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1. 发明申请

US20080175881A1 Blood-contacting medical devices for the release of nitric oxide and anti-restenotic agents 审中-公开
标题翻译：用于释放一氧化氮和抗再狭窄剂的血液接触医疗装置
公开(公告)号：US20080175881A1
公开(公告)日：2008-07-24
申请号：US11654884
申请日：2007-01-18
申请人： J. Thomas Ippoliti , Scott Schewe , Michele Zoromski , Robert W. Warner , Liliana Atanasoska , Jan Weber
发明人： J. Thomas Ippoliti , Scott Schewe , Michele Zoromski , Robert W. Warner , Liliana Atanasoska , Jan Weber
IPC分类号： A61L31/16 , A61L31/10 , A61F2/82
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/416 , A61L2300/45
摘要： According to an aspect of the present invention, implantable or insertable blood-contacting devices are provided, which contain one or more release regions that release nitric oxide and one or more anti-restenotic agents. The release region contains one or more polymeric components. The release region also optionally contains one or more inorganic components. Nitric oxide producing groups may be attached to the polymeric component(s), to the optional inorganic component(s), or both. The one or more anti-restenotic agents may be admixed with the polymeric and optional inorganic components, attached to the polymeric component(s), attached to the optional inorganic component(s), or a combination thereof.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的血液接触装置，其包含一个或多个释放一氧化氮的释放区域和一种或多种抗再狭窄剂。释放区域包含一种或多种聚合物组分。释放区域还任选地含有一种或多种无机组分。一氧化碳生成基团可以连接到聚合物组分，任选的无机组分或两者。一种或多种抗再狭窄剂可以与附着于任选的无机组分的一种或多种聚合物组分的聚合物和任选的无机组分或其组合物混合。

2. 发明申请

US20090324679A1 MEDICAL COPOLYMERS 有权
标题翻译：医用共聚物
公开(公告)号：US20090324679A1
公开(公告)日：2009-12-31
申请号：US12491467
申请日：2009-06-25
申请人： J. Thomas Ippoliti , Scott Schewe , Robert W. Warner , Michele Zoromski
发明人： J. Thomas Ippoliti , Scott Schewe , Robert W. Warner , Michele Zoromski
IPC分类号： A61F2/00 , A61K9/14
CPC分类号： C08G61/08 , A61L31/06 , A61L31/10 , C08G61/12 , C08G2261/147 , C08G2261/3324 , C08G2261/3342 , C08G2261/418
摘要： According to an aspect of the present invention, medical copolymers are provided which comprise (a) a polymer backbone comprising (i) a plurality of —C═C— groups within the polymer backbone, (ii) a plurality of -R9- groups within the polymer backbone, wherein R9 comprises a radical-substituted C2-C10 cyclic or heterocyclic group, or (iii) both a plurality of —C═C— groups and a plurality of -R9- groups within the polymer backbone (b) a plurality of hydrocarbon-based pendant groups along the polymer backbone that comprise a saturated or unsaturated carbon chain of at least four carbons in length, and (c) a plurality of zwitterionic pendant groups along the polymer backbone that comprise a positively charged quaternary ammonium group and a negatively charged phosphate group. Further aspects of the invention, among others, relate to methods of forming such copolymers, medical products that contain such copolymers, and methods of making such medical products.
摘要翻译：根据本发明的一个方面，提供了医用共聚物，其包含（a）聚合物主链，其包含（i）聚合物主链内的多个-CC-基团，（ii）聚合物内的多个-R9-基团骨架，其中R9包含自由基取代的C 2 -C 10环状或杂环基团，或（iii）聚合物主链（b）中的多个-CC-基团和多个-R9-基团，多个烃基沿聚合物主链的侧基包含长度为至少四个碳原子的饱和或不饱和碳链，以及（c）沿聚合物主链的多个两性离子侧基，其包含带正电荷的季铵基和带负电荷的磷酸基。本发明的其它方面尤其涉及形成这种共聚物的方法，含有这种共聚物的医药产品，以及制备这种医药产品的方法。

