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1. 发明申请

US20100066880A1 MICROCHIP AND METHOD FOR CELL SORTING 审中-公开
标题翻译：细胞分离的微孔和方法
公开(公告)号：US20100066880A1
公开(公告)日：2010-03-18
申请号：US12308442
申请日：2007-06-15
申请人： Setsuya Sato , Toshiyuki Yamato , Katsuaki Hayashi , Yoshitaka Matsumoto , Isamu Oh
发明人： Setsuya Sato , Toshiyuki Yamato , Katsuaki Hayashi , Yoshitaka Matsumoto , Isamu Oh
IPC分类号： H04N5/335 , H04N5/225
CPC分类号： G01N15/1484 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2300/0864 , B01L2400/0454 , B01L2400/0487 , C12M47/04 , G01N15/1459 , G01N15/1463 , G01N2015/149
摘要： [Problems] To provide a microchip for cell sorting to obtain the desired cell from a number of cells quickly and accurately by combining the advantages from both methods using the optical tweezer and the liquid supply to the micro channel.[Means for solving problems] A microchip for sorting at least one cell including a base, the base comprising: a cell supply channel for supplying and flowing a liquid containing cells; a cell supply channel including an inlet port in liquid communication with a supply mechanism and a drain port in liquid communication with a drain mechanism; a cell sorting channel intersecting with the cell supply channel at their middle point, the cell sorting channel including an inlet port in liquid communication with a supply mechanism and a drain port in liquid communication with a drain mechanism.
摘要翻译： [问题]提供一种用于细胞分选的微芯片，通过结合使用光学镊子的两种方法和向微通道的液体供应的优点，快速而准确地从许多细胞获得所需的细胞。解决问题的手段一种用于对至少一个包括基底的电池进行分选的微型芯片，所述基底包括：用于供给和流动含有细胞的液体的电池供给通道; 电池供应通道，其包括与供给机构液体连通的入口和与排出机构液体连通的排出口; 细胞分选通道在其中点处与细胞供应通道相交，细胞分选通道包括与供给机构液体连通的入口和与排出机构液体连通的排出口。

2. 发明申请

US20100043882A1 Microship and method for cell arrangement 审中-公开
标题翻译：细胞和细胞排列方法
公开(公告)号：US20100043882A1
公开(公告)日：2010-02-25
申请号：US12308434
申请日：2007-06-15
申请人： Setsuya Sato , Toshiyuki Yamato , Katsuaki Hayashi , Yoshitaka Matsumoto , Takahiro Ochiya , Isamu Oh
发明人： Setsuya Sato , Toshiyuki Yamato , Katsuaki Hayashi , Yoshitaka Matsumoto , Takahiro Ochiya , Isamu Oh
IPC分类号： F16L41/00
CPC分类号： C12M33/00 , B01L3/502761 , G01N15/1056 , Y10T137/0318 , Y10T137/85938
摘要： [Problems]To provide a microchip for cell arranging which transfers and arranges the cell accurately and quickly, by combining advantages of the method of an optical tweezer and of micro channel.[Means for Solving Problems]A microchip for arranging cells, including a base, the base comprising: at least one cell supply channel including a cell inlet port in liquid communication with a supply mechanism configured to supply the cells into the cell supply channel; at least one cell drain channel including a cell drain port in fluid communication with a drain mechanism, the cell drain channel configured to guide the cells to the cell drain port; at least one reservoir for temporarily storing the cells flowing between the cell supply channel and the cell drain channel; at least one cell arrangement portion for receiving cells introduced from the reservoir, the cell arrangement portion comprising plural compartments partitioned by a wall; and at least one junction channel extending from the cell arrangement portion to the reservoir; wherein the reservoir is wider than the cell supply channel, the cell drain channel and the junction channel.
摘要翻译： [问题]通过组合光镊方法和微通道的优点，提供一种用于细胞排列的微芯片，其通过精确而快速地传送和排列细胞。解决问题的手段一种用于布置电池的微芯片，包括基座，所述基座包括：至少一个电池供应通道，包括与供配给将电池供应到电池供应通道的供电机构液体连通的电池入口; 至少一个单元排放通道，包括与漏极机构流体连通的单元排出端口，所述单元排放通道被配置为将单元引导到单元排放端口; 至少一个存储器，用于临时存储在单元供应通道和单元排放通道之间流动的单元; 至少一个用于接收从储存器引入的单元的单元布置部分，单元布置部分包括由壁分隔的多个隔室; 以及从单元布置部分延伸到储存器的至少一个接合通道; 其中所述储存器比所述电池供给通道，所述电池排出通道和所述接合通道宽。

