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1. 发明申请

US20090299468A1 ENDOPROSTHESIS COATING 审中-公开
标题翻译：内部涂层
公开(公告)号：US20090299468A1
公开(公告)日：2009-12-03
申请号：US12469203
申请日：2009-05-20
申请人： Scott R. Schewe , Jan Weber , Michele Zoromski , Robert W. Warner
发明人： Scott R. Schewe , Jan Weber , Michele Zoromski , Robert W. Warner
IPC分类号： A61F2/06 , B05D1/24
CPC分类号： A61L31/082 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/608 , A61L2300/62 , A61L2420/08
摘要： An endoprosthesis, e.g., a stent (e.g., a drug eluting stent), includes a surface, a first layer having a polyelectrolyte deposited on the surface, a plurality of polymeric particles deposited on the first layer, and a coating of a porous material deposited on the plurality of polymeric particles. At least one particle of the plurality of polymeric particles includes a polymer matrix and a drug distributed in the polymer matrix. A method of making the endoprosthesis is also disclosed.
摘要翻译：内置假体，例如支架（例如，药物洗脱支架）包括表面，沉积在表面上的聚电解质的第一层，沉积在第一层上的多个聚合物颗粒和沉积在多孔材料上的涂层在多个聚合物颗粒上。多个聚合物颗粒中的至少一个颗粒包括分散在聚合物基质中的聚合物基质和药物。还公开了制造内用假体的方法。

2. 发明申请

US20090048659A1 Medical devices having sol-gel derived ceramic regions with molded submicron surface features 审中-公开
标题翻译：具有溶胶 - 凝胶衍生的陶瓷区域的模制亚微米表面特征的医疗装置
公开(公告)号：US20090048659A1
公开(公告)日：2009-02-19
申请号：US11893849
申请日：2007-08-17
申请人： Jan Weber , Liliana Atanasoska , Michele Zoromski , Robert W. Warner
发明人： Jan Weber , Liliana Atanasoska , Michele Zoromski , Robert W. Warner
IPC分类号： A61F2/06 , A61K45/00 , C04B35/119
CPC分类号： A61L31/16 , A61L27/306 , A61L27/54 , A61L27/56 , A61L29/106 , A61L29/146 , A61L29/16 , A61L31/088 , A61L31/146 , A61L2300/00 , A61L2400/12
摘要： According to one aspect of the present invention, implantable or insertable medical devices are provided, which contain sol-gel derived ceramic regions which have molded submicron surface features.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含具有模制亚微米表面特征的溶胶 - 凝胶衍生的陶瓷区域。

3. 发明申请

US20080175881A1 Blood-contacting medical devices for the release of nitric oxide and anti-restenotic agents 审中-公开
标题翻译：用于释放一氧化氮和抗再狭窄剂的血液接触医疗装置
公开(公告)号：US20080175881A1
公开(公告)日：2008-07-24
申请号：US11654884
申请日：2007-01-18
申请人： J. Thomas Ippoliti , Scott Schewe , Michele Zoromski , Robert W. Warner , Liliana Atanasoska , Jan Weber
发明人： J. Thomas Ippoliti , Scott Schewe , Michele Zoromski , Robert W. Warner , Liliana Atanasoska , Jan Weber
IPC分类号： A61L31/16 , A61L31/10 , A61F2/82
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/416 , A61L2300/45
摘要： According to an aspect of the present invention, implantable or insertable blood-contacting devices are provided, which contain one or more release regions that release nitric oxide and one or more anti-restenotic agents. The release region contains one or more polymeric components. The release region also optionally contains one or more inorganic components. Nitric oxide producing groups may be attached to the polymeric component(s), to the optional inorganic component(s), or both. The one or more anti-restenotic agents may be admixed with the polymeric and optional inorganic components, attached to the polymeric component(s), attached to the optional inorganic component(s), or a combination thereof.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的血液接触装置，其包含一个或多个释放一氧化氮的释放区域和一种或多种抗再狭窄剂。释放区域包含一种或多种聚合物组分。释放区域还任选地含有一种或多种无机组分。一氧化碳生成基团可以连接到聚合物组分，任选的无机组分或两者。一种或多种抗再狭窄剂可以与附着于任选的无机组分的一种或多种聚合物组分的聚合物和任选的无机组分或其组合物混合。