3. 发明授权

US08187623B2 Medical copolymers 有权
标题翻译：医用共聚物
公开(公告)号：US08187623B2
公开(公告)日：2012-05-29
申请号：US12491467
申请日：2009-06-25
申请人： J. Thomas Ippoliti , Scott Schewe , Robert W. Warner , Michele Zoromski
发明人： J. Thomas Ippoliti , Scott Schewe , Robert W. Warner , Michele Zoromski
IPC分类号： A61F2/00 , A61K9/14
CPC分类号： C08G61/08 , A61L31/06 , A61L31/10 , C08G61/12 , C08G2261/147 , C08G2261/3324 , C08G2261/3342 , C08G2261/418
摘要： Medical copolymers are provided which comprise (a) a polymer backbone comprising (i) a plurality of —C═C— groups within the polymer backbone, (ii) a plurality of —R9— groups within the polymer backbone, wherein R9 comprises a radical-substituted C2-C10 cyclic or heterocyclic group, or (iii) both a plurality of —C═C— groups and a plurality of —R9— groups within the polymer backbone, (b) a plurality of hydrocarbon-based pendant groups along the polymer backbone that comprise a saturated or unsaturated carbon chain of at least four carbons in length, and (c) a plurality of zwitterionic pendant groups along the polymer backbone that comprise a positively charged quaternary ammonium group and a negatively charged phosphate group. Methods of forming such copolymers, medical products that contain such copolymers, and methods of making such medical products are also disclosed.
摘要翻译：提供医疗共聚物，其包含（a）聚合物主链，其包含（i）聚合物主链内的多个-C≡C-基团，（ii）聚合物主链内的多个-R9-基团，其中R9包含基团 - 取代的C 2 -C 10环状或杂环基团，或（iii）聚合物主链内的多个-C≡C-基团和多个-R9-基团，（b）多个基于烃基的侧基包括长度为至少四个碳的饱和或不饱和碳链的聚合物主链，和（c）沿聚合物主链的多个两性离子侧基，其包含带正电荷的季铵基和带负电荷的磷酸基。还公开了形成这种共聚物的方法，含有这些共聚物的医药产品，以及制造这种医药产品的方法。

4. 发明授权

US08653155B2 Polymers having lipophilic hydrocarbon and biodegradable polymeric segments 失效
标题翻译：具有亲油性烃和可生物降解聚合物链段的聚合物
公开(公告)号：US08653155B2
公开(公告)日：2014-02-18
申请号：US12855573
申请日：2010-08-12
申请人： J. Thomas Ippoliti , Joshua Speros , Scott Schewe , Robert W. Warner , Dan Everson
发明人： J. Thomas Ippoliti , Joshua Speros , Scott Schewe , Robert W. Warner , Dan Everson
IPC分类号： A61F2/02 , A61F2/82 , A61F2/50 , A61L24/00 , A61L26/00
CPC分类号： C08G63/08
摘要： The present invention pertains, among other things, to polymers having one or more lipophilic hydrocarbon segments and one or more biodegradable polymeric segments, to methods of making such polymers and to products formed using such polymers.
摘要翻译：本发明尤其涉及具有一个或多个亲油性烃链段和一个或多个可生物降解的聚合物链段的聚合物，制备这种聚合物的方法以及使用这种聚合物形成的产物。

