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1. 发明申请

US20050056540A1 Loading features for channel array 有权
标题翻译：加载通道阵列的功能
公开(公告)号：US20050056540A1
公开(公告)日：2005-03-17
申请号：US10661231
申请日：2003-09-12
申请人： Paul Ramstad , Sean Desmond , John Shigeura , Richard Reel , Richard Morris , Janice Shigeura
发明人： Paul Ramstad , Sean Desmond , John Shigeura , Richard Reel , Richard Morris , Janice Shigeura
IPC分类号： G01N27/447 , G01L1/20 , C07K1/26 , G01N27/453
CPC分类号： G01N27/44743
摘要： Apparatus and method for loading a channel device for electrophoretic separation including cilia which can be deflected into wells of a multi-well tray.
摘要翻译：用于装载用于电泳分离的通道装置的装置和方法，包括可以偏转到多孔盘的孔中的纤毛。

2. 发明申请

US20060046304A1 Thermal device, system, and method, for fluid processing device 有权
公开(公告)号：US20060046304A1
公开(公告)日：2006-03-02
申请号：US10926915
申请日：2004-08-26
申请人： John Shigeura , Janice Shigeura , Sean Desmond , David Cox
发明人： John Shigeura , Janice Shigeura , Sean Desmond , David Cox
IPC分类号： G01N33/00
CPC分类号： G05D23/24 , G05D23/192 , G05D23/20 , G05D23/22 , Y02P20/129 , Y10S435/809
摘要： A device, system, and method are provided for thermally treating a fluid processing device. According to various embodiments, a system is provided that can include a thermal device and a fluid processing device holder. The thermal device can include a first block having a thermal conductivity greater than 0.5 Watt per centimeter Kelvin (W/cm·K), a second block having a thermal conductivity greater than 0.5 W/cm·K, and a heat-pump device disposed between the first block and the second block. The heat-pump device can transfer thermal energy from at least one of the first block and the second block to the other of the first block and the second block. The fluid processing device holder can hold a fluid processing device in a heat-transfer position with respect to the first block and the second block. The fluid processing device can be a microfluidic device.

3. 发明申请

US20060006068A1 Capillary array assembly for loading samples from a device, and method 有权
标题翻译：用于从装置加载样品的毛细管阵列组件和方法
公开(公告)号：US20060006068A1
公开(公告)日：2006-01-12
申请号：US10887477
申请日：2004-07-08
申请人： Sean Desmond , John Shigeura , Janice Shigeura
发明人： Sean Desmond , John Shigeura , Janice Shigeura
IPC分类号： G01N27/26
CPC分类号： G01N27/44743 , G01N27/44782
摘要： A capillary array assembly is provided that can be used to inject samples into an electrophoresis device. The capillary array assembly can include an injection end that can be arranged to interface with output wells of a fluid processing device, for example, a microfluidic card-type device.
摘要翻译：提供了可用于将样品注入电泳装置的毛细管阵列组件。毛细管阵列组件可以包括注射端，其可被布置成与流体处理装置的输出孔（例如，微流控卡型装置）相接合。

4. 发明申请

US20080094627A1 Time-delay integration in a flow cytometry system 有权
标题翻译：流式细胞术系统中的延时整合
公开(公告)号：US20080094627A1
公开(公告)日：2008-04-24
申请号：US11644412
申请日：2006-12-22
申请人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
发明人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting analytes in a sample is provided. The apparatus can include: a flow cytometry system including one or more detection zones; one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from detectable analytes in the one or more detection zones, which have been excited by the radiation, wherein at least one detector includes an output; a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector; and a sorting mechanism, for example, to effect flow cytometry. Methods for detecting analytes in a sample are also provided.
摘要翻译：提供了一种用于检测样品中分析物的装置。该装置可以包括：流式细胞术系统，其包括一个或多个检测区域; 一个或多个辐射源被设置用于用辐射照射一个或多个检测区域; 至少一个检测器，其被设置用于收集对应于已被所述辐射激发的所述一个或多个检测区域中的可检测分析物发射的光信号的电荷，其中至少一个检测器包括输出; 耦合到所述至少一个检测器的系统，用于通过在读取所述至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分; 以及分选机制，例如进行流式细胞术。还提供了检测样品中分析物的方法。

5. 发明申请

US20080043235A1 Electrophoretic system with multi-notch filter and laser excitation source 有权
标题翻译：具有多陷波滤波器和激光源的电泳系统
公开(公告)号：US20080043235A1
公开(公告)日：2008-02-21
申请号：US11894829
申请日：2007-08-22
申请人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
发明人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N21/6456 , B82Y10/00 , B82Y20/00 , G01N27/44721 , G01N2021/6417 , G01N2021/6419 , G01N2021/6471 , G01N2201/0628
摘要： Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecting at least one charge corresponding to an emission beam emitted from the detection zone, the detector having an output; and a time delay integration system coupled to the detector for effecting time delay integration of the at least one charge by accumulating the at least one charge before reading the at least one charge at the output of the detector. Various embodiments provide an apparatus with a multi-notch filter. Various embodiments provide a solid state laser, a micro-wire laser, or an organic light-emitting diode as a irradiation source.
摘要翻译：提供了用于检测样品中分析物的装置和方法。该装置可以包括：具有检测区域的一个或多个通道; 设置用于辐射照射检测区域的一个或多个照射源; 检测器，其能够收集对应于从所述检测区域发射的发射光束的至少一个电荷，所述检测器具有输出; 以及耦合到所述检测器的时间延迟积分系统，用于通过在所述检测器的输出读取所述至少一个电荷之前积累所述至少一个电荷来实现所述至少一个电荷的时间延迟积分。各种实施例提供具有多陷波滤波器的装置。各种实施例提供固态激光器，微线激光器或有机发光二极管作为照射源。

