode elements to which actuation voltages are applied. A pre-charging structure defines a channel in fluid communication with the gap wherein the channel receives an input of a fluid reservoir for generation of the liquid droplet, and the pre-charging structure includes an electrical element electrically exposed to the channel. The electrical element pre-charges the fluid reservoir within the channel, and a portion of the gap containing the liquid droplet spaced apart from the channel is electrically isolated from the electrical element such that the liquid droplet is at a floating electrical potential when located within said portion of the gap. The electrical element may be an electrode portion that is exposed to the channel, or an externally connected pre-charging element inserted into the channel.

2. 发明授权

US09662651B2 Active matrix device and method of driving the same 有权
公开(公告)号：US09662651B2
公开(公告)日：2017-05-30
申请号：US14620407
申请日：2015-02-12
申请人： Sharp Kabushiki Kaisha
发明人： Benjamin James Hadwen
IPC分类号： B01L3/00 , G01N27/447 , G02B26/00 , G01N27/416 , G01R31/12 , G06F3/041
CPC分类号： B01L3/502792 , B01L3/502707 , B01L3/50273 , B01L2200/10 , B01L2200/143 , B01L2200/148 , B01L2300/024 , B01L2300/0816 , B01L2300/0819 , B01L2400/0421 , B01L2400/0427 , G01N27/4163 , G01N27/44791 , G02B26/005 , G06F3/0412
摘要： An active matrix electrowetting on dielectric (AM-EWOD) device includes a plurality of array elements configured to manipulate one or more droplets of fluid on an array, each of the array elements including a corresponding array element circuit. Each array element circuit includes a top substrate electrode and a drive electrode between which the one or more droplets may be positioned, with an insulator layer being interposed between the one or more droplets and the drive electrode; and write circuitry configured to write data to the array element. At least some of the array element circuits include measure circuitry configured to detect a pinhole defect in the insulator layer.

3. 发明申请

US20170056887A1 DROPLET MICROFLUIDIC DEVICE AND METHODS OF SENSING THE RESULTS OF AN ASSAY THEREIN 审中-公开
标题翻译：滴眼液微流体装置及其测定结果的方法
公开(公告)号：US20170056887A1
公开(公告)日：2017-03-02
申请号：US14838797
申请日：2015-08-28
申请人： Sharp Kabushiki Kaisha , ASSOCIATES OF CAPE COD INCORPORATED
发明人： Benjamin James Hadwen , Adrian Marc Simon Jacobs , Jason Roderick Hector , Michael James Brownlow , Masahiro Adachi , Alison Mary Skinner , Mark Childs
IPC分类号： B01L3/00
CPC分类号： B01L3/502792 , B01L2300/0645 , B01L2300/0816 , B01L2300/0887 , B01L2400/0427 , G01N33/579
摘要： A method of determining the result of an assay in a microfluidic device includes the steps of: dispensing a sample droplet onto a first portion of an electrode array of the microfluidic device; dispensing a reagent droplet onto a second portion of the electrode array of the microfluidic device; controlling actuation voltages applied to the electrode array to mix the sample droplet and the reagent droplet into a product droplet; sensing a dynamic property of the product droplet; and determining an assay of the sample droplet based on the sensed dynamic property. The dynamic property is a physical property of the product droplet that influences a transport property of the product droplet on the electrode array. Example dynamic properties of the product droplet include the moveable state, split-able state, and viscosity based on droplet properties. The method may be used to perform an amoebocyte lysate (LAL) assay.
摘要翻译：确定微流体装置中的测定结果的方法包括以下步骤：将样品液滴分配到微流体装置的电极阵列的第一部分上; 将试剂液滴分配到微流体装置的电极阵列的第二部分上; 控制施加到电极阵列的致动电压以将样品液滴和试剂液滴混合成产物液滴; 感测产品液滴的动态特性; 以及基于所感测的动态特性来确定样品液滴的测定。动态特性是影响产品液滴在电极阵列上的传输特性的产物液滴的物理性质。产品液滴的示例动态特性包括基于液滴性质的可移动状态，可分离状态和粘度。该方法可用于进行变形细胞裂解物（LAL）测定。