5. 发明申请

US20110166249A1 POLYMERS HAVING LIPOPHILIC HYDROCARBON AND BIODEGRADABLE POLYMERIC SEGMENTS 失效
标题翻译：具有脂质烃和可生物降解聚合物部分的聚合物
公开(公告)号：US20110166249A1
公开(公告)日：2011-07-07
申请号：US12855573
申请日：2010-08-12
申请人： J. Thomas Ippoliti , Joshua Speros , Scott Schewe , Robert W. Warner , Dan Everson
发明人： J. Thomas Ippoliti , Joshua Speros , Scott Schewe , Robert W. Warner , Dan Everson
IPC分类号： A61L27/34 , C08G63/08 , C07C69/34 , C09J167/08
CPC分类号： C08G63/08
摘要： The present invention pertains, among other things, to polymers having one or more lipophilic hydrocarbon segments and one or more biodegradable polymeric segments, to methods of making such polymers and to products formed using such polymers.
摘要翻译：本发明尤其涉及具有一个或多个亲油性烃链段和一个或多个可生物降解的聚合物链段的聚合物，制备这种聚合物的方法以及使用这种聚合物形成的产物。

6. 发明申请

US20100298769A1 IMPLANTABLE MEDICAL DEVICES FOR THERAPEUTIC AGENT DELIVERY 审中-公开
标题翻译：用于治疗药物递送的可植入医疗装置
公开(公告)号：US20100298769A1
公开(公告)日：2010-11-25
申请号：US12783024
申请日：2010-05-19
申请人： Scott Schewe , Robert W. Warner , J. Thomas Ippoliti , Hollie Beckord
发明人： Scott Schewe , Robert W. Warner , J. Thomas Ippoliti , Hollie Beckord
IPC分类号： A61M29/00 , A61F2/00 , A61K47/36 , A61P9/00
CPC分类号： A61L27/54 , A61L27/20 , A61L29/043 , A61L29/16 , A61L31/042 , A61L31/16 , A61L2300/416 , A61L2300/42 , C08L5/08 , C08L5/10
摘要： Various aspects of the invention relate to implantable medical devices, which comprise a layer of material (e.g., in the form of a sheet, tube, etc.) that comprises a bioerodible polymer and a therapeutic agent. Other aspects of the invention relate to methods of forming such devices. Still other aspects of the invention relate to methods of treatment using such devices.
摘要翻译：本发明的各个方面涉及可植入医疗装置，其包括包含生物可腐蚀聚合物和治疗剂的材料层（例如，片状，管状等）。本发明的其它方面涉及形成这种装置的方法。本发明的其它方面涉及使用这种装置的治疗方法。

7. 发明授权

US08481643B2 Nanoparticle precursor structures, nanoparticle structures, and composite materials 有权
标题翻译：纳米颗粒前体结构，纳米颗粒结构和复合材料
公开(公告)号：US08481643B2
公开(公告)日：2013-07-09
申请号：US12887354
申请日：2010-09-21
申请人： J. Thomas Ippoliti , Scott R. Schewe , Liliana L. Atanasoska , Robert W. Warner
发明人： J. Thomas Ippoliti , Scott R. Schewe , Liliana L. Atanasoska , Robert W. Warner
IPC分类号： C08L83/02
CPC分类号： C08J5/005 , B82Y30/00 , C08K9/04 , Y10S977/773 , Y10S977/778 , Y10S977/783 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998 , Y10T428/31663
摘要： Nanoparticle precursor structures, nanoparticle structures, and composite materials that include the nanoparticle structures in a polymer to form a composite material. The nanoparticle structures have chemical linkage moieties capable of forming non-covalent bonds with portions of a polymer for the composite material. Such composite materials are useful as biomaterials in medical devices.
摘要翻译：纳米颗粒前体结构，纳米颗粒结构和复合材料，其包括聚合物中的纳米颗粒结构以形成复合材料。纳米颗粒结构具有能与复合材料的聚合物部分形成非共价键的化学连接部分。这种复合材料可用作医疗器械中的生物材料。

