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1. 发明申请

US20100330009A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS 有权
标题翻译：氧化铝类抗氧化剂和紫外线吸收剂
公开(公告)号：US20100330009A1
公开(公告)日：2010-12-30
申请号：US12528357
申请日：2008-02-29
申请人： Barbara Wagner , Sebastien Mongiat , Bernd Herzog , Werner Baschong , Andreas Buthe , Reinhold Ohrlein
发明人： Barbara Wagner , Sebastien Mongiat , Bernd Herzog , Werner Baschong , Andreas Buthe , Reinhold Ohrlein
IPC分类号： A61K8/60 , A61K31/352 , C07D493/04 , A61K31/7048 , C07H17/04 , A61K31/7084 , A61K31/655 , A61K31/4355 , C07D491/04 , A61K8/92 , A61K8/49 , A61P17/00 , A61Q1/06 , A61Q1/10 , A61Q1/12 , A61Q5/00 , A61Q17/04 , C12P19/60 , C12P17/12 , C12P17/06 , A23L3/34
CPC分类号： C07D493/04 , A61K8/4973 , A61K8/498 , A61K2800/522 , A61Q17/04 , C07D491/04
摘要： The present invention relates to derivatives of the 1H-pyrano[4,3-b]benzofuran-1-one structure and their nitrogen analogues which possess powerful antioxidant properties combined with a highly effective UV absorbing functionality in one molecule. These compounds are especially useful in cosmetical and dermatological formulations.
摘要翻译：本发明涉及具有强大抗氧化性能的1H-吡喃并[4,3-b]苯并呋喃-1-酮结构的衍生物及其在一个分子中与高效UV吸收官能团结合的氮类似物。这些化合物在美容和皮肤病学制剂中特别有用。

2. 发明申请

US20090258041A1 Protection of Oxidizable Agents 审中-公开
标题翻译：氧化剂的保护
公开(公告)号：US20090258041A1
公开(公告)日：2009-10-15
申请号：US12083557
申请日：2006-06-21
申请人： Sebastien Mongiat , Werner Baschong , Bernd Herzog
发明人： Sebastien Mongiat , Werner Baschong , Bernd Herzog
IPC分类号： A61K8/02 , A61P17/02
CPC分类号： A61K31/05 , A61K8/11 , A61K8/14 , A61K8/347 , A61K8/37 , A61K8/375 , A61K8/42 , A61K8/46 , A61K8/466 , A61K8/4926 , A61K8/4966 , A61K8/4973 , A61K8/553 , A61K8/671 , A61K8/676 , A61K31/222 , A61K31/255 , A61K31/34 , A61K31/445 , A61K2800/412 , A61K2800/413 , A61K2800/522 , A61Q1/02 , A61Q5/02 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： Formulations for cosmetical or pharmaceutical use contain an antioxidant in encapsulated form and a cosmetically or pharmaceutically acceptable carrier. The antioxidant is selected from carbon bridged hindered phenoles, ester bridged hindered phenoles, amide bridged hindered phenoles, lactones of hindered phenoles, sterically hindered oxylamines and sterically hindered hydroxylamines. The encapsulated antioxidant is of high activity and suitable to protect a further active ingredient, e.g. oxidizable natural substances, vitamins, fragrances, and extracts from plants fungi, algae or animals, from premature degradation, especially when coencapsulated together with the ingredient. The formulations are useful inter alia for the preparation of a cosmetical or pharmaceutical skin care or skin delivery formulation, injectable solution, infusion solution, eye drop, drinking solution, a dietary or enriched food, an oral care formulation, drinking gargles, in-halants, or as a food additive.
摘要翻译：化妆品或药物用途的制剂含有包封形式的抗氧化剂和化妆品或药学上可接受的载体。抗氧化剂选自碳桥接的受阻酚，酯桥接的受阻酚，酰胺桥接的受阻酚，受阻酚的内酯，空间位阻的羟胺和空间位阻羟胺。包封的抗氧化剂具有高活性并且适于保护另外的活性成分，例如，可氧化的天然物质，维生素，香料，以及来自植物真菌，藻类或动物的提取物，过早降解，特别是当与成分一起胶囊时。该制剂尤其用于制备美容或药物皮肤护理或皮肤递送制剂，可注射溶液，输注溶液，滴眼剂，饮用溶液，饮食或富含食物，口腔护理制剂，饮用漱口剂，漱口剂，或作为食品添加剂。