3. 发明申请

US20050276456A1 Cell-operating device 审中-公开
标题翻译：手机操作装置
公开(公告)号：US20050276456A1
公开(公告)日：2005-12-15
申请号：US11139015
申请日：2005-05-26
申请人： Toshiyuki Yamato , Yoshitaka Matsumoto , Katsuaki Hayashi , Isamu Oh , Setsuya Sato
发明人： Toshiyuki Yamato , Yoshitaka Matsumoto , Katsuaki Hayashi , Isamu Oh , Setsuya Sato
IPC分类号： C12M1/34 , G02B21/36 , G06K9/00
CPC分类号： G06K9/00127 , C12M41/36 , C12M47/04 , G02B21/365
摘要： The present invention provides a cell-operating device comprising a laser light source and a microscope to observe cell sample fluorescently labeled and a camera to take the images of the cell sample that is observed with said microscope and a computer to capture the digital image data obtained by said camera and a group of mirrors comprising electronic control mirrors of which optical axis can be adjusted so that the laser light irradiated from said laser light source can be guided in to said microscope. The computer includes a binarization program for binarizing said digital image data by identifying whether each pixel of said digital image data captures a part of said cell sample according to the fluorescence luminance of each pixel. The computer has an identification program for identifying the boundaries between adjacent different values in the binarized digital image and joins the boundaries into an isolated closed curve, and a data processing program for processing said binarized digital data so that in all the area within said isolated closed curve a cell exists, and a calculation program to divide said binarized digital image data, after running said data processing program, into sections with a predefined size and identify the center of gravity coordinate of each section, and an adjustment program to adjust the optical axis of said electronic control mirrors so that said laser irradiates said center of gravity coordinate. Thus, the present invention is a cell-operating device that the laser light from said laser light source irradiates said center of gravity coordinate.
摘要翻译：本发明提供了一种细胞操作装置，其包括激光光源和显微镜以观察荧光标记的细胞样品，以及相机拍摄用所述显微镜观察的细胞样品的图像和计算机，以捕获获得的数字图像数据通过所述相机和一组镜子，包括可以调节光轴的电子控制反射镜，使得可以将从所述激光源照射的激光引导到所述显微镜。计算机包括二进制化程序，用于通过识别所述数字图像数据的每个像素是否根据每个像素的荧光亮度捕获所述细胞样本的一部分来二值化所述数字图像数据。计算机具有用于识别二进制数字图像中的相邻不同值之间的边界的识别程序，并将边界连接成隔离闭合曲线，以及用于处理所述二进制数字数据的数据处理程序，使得在所述隔离闭合的所有区域内曲线单元存在，以及计算程序，用于在运行所述数据处理程序之后将所述二进制数字图像数据划分成具有预定尺寸的区段，并且识别每个区段的重心坐标，以及调整程序以调整光轴的所述电子控制反射镜，使得所述激光器照射所述重心坐标。因此，本发明是一种电池操作装置，来自所述激光光源的激光照射所述重心坐标。

