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1. 发明授权

US6139511A Guidewire with variable coil configuration 失效
标题翻译：导丝可变线圈配置
公开(公告)号：US6139511A
公开(公告)日：2000-10-31
申请号：US106918
申请日：1998-06-29
申请人： Scott J. Huter , William J. Boyle , Richard S. Stack
发明人： Scott J. Huter , William J. Boyle , Richard S. Stack
IPC分类号： A61B5/00 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/09083
摘要： The present invention is directed to a guidewire having an elongate core member with a proximal section and a distal section. The distal section has at least one tapered segment, wherein the elongate core member tapers distally to a reduced diameter. Preferably, the tapered segments of the distal section of the elongate core member are marked with radiopaque markers to indicate where a tapered segment begins or ends. A proximal coil having a rectangular cross section and at least one distal coil having a round cross section are disposed around at least a portion of the distal section of the elongate core member. The proximal end of the proximal coil is attached to the distal section of the elongate core member. The distal coils can be made of a material that is radiopaque or non-radiopaque. If one of the distal coils is radiopaque, it may be made from a radiopaque material or it may be made of a hollow tube of non-radiopaque material that is filled with material that is at least partially radiopaque. The proximal end of the distal most coil is attached to the distal end of the proximal coil, and the distal end of the distal most coil is attached to the distal section of the elongate core member.
摘要翻译：本发明涉及一种具有细长芯部件的导丝，其具有近端部分和远端部分。远侧部分具有至少一个锥形部分，其中细长芯部件向远端逐渐变细直径减小。优选地，细长芯部件的远端部分的锥形部分用不透射线的标记标记，以指示锥形部分开始或结束的位置。具有矩形截面的近端线圈和具有圆形横截面的至少一个远端线圈设置在细长芯部件的远端部分的至少一部分周围。近端线圈的近端附接到细长芯构件的远端部分。远侧线圈可以由不透射线或非不透射线的材料制成。如果远端线圈之一是不透射线的，则其可以由不透射线材料制成，或者其可以由填充有至少部分不透射线的材料的非不透射线材料的中空管制成。最远端线圈的近端附接到近端线圈的远端，并且最远端线圈的远端附接到细长芯构件的远端部分。

2. 发明授权

US07217255B2 Embolic protection devices 有权
标题翻译：栓塞保护装置
公开(公告)号：US07217255B2
公开(公告)日：2007-05-15
申请号：US10386071
申请日：2003-03-10
申请人： William J. Boyle , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Richard S. Stack , Kent C. B. Stalker , Christopher Tarapata , John D. Whitfield
发明人： William J. Boyle , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Richard S. Stack , Kent C. B. Stalker , Christopher Tarapata , John D. Whitfield
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guide wire and is deployed within the patient's vasculature as the guide wire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guide wire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.
摘要翻译：一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。在一个实施例中，过滤组件附接到导丝的远端，并且当导丝被操纵进入治疗区域时，其被布置在患者的脉管系统内。以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

3. 发明授权

US06540722B1 Embolic protection devices 有权
标题翻译：栓塞保护装置
公开(公告)号：US06540722B1
公开(公告)日：2003-04-01
申请号：US09490319
申请日：2000-01-24
申请人： William J. Boyle , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Richard S. Stack , Kent C. B. Stalker , Christopher Tarapata , John D. Whitfield
发明人： William J. Boyle , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Richard S. Stack , Kent C. B. Stalker , Christopher Tarapata , John D. Whitfield
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guide wire and is deployed within the patient's vasculature as the guide wire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guide wire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.
摘要翻译：一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。在一个实施例中，过滤组件附接到导丝的远端，并且当导丝被操纵进入治疗区域时，其被布置在患者的脉管系统内。以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

4. 发明授权

US07425215B2 Delivery systems for embolic filter devices 有权
标题翻译：栓塞过滤装置的输送系统
公开(公告)号：US07425215B2
公开(公告)日：2008-09-16
申请号：US10385162
申请日：2003-03-10
申请人： William J. Boyle , Benjamin C. Huter , Scott J. Huter
发明人： William J. Boyle , Benjamin C. Huter , Scott J. Huter
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2/95 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008 , A61M25/0668
摘要： A delivery system for an expandable filter device includes a dual lumen delivery sheath which has a lumen for receiving the expandable filter device and a lumen for receiving a primary guide wire. The primary guide wire is utilized to place the delivery sheath and expandable filter into the desired region of the patient's vasculature via an over-the-wire or rapid-exchange arrangement. The delivery sheath can be protracted over the expandable filter device to allow the filter to be deployed within the patient's vasculature at the desired location. The delivery system can be embodied in an alternative design in which the primary guide wire extends through a guide wire lumen located in an obturator which forms part of the expandable filter device. Again, the primary guide wire is utilized to maneuver the filter device into the desired area via an over-the-wire arrangement. A slit extending longitudinally along the length of the sheath facilitates the removal of the guide wire and delivery sheath from the patient's vasculature.
摘要翻译：用于可膨胀过滤器装置的递送系统包括双腔输送护套，其具有用于接收可膨胀过滤器装置的内腔和用于接收主导丝的管腔。主引导线用于通过线上或快速交换布置将输送护套和可扩张过滤器放置在患者血管的期望区域中。输送护套可以延伸在可膨胀的过滤器装置上，以允许过滤器在病人的脉管系统中部署在期望的位置。输送系统可以以替代设计来体现，其中主导丝延伸穿过位于形成可膨胀过滤器装置的一部分的闭孔器中的导丝管腔。再次，主引导线用于通过线上布置来将过滤器装置操纵到期望的区域。沿鞘的长度纵向延伸的狭缝有助于从患者的脉管系统移除导丝和输送鞘。

