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1. 发明授权

US5206384A Actinonin derivatives and pharmaceutically acceptable salts thereof 失效
标题翻译： ACTINONIN衍生物及其药物可接受的盐
公开(公告)号：US5206384A
公开(公告)日：1993-04-27
申请号：US754543
申请日：1991-09-04
申请人： Seiji Shibahara , Yoshiyuki Koyama , Shigeharu Inoue , Mitsugu Hachisu , Shinichi Kondo , Takaaki Aoyagi , Tomio Takeuchi
发明人： Seiji Shibahara , Yoshiyuki Koyama , Shigeharu Inoue , Mitsugu Hachisu , Shinichi Kondo , Takaaki Aoyagi , Tomio Takeuchi
IPC分类号： A61K31/40 , A61K38/55 , A61P9/00 , A61P9/12 , A61P43/00 , C07D207/08 , C07D207/16 , C07K5/06 , C07K14/81 , C12N9/99
CPC分类号： C07D207/08 , C07D207/16
摘要： A novel actinonin derivative and a salt thereof are provided, which are useful as enzyme inhibitors and particularly have strong inhibitory activities against enkephalinase and angiotensin-converting enzymes. This actinonin derivative is represented by general formula (I): ##STR1## wherein R.sup.1 is sulfoxymethyl or carboxyl or a substituted carboxyl group selected from carboxamide, hydroxyaminocarbonyl and alkoxycarbonyl groups; and R.sup.2 is hydroxyl, alkoxy, hydroxyamino or sulfoxyamino group.

2. 发明授权

US5003055A Anthracycline derivatives having inhibitory activity against reverse transcriptase of human immunodeficiency virus 失效
标题翻译：对人类免疫缺陷病毒逆转录酶具有抑制活性的蒽环类衍生物
公开(公告)号：US5003055A
公开(公告)日：1991-03-26
申请号：US248417
申请日：1988-09-23
申请人： Tomio Takeuchi , Shinichi Kondo , Daishiro Ikeda , Yoshiyuki Koyama , Keiichi Ajito , Kazuo Umezawa , Sonoko Hirose
发明人： Tomio Takeuchi , Shinichi Kondo , Daishiro Ikeda , Yoshiyuki Koyama , Keiichi Ajito , Kazuo Umezawa , Sonoko Hirose
IPC分类号： C07C65/21 , C07H17/08
CPC分类号： C07H17/08 , C07C65/21
摘要： As new compounds are now provided 14-O-(3,4-disubstituted benzoyl)adriamycins which are of low cytotoxicity and exhibit a high activity inhibitory to the reverse transcriptase of human immunodeficiency virus (HIV) and which can inhibit propagation of HIV.

3. 发明授权

US5478575A Polymers having benzeneboronic acid groups and insulin complexes of same of a sugar response type 失效
标题翻译：具有苯硼酸基团的聚合物和具有糖响应型的相同的胰岛素复合物
公开(公告)号：US5478575A
公开(公告)日：1995-12-26
申请号：US37383
申请日：1993-03-26
申请人： Tsuyoshi Miyazaki , Yoshishige Murata , Daijiro Shiino , Kazunori Waki , Yasuhisa Sakurai , Teruo Okano , Kazunori Kataoka , Yoshiyuki Koyama , Masayuki Yokoyama , Shigeru Kitano
发明人： Tsuyoshi Miyazaki , Yoshishige Murata , Daijiro Shiino , Kazunori Waki , Yasuhisa Sakurai , Teruo Okano , Kazunori Kataoka , Yoshiyuki Koyama , Masayuki Yokoyama , Shigeru Kitano
IPC分类号： A61K9/00 , A61K47/32 , A61K47/36 , A61K47/48 , A61K38/28
CPC分类号： A61K9/0019 , A61K47/32 , A61K47/36 , A61K47/48176 , A61K47/4823 , Y10S514/866
摘要： The present invention provides a polymer complex of a sugar response type having boronic acid groups in the polymer. Medicines may be contained or linked, preferably, the medicines have hydroxy groups. The polymer having boronic acid groups and the medicine having hydroxy groups may be linked by boronic acid ester bonds. The complex may also comprises polymers having boronic acid groups and polymers having hydroxy groups, and these polymers may be cross-linked.
摘要翻译：本发明提供了在聚合物中具有硼酸基团的糖响应型聚合物复合物。药物可以包含或连接，优选地，药物具有羟基。具有硼酸基团的聚合物和具有羟基的药物可以通过硼酸酯键连接。络合物还可以包含具有硼酸基团的聚合物和具有羟基的聚合物，并且这些聚合物可以是交联的。

4. 发明授权

US10716874B2 Material to form a hydrogel 有权
公开(公告)号：US10716874B2
公开(公告)日：2020-07-21
申请号：US15632090
申请日：2017-06-23
申请人： Yoshiyuki Koyama
发明人： Yoshiyuki Koyama , Tomoko Ito
IPC分类号： A61L26/00 , A61L15/60 , A61L15/22 , A61L31/14 , A61L31/04 , C08L39/06
摘要： A soft film, a sponge, or a sheet in the dried state is provided, which is capable of forming a hydrogel absorbing water or blood. The film is obtainable by preparing a film-state material in the dried state from either a solution of poly(acrylic acid) or a solution of polyvinylpyrrolidone, and bringing the film-state material into contact with the other remaining solution, and then drying or freeze-drying it.

5. 发明授权

US08492142B2 Freeze-dried product for introducing nucleic acid, oligonucleic acid or derivative thereof 失效
标题翻译：用于引入核酸，低聚核酸或其衍生物的冷冻干燥产品
公开(公告)号：US08492142B2
公开(公告)日：2013-07-23
申请号：US13396875
申请日：2012-02-15
申请人： Yoshiyuki Koyama , Tomoko Ito
发明人： Yoshiyuki Koyama , Tomoko Ito
IPC分类号： C12N15/00
CPC分类号： C12N15/87 , A61K9/141 , A61K9/19 , A61K31/7088 , A61K47/542 , A61K47/543 , A61K47/59 , A61K47/60 , A61K47/61 , A61K47/6921 , A61K48/00 , A61K48/0091 , C12N15/1003 , C12N15/63
摘要： A freeze-dried product of a complex containing (i) a nucleic acid, an oligonucleic acid or a derivative thereof, (ii) polyethyleneimine and (iii) hyaluronic acid or chondroitin sulfate. The freeze-dried product can be used to introduce a nucleic acid or an oligonucleotide into a cell.
摘要翻译：包含（i）核酸，寡核酸或其衍生物，（ii）聚乙烯亚胺和（iii）透明质酸或硫酸软骨素的复合物的冷冻干燥产物。冷冻干燥产物可用于将核酸或寡核苷酸引入细胞。

6. 发明授权

US4393058A Cephalosporin compounds 失效
标题翻译：头孢菌素化合物
公开(公告)号：US4393058A
公开(公告)日：1983-07-12
申请号：US188417
申请日：1980-09-18
申请人： Osamu Makabe , Yasushi Murai , Tuneo Okonogi , Masahiro Onodera , Yoshiyuki Koyama , Takashi Yoshida
发明人： Osamu Makabe , Yasushi Murai , Tuneo Okonogi , Masahiro Onodera , Yoshiyuki Koyama , Takashi Yoshida
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07C45/71 , C07D213/80 , C07D213/82 , C07D213/85 , C07D501/36
CPC分类号： C07D213/80 , C07C45/71 , C07D213/82 , C07D213/85
摘要： Cephalosporin compounds, intermediate compounds therefor, and processes for preparation thereof are described; the compounds have the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 can each represent hydrogen, a hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted phenylalkoxy group; R.sub.3 represents hydrogen or a lower alkyl group; R.sub.4 represents hydrogen or a hydroxyl group; and R.sub.5 represents ##STR2## wherein R.sub.6 is hydrogen, a lower alkyl group, an aminoalkyl group, an aminoaralkyl group, a --(CH.sub.2).sub.n --SO.sub.3 Na group, or a --(CH.sub.2).sub.n --COR.sub.9 group [wherein R.sub.9 is a hydroxyl group, an OM group (wherein M is an alkali metal), an alkoxy group, or an ##STR3## group, (wherein R.sub.10 and R.sub.11, which may be the same or different, can represent hydrogen or an alkyl group), and n is 0 or an integer of from 1 to 4]; R.sub.7 is hydrogen, a lower alkyl group, an amino group, or a substituted or unsubstituted aryl group; and R.sub.8 represents hydrogen or a lower alkyl group; or, a pharmaceutically acceptable salt thereof.
摘要翻译：描述头孢菌素化合物，其中间体化合物及其制备方法; 化合物具有式（I）其中R 1和R 2各自表示氢，羟基，低级烷氧基或取代或未取代的苯基烷氧基; R3表示氢或低级烷基; R4代表氢或羟基; 其中R6为氢，低级烷基，氨基烷基，氨基烷基， - （CH2）n-SO3Na基或 - （CH2）n-COR9基[ 其中R 9为羟基，OM基（其中M为碱金属），烷氧基或基团（其中R10和R11可以相同或不同，表示氢或烷基组），n为0或1〜4的整数]。 R7是氢，低级烷基，氨基或取代或未取代的芳基; R8代表氢或低级烷基; 或其药学上可接受的盐。

7. 发明授权

US07550512B2 Medical polymers and uses thereof 失效
标题翻译：医用聚合物及其用途
公开(公告)号：US07550512B2
公开(公告)日：2009-06-23
申请号：US10859598
申请日：2004-06-03
申请人： Toshinori Sato , Yoshiyuki Koyama , Tetsuji Yamaoka
发明人： Toshinori Sato , Yoshiyuki Koyama , Tetsuji Yamaoka
IPC分类号： A61K47/34 , A61K47/30 , C08G65/329
CPC分类号： C08G65/334 , A61K47/34 , A61K47/36 , A61K47/60 , A61K47/61 , A61K48/00 , A61K48/0041 , C08G65/14 , C08G65/329 , C08G65/3324 , C08L2205/05
摘要： The present invention provides a polyethylene glycol derivative having sugar residue-containing side chains and carboxyl group-containing side chains, and a method of preparing the same. The present invention also provides a carrier for drug delivery systems and a carrier for gene transfer, both comprising the polyethylene glycol derivative.
摘要翻译：本发明提供了含糖残基侧链和含羧基侧链的聚乙二醇衍生物及其制备方法。本发明还提供了用于药物递送系统的载体和用于基因转移的载体，两者都包含聚乙二醇衍生物。

8. 发明授权

US5130126A Polymer-drug conjugate and a method of producing it 失效
标题翻译：聚合物 - 药物共轭物及其生产方法
公开(公告)号：US5130126A
公开(公告)日：1992-07-14
申请号：US676384
申请日：1991-03-28
申请人： Yoshiyuki Koyama , Shuji Kojima , Tsuyoshi Miyazaki , Akinori Suginaka , Takeo Matsumoto , Yoshishige Murata
发明人： Yoshiyuki Koyama , Shuji Kojima , Tsuyoshi Miyazaki , Akinori Suginaka , Takeo Matsumoto , Yoshishige Murata
IPC分类号： A61K31/557 , A61K47/48
CPC分类号： A61K47/48215 , A61K31/557 , Y10S514/925
摘要： The present invention provides a polymer-combined drug having directional characteristics to digestive organs, wherein it comprises a medicine combined with a polymer which has an alkyleneoxy group as a repeating unit. The polymer-combined drug is produced by reacting a polyoxyalkylene glycol having one or more terminal functional groups and a medicine, if necessary in a solvent, and if necessary in the presence of a catalyst. It is able to administer the drug orally or by intravenous injection so as to maintain the concentration in blood stably for a long time, and to absorb or take in digestive organs such as the stomach and intestines directly.
摘要翻译：本发明提供了具有消化器官方向特性的聚合物组合药物，其中包含与具有亚烷基氧基作为重复单元的聚合物组合的药物。通过使具有一个或多个末端官能团的聚氧亚烷基二醇和药物（如果需要在溶剂中）和必要时在催化剂存在下反应来制备聚合物组合药物。能够口服给药或静脉注射，以保持血液中的浓度长时间稳定，并直接吸收或摄入消化器官如肠胃。

9. 发明公开

US20240277891A1 MEDICAL TREATMENT MATERIAL AND METHOD FOR PRODUCING SAME 审中-公开
公开(公告)号：US20240277891A1
公开(公告)日：2024-08-22
申请号：US18571487
申请日：2022-06-27
申请人： Yoshiyuki Koyama , TOAGOSEI CO., LTD.
发明人： Yoshiyuki Koyama , Tomoko Ito , Kenichi Nakamura , Ayaka Ouchi
IPC分类号： A61L26/00 , C08J5/18
CPC分类号： A61L26/008 , A61L26/0052 , C08J5/18 , C08J2333/02 , C08J2333/10 , C08J2433/02 , C08J2439/06
摘要： A medical treatment material that forms a hydrogel upon contact with water contains a polymer (A) including a structural unit derived from an ethylenic unsaturated monomer (ma) which has a carboxyl group and a molecular weight of 115 or less, and a polymer (B) including a structural unit derived from an ethylenic unsaturated monomer (mb) which has a functional group E that is capable of forming a hydrogen bond with a carboxyl group, the polymer (B) not being the polymer (A). At least one of the polymer (A) and the polymer (B) includes a structural unit derived from an ethylenic unsaturated monomer (mc) differing from the ethylenic unsaturated monomers (ma) and (mb), and the monomer (mc) is not an ethylenic unsaturated monomer having a cross-linkable functional group.

10. 发明授权

US11045575B2 Material to form a hydrogel 有权
公开(公告)号：US11045575B2
公开(公告)日：2021-06-29
申请号：US16898990
申请日：2020-06-11
申请人： Yoshiyuki Koyama
发明人： Yoshiyuki Koyama , Tomoko Ito
IPC分类号： A61L26/00 , A61L15/60 , A61L15/22 , A61L31/14 , A61L31/04 , C08L39/06
摘要： A soft film, a sponge, or a sheet in the dried state is provided, which is capable of forming a hydrogel absorbing water or blood. The film is obtainable by preparing a film-state material in the dried state from either a solution of poly(acrylic acid) or a solution of polyvinylpyrrolidone, and bringing the film-state material into contact with the other remaining solution, and then drying or freeze-drying it.

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