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1. 发明授权

US07900855B2 Method for producing fullerene suspension 有权
标题翻译：富勒烯悬浮液的制备方法
公开(公告)号：US07900855B2
公开(公告)日：2011-03-08
申请号：US12069172
申请日：2008-02-07
申请人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo
发明人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo
IPC分类号： B02C1/00 , B02C11/08 , B02C21/00 , B02C23/00
CPC分类号： B82Y40/00 , B01J19/121 , B82Y30/00 , C01B32/15 , C01B32/152
摘要： The present invention provides a fullerene suspension and a method for producing a fullerene suspension having high dispersion stability without any chemical compound. Also, the fullerene suspension and its producing method makes it possible to be applied in various fields including the field of medical and pharmaceutical science and the field of foods and environment, in which the fullerene suspension obtained by the prior methods had not been applied. The fullerene is ground to form nanoparticles by irradiating a fullerene in a poor solvent with a laser. The pulse laser having a width of several-ten femtoseconds to several-hundred nanoseconds is appropriately applied.
摘要翻译：本发明提供一种富勒烯悬浮液和一种具有高分散稳定性的富勒烯悬浮液的方法，而没有任何化合物。此外，富勒烯悬浮液及其制造方法可以应用于医疗和制药科学以及食品和环境领域的各个领域，其中通过现有方法获得的富勒烯悬浮液未被应用。通过用激光在不良溶剂中照射富勒烯来研磨富勒烯以形成纳米颗粒。适当地施加宽度为几十飞秒至数百纳秒的脉冲激光器。

2. 发明申请

US20070284769A1 APPARATUS FOR FORMING ULTRAFINE PARTICLES 失效
标题翻译：用于形成超细颗粒的装置
公开(公告)号：US20070284769A1
公开(公告)日：2007-12-13
申请号：US11748842
申请日：2007-05-15
申请人： Hiroyuki Kato , Isao Umeda , Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Kazuya Hirata , Motohiko Nohmi
发明人： Hiroyuki Kato , Isao Umeda , Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Kazuya Hirata , Motohiko Nohmi
IPC分类号： B82B3/00 , B02C19/18
CPC分类号： B02C19/18 , B01J19/0093 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00934 , B01J2219/00984 , Y10S977/901
摘要： An apparatus for forming ultrafine particles, including: a light source generating a laser beam to be irradiated at an organic substance; at least one microflow channel capable of passing therethrough a suspension containing the organic substance; and a flow device for allowing the suspension containing the organic substance to continuously or intermittently pass through the microflow channel, the organic substance present in the microflow channel being irradiated with the laser beam at least once within a predetermined period, thereby forming ultrafine particles of the organic substance.
摘要翻译：一种用于形成超微粒子的装置，包括：产生要在有机物质上照射的激光束的光源; 至少一个能够通过其中含有有机物的悬浮液的微流道; 以及用于允许包含有机物质的悬浮液连续或间歇地通过微流道的流动装置，存在于微流道中的有机物质在预定时间内至少一次被激光束照射，由此形成超细颗粒有机物质。

3. 发明授权

US07247203B2 Process for producing crystalline nucleus and method of screening crystallization conditions 失效
标题翻译：生产晶核的方法和筛选结晶条件的方法
公开(公告)号：US07247203B2
公开(公告)日：2007-07-24
申请号：US10525809
申请日：2003-08-25
申请人： Takatomo Sasaki , Yusuke Mori , Masashi Yoshimura , Hiroaki Adachi , Hiroshi Masuhara , Youichiroh Hosokawa , Kazufumi Takano
发明人： Takatomo Sasaki , Yusuke Mori , Masashi Yoshimura , Hiroaki Adachi , Hiroshi Masuhara , Youichiroh Hosokawa , Kazufumi Takano
IPC分类号： C30B29/54
CPC分类号： C30B7/00 , C30B29/58 , Y10S117/904
摘要： The present invention relates to a process for producing high-quality crystals of protein or organic substances easily and efficiently. A solution of protein or an organic substance is prepared and then is cooled slowly to be supersaturated to a low degree. This supersaturated solution is irradiated with a femtosecond laser 10. A local explosion phenomenon occurs at the focal point of the laser and thereby a crystalline nucleus is generated. A high-quality crystal is obtained when a crystal is grown on the crystalline nucleus over a long period of time. The femtosecond laser to be used herein can be a titanium:sapphire laser having a wavelength of 800 nm, a duration of 120 fs, a frequency of 1 kHz, and an output of 400 mW.
摘要翻译：本发明涉及容易高效地生产蛋白质或有机物质的优质晶体的方法。制备蛋白质或有机物质的溶液，然后缓慢冷却至低饱和度。用飞秒激光10照射该过饱和溶液。在激光的焦点发生局部爆炸现象，从而产生晶核。当晶体长时间在晶核上生长时，获得高质量的晶体。本文使用的飞秒激光可以是波长为800nm，持续时间为120fs，频率为1kHz，输出为400mW的钛：蓝宝石激光。

4. 发明申请

US20100068794A1 Cell Fusion Chip 审中-公开
标题翻译：细胞融合芯片
公开(公告)号：US20100068794A1
公开(公告)日：2010-03-18
申请号：US12225977
申请日：2007-03-27
申请人： Isamu Oh , Hiroshi Masuhara , Toshiyuki t Yamato , Katsuaki Hayashi , Yasuji Adachi , Sato Setsuya
发明人： Isamu Oh , Hiroshi Masuhara , Toshiyuki t Yamato , Katsuaki Hayashi , Yasuji Adachi , Sato Setsuya
IPC分类号： C12M3/00
CPC分类号： C12M35/02
摘要： (Problems) To provide a cell fusion chip, which allows to perform a cell fusion on a single chip, excels in the operating efficiency, does not require experience so much in cell feed or recovery, and has no risk of the contamination to the cells during the operation.(Means for Solving Problems) The present invention provides a cell fusion chip comprising: an isolation chamber for receiving isolated cells to be subjected to an fusion operation; a fusion chamber for fusing the cells together supplied from the isolation chamber; a culture chamber for culturing the cells fused in the fusion chamber; a first channel for connecting the isolation chamber and the fusion chamber; and a second channel for connecting the fusion chamber and the culture chamber, wherein the isolation chamber, the fusion chamber, the culture chamber, the first channel and the second channel are formed on a single chip.
摘要翻译：（问题）为了提供能够在单个芯片上进行细胞融合的细胞融合芯片，其操作效率优异，在细胞进料或回收中不需要经验，并且没有细胞污染的风险在操作期间。（解决问题的手段）本发明提供一种细胞融合芯片，包括：隔离室，用于接收待进行融合操作的分离细胞; 用于将从隔离室供应的单元熔合的熔化室; 用于培养在所述融合室中熔融的细胞的培养室; 用于连接隔离室和熔化室的第一通道; 以及用于连接熔融室和培养室的第二通道，其中隔离室，熔化室，培养室，第一通道和第二通道形成在单个芯片上。

5. 发明申请

US20080237376A1 Method of producing medicinal nanoparticle suspension 失效
标题翻译：生产药用纳米颗粒悬浮液的方法
公开(公告)号：US20080237376A1
公开(公告)日：2008-10-02
申请号：US11798621
申请日：2007-05-15
申请人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Hiroyuki Kato , Isao Umeda
发明人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Hiroyuki Kato , Isao Umeda
IPC分类号： B02C19/18
CPC分类号： A61K9/10 , A61K9/14 , A61K31/475 , B01J19/10 , B01J19/121 , B01J2219/089
摘要： A method of producing a medicinal nanoparticle suspension is provided, wherein a medicinal ingredient added in a suspending solution is ground to form nanoparticles of the medicinal ingredient by irradiating the suspending solution with a laser. The process is implemented after adding a poorly water-soluble or water-insoluble medicinal ingredient of a drug in a poor solvent to form the suspending solution.
摘要翻译：提供一种生产药用纳米颗粒悬浮液的方法，其中通过用激光照射悬浮溶液将加入悬浮液中的药物成分研磨成药物成分的纳米颗粒。在不良溶剂中加入难溶于水或不溶于水的药物成分的药物后，进行上述处理，形成悬浮液。