5. 发明授权

US07241304B2 Flexible and conformable embolic filtering devices 有权
标题翻译：灵活和适应性栓塞过滤装置
公开(公告)号：US07241304B2
公开(公告)日：2007-07-10
申请号：US10027915
申请日：2001-12-21
申请人： William J. Boyle , Benjamin C. Huter , Scott J. Huter , John E. Papp
发明人： William J. Boyle , Benjamin C. Huter , Scott J. Huter , John E. Papp
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0008 , A61F2230/008
摘要： A self-expanding cage for use in conjunction with an embolic filtering device includes one or more circumferential members adapted to expand from an unexpanded position to a expanded position within the patient's body vessel. At least one proximal strut and at least one distal strut are attached to the circumferential member to form the basket. The circumferential member may include a plurality of bending regions which enhance the ability of the circumferential member to move between the unexpanded and expanded positions. The proximal and distal struts can be attached to one of the bending regions. When two or more circumferential members are utilized, each member may be connected by a connecting strut which may be connected at a bending region. The connecting strut can be a straight segment or may have a non-linear shape to provide additional flexibility. The expandable cage can be mounted to a elongated member, such as a guide wire, and can be either permanently mounted or rotatably mounted thereto.
摘要翻译：用于与栓塞过滤装置结合使用的自膨胀笼包括适于从未膨胀位置扩展到患者体内容器内的扩张位置的一个或多个周向构件。至少一个近端支柱和至少一个远端支柱附接到周向构件以形成篮。周向构件可以包括多个弯曲区域，这些弯曲区域增强了圆周构件在未膨胀和膨胀位置之间移动的能力。近端和远端支柱可以附接到一个弯曲区域。当使用两个或更多个周向构件时，每个构件可以通过可在弯曲区域处连接的连接支柱连接。连接支柱可以是直线段，或者可以具有非线性形状以提供额外的灵活性。可扩展的保持架可以安装到诸如导丝的细长构件上，并且可以永久地安装或可旋转地安装在其上。

6. 发明授权

US08845583B2 Embolic protection devices 有权
标题翻译：栓塞保护装置
公开(公告)号：US08845583B2
公开(公告)日：2014-09-30
申请号：US11651667
申请日：2007-01-10
申请人： William J. Boyle , David H. Burkett , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Arkady Kokish , Kent C. B. Stalker , Chicheng Wang , John D. Whitfield
发明人： William J. Boyle , David H. Burkett , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Arkady Kokish , Kent C. B. Stalker , Chicheng Wang , John D. Whitfield
IPC分类号： A61M29/00 , A61F2/01
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guidewire and is deployed within the patient's vasculature as the guidewire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guidewire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.
摘要翻译：一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。在一个实施例中，过滤组件附接到导丝的远端，并且当导线被操纵进入治疗区域时，其部署在患者的脉管系统内。以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

7. 发明授权

US07678128B2 Delivery and recovery sheaths for medical devices 失效
标题翻译：用于医疗器械的输送和恢复护套
公开(公告)号：US07678128B2
公开(公告)日：2010-03-16
申请号：US09897295
申请日：2001-06-29
申请人： William J. Boyle , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , John E. Papp , Charles R. Peterson , Kent C. B. Stalker
发明人： William J. Boyle , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , John E. Papp , Charles R. Peterson , Kent C. B. Stalker
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2/95 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： A deployment control system provides controlled deployment of an embolic protection device which may include a guide wire, an expandable filter attached to the guide wire near its distal end, and a restraining sheath that maintains the expanded filter in a collapsed position. The deployment control system includes a torque control device which allows the physician to torque the guide wire into the patient's anatomy and a mechanism for preventing the guide wire from buckling as the restraining sheath is being retracted to deploy the expandable filter. A recovery control system for recovering the embolic protection device includes an inner catheter which extends within a lumen of an outer recovery sheath in a coaxial arrangement. A distal portion of the inner catheter extends beyond another recovery sheath during advancement of the recovery system into the vasculature. The recovery sheath can be advanced over the inner catheter to collapse the expandable filter. The proximal ends of the inner catheter and recovery sheath include handle portions having snap mechanisms which hold the components together as the recovery system is being advanced into the patