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1. 发明授权

US07288075B2 Methods and devices utilizing rheological materials 失效
标题翻译：使用流变材料的方法和装置
公开(公告)号：US07288075B2
公开(公告)日：2007-10-30
申请号：US10183072
申请日：2002-06-27
申请人： Shailendra K. Parihar , Thomas P. Ryan , Timothy Dietz , Parris S. Wellman , Kevin S. Weadock , T. Anh Le , Peter Douglas , Simon Cohn , Daniel Gordon , Rajesh Pendekanti , Raghuveer Basude , Robert S. Casar , Howard A. Stone
发明人： Shailendra K. Parihar , Thomas P. Ryan , Timothy Dietz , Parris S. Wellman , Kevin S. Weadock , T. Anh Le , Peter Douglas , Simon Cohn , Daniel Gordon , Rajesh Pendekanti , Raghuveer Basude , Robert S. Casar , Howard A. Stone
IPC分类号： A61B5/103 , A61B5/117 , A61B5/00 , A61C19/00 , A61C9/00 , A61C5/04 , A61C19/04
CPC分类号： A61B17/29 , A43B3/0005 , A43B7/146 , A43B7/28 , A61B17/02 , A61B17/32053 , A61B17/62 , A61B18/1492 , A61B2017/003 , A61B2017/00398 , A61B2017/0243 , A61B2017/2905 , A61B2017/2939 , A61C9/00 , A61C9/0013 , F16F13/30 , H04R25/558 , H04R25/652 , H04R25/658
摘要： Impression devices are provided for making an impression of a desired feature. The impression devices include: a flexible bladder having a cavity formed therein, the flexible bladder being capable of conforming to the details of the desired feature; a rheological material, such as a magnetorheological fluid, disposed in the cavity of the flexible bladder; and an activator for applying an external stimulus to the rheological material to change the state of the rheological material and thereby capture an impression of the desired feature.
摘要翻译：提供了印象设备，用于产生所需功能的印象。压印装置包括：柔性气囊，其中形成有空腔，柔性气囊能够符合所需特征的细节; 设置在柔性气囊的空腔中的流变材料，例如磁流变流体; 以及用于将外部刺激施加到流变材料以改变流变材料的状态并由此捕获所需特征的印象的激活剂。

2. 发明授权

US06808518B2 Methods and devices for treating diseased blood vessels 有权
标题翻译：用于治疗患病血管的方法和装置
公开(公告)号：US06808518B2
公开(公告)日：2004-10-26
申请号：US09965949
申请日：2001-09-28
申请人： Parris S. Wellman , Kevin S. Weadock
发明人： Parris S. Wellman , Kevin S. Weadock
IPC分类号： A61M3100
CPC分类号： A61M37/0015 , A61M25/1011 , A61M29/02 , A61M37/00 , A61M2025/105 , A61M2025/1052 , A61M2025/1086 , A61M2037/003
摘要： The present invention provides a mechanism by which the physical properties of diseased blood vessel walls can be manipulated to achieve an effective vessel lumen diameter for a prolonged period of time. The methods and devices of the present invention selectively isolate and treat the medial or adventitial layers of these diseased blood vessels. The invention is based on the delivery of proteolytic enzymes and crosslinking agents via specialized delivery devices to a select layer of the diseased blood vessel wall. By isolating and treating these layers of the artery, collagen degrading and collagen crosslinking agents can be delivered so as to affect the diameter of the blood vessels and control blood flow therein.
摘要翻译：本发明提供了一种机制，通过该机制可以操纵患病血管壁的物理性能以在更长的时间内实现有效的血管腔直径。本发明的方法和装置选择性地分离和治疗这些患病血管的内侧或外膜层。本发明基于通过专门的递送装置将蛋白水解酶和交联剂递送到患病血管壁的选择层。通过分离和处理这些动脉层，可以递送胶原蛋白降解和胶原交联剂，以便影响血管的直径并控制其中的血流。