4. 发明申请

US20080057558A1 Method and apparatus for separating cells 审中-公开
标题翻译：用于分离细胞的方法和装置
公开(公告)号：US20080057558A1
公开(公告)日：2008-03-06
申请号：US11893372
申请日：2007-08-15
申请人： Hideo Niwa , Akira Kobayashi , Setsuya Sato , Yoshitaka Matsumoto , Isamu Oh
发明人： Hideo Niwa , Akira Kobayashi , Setsuya Sato , Yoshitaka Matsumoto , Isamu Oh
IPC分类号： C12N13/00 , C12M1/42
CPC分类号： G02B21/365 , C12M47/04 , G02B21/0088 , G02B21/16
摘要： The present invention provides a method and an apparatus for selectively removing non-target cells from a mixed cell population of different types of cells to selectively separate target cells. Individual cells or cell groups of at least two cells from a mixed cell population of different types of cells are placed on a certain two-dimensional, coordinate system. Then a distinction is made among the individual cells or cells in the cell groups, based on the shape or size of the cells or by using a cell marker. Physical energy such as laser light is applied to the positions or regions occupied by non-target cells or cell groups including non-target cells in order to selectively kill the non-target cells or cause dysfunction of the non-target cells.
摘要翻译：本发明提供一种用于从不同类型细胞的混合细胞群体中选择性除去非靶细胞以选择性分离靶细胞的方法和装置。来自不同类型细胞的混合细胞群体的至少两个细胞的单个细胞或细胞群被放置在某个二维坐标系上。然后，基于细胞的形状或大小或通过使用细胞标记，在细胞组中的各个细胞或细胞之间进行区分。将诸如激光的物理能量施加到非靶细胞或包括非靶细胞的细胞群占据的位置或区域，以选择性地杀死非靶细胞或引起非靶细胞的功能障碍。

5. 发明申请

US20100068794A1 Cell Fusion Chip 审中-公开
标题翻译：细胞融合芯片
公开(公告)号：US20100068794A1
公开(公告)日：2010-03-18
申请号：US12225977
申请日：2007-03-27
申请人： Isamu Oh , Hiroshi Masuhara , Toshiyuki t Yamato , Katsuaki Hayashi , Yasuji Adachi , Sato Setsuya
发明人： Isamu Oh , Hiroshi Masuhara , Toshiyuki t Yamato , Katsuaki Hayashi , Yasuji Adachi , Sato Setsuya
IPC分类号： C12M3/00
CPC分类号： C12M35/02
摘要： (Problems) To provide a cell fusion chip, which allows to perform a cell fusion on a single chip, excels in the operating efficiency, does not require experience so much in cell feed or recovery, and has no risk of the contamination to the cells during the operation.(Means for Solving Problems) The present invention provides a cell fusion chip comprising: an isolation chamber for receiving isolated cells to be subjected to an fusion operation; a fusion chamber for fusing the cells together supplied from the isolation chamber; a culture chamber for culturing the cells fused in the fusion chamber; a first channel for connecting the isolation chamber and the fusion chamber; and a second channel for connecting the fusion chamber and the culture chamber, wherein the isolation chamber, the fusion chamber, the culture chamber, the first channel and the second channel are formed on a single chip.
摘要翻译：（问题）为了提供能够在单个芯片上进行细胞融合的细胞融合芯片，其操作效率优异，在细胞进料或回收中不需要经验，并且没有细胞污染的风险在操作期间。（解决问题的手段）本发明提供一种细胞融合芯片，包括：隔离室，用于接收待进行融合操作的分离细胞; 用于将从隔离室供应的单元熔合的熔化室; 用于培养在所述融合室中熔融的细胞的培养室; 用于连接隔离室和熔化室的第一通道; 以及用于连接熔融室和培养室的第二通道，其中隔离室，熔化室，培养室，第一通道和第二通道形成在单个芯片上。

