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1. 发明授权

US4393058A Cephalosporin compounds 失效
标题翻译：头孢菌素化合物
公开(公告)号：US4393058A
公开(公告)日：1983-07-12
申请号：US188417
申请日：1980-09-18
申请人： Osamu Makabe , Yasushi Murai , Tuneo Okonogi , Masahiro Onodera , Yoshiyuki Koyama , Takashi Yoshida
发明人： Osamu Makabe , Yasushi Murai , Tuneo Okonogi , Masahiro Onodera , Yoshiyuki Koyama , Takashi Yoshida
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07C45/71 , C07D213/80 , C07D213/82 , C07D213/85 , C07D501/36
CPC分类号： C07D213/80 , C07C45/71 , C07D213/82 , C07D213/85
摘要： Cephalosporin compounds, intermediate compounds therefor, and processes for preparation thereof are described; the compounds have the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 can each represent hydrogen, a hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted phenylalkoxy group; R.sub.3 represents hydrogen or a lower alkyl group; R.sub.4 represents hydrogen or a hydroxyl group; and R.sub.5 represents ##STR2## wherein R.sub.6 is hydrogen, a lower alkyl group, an aminoalkyl group, an aminoaralkyl group, a --(CH.sub.2).sub.n --SO.sub.3 Na group, or a --(CH.sub.2).sub.n --COR.sub.9 group [wherein R.sub.9 is a hydroxyl group, an OM group (wherein M is an alkali metal), an alkoxy group, or an ##STR3## group, (wherein R.sub.10 and R.sub.11, which may be the same or different, can represent hydrogen or an alkyl group), and n is 0 or an integer of from 1 to 4]; R.sub.7 is hydrogen, a lower alkyl group, an amino group, or a substituted or unsubstituted aryl group; and R.sub.8 represents hydrogen or a lower alkyl group; or, a pharmaceutically acceptable salt thereof.
摘要翻译：描述头孢菌素化合物，其中间体化合物及其制备方法; 化合物具有式（I）其中R 1和R 2各自表示氢，羟基，低级烷氧基或取代或未取代的苯基烷氧基; R3表示氢或低级烷基; R4代表氢或羟基; 其中R6为氢，低级烷基，氨基烷基，氨基烷基， - （CH2）n-SO3Na基或 - （CH2）n-COR9基[ 其中R 9为羟基，OM基（其中M为碱金属），烷氧基或基团（其中R10和R11可以相同或不同，表示氢或烷基组），n为0或1〜4的整数]。 R7是氢，低级烷基，氨基或取代或未取代的芳基; R8代表氢或低级烷基; 或其药学上可接受的盐。

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