3. 发明申请

US20120093896A1 USE OF NANODISPERSIONS TO PROTECT WATER-SOLUBLE INGREDIENTS IN COSMETIC END FORMULATIONS 审中-公开
标题翻译：使用纳米尺寸来保护化妆品配方中的水溶性成分
公开(公告)号：US20120093896A1
公开(公告)日：2012-04-19
申请号：US12669972
申请日：2008-07-22
申请人： Sébastien Mongiat , Julie Grumelard , Werner Baschong , Bernd Herzog
发明人： Sébastien Mongiat , Julie Grumelard , Werner Baschong , Bernd Herzog
IPC分类号： A61K8/04 , A61K8/66 , A61K8/02 , A61Q19/00 , A61Q5/00 , A61K8/67 , A61Q1/12 , B82Y40/00 , B82Y99/00
CPC分类号： A61K8/676 , A61K8/04 , A61K8/345 , A61K8/375 , A61K8/4993 , A61K8/553 , A61K8/68 , A61K8/86 , A61K8/894 , A61K8/898 , A61K8/90 , A61K2800/413 , A61K2800/52 , A61K2800/522 , A61Q19/00 , B82Y5/00
摘要： The invention describes the use of a nanodispersion, which comprises: a) a membrane-forming molecule, b) a co-emulsifier, c) a lipophilic component, and d) a water-soluble ingredient sensitive to oxidation in cosmetic end formulations, the nanodispersion being obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous liquid is obtained (so-called nanodispersion pre-phase), and (β) adding the water or aqueous phase (discontinuous phase) which contains the water-soluble ingredient and optionally the non-aqueous polar organic solvent to the liquid obtained in step (α). Component (d) is preferably ascorbic acid or vitamin C.
摘要翻译：本发明描述了纳米分散体的使用，其包括：a）成膜分子，b）共乳化剂，c）亲脂性组分，和d）在化妆品末端制剂中对氧化敏感的水溶性成分，通过（α）混合组分（a），（b）和（c）直到获得均匀的液体（所谓的纳米分散前相）和（＆bgr）加入水或水相（不连续的）可获得的纳米分散体相），其包含水溶性成分和任选的非水极性有机溶剂与步骤（α）中获得的液体。组分（d）优选为抗坏血酸或维生素C.

4. 发明授权

US08383088B2 Coumestan-like antioxidants and UV absorbants 有权
标题翻译：辅酶样抗氧化剂和紫外线吸收剂
公开(公告)号：US08383088B2
公开(公告)日：2013-02-26
申请号：US12528357
申请日：2008-02-29
申请人： Barbara Wagner , Sébastien Mongiat , Bernd Herzog , Werner Baschong , Andreas Buthe , Reinhold Öhrlein
发明人： Barbara Wagner , Sébastien Mongiat , Bernd Herzog , Werner Baschong , Andreas Buthe , Reinhold Öhrlein
IPC分类号： A61K8/00 , A61K8/18 , A61Q17/04 , A61Q1/02 , A61Q19/04 , A61Q1/00 , A61Q1/12 , A61Q5/00 , A61Q9/00
CPC分类号： C07D493/04 , A61K8/4973 , A61K8/498 , A61K2800/522 , A61Q17/04 , C07D491/04
摘要： The present invention relates to derivatives of the 1H-pyrano[4,3-b]benzofuran-1-one structure and their nitrogen analogues which possess powerful antioxidant properties combined with a highly effective UV absorbing functionality in one molecule. These compounds are especially useful in cosmetical and dermatological formulations.
摘要翻译：本发明涉及具有强大抗氧化性能的1H-吡喃并[4,3-b]苯并呋喃-1-酮结构的衍生物及其在一个分子中与高效UV吸收官能团结合的氮类似物。这些化合物在美容和皮肤病学制剂中特别有用。

5. 发明授权

US11103733B2 Water based concentrated product forms of oil-soluble organic UV absorbers 有权
公开(公告)号：US11103733B2
公开(公告)日：2021-08-31
申请号：US12664666
申请日：2008-06-30
申请人： Stefan Müller , Brigitte Lindemann , Bernd Herzog
发明人： Stefan Müller , Brigitte Lindemann , Bernd Herzog
IPC分类号： A61Q17/04 , A61K8/11 , A61K8/58 , A61K8/37 , A61K8/35 , A61K8/44 , A61K8/81 , A61K8/893 , A61K8/49
摘要： The instant invention refers to the use of a concentrated aqueous polymer dispersion with an average particle size of less than 1000 nm comprising (a) a polymer carrier prepared by heterophase radical polymerization of at least one ethylenically unsaturated monomer in the presence of (b) an oil-soluble organic UV absorber selected from the class of p-aminobenzoic acid derivatives; salicylic acid derivatives; benzophenone derivatives; diphenyl acrylate derivatives; benzofuran derivatives; polymeric UV absorbers, comprising one or more organosilicon radicals; cinnamic acid derivatives; camphor derivatives; s-triazine derivatives; trianilino-s-triazine derivatives; menthyl anthranilates; and benzotriazole derivatives; wherein the weight ratio of the oil-soluble organic UV absorber (b) to polymer carrier (a) is greater than 50 parts UV absorber per 100 parts of carrier; for the protection of human and animal hair and skin against the damaging effect of UV radiation. The concentrated aqueous polymer dispersions show unexpectedly high sunscreen effects and a positive skin feeling.