4. 发明申请

US20080057105A1 MEDICAL DEVICES HAVING NANOSTRUCTURED COATING FOR MACROMOLECULE DELIVERY 审中-公开
标题翻译：具有用于大分子递送的纳米结构涂层的医疗装置
公开(公告)号：US20080057105A1
公开(公告)日：2008-03-06
申请号：US11847934
申请日：2007-08-30
申请人： Liliana Atanasoska , Jan Weber , Robert W. Warner , Michele Zoromski
发明人： Liliana Atanasoska , Jan Weber , Robert W. Warner , Michele Zoromski
IPC分类号： A61F2/02 , A61K31/7052 , A61P43/00
CPC分类号： A61L27/58 , A61L27/28 , A61L31/08 , A61L31/148 , A61L2400/12 , A61L2420/04
摘要： A medical device having a biodegradable coating comprising an inorganic material complexed to macromolecules. Biodegradation of the biodegradable coating releases nanoparticles of the inorganic material with macromolecules complexed to the released nanoparticles. The inorganic material may be applied directly onto the medical device as a nanostructured coating or be dispersed within or under a layer of biodegradable polymer. The medical device body may comprise a biodegradable metallic material. Also provided is a method of delivering macromolecules to body tissue using the medical device of the present invention.
摘要翻译：具有包含与大分子复合的无机材料的可生物降解涂层的医疗装置。可生物降解涂层的生物降解通过与释放的纳米颗粒络合的大分子释放无机材料的纳米颗粒。无机材料可以作为纳米结构涂层直接施加到医疗装置上，或者分散在可生物降解的聚合物层内或下面。医疗装置主体可以包括可生物降解的金属材料。还提供了使用本发明的医疗装置将大分子递送到身体组织的方法。

5. 发明申请

US20080188825A1 Catheters and medical balloons 审中-公开
标题翻译：导管和医用气球
公开(公告)号：US20080188825A1
公开(公告)日：2008-08-07
申请号：US11701148
申请日：2007-02-01
申请人： Liliana Atanasoska , Jan Weber , Scott R. Schewe , Robert W. Warner , John Chen
发明人： Liliana Atanasoska , Jan Weber , Scott R. Schewe , Robert W. Warner , John Chen
IPC分类号： A61M25/10
CPC分类号： A61L29/126
摘要： Medical balloons and/or catheters are disclosed that include a wall that includes a composite material. The composite material includes a polymeric material and particles that include an allotrope of carbon. In some instances, at least some of the particles are covalently bonded to the polymeric material. Methods for making such medical balloons and/or catheters are also disclosed.
摘要翻译：公开了包括包括复合材料的壁的医疗气囊和/或导管。复合材料包括聚合物材料和包含碳同素异形体的颗粒。在一些情况下，至少一些颗粒共价键合到聚合物材料上。还公开了制造这种医用气囊和/或导管的方法。