6. 发明申请

US20080217445A1 Method for producing fullerene suspension 有权
标题翻译：富勒烯悬浮液的制备方法
公开(公告)号：US20080217445A1
公开(公告)日：2008-09-11
申请号：US12069172
申请日：2008-02-07
申请人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo
发明人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo
IPC分类号： B02C19/00
CPC分类号： B82Y40/00 , B01J19/121 , B82Y30/00 , C01B32/15 , C01B32/152
摘要： The present invention provides a fullerene suspension and a method for producing a fullerene suspension having high dispersion stability without any chemical compound. Also, the fullerene suspension and its producing method makes it possible to be applied in various fields including the field of medical and pharmaceutical science and the field of foods and environment, in which the fullerene suspension obtained by the prior methods had not been applied. The fullerene is ground to form nanoparticles by irradiating a fullerene in a poor solvent with a laser. The pulse laser having a width of several-ten femtoseconds to several-hundred nanoseconds is appropriately applied.
摘要翻译：本发明提供一种富勒烯悬浮液和一种具有高分散稳定性的富勒烯悬浮液的方法，而没有任何化合物。此外，富勒烯悬浮液及其制造方法可以应用于医疗和制药科学以及食品和环境领域的各个领域，其中通过现有方法获得的富勒烯悬浮液未被应用。通过用激光在不良溶剂中照射富勒烯来研磨富勒烯以形成纳米颗粒。适当地施加宽度为几十飞秒至数百纳秒的脉冲激光器。

7. 发明申请

US20080237376A1 Method of producing medicinal nanoparticle suspension 失效
标题翻译：生产药用纳米颗粒悬浮液的方法
公开(公告)号：US20080237376A1
公开(公告)日：2008-10-02
申请号：US11798621
申请日：2007-05-15
申请人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Hiroyuki Kato , Isao Umeda
发明人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Hiroyuki Kato , Isao Umeda
IPC分类号： B02C19/18
CPC分类号： A61K9/10 , A61K9/14 , A61K31/475 , B01J19/10 , B01J19/121 , B01J2219/089
摘要： A method of producing a medicinal nanoparticle suspension is provided, wherein a medicinal ingredient added in a suspending solution is ground to form nanoparticles of the medicinal ingredient by irradiating the suspending solution with a laser. The process is implemented after adding a poorly water-soluble or water-insoluble medicinal ingredient of a drug in a poor solvent to form the suspending solution.
摘要翻译：提供一种生产药用纳米颗粒悬浮液的方法，其中通过用激光照射悬浮溶液将加入悬浮液中的药物成分研磨成药物成分的纳米颗粒。在不良溶剂中加入难溶于水或不溶于水的药物成分的药物后，进行上述处理，形成悬浮液。

8. 发明申请

US20130096097A1 PHARMACEUTICAL MULTIMERIC PARTICLES, AND MANUFACTURING METHOD FOR SAME 审中-公开
标题翻译：药用多功能颗粒及其制造方法
公开(公告)号：US20130096097A1
公开(公告)日：2013-04-18
申请号：US13702205
申请日：2011-06-07
申请人： Hitoshi Kasai , Hachiro Nakanishi , Koichi Baba , Hidetoshi Oikawa , Tastuya Murakami , Hiroshi Imahori , Misturu Hashida , Isamu Oh
发明人： Hitoshi Kasai , Hachiro Nakanishi , Koichi Baba , Hidetoshi Oikawa , Tastuya Murakami , Hiroshi Imahori , Misturu Hashida , Isamu Oh
IPC分类号： A61K9/10
CPC分类号： A61K9/10 , A61K9/5123 , A61K31/4745 , A61K31/573 , A61K47/55
摘要： [Problem] The purpose of the present invention is to provide organic particles containing pharmaceutical particles of which the particles are small and the particle size distribution is narrow, and a manufacturing method for the same.[Solution] Provided are pharmaceutical multimeric particles of which the particles are small and the particle size distribution is narrow and which are characterized in being obtained by pouring into water a solution of a pharmaceutical multimer dissolved in a water-miscible organic solvent, and a manufacturing method for the pharmaceutical multimeric particles. Pharmaceutical dimeric particles thereof are characterized in being obtained by pouring into water a solution of a compound represented by general formula (I) dissolved in a water-miscible organic solvent.
摘要翻译：本发明的目的是提供含有粒子小，粒径分布狭窄的药物粒子的有机粒子及其制造方法。 [解决方案]提供了颗粒小且粒度分布窄的药物多聚体颗粒，其特征在于通过将溶解在水混溶性有机溶剂中的药物多聚体的溶液倒入水中而获得，药物多聚体颗粒的方法。其特征在于通过将溶解在与水可混溶的有机溶剂中的通式（I）表示的化合物的溶液倒入水中而获得的药物二聚体颗粒。