6. 发明授权

US07790769B2 Merocyanine derivatives 有权
标题翻译：梅花菁衍生物
公开(公告)号：US07790769B2
公开(公告)日：2010-09-07
申请号：US12086647
申请日：2006-12-11
申请人： Barbara Wagner , Astrid Walther , Bernd Herzog
发明人： Barbara Wagner , Astrid Walther , Bernd Herzog
IPC分类号： A61K31/136 , C07C211/26
CPC分类号： C07C317/44 , C07C255/31 , C07C2601/16
摘要： Disclosed are merocyanine derivatives of formula (1), wherein R1 and R2 independently from each other are branched C4-C22alkyl; or branched C4-C12 alkenyl; R3 and R4 independently from each other are cyano; COR7, COOR7; CONR7R8; SO2(C6-C12)aryl; C2-C12alk-1-enyl; C3-C12cycloalk-1-enyl; C2-C12alk-1-inyl; C2-C12heteroalkyl; C3-C5heterocycloalkyl; C6-C10aryl; or C1-C9heteroaryl; wherein at least one of R3 and R4 is cyano; R5 and R6 independently from each other are hydrogen; C1-C6alkyl; C5-C8cycloalkyl which may be substituted by one or more than one C1-C4alkyl; and R7 and R8 independently from each other are hydrogen; C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; —(CH2)tCOOH; C7-C12aralkyl; C1-C12heteroalkyl; C2-C11heteroaralkyl; C6-C10aryl; C1-C9heteroaryl. The compounds are useful as UV absorbers for protecting human hair and skin against the damaging effect of UV radiation.
摘要翻译：公开了式（1）的部花青衍生物，其中R 1和R 2彼此独立地为支链C 4 -C 22烷基; 或支链C 4 -C 12烯基; R 3和R 4彼此独立地是氰基; COR7，COOR7; CONR7R8; SO2（C6-C12）芳基; C2-C12烷-1-烯基; C 3 -C 12环烯-1-烯基; C2-C12alk-1-inyl; C 2 -C 12杂烷基; C3-C5杂环烷基; C6-C10芳基; 或C 1 -C 9杂芳基; 其中R 3和R 4中的至少一个是氰基; R5和R6彼此独立地是氢; C1-C6烷基; 可被一个或多于一个C 1 -C 4烷基取代的C 5 -C 8环烷基; 并且R 7和R 8彼此独立地是氢; C 1 -C 22烷基; C 2 -C 12烯基; C 2 -C 12炔基; C 3 -C 12环烷基; C3-C12环烯基; - （CH 2）t COOH; C7-C12芳烷基; C 1 -C 12杂烷基; C 2 -C 11杂芳烷基; C6-C10芳基; C1-C9杂芳基。这些化合物可用作紫外线吸收剂，用于保护人体毛发和皮肤免受紫外线辐射的破坏作用。