8. 发明授权

US07470466B2 Nanoparticle structures and composite materials comprising a silicon-containing compound having a chemical linker that forms a non-covalent bond with a polymer 有权
标题翻译：纳米颗粒结构和复合材料，其包含具有与聚合物形成非共价键的化学接头的含硅化合物
公开(公告)号：US07470466B2
公开(公告)日：2008-12-30
申请号：US11317963
申请日：2005-12-23
申请人： J. Thomas Ippoliti , Scott R. Schewe , Liliana L. Atanasoska , Robert W. Warner
发明人： J. Thomas Ippoliti , Scott R. Schewe , Liliana L. Atanasoska , Robert W. Warner
IPC分类号： B32B5/16
CPC分类号： C08J5/005 , B82Y30/00 , C08K9/04 , Y10S977/773 , Y10S977/778 , Y10S977/783 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998 , Y10T428/31663
摘要： Nanoparticle precursor structures, nanoparticle structures, and composite materials that include the nanoparticle structures in a polymer to form a composite material. The nanoparticle structures have chemical linkage moieties capable of forming non-covalent bonds with portions of a polymer for the composite material. Such composite materials are useful as biomaterials in medical devices.
摘要翻译：纳米颗粒前体结构，纳米颗粒结构和复合材料，其包括聚合物中的纳米颗粒结构以形成复合材料。纳米颗粒结构具有能与复合材料的聚合物部分形成非共价键的化学连接部分。这种复合材料可用作医疗器械中的生物材料。

9. 发明申请

US20110009541A1 NANOPARTICLE PRECURSOR STRUCTURES, NANOPARTICLE STRUCTURES, AND COMPOSITE MATERIALS 有权
标题翻译：纳米材料前体结构，纳米结构和复合材料
公开(公告)号：US20110009541A1
公开(公告)日：2011-01-13
申请号：US12887354
申请日：2010-09-21
申请人： J. Thomas Ippoliti , Scott R. Schewe , Liliana L. Atanasoska , Robert W. Warner
发明人： J. Thomas Ippoliti , Scott R. Schewe , Liliana L. Atanasoska , Robert W. Warner
IPC分类号： C08K5/5415
CPC分类号： C08J5/005 , B82Y30/00 , C08K9/04 , Y10S977/773 , Y10S977/778 , Y10S977/783 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998 , Y10T428/31663
摘要： Nanoparticle precursor structures, nanoparticle structures, and composite materials that include the nanoparticle structures in a polymer to form a composite material. The nanoparticle structures have chemical linkage moieties capable of forming non-covalent bonds with portions of a polymer for the composite material. Such composite materials are useful as biomaterials in medical devices.
摘要翻译：纳米颗粒前体结构，纳米颗粒结构和复合材料，其包括聚合物中的纳米颗粒结构以形成复合材料。纳米颗粒结构具有能与复合材料的聚合物部分形成非共价键的化学连接部分。这种复合材料可用作医疗器械中的生物材料。

10. 发明授权

US07799426B2 Nanoparticle structures comprising silicon oxide-based polymer, and composite materials 有权
标题翻译：纳米颗粒结构包括氧化硅基聚合物和复合材料
公开(公告)号：US07799426B2
公开(公告)日：2010-09-21
申请号：US12266984
申请日：2008-11-07
申请人： J. Thomas Ippoliti , Scott R. Schewe , Liliana L. Atanasoska , Robert W. Warner
发明人： J. Thomas Ippoliti , Scott R. Schewe , Liliana L. Atanasoska , Robert W. Warner
IPC分类号： B32B5/16
CPC分类号： C08J5/005 , B82Y30/00 , C08K9/04 , Y10S977/773 , Y10S977/778 , Y10S977/783 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998 , Y10T428/31663
摘要： Nanoparticle precursor structures, nanoparticle structures, and composite materials that include the nanoparticle structures in a polymer to form a composite material. The nanoparticle structures have chemical linkage moieties capable of forming non-covalent bonds with portions of a polymer for the composite material. Such composite materials are useful as biomaterials in medical devices.
摘要翻译：纳米颗粒前体结构，纳米颗粒结构和复合材料，其包括聚合物中的纳米颗粒结构以形成复合材料。纳米颗粒结构具有能与复合材料的聚合物部分形成非共价键的化学连接部分。这种复合材料可用作医疗器械中的生物材料。

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