4. 发明申请

US20160305906A1 MULTIFUNCTION ELECTRODE WITH COMBINED HEATING AND EWOD DRIVE FUNCTIONALITY 有权
标题翻译：具有组合加热和EWOD驱动功能的多功能电极
公开(公告)号：US20160305906A1
公开(公告)日：2016-10-20
申请号：US14686833
申请日：2015-04-15
申请人： Sharp Kabushiki Kaisha
发明人： Robert Julian Amos , Benjamin James Hadwen , Adrian Marc Simon Jacobs , Emma Jayne Walton , Christopher James Brown , Jonathan Buse
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , B01L3/502792 , B01L7/52 , B01L2200/147 , B01L2300/024 , B01L2300/0809 , B01L2300/1827 , G01N27/44704
摘要： An EWOD (or AM-EWOD) device includes a reference electrode and a plurality of array elements, each array element including an array element electrode, and control electronics. In a first mode optimized for EWOD actuation, the control electronics is configured to control a supply of time varying voltages to the array element electrodes and the reference electrode, thereby generating an actuation voltage as a potential difference between voltages at the array element electrodes and the reference electrode. The reference electrode includes a first electrical connection and a second electrical connection. In a second mode, the control electronics further is configured to supply an electrical current flow between the first electrical connection and the second electrical connection to generate resistance heat for controlling temperature of the EWOD device. Control may include sensing a temperature of the EWOD device, and switching between operating in the first or second mode based on the sensed temperature.
摘要翻译： EWOD（或AM-EWOD）装置包括参考电极和多个阵列元件，每个阵列元件包括阵列元件电极和控制电子器件。在针对EWOD致动优化的第一模式中，控制电子器件被配置为控制向阵列元件电极和参考电极提供时变电压，由此产生作为阵列元件电极和参比电极。参考电极包括第一电连接和第二电连接。在第二模式中，控制电子器件还被配置为在第一电连接和第二电连接之间提供电流，以产生用于控制EWOD装置的温度的电阻热。控制可以包括感测EWOD设备的温度，以及基于所感测的温度在第一或第二模式之间切换。

5. 发明授权

US09169573B2 AM-EWOD device and method of driving with variable voltage AC driving 有权
标题翻译： AM-EWOD装置及采用可变电压交流驱动的方法
公开(公告)号：US09169573B2
公开(公告)日：2015-10-27
申请号：US13747597
申请日：2013-01-23
申请人： SHARP KABUSHIKI KAISHA
发明人： Benjamin James Hadwen
IPC分类号： C25B15/00 , B01L3/00 , G09G3/34
CPC分类号： C25B15/00 , B01L3/502792 , B01L2200/0673 , B01L2300/0645 , B01L2300/0816 , B01L2300/089 , B01L2300/161 , B01L2400/0427 , G09G3/348 , G09G2230/00 , G09G2300/0819 , G09G2300/0857 , G09G2320/0693
摘要： An active matrix electrowetting on dielectric (AM-EWOD) device includes a substrate electrode and a plurality of array elements, each array element including an array element electrode. The AM-EWOD device further includes thin film electronics disposed on a substrate. The thin film electronics includes first circuitry configured to supply a first time varying signal V1 to the array element electrodes, and second circuitry configured to supply a second time varying signal V2 to the substrate electrode. An actuation voltage is defined by a potential difference between V2 and V1, and the first circuitry further is configured to adjust the amplitude of V1 to adjust the actuation voltage. V1 may be adjusted to adjust the actuation voltage while V2 remains unchanged. The actuation voltage may be controlled to operate the AM-EWOD device between high and low voltage modes of operation in accordance with different droplet manipulation operations to be performed.
摘要翻译：在电介质（AM-EWOD）器件上的有源矩阵电润湿包括衬底电极和多个阵列元件，每个阵列元件包括阵列元件电极。 AM-EWOD装置还包括设置在基板上的薄膜电子设备。薄膜电子器件包括被配置为向阵列元件电极提供第一时变信号V1的第一电路，以及被配置为向衬底电极提供第二时变信号V2的第二电路。驱动电压由V2和V1之间的电位差定义，并且第一电路还被配置为调整V1的振幅以调节致动电压。 V1可以被调节以调节致动电压，而V2保持不变。可以根据要执行的不同的液滴操作操作来控制致动电压以在高压和低压操作模式之间操作AM-EWOD装置。