7. 发明授权

US07772242B2 Merocyanine derivatives 有权
公开(公告)号：US07772242B2
公开(公告)日：2010-08-10
申请号：US11630489
申请日：2005-06-20
申请人： Barbara Wagner , Frank Bienewald , Heinz Wolleb , Olof Wallquist , Bernd Herzog , Thomas Ehlis , Jürg Haase
发明人： Barbara Wagner , Frank Bienewald , Heinz Wolleb , Olof Wallquist , Bernd Herzog , Thomas Ehlis , Jürg Haase
IPC分类号： A61K31/519 , A61K31/445 , A61K31/16 , A61K31/165
CPC分类号： A61K8/498 , A61K8/4913 , A61K8/494 , A61Q17/04
摘要： Disclosed is the use of the compounds of formula wherein Q is —OH; —OR7; —NH2; —NHR7; —NR7R8; or —N═R9; T is —COR5; —CN; or —SO2—(C6-C12)aryl; R1 is hydrogen; —OR7, —SR7; —NHR7; —NR7R8; C1-C22alkyl; C2-C12Alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12heteroalkyl, C2-C11heteroaralkyl; C6-C10aryl; or C1-C9heteroaryl; R2 and R3 independently from each other are C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl, C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12heteroalkyl; C3-C12cycloheteroalkyl; C2-C11heteroaralkyl, C6-C10aryl; or C1-C9heteroaryl; R4 is cyano; COR7, COOR7; CONH2; CONHR7; CONR7R8; SO2(C6-C12)aryl, C2-C12alk-1 -enyl; C3-C12cycloalk-1-enyl; C2-C12alk-1-inyl; C2-C12heteroalkyl, C3-C5heterocycloalkyl, C6-C10aryl; or C1-C9heteroaryl; R5 is —COR7; —COOR7; —OR7; —SR7, —NHR7, —NR7R8; C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12alkylphenyl; C1-C12alkoxy-C6-C10aryl; C1-C12heteroalkyl; C2-C11heteroaralkyl; C3-C12cycloheteroalkyl; C6-C10aryl; C1-C12alkoxy-C6-C10aryl or C1-C9heteroaryl; R6, R7 and R8 independently from each other are hydrogen; C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12heteroalkyl; C2-C11heteroaralkyl; C6-C10aryl; o-C6-C10aryl; or C1-C9heteroaryl; R9 is a (C1-C6)alkylidene radical; or R1 and R2, R1 and Q, R1 and R4, R1 and R6, R2 and R3, R3 and Q, R6 and Q, T and Q, each independently, are linked together, so that 1, 2, 3 or 4 carbocyclic or N, O and/or S-heterocyclic rings are formed, wherein each of them, independently from each other, may be condensed with an aromatic or heteroaromatic ring, and/or more N-, O- and/or S-heterocycic rings, and each N atom in a N-heterocyclic ring may be substituted by C1-C22alkyl; and n is a number from 1 to 4; for protecting of human hair and skin against the damaging effect of UV radiation.

8. 发明申请

US20100008873A1 Use of benzotriazole derivatives for photostabilisation 有权
标题翻译：苯并三唑衍生物用于光稳定化
公开(公告)号：US20100008873A1
公开(公告)日：2010-01-14
申请号：US11919104
申请日：2006-04-20
申请人： Stefan Müller , Jochen Giesinger , Thomas Ehlis , Bernd Herzog , Peter König , Gilbert Kreyer , Katja Quass
发明人： Stefan Müller , Jochen Giesinger , Thomas Ehlis , Bernd Herzog , Peter König , Gilbert Kreyer , Katja Quass
IPC分类号： A61K8/49 , A61P17/04
CPC分类号： A61Q17/04 , A61K8/496 , A61K2800/52
摘要： Use of benzotriazole derivatives of formula (1), wherein R1 is C1-C30alkyl; C1C5alkoxy; C1-C5alkoxycarbonyl; C5-C7cycloalkyl; C6-C10aryl; aralkyl; —SO3M; a radical of formula (1a) R3 is hydrogen; C1C5alkyl; C1C5alkoxy; halogen, preferably Cl; or hydroxy; R4 and R5 are each independently of the other hydrogen; or d-C5alkyl; m is 1 or 2; n is O or 1; if m=1, R2 is hydrogen; unsubstituted or phenyl-substituted d-C1-C12alkyl; or C6-C10aryl; if m=2, R2 is the direct bond; or —(CH2)p—; and p is 1 to 3; for enhancing the photostability of cosmetic or dermatologic compositions comprising at least one further organic UV absorber.
摘要翻译：式（1）的苯并三唑衍生物的用途，其中R 1是C 1 -C 30烷基; C1C5烷氧基 C1-C5烷氧基羰基; C5-C7环烷基; C6-C10芳基; 芳烷基 -SO3M; 式（1a）的基团R 3是氢; C 1 -C 5烷基; C1C5烷氧基卤素，优选Cl; 或羟基; R4和R5各自独立地为氢; 或d-C 5烷基; m为1或2; n为0或1; 如果m = 1，则R2为氢; 未取代或苯基取代的d-C 1 -C 12烷基; 或C 6 -C 10芳基; 如果m = 2，则R2是直接键; 或 - （CH 2）p - ; p为1〜3; 用于增强包含至少一种另外的有机UV吸收剂的化妆品或皮肤病学组合物的光稳定性。