6. 发明申请

US20090324679A1 MEDICAL COPOLYMERS 有权
标题翻译：医用共聚物
公开(公告)号：US20090324679A1
公开(公告)日：2009-12-31
申请号：US12491467
申请日：2009-06-25
申请人： J. Thomas Ippoliti , Scott Schewe , Robert W. Warner , Michele Zoromski
发明人： J. Thomas Ippoliti , Scott Schewe , Robert W. Warner , Michele Zoromski
IPC分类号： A61F2/00 , A61K9/14
CPC分类号： C08G61/08 , A61L31/06 , A61L31/10 , C08G61/12 , C08G2261/147 , C08G2261/3324 , C08G2261/3342 , C08G2261/418
摘要： According to an aspect of the present invention, medical copolymers are provided which comprise (a) a polymer backbone comprising (i) a plurality of —C═C— groups within the polymer backbone, (ii) a plurality of -R9- groups within the polymer backbone, wherein R9 comprises a radical-substituted C2-C10 cyclic or heterocyclic group, or (iii) both a plurality of —C═C— groups and a plurality of -R9- groups within the polymer backbone (b) a plurality of hydrocarbon-based pendant groups along the polymer backbone that comprise a saturated or unsaturated carbon chain of at least four carbons in length, and (c) a plurality of zwitterionic pendant groups along the polymer backbone that comprise a positively charged quaternary ammonium group and a negatively charged phosphate group. Further aspects of the invention, among others, relate to methods of forming such copolymers, medical products that contain such copolymers, and methods of making such medical products.
摘要翻译：根据本发明的一个方面，提供了医用共聚物，其包含（a）聚合物主链，其包含（i）聚合物主链内的多个-CC-基团，（ii）聚合物内的多个-R9-基团骨架，其中R9包含自由基取代的C 2 -C 10环状或杂环基团，或（iii）聚合物主链（b）中的多个-CC-基团和多个-R9-基团，多个烃基沿聚合物主链的侧基包含长度为至少四个碳原子的饱和或不饱和碳链，以及（c）沿聚合物主链的多个两性离子侧基，其包含带正电荷的季铵基和带负电荷的磷酸基。本发明的其它方面尤其涉及形成这种共聚物的方法，含有这种共聚物的医药产品，以及制备这种医药产品的方法。

7. 发明申请

US20090297581A1 MEDICAL DEVICES HAVING ELECTRODEPOSITED COATINGS 审中-公开
标题翻译：具有电沉积涂层的医疗器械
公开(公告)号：US20090297581A1
公开(公告)日：2009-12-03
申请号：US12472234
申请日：2009-05-26
申请人： Liliana Atanasoska , Wayne Falk , Michele Zoromski , Robert W. Warner
发明人： Liliana Atanasoska , Wayne Falk , Michele Zoromski , Robert W. Warner
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61L31/08 , A61L2300/416 , A61L2300/606 , A61L2300/624 , A61L2420/04
摘要： According to one aspect, the present invention provides implantable or insertable medical devices that comprise a conductive substrate and an electrodeposited coating over the substrate. The electrodeposited coating includes (a) one or more types of inorganic materials, (b) one or more types of polymeric materials and (c) optionally, one or more types of therapeutic agents. Still other aspects of the invention concern methods of making and using such devices.
摘要翻译：根据一个方面，本发明提供了可植入或可插入的医疗装置，其包括导电基底和在基底上的电沉积涂层。电沉积涂层包括（a）一种或多种类型的无机材料，（b）一种或多种类型的聚合材料和（c）任选的一种或多种类型的治疗剂。本发明的其它方面涉及制造和使用这些装置的方法。

8. 发明授权

US08187623B2 Medical copolymers 有权
标题翻译：医用共聚物
公开(公告)号：US08187623B2
公开(公告)日：2012-05-29
申请号：US12491467
申请日：2009-06-25
申请人： J. Thomas Ippoliti , Scott Schewe , Robert W. Warner , Michele Zoromski
发明人： J. Thomas Ippoliti , Scott Schewe , Robert W. Warner , Michele Zoromski
IPC分类号： A61F2/00 , A61K9/14
CPC分类号： C08G61/08 , A61L31/06 , A61L31/10 , C08G61/12 , C08G2261/147 , C08G2261/3324 , C08G2261/3342 , C08G2261/418
摘要： Medical copolymers are provided which comprise (a) a polymer backbone comprising (i) a plurality of —C═C— groups within the polymer backbone, (ii) a plurality of —R9— groups within the polymer backbone, wherein R9 comprises a radical-substituted C2-C10 cyclic or heterocyclic group, or (iii) both a plurality of —C═C— groups and a plurality of —R9— groups within the polymer backbone, (b) a plurality of hydrocarbon-based pendant groups along the polymer backbone that comprise a saturated or unsaturated carbon chain of at least four carbons in length, and (c) a plurality of zwitterionic pendant groups along the polymer backbone that comprise a positively charged quaternary ammonium group and a negatively charged phosphate group. Methods of forming such copolymers, medical products that contain such copolymers, and methods of making such medical products are also disclosed.
摘要翻译：提供医疗共聚物，其包含（a）聚合物主链，其包含（i）聚合物主链内的多个-C≡C-基团，（ii）聚合物主链内的多个-R9-基团，其中R9包含基团 - 取代的C 2 -C 10环状或杂环基团，或（iii）聚合物主链内的多个-C≡C-基团和多个-R9-基团，（b）多个基于烃基的侧基包括长度为至少四个碳的饱和或不饱和碳链的聚合物主链，和（c）沿聚合物主链的多个两性离子侧基，其包含带正电荷的季铵基和带负电荷的磷酸基。还公开了形成这种共聚物的方法，含有这些共聚物的医药产品，以及制造这种医药产品的方法。