3. 发明授权

US06907297B2 Expandable intracardiac return electrode and method of use 有权
标题翻译：可扩展心内返回电极及其使用方法
公开(公告)号：US06907297B2
公开(公告)日：2005-06-14
申请号：US10032296
申请日：2001-12-21
申请人： Parris S. Wellman , Rajesh Pendekanti , Jia Hua Xiao
发明人： Parris S. Wellman , Rajesh Pendekanti , Jia Hua Xiao
IPC分类号： A61B18/14 , A61B18/16 , A61N1/06 , A61N1/00
CPC分类号： A61B18/1482 , A61B18/16 , A61B2018/00363 , A61B2018/00577 , A61N1/06
摘要： A method of forming a lesion at a predetermined heart location is provided. An energy-delivering electrode is positioned proximal to the predetermined heart location; a return electrode is positioned in contact with cardiac tissue. An electrosurgical current, capable of delivering energy through the energy-delivering electrode to the predetermined heart location at a magnitude and for a duration effective to form a lesion is established. A system for treating atrial fibrillation by forming transmural lesions and a heart-positioning device including a return electrode are also provided. In one embodiment, one of the electrodes includes at least a portion that is selectively movable between a first, retracted position in which the electrode is adapted to be deployed through tissue, and a second, expanded position in which the electrode is adapted to be placed within a chamber of a heart.
摘要翻译：提供了在预定心脏位置处形成病变的方法。能量输送电极位于预定的心脏位置附近; 定位回返电极与心脏组织接触。建立了一种电外科电流，其能够以有效形成损伤的量级和持续时间将能量通过能量输送电极输送到预定的心脏位置。还提供了一种通过形成透壁病变治疗房颤的系统和包括返回电极的心脏定位装置。在一个实施例中，电极中的一个包括至少一部分，其可选择性地在电极适于通过组织展开的第一缩回位置和第二扩展位置之间移动，其中电极适于放置在其中在心脏的一个房间内

4. 发明授权

US06616661B2 Surgical device for clamping, ligating, and severing tissue 失效
公开(公告)号：US06616661B2
公开(公告)日：2003-09-09
申请号：US09967204
申请日：2001-09-28
申请人： Parris S. Wellman , Kevin S. Weadock , Robert Nering
发明人： Parris S. Wellman , Kevin S. Weadock , Robert Nering
IPC分类号： A61B1732
CPC分类号： A61B18/1482 , A61B17/00008 , A61B18/1442 , A61B2018/00404 , A61B2018/00595 , A61B2018/00601 , A61B2018/1412 , A61B2018/1455
摘要： A surgical device for severing tissue, the surgical device comprising; a first shaft having a first internal lumen and a first slot disposed at a distal end; a clamp slidingly disposed in the first slot between open and closed positions to capture tissue in the first slot, the clamp having a clamping surface disposed at a distal end; at least one electrode for applying RF energy to the tissue captured in the first slot; a cutting blade slidingly disposed in the first slot between open and closed positions, the cutting blade having a cutting edge to sever the tissue; first actuation means for actuating the clamp between the open and closed positions; and second actuation means for actuating the cutting blade between the open and closed positions.

5. 发明授权

US07611484B2 Methods and devices for treating diseased blood vessels 有权
标题翻译：用于治疗患病血管的方法和装置
公开(公告)号：US07611484B2
公开(公告)日：2009-11-03
申请号：US10833614
申请日：2004-04-28
申请人： Parris S. Wellman , Kevin S. Weadock
发明人： Parris S. Wellman , Kevin S. Weadock
IPC分类号： A61M29/00
CPC分类号： A61M37/0015 , A61M25/1011 , A61M29/02 , A61M37/00 , A61M2025/105 , A61M2025/1052 , A61M2025/1086 , A61M2037/003
摘要： The present invention provides a mechanism by which the physical properties of diseased blood vessel walls can be manipulated to achieve an effective vessel lumen diameter for a prolonged period of time. The methods and devices of the present invention selectively isolate and treat the medial or adventitial layers of these diseased blood vessels. The invention is based on the delivery of proteolytic enzymes and crosslinking agents via specialized delivery devices to a select layer of the diseased blood vessel wall. By isolating and treating these layers of the artery, collagen degrading and collagen crosslinking agents can be delivered so as to affect the diameter of the blood vessels and control blood flow therein.
摘要翻译：本发明提供了一种机制，通过该机制可以操纵患病血管壁的物理性能以在更长的时间内实现有效的血管腔直径。本发明的方法和装置选择性地分离和治疗这些患病血管的内侧或外膜层。本发明基于通过专门的递送装置将蛋白水解酶和交联剂递送到患病血管壁的选择层。通过分离和处理这些动脉层，可以递送胶原蛋白降解和胶原交联剂，以便影响血管的直径并控制其中的血流。