9. 发明授权

US07178511B2 Apparatus for controlling a pressure in a fuel inflow line 有权
标题翻译：用于控制燃料流入管线中的压力的装置
公开(公告)号：US07178511B2
公开(公告)日：2007-02-20
申请号：US11040677
申请日：2005-01-20
申请人： Lothar Dickenscheid , Bernd Herzog
发明人： Lothar Dickenscheid , Bernd Herzog
IPC分类号： F02M37/00
CPC分类号： F16K15/042 , F02M37/106 , F16K15/028 , F16K17/0406 , F16K17/0413 , F16K17/044
摘要： In an apparatus (12) for controlling a pressure in a fuel inflow line of a motor vehicle, a shutoff valve (20) and a pressure limiting valve (21) are arranged in a connection (19). The connection (19) is arranged between an inflow junction (16) which leads to the inflow line and an outflow junction (17) which is led into a fuel container. The pressure limiting valve (21) opens above a first pressure and throttles the flow of the fuel through the connection (19). The shutoff valve (20) closes above a second pressure, the second pressure being higher than the first pressure. This ensures that, when a fuel delivery unit is at a standstill, the pressure in the inflow line does not exceed the first pressure and that, during operation of the delivery unit, the pressure in the inflow line can rise above the second pressure and an internal combustion engine of the motor vehicle is supplied sufficiently with fuel.
摘要翻译：在用于控制机动车辆的燃料流入管路中的压力的装置（12）中，截止阀（20）和限压阀（21）被布置在连接（19）中。连接件（19）设置在通向流入管线的流入结（16）和被引入燃料容器的流出结（17）之间。压力限制阀（21）在第一压力之上打开并且通过连接件（19）节流燃料的流动。截止阀（20）在第二压力以上闭合，第二压力高于第一压力。这确保了当燃料输送单元处于停止状态时，流入管线中的压力不超过第一压力，并且在输送单元的操作期间，流入管线中的压力可以升高到高于第二压力，并且机动车辆的内燃机被充分地供给燃料。

10. 发明授权

US6111103A Diresorcinyl-alkoxy- and -aryloxy-s-triazines 失效
标题翻译：二氧化物 - 烷氧基 - 和 - 芳氧基-s-三嗪
公开(公告)号：US6111103A
公开(公告)日：2000-08-29
申请号：US287029
申请日：1999-04-06
申请人： Thomas Ehlis , Elek Borsos , Helmut Luther , Bernd Herzog
发明人： Thomas Ehlis , Elek Borsos , Helmut Luther , Bernd Herzog
IPC分类号： A61K8/00 , A61K8/49 , A61Q17/04 , C07D251/22 , C07D251/26 , C07D405/12 , C08K5/3492 , C09K3/00 , C09K15/30
CPC分类号： C07D405/12 , A61K8/4966 , A61Q17/04 , C07D251/22
摘要： The invention relates to diresorcinyl-alkoxy- and -aryloxy-triazines of the formula ##STR1## in which R.sub.1 is C.sub.2 -C.sub.30 alkyl; C.sub.2 -C.sub.30 alkenyl; unsubstituted or C.sub.1 -C.sub.5 alkyl-mono- or polysubstituted C.sub.5 -C.sub.12 cycloalkyl, C.sub.1 -C.sub.5 alkoxy-C.sub.1 -C.sub.12 alkyl; amino-C.sub.1 -C.sub.12 alkyl; C.sub.1 -C.sub.5 monoalkylamino-C.sub.1 -C.sub.12 alkyl; C.sub.1 -C.sub.5 dialkylamino-C.sub.1 -C.sub.12 alkyl; a radical of the formula ##STR2## R.sub.2, R.sub.3 and R.sub.4, independently of one another, are hydrogen, hydroxyl, C.sub.1 -C.sub.30 alkyl, C.sub.1 -C.sub.30 alkenyl,R.sub.5 is hydrogen; or C.sub.1 -C.sub.5 alkyl;m.sub.1 is 0 or 1; andn.sub.1 is 1 to 5.The novel compounds are suitable as cosmetic UV-A absorbers.
摘要翻译：本发明涉及下式的二缩水甘油基 - 烷氧基 - 和 - 芳氧基 - 三嗪，其中R 1是C 2 -C 30烷基; C2-C30烯基; 未取代的或C 1 -C 5烷基 - 单取代或多取代的C 5 -C 12环烷基，C 1 -C 5烷氧基-C 1 -C 12烷基; 氨基-C 1 -C 12烷基; C 1 -C 5单烷基氨基-C 1 -C 12烷基; C 1 -C 5二烷基氨基-C 1 -C 12烷基; 式R2，R3和R4彼此独立的基团是氢，羟基，C 1 -C 30烷基，C 1 -C 30烯基，R 5是氢; 或C 1 -C 5烷基; m1为0或1; n1为1〜5。新化合物适合作为化妆品UV-A吸收剂。

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