6. 发明申请

US20170076676A1 ACTIVE MATRIX DEVICE AND METHOD OF DRIVING 审中-公开
标题翻译：主动矩阵装置及其驱动方法
公开(公告)号：US20170076676A1
公开(公告)日：2017-03-16
申请号：US14854607
申请日：2015-09-15
申请人： Sharp Kabushiki Kaisha
发明人： Benjamin James Hadwen
IPC分类号： G09G3/34 , G02B26/00
CPC分类号： G09G3/348 , B01L3/50273 , G02B26/005 , G09G2300/0421 , G09G2310/0208 , G09G2310/0294 , G09G2310/062 , G09G2320/0295
摘要： An active matrix electro-wetting on dielectric (AM-EWOD) device includes a plurality of array elements arranged in an array, each of the array elements including array element circuitry, an element electrode, and a reference electrode. The array element circuitry includes an actuation circuit configured to apply actuation voltages to the electrodes, and an impedance sensor circuit configured to sense impedance at the array element electrode to determine a droplet property at the array element. The impedance sensor circuit is operated by perturbing a potential applied to the reference electrode. The AM-EWOD device includes a common row addressing line. The impedance sensor circuit further is operated by supplying voltage signals over the common addressing line to effect both a reset operation and an operation for selecting a row in the array to be sensed. The circuitry isolates the array element from the actuation voltage during operating the impedance sensor circuit.
摘要翻译：在电介质（AM-EWOD）器件上的有源矩阵电润湿包括排列成阵列的多个阵列元件，每个阵列元件包括阵列元件电路，元件电极和参考电极。阵列元件电路包括被配置为向电极施加致动电压的致动电路，以及被配置为感测阵列元件电极处的阻抗以确定阵列元件处的液滴特性的阻抗传感器电路。通过扰乱施加到参考电极的电位来操作阻抗传感器电路。 AM-EWOD设备包括公共行寻址行。阻抗传感器电路进一步通过在公共寻址线上提供电压信号来进行操作，以实现复位操作和用于选择要感测的阵列中的行的操作。在操作阻抗传感器电路期间，电路将阵列元件与致动电压隔离。

7. 发明申请

US20140202863A1 AM-EWOD DEVICE AND METHOD OF DRIVING WITH VARIABLE VOLTAGE AC DRIVING 有权
标题翻译： AM-EWOD设备和使用可变电压交流驱动的方法
公开(公告)号：US20140202863A1
公开(公告)日：2014-07-24
申请号：US13747597
申请日：2013-01-23
申请人： SHARP KABUSHIKI KAISHA
发明人： Benjamin James Hadwen
IPC分类号： C25B15/00
CPC分类号： C25B15/00 , B01L3/502792 , B01L2200/0673 , B01L2300/0645 , B01L2300/0816 , B01L2300/089 , B01L2300/161 , B01L2400/0427 , G09G3/348 , G09G2230/00 , G09G2300/0819 , G09G2300/0857 , G09G2320/0693
摘要： An active matrix electrowetting on dielectric (AM-EWOD) device includes a substrate electrode and a plurality of array elements, each array element including an array element electrode. The AM-EWOD device further includes thin film electronics disposed on a substrate. The thin film electronics includes first circuitry configured to supply a first time varying signal V1 to the array element electrodes, and second circuitry configured to supply a second time varying signal V2 to the substrate electrode. An actuation voltage is defined by a potential difference between V2 and V1, and the first circuitry further is configured to adjust the amplitude of V1 to adjust the actuation voltage. V1 may be adjusted to adjust the actuation voltage while V2 remains unchanged. The actuation voltage may be controlled to operate the AM-EWOD device between high and low voltage modes of operation in accordance with different droplet manipulation operations to be performed.
摘要翻译：在电介质（AM-EWOD）器件上的有源矩阵电润湿包括衬底电极和多个阵列元件，每个阵列元件包括阵列元件电极。 AM-EWOD装置还包括设置在基板上的薄膜电子设备。薄膜电子器件包括被配置为向阵列元件电极提供第一时变信号V1的第一电路，以及被配置为向衬底电极提供第二时变信号V2的第二电路。驱动电压由V2和V1之间的电位差定义，并且第一电路还被配置为调整V1的振幅以调节致动电压。 V1可以被调节以调节致动电压，而V2保持不变。可以根据要执行的不同的液滴操作操作来控制致动电压以在高压和低压操作模式之间操作AM-EWOD装置。

8. 发明申请

US20190030537A1 MICROFLUIDIC DEVICE WITH DROPLET PRE-CHARGE ON INPUT 审中-公开
公开(公告)号：US20190030537A1
公开(公告)日：2019-01-31
申请号：US15661609
申请日：2017-07-27
申请人： Sharp Life Science (EU) Limited , SHARP KABUSHIKI KAISHA
发明人： Benjamin James Hadwen , Sinéad Matthews , Lesley Ann PARRY-JONES , Adam Robinson , Tomohiro KOSAKA , Takeshi HARA , Tomoko TERANISHI
IPC分类号： B01L3/00
CPC分类号： B01L3/502784 , B01L3/0241 , B01L3/502715 , B01L3/50273 , B01L3/502792 , B01L2200/027 , B01L2200/0642 , B01L2200/0673 , B01L2200/12 , B01L2300/0819 , B01L2300/0887 , B01L2300/089 , B01L2300/161 , B01L2400/0415 , B01L2400/0421 , B01L2400/0427
摘要： An EWOD device includes opposing substrates defining a gap and each including an insulating surface facing the gap. Array elements include electrode elements to which actuation voltages are applied. A pre-charging structure defines a channel in fluid communication with the gap wherein the channel receives an input of a fluid reservoir for generation of the liquid droplet, and the pre-charging structure includes an electrical element electrically exposed to the channel. The electrical element pre-charges the fluid reservoir within the channel, and a portion of the gap containing the liquid droplet spaced apart from the channel is electrically isolated from the electrical element such that the liquid droplet is at a floating electrical potential when located within said portion of the gap. The electrical element may be an electrode portion that is exposed to the channel, or an externally connected pre-charging element inserted into the channel.