6. 发明授权

US06527771B1 Surgical device for endoscopic vein harvesting 失效
标题翻译：用于内窥镜静脉采集的手术装置
公开(公告)号：US06527771B1
公开(公告)日：2003-03-04
申请号：US09967185
申请日：2001-09-28
申请人： Kevin S. Weadock , Parris S. Wellman
发明人： Kevin S. Weadock , Parris S. Wellman
IPC分类号： A61B1732
CPC分类号： A61B17/00008 , A61B18/1442 , A61B2018/00345 , A61B2018/00404 , A61B2018/00601 , A61B2018/00607
摘要： A surgical device including: a first shaft having a first projection radially offset from an axial direction of the first shaft, the first projection having a first clamping surface; a second shaft slidably disposed relative to the first shaft, the second shaft having a second projection radially offset from the axial direction, the second projection having a second clamping surface; a dissector for dissecting tissue from a blood vessel to be harvested; a first actuator for sliding the second projection relative to the first projection to capture a side branch of the vessel between the first and second clamping surfaces; at least one electrode for applying cauterizing energy to cauterize the captured side branch; a cutting blade movably disposed on one of the first or second projections; and a second actuator for moving the cutting blade to sever the side branch captured between the first and second projections.
摘要翻译：一种手术装置，包括：第一轴，其具有从所述第一轴的轴向方向径向偏移的第一突起，所述第一突起具有第一夹紧表面; 相对于第一轴可滑动地设置的第二轴，第二轴具有径向偏离轴向的第二突起，第二突起具有第二夹紧表面; 用于从要收获的血管解剖组织的解剖器; 第一致动器，用于相对于第一突起滑动第二突起，以捕获容器在第一和第二夹紧表面之间的侧分支; 至少一个电极，用于施加烧灼能量以灼烧所捕获的侧分支; 可移动地设置在所述第一或第二突起之一上的切割刀片; 以及用于移动切割刀片以切断在第一和第二突起之间捕获的侧分支的第二致动器。

7. 发明授权

US06695838B2 System and method for performing cardiac tissue ablation 有权
标题翻译：用于进行心脏组织消融的系统和方法
公开(公告)号：US06695838B2
公开(公告)日：2004-02-24
申请号：US09966765
申请日：2001-09-28
申请人： Parris S. Wellman , Rajesh Pendekanti
发明人： Parris S. Wellman , Rajesh Pendekanti
IPC分类号： A61B1818
CPC分类号： A61B18/1482 , A61B18/16 , A61B2018/00363 , A61B2018/00577
摘要： A method of forming a lesion at a predetermined heart location is provided. An energy-delivering electrode is positioned proximal to the predetermined heart location; a return electrode is positioned in contact with cardiac tissue. An electrosurgical current, capable of delivering energy through the energy-delivering electrode to the predetermined heart location at a magnitude and for a duration effective to form a lesion is established. A system for treating atrial fibrillation by forming transmural lesions and a heart-positioning device including a return electrode are also provided.
摘要翻译：提供了在预定心脏位置处形成病变的方法。能量输送电极位于预定的心脏位置附近; 定位回返电极与心脏组织接触。建立了一种电外科电流，其能够以有效形成损伤的量级和持续时间将能量通过能量输送电极输送到预定的心脏位置。还提供了一种通过形成透壁病变治疗房颤的系统和包括返回电极的心脏定位装置。