6. 发明申请

US20050036142A1 Electrophoretic system with multi-notch filter and laser excitation source 有权
标题翻译：具有多陷波滤波器和激光源的电泳系统
公开(公告)号：US20050036142A1
公开(公告)日：2005-02-17
申请号：US10887528
申请日：2004-07-08
申请人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
发明人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
IPC分类号： G01N21/00 , G01N21/63 , G01N27/27
CPC分类号： G01N21/6456 , B82Y10/00 , B82Y20/00 , G01N27/44721 , G01N2021/6417 , G01N2021/6419 , G01N2021/6471 , G01N2201/0628
摘要： Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecting at least one charge corresponding to an emission beam emitted from the detection zone, the detector having an output; and a time delay integration system coupled to the detector for effecting time delay integration of the at least one charge by accumulating the at least one charge before reading the at least one charge at the output of the detector. Various embodiments provide an apparatus with a multi-notch filter. Various embodiments provide a solid state laser, a micro-wire laser, or an organic light-emitting diode as a irradiation source.
摘要翻译：提供了用于检测样品中分析物的装置和方法。该装置可以包括：具有检测区域的一个或多个通道; 设置用于辐射照射检测区域的一个或多个照射源; 检测器，其能够收集对应于从所述检测区域发射的发射光束的至少一个电荷，所述检测器具有输出; 以及耦合到所述检测器的时间延迟积分系统，用于通过在所述检测器的输出读取所述至少一个电荷之前积累所述至少一个电荷来实现所述至少一个电荷的时间延迟积分。各种实施例提供具有多陷波滤波器的装置。各种实施例提供固态激光器，微线激光器或有机发光二极管作为照射源。

7. 发明申请

US20050030534A1 Time-delay integration in a flow cytometry system 有权
标题翻译：流式细胞术系统中的延时整合
公开(公告)号：US20050030534A1
公开(公告)日：2005-02-10
申请号：US10887486
申请日：2004-07-08
申请人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
发明人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
IPC分类号： G01N21/00 , G01N21/63 , G01N27/27
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting analytes in a sample is provided. The apparatus can include: a flow cytometry system including one or more detection zones; one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from detectable analytes in the one or more detection zones, which have been excited by the radiation, wherein at least one detector includes an output; a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector; and a sorting mechanism, for example, to effect flow cytometry. Methods for detecting analytes in a sample are also provided.
摘要翻译：提供了一种用于检测样品中分析物的装置。该装置可以包括：流式细胞术系统，其包括一个或多个检测区域; 一个或多个辐射源被设置用于用辐射照射一个或多个检测区域; 至少一个检测器，其被设置用于收集对应于已被所述辐射激发的所述一个或多个检测区域中的可检测分析物发射的光信号的电荷，其中至少一个检测器包括输出; 耦合到所述至少一个检测器的系统，用于通过在读取所述至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分; 以及分选机制，例如进行流式细胞术。还提供了检测样品中分析物的方法。

8. 发明申请

US20050161192A1 Heat transfer for thermal cycling 有权
标题翻译：热循环换热
公开(公告)号：US20050161192A1
公开(公告)日：2005-07-28
申请号：US10763537
申请日：2004-01-23
申请人： John Shigeura , Janice Shigeura
发明人： John Shigeura , Janice Shigeura
IPC分类号： B01L3/00 , B01L7/00 , B04B15/02 , G01N35/00 , F25B21/02 , B41B1/00 , B41F1/00 , B41J1/00 , F25B29/00 , F25D25/00 , F28D11/00 , F28F5/00 , G06F15/00 , G06K1/00
CPC分类号： B01L3/50851 , B01L7/52 , B01L2300/0803 , B01L2300/1822 , B01L2300/1838 , B01L2400/0409 , B01L2400/086 , G01N2035/00237 , G01N2035/00346
摘要： The present application relates to an apparatus and method for heat transfer for thermal cycling.
摘要翻译：本申请涉及用于热循环的热传递的装置和方法。

9. 发明申请

US20130011842A1 DNA Sequencing System 有权
标题翻译： DNA测序系统
公开(公告)号：US20130011842A1
公开(公告)日：2013-01-10
申请号：US13619298
申请日：2012-09-14
申请人： Mark F. OLDHAM , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice Shigeura
发明人： Mark F. OLDHAM , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice Shigeura
IPC分类号： G01N21/64
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译：提供了一种用于检测标记珠粒的装置。该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

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