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    • 4. 发明授权
    • Medical copolymers
    • 医用共聚物
    • US08187623B2
    • 2012-05-29
    • US12491467
    • 2009-06-25
    • J. Thomas IppolitiScott ScheweRobert W. WarnerMichele Zoromski
    • J. Thomas IppolitiScott ScheweRobert W. WarnerMichele Zoromski
    • A61F2/00A61K9/14
    • C08G61/08A61L31/06A61L31/10C08G61/12C08G2261/147C08G2261/3324C08G2261/3342C08G2261/418
    • Medical copolymers are provided which comprise (a) a polymer backbone comprising (i) a plurality of —C═C— groups within the polymer backbone, (ii) a plurality of —R9— groups within the polymer backbone, wherein R9 comprises a radical-substituted C2-C10 cyclic or heterocyclic group, or (iii) both a plurality of —C═C— groups and a plurality of —R9— groups within the polymer backbone, (b) a plurality of hydrocarbon-based pendant groups along the polymer backbone that comprise a saturated or unsaturated carbon chain of at least four carbons in length, and (c) a plurality of zwitterionic pendant groups along the polymer backbone that comprise a positively charged quaternary ammonium group and a negatively charged phosphate group. Methods of forming such copolymers, medical products that contain such copolymers, and methods of making such medical products are also disclosed.
    • 提供医疗共聚物,其包含(a)聚合物主链,其包含(i)聚合物主链内的多个-C≡C-基团,(ii)聚合物主链内的多个-R9-基团,其中R9包含基团 - 取代的C 2 -C 10环状或杂环基团,或(iii)聚合物主链内的多个-C≡C-基团和多个-R9-基团,(b)多个基于烃基的侧基 包括长度为至少四个碳的饱和或不饱和碳链的聚合物主链,和(c)沿聚合物主链的多个两性离子侧基,其包含带正电荷的季铵基和带负电荷的磷酸基。 还公开了形成这种共聚物的方法,含有这些共聚物的医药产品,以及制造这种医药产品的方法。