9. 发明授权

US07470466B2 Nanoparticle structures and composite materials comprising a silicon-containing compound having a chemical linker that forms a non-covalent bond with a polymer 有权
标题翻译：纳米颗粒结构和复合材料，其包含具有与聚合物形成非共价键的化学接头的含硅化合物
公开(公告)号：US07470466B2
公开(公告)日：2008-12-30
申请号：US11317963
申请日：2005-12-23
申请人： J. Thomas Ippoliti , Scott R. Schewe , Liliana L. Atanasoska , Robert W. Warner
发明人： J. Thomas Ippoliti , Scott R. Schewe , Liliana L. Atanasoska , Robert W. Warner
IPC分类号： B32B5/16
CPC分类号： C08J5/005 , B82Y30/00 , C08K9/04 , Y10S977/773 , Y10S977/778 , Y10S977/783 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998 , Y10T428/31663
摘要： Nanoparticle precursor structures, nanoparticle structures, and composite materials that include the nanoparticle structures in a polymer to form a composite material. The nanoparticle structures have chemical linkage moieties capable of forming non-covalent bonds with portions of a polymer for the composite material. Such composite materials are useful as biomaterials in medical devices.
摘要翻译：纳米颗粒前体结构，纳米颗粒结构和复合材料，其包括聚合物中的纳米颗粒结构以形成复合材料。纳米颗粒结构具有能与复合材料的聚合物部分形成非共价键的化学连接部分。这种复合材料可用作医疗器械中的生物材料。

10. 发明授权

US08481643B2 Nanoparticle precursor structures, nanoparticle structures, and composite materials 有权
标题翻译：纳米颗粒前体结构，纳米颗粒结构和复合材料
公开(公告)号：US08481643B2
公开(公告)日：2013-07-09
申请号：US12887354
申请日：2010-09-21
申请人： J. Thomas Ippoliti , Scott R. Schewe , Liliana L. Atanasoska , Robert W. Warner
发明人： J. Thomas Ippoliti , Scott R. Schewe , Liliana L. Atanasoska , Robert W. Warner
IPC分类号： C08L83/02
CPC分类号： C08J5/005 , B82Y30/00 , C08K9/04 , Y10S977/773 , Y10S977/778 , Y10S977/783 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998 , Y10T428/31663
摘要： Nanoparticle precursor structures, nanoparticle structures, and composite materials that include the nanoparticle structures in a polymer to form a composite material. The nanoparticle structures have chemical linkage moieties capable of forming non-covalent bonds with portions of a polymer for the composite material. Such composite materials are useful as biomaterials in medical devices.
摘要翻译：纳米颗粒前体结构，纳米颗粒结构和复合材料，其包括聚合物中的纳米颗粒结构以形成复合材料。纳米颗粒结构具有能与复合材料的聚合物部分形成非共价键的化学连接部分。这种复合材料可用作医疗器械中的生物材料。

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