6. 发明申请

US20100280580A1 Biostimulation Apparatus, Gene Control Apparatus, and Muscle-Related Disorder Therapeutic Apparatus 有权
标题翻译：生物刺激仪，基因控制装置和肌肉相关疾病治疗仪
公开(公告)号：US20100280580A1
公开(公告)日：2010-11-04
申请号：US12678998
申请日：2008-09-18
申请人： Yoichiro Hosokawa , Hiroshi Masuhara , Kazunori Okano , Yutaka Tkaoka , Mika Ohta , Akihiko Ito
发明人： Yoichiro Hosokawa , Hiroshi Masuhara , Kazunori Okano , Yutaka Tkaoka , Mika Ohta , Akihiko Ito
IPC分类号： A61N5/067
CPC分类号： A61N5/0619 , A61N2005/0644 , A61N2005/067
摘要： A biostimulation apparatus of the present invention includes a laser oscillator for oscillating an ultra short pulsed laser beam and an optical system for focusing the ultra short pulsed laser beam, wherein the ultra short pulsed laser beam is focused by the optical system at a target portion of a living subject to cause the target portion to be irradiated with the laser beam to stimulate an acupuncture point, and wherein the target portion is either the acupuncture point or its periphery.
摘要翻译：本发明的生物刺激装置包括用于振荡超短脉冲激光束的激光振荡器和用于聚焦超短脉冲激光束的光学系统，其中超短脉冲激光束被光学系统聚焦在目标部分使激光束照射目标部分以刺激针刺点的活体，并且其中目标部分是针刺点或其周边。

7. 发明申请

US20080217445A1 Method for producing fullerene suspension 有权
标题翻译：富勒烯悬浮液的制备方法
公开(公告)号：US20080217445A1
公开(公告)日：2008-09-11
申请号：US12069172
申请日：2008-02-07
申请人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo
发明人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo
IPC分类号： B02C19/00
CPC分类号： B82Y40/00 , B01J19/121 , B82Y30/00 , C01B32/15 , C01B32/152
摘要： The present invention provides a fullerene suspension and a method for producing a fullerene suspension having high dispersion stability without any chemical compound. Also, the fullerene suspension and its producing method makes it possible to be applied in various fields including the field of medical and pharmaceutical science and the field of foods and environment, in which the fullerene suspension obtained by the prior methods had not been applied. The fullerene is ground to form nanoparticles by irradiating a fullerene in a poor solvent with a laser. The pulse laser having a width of several-ten femtoseconds to several-hundred nanoseconds is appropriately applied.
摘要翻译：本发明提供一种富勒烯悬浮液和一种具有高分散稳定性的富勒烯悬浮液的方法，而没有任何化合物。此外，富勒烯悬浮液及其制造方法可以应用于医疗和制药科学以及食品和环境领域的各个领域，其中通过现有方法获得的富勒烯悬浮液未被应用。通过用激光在不良溶剂中照射富勒烯来研磨富勒烯以形成纳米颗粒。适当地施加宽度为几十飞秒至数百纳秒的脉冲激光器。