9. 发明申请

US20170059523A1 DROPLET MICROFLUIDIC DEVICE AND METHODS OF SENSING THE RESULTS OF AN ASSAY THEREIN 审中-公开
公开(公告)号：US20170059523A1
公开(公告)日：2017-03-02
申请号：US14838781
申请日：2015-08-28
申请人： Sharp Kabushiki Kaisha
发明人： Benjamin James Hadwen , Adrian Marc Simon Jacobs , Jason Roderick Hector , Michael James Brownlow , Masahiro Adachi , Alison Mary Skinner , Mark Childs
IPC分类号： G01N27/447 , C12Q1/68 , G01N33/49 , B01L3/00
CPC分类号： G01N33/4905 , B01L3/502792 , B01L2200/14 , B01L2200/148 , B01L2300/0645 , B01L2300/0819 , B01L2300/1822 , B01L2400/0427 , B01L2400/0677 , C12Q1/6816 , C12Q1/6844 , G01N30/6095 , G01N33/579 , G01N2030/8813 , C12Q2563/116 , C12Q2563/159 , C12Q2565/607 , C12Q2565/629
摘要： A method of determining the result of an assay in a microfluidic device includes the steps of: dispensing a sample droplet onto a first portion of an electrode array of the microfluidic device; dispensing a reagent droplet onto a second portion of the electrode array of the microfluidic device; controlling actuation voltages applied to the electrode array to mix the sample droplet and the reagent droplet into a product droplet; sensing a dynamic property of the product droplet; and determining an assay of the sample droplet based on the sensed dynamic property. The dynamic property is a physical property of the product droplet that influences a transport property of the product droplet on the electrode array. Example dynamic properties of the product droplet include the moveable state, split-able state, and viscosity based on droplet properties. The method may be used to perform an amoebocyte lysate (LAL) assay.

10. 发明授权

US09539573B1 EWOD device with calibrated serial dilution function 有权
标题翻译： EWOD设备具有校准的串行稀释功能
公开(公告)号：US09539573B1
公开(公告)日：2017-01-10
申请号：US14747177
申请日：2015-06-23
申请人： Sharp Kabushiki Kaisha
发明人： Benjamin James Hadwen , Christopher James Brown , Julie Karen Deacon
IPC分类号： B01L3/00 , G01N27/02 , G01N27/22 , G01N27/447
CPC分类号： G01N27/44791 , B01F13/0071 , B01F13/0076 , B01F2003/0896 , B01L3/502792
摘要： In a method of performing dilution of a droplet in an EWOD device, a parent droplet is provided on an electrode array of the EWOD device, wherein the parent droplet has a first concentration of a species. A diluent droplet also is provided on the electrode array of the EWOD device. The method includes controlling actuation voltages applied to the electrode array of the EWOD device to join the parent droplet and the diluent droplet into a product droplet having a diluted second concentration of the species different from the first concentration in the parent droplet. The actuation voltages then are controlled to split the product droplet into one or more daughter droplets having the second concentration of the species. A dilution ratio may be calibrated based on the volumes of the droplets. Serial dilution steps may be performed to generate daughter droplets of different species concentrations at each step.
摘要翻译：在EWOD装置中进行液滴稀释的方法中，在EWOD装置的电极阵列上提供母液滴，其中母液滴具有物种的第一浓度。还在EWOD装置的电极阵列上提供稀释液滴。该方法包括控制施加到EWOD装置的电极阵列的致动电压，以将母液滴和稀释液液滴接合到具有与母液中第一浓度不同的稀释的第二浓度的产物液滴中。然后控制致动电压以将产品液滴分成具有该物质的第二浓度的一个或多个子液滴。可以基于液滴的体积校准稀释比。可以进行串行稀释步骤以在每个步骤产生不同物种浓度的子液滴。

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