9. 发明授权

US07900855B2 Method for producing fullerene suspension 有权
标题翻译：富勒烯悬浮液的制备方法
公开(公告)号：US07900855B2
公开(公告)日：2011-03-08
申请号：US12069172
申请日：2008-02-07
申请人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo
发明人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo
IPC分类号： B02C1/00 , B02C11/08 , B02C21/00 , B02C23/00
CPC分类号： B82Y40/00 , B01J19/121 , B82Y30/00 , C01B32/15 , C01B32/152
摘要： The present invention provides a fullerene suspension and a method for producing a fullerene suspension having high dispersion stability without any chemical compound. Also, the fullerene suspension and its producing method makes it possible to be applied in various fields including the field of medical and pharmaceutical science and the field of foods and environment, in which the fullerene suspension obtained by the prior methods had not been applied. The fullerene is ground to form nanoparticles by irradiating a fullerene in a poor solvent with a laser. The pulse laser having a width of several-ten femtoseconds to several-hundred nanoseconds is appropriately applied.
摘要翻译：本发明提供一种富勒烯悬浮液和一种具有高分散稳定性的富勒烯悬浮液的方法，而没有任何化合物。此外，富勒烯悬浮液及其制造方法可以应用于医疗和制药科学以及食品和环境领域的各个领域，其中通过现有方法获得的富勒烯悬浮液未被应用。通过用激光在不良溶剂中照射富勒烯来研磨富勒烯以形成纳米颗粒。适当地施加宽度为几十飞秒至数百纳秒的脉冲激光器。

10. 发明申请

US20070284769A1 APPARATUS FOR FORMING ULTRAFINE PARTICLES 失效
标题翻译：用于形成超细颗粒的装置
公开(公告)号：US20070284769A1
公开(公告)日：2007-12-13
申请号：US11748842
申请日：2007-05-15
申请人： Hiroyuki Kato , Isao Umeda , Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Kazuya Hirata , Motohiko Nohmi
发明人： Hiroyuki Kato , Isao Umeda , Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Kazuya Hirata , Motohiko Nohmi
IPC分类号： B82B3/00 , B02C19/18
CPC分类号： B02C19/18 , B01J19/0093 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00934 , B01J2219/00984 , Y10S977/901
摘要： An apparatus for forming ultrafine particles, including: a light source generating a laser beam to be irradiated at an organic substance; at least one microflow channel capable of passing therethrough a suspension containing the organic substance; and a flow device for allowing the suspension containing the organic substance to continuously or intermittently pass through the microflow channel, the organic substance present in the microflow channel being irradiated with the laser beam at least once within a predetermined period, thereby forming ultrafine particles of the organic substance.
摘要翻译：一种用于形成超微粒子的装置，包括：产生要在有机物质上照射的激光束的光源; 至少一个能够通过其中含有有机物的悬浮液的微流道; 以及用于允许包含有机物质的悬浮液连续或间歇地通过微流道的流动装置，存在于微流道中的有机物质在预定时间内至少一次被激光束照射，由此形成超细颗粒有机物质。

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