8. 发明授权

US5469255A Method and apparatus for spectrometric measurement of particulate surfaces 失效
标题翻译：颗粒表面光谱测量方法和装置
公开(公告)号：US5469255A
公开(公告)日：1995-11-21
申请号：US186991
申请日：1994-01-27
申请人： Kenji Kamada , Keiji Sasaki , Noboru Kitamura , Hiroshi Masuhara
发明人： Kenji Kamada , Keiji Sasaki , Noboru Kitamura , Hiroshi Masuhara
IPC分类号： G01N15/00 , G01N21/63 , G01J3/42 , G01J3/443
CPC分类号： G01N21/636 , G01N15/00 , G01N2021/637
摘要： A method of spectrometry is disclosed for measuring transient absorbance and transient absorption spectrum of a substance to be measured at interfaces in liquid phase of particulates containing a fluorescent pigment and the substance to be measured by the utilization of optical resonance phenomenon. An apparatus for carrying out the method is also disclosed and comprises: (a) a pulse laser oscillator for exciting the fluorescent pigment and the substance to be measured, respectively; (b) an optical delay device for causing delay of any one of pulse laser beams of two kinds of wavelengths generated by the pulse laser oscillator; (c) a microscope system for condensing laser beams generated by the pulse laser oscillator and irradiating the condensed beams to the sample; and (d) a detector for detecting light emission of the sample. According to the method of the present invention, it is possible to measure transient absorbance and transient absorption spectrum at a high sensitivity even when particulates containing the substance to be measured in liquid phase are present.
摘要翻译：公开了一种用于测量在含有荧光颜料的微粒的液相界面处的物质的瞬时吸光度和瞬时吸收光谱的方法，以及通过利用光学共振现象来测量的物质。还公开了一种用于实施该方法的装置，包括：（a）分别激发荧光颜料和待测物质的脉冲激光振荡器; （b）用于使由脉冲激光振荡器产生的两种波长的脉冲激光束中的任一种延迟的光延迟装置; （c）用于聚集由脉冲激光振荡器产生的激光束并将聚光束照射到样品的显微镜系统; 和（d）用于检测样品的光发射的检测器。根据本发明的方法，即使存在含有在液相中待测物质的微粒，也能以高灵敏度测定瞬时吸光度和瞬时吸收光谱。

9. 发明授权

US5393957A Laser microprocessing and the device therefor 失效
标题翻译：激光微加工及其设备
公开(公告)号：US5393957A
公开(公告)日：1995-02-28
申请号：US987594
申请日：1992-12-09
申请人： Hiroaki Misawa , Keiji Sasaki , Masanori Koshioka , Noboru Kitamura , Hiroshi Masuhara
发明人： Hiroaki Misawa , Keiji Sasaki , Masanori Koshioka , Noboru Kitamura , Hiroshi Masuhara
IPC分类号： B01J13/20 , B01J19/12 , B23K26/03 , B23K26/42 , G01N21/63 , B23K26/00
CPC分类号： B23K26/032 , B01J13/20 , B01J19/121 , B23K26/03 , B23K26/60 , G01N21/631
摘要： The present invention provides microprocessing and the device therefor which is characterized by radiating proessing pulse laser together with trapping laser to perform the modification and processing of particles and micropcapsules.In the case of using such method for implosion, the reaction group is caused to be released by imploding the micro capsule with the reactive goup enclosed to implosion, permitting specified reaction and processing.
摘要翻译：本发明提供微处理及其装置，其特征在于将激光脉冲激光与捕获激光一起辐射，以进行颗粒和微胶囊的改性和加工。在使用这种内爆方法的情况下，通过将反应性聚合物封闭在内爆中使微胶囊开启而使反应组释放，允许指定的反应和加工。

10. 发明授权

US08317847B2 Biostimulation apparatus, gene control apparatus, and muscle-related disorder therapeutic apparatus 有权
标题翻译：生物刺激仪，基因控制装置和肌肉相关障碍治疗仪
公开(公告)号：US08317847B2
公开(公告)日：2012-11-27
申请号：US12678998
申请日：2008-09-18
申请人： Yoichiro Hosokawa , Hiroshi Masuhara , Kazunori Okano , Yutaka Takaoka , Mika Ohta , Akihiko Ito
发明人： Yoichiro Hosokawa , Hiroshi Masuhara , Kazunori Okano , Yutaka Takaoka , Mika Ohta , Akihiko Ito
IPC分类号： A61N5/06 , A61N7/00 , A61F7/12
CPC分类号： A61N5/0619 , A61N2005/0644 , A61N2005/067
摘要： A biostimulation apparatus of the present invention includes a laser oscillator for oscillating an ultra short pulsed laser beam and an optical system for focusing the ultra short pulsed laser beam, wherein the ultra short pulsed laser beam is focused by the optical system at a target portion of a living subject to cause the target portion to be irradiated with the laser beam to stimulate an acupuncture point, and wherein the target portion is either the acupuncture point or its periphery.
摘要翻译：本发明的生物刺激装置包括用于振荡超短脉冲激光束的激光振荡器和用于聚焦超短脉冲激光束的光学系统，其中超短脉冲激光束被光学系统聚焦在目标部分使激光束照射目标部分以刺激针刺点的活体，并且其中目标部分是针刺点或其周边。

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