8. 发明授权

US06652518B2 Transmural ablation tool and method 有权
公开(公告)号：US06652518B2
公开(公告)日：2003-11-25
申请号：US09966813
申请日：2001-09-28
申请人： Parris S. Wellman , Rajesh Pendekanti
发明人： Parris S. Wellman , Rajesh Pendekanti
IPC分类号： A61B1818
CPC分类号： A61B18/1442 , A61B18/1402 , A61B18/148 , A61B2018/00291 , A61B2018/00351
摘要： An ablation method and device contacts one surface of a target layer and positions the tissue to ablate entirely through the layer. The tissue may be a wall of the heart (ablated, for example, to form blocking lesions for atrial fibrillation), and ablation may be performed with the heart stopped or beating, and effected by either endocardial or epicardial contact. Access may be through an open incision or a minimally invasive technique involving a small opening through which one or more elongated surgical tools are inserted. Illustratively, an atrial ablation treatment can be performed prophylactically (after CABG), or independently to treat an existing condition. A tool of the present invention has a handle at a proximal end, a bipolar ablation head, and an elongated body interconnecting the handle and the ablation head. A channel or contoured surface fixes and bends the tissue such that inter-electrode conduction paths span the thickness of the layer, thus dependably creating a fully transmural ablation lesion. The oriented transmural energy conduction paths reduce the possibility of inducing coagulation of blood in the heart chamber. One bipolar assembly has an electrode spacing of approximately ten millimeters across a channel of about five millimeters depth. Preferably the ablation head forms a suction holder, connected through internal passages to a vacuum pressure of about 100-500 mmHg, and immobilizes the contacted tissue.

9. 发明授权

US06997719B2 Training model for endoscopic vessel harvesting 失效
标题翻译：内窥镜血管收获训练模型
公开(公告)号：US06997719B2
公开(公告)日：2006-02-14
申请号：US10183270
申请日：2002-06-27
申请人： Parris S. Wellman , William McJames , Daniel Gordon
发明人： Parris S. Wellman , William McJames , Daniel Gordon
IPC分类号： G09B23/28
CPC分类号： G09B23/285
摘要： A leg model, designed to teach endoscopic saphenous vein harvesting, is provided that accurately models the anatomy of the saphenous vein in the human thigh, and closely approximates the subcutaneous tissues in a human. The subcutaneous tissue is formulated and manufactured such that the saphenous vein adheres to the subcutaneous tissue to simulate the adhesion in a human leg. The model includes a reusable base and a replaceable single use insert. The base is size and configured to receive the insert. The tray can include a slit located at a point along its length that permits the ends of the tray to rotate about the slit so that the ends can be bent with respect to one another.
摘要翻译：提供旨在教导内窥镜隐静脉收获的腿模型，其精确地模拟人大腿隐静脉的解剖结构，并且紧密接近人体的皮下组织。配制和制造皮下组织，使得隐静脉粘附到皮下组织以模拟人腿中的粘附。该模型包括可重复使用的基座和可更换的单用插入件。基座是大小并配置为接收插入。托盘可以包括位于沿其长度的点处的狭缝，其允许托盘的端部围绕狭缝旋转，使得端部可以相对于彼此弯曲。

10. 发明授权

US09568575B2 Conduit-containing devices and methods for analyte processing and detection 有权
标题翻译：用于分析物处理和检测的含导管的装置和方法
公开(公告)号：US09568575B2
公开(公告)日：2017-02-14
申请号：US13878935
申请日：2011-10-19
申请人： Thomas Jay Lowery, Jr. , Parris S. Wellman , John J. McDonough , James Franklin Chepin , Charles William Rittershaus , Vasiliki Demas , Alison Skelley
发明人： Thomas Jay Lowery, Jr. , Parris S. Wellman , John J. McDonough , James Franklin Chepin , Charles William Rittershaus , Vasiliki Demas , Alison Skelley
IPC分类号： G01V3/00 , G01R33/465 , G01R33/28 , G01R33/30 , G01R33/44
CPC分类号： G01R33/465 , G01R33/281 , G01R33/30 , G01R33/302 , G01R33/448
摘要： This invention features devices and methods for analyte processing and detection, and use of such methods, e.g., in the treatment and diagnosis of disease or determining the presence of a pathogen.
摘要翻译：本发明的特征在于用于分析物处理和检测的装置和方法，以及使用这些方法，例如在疾病的治疗和诊断中或确定病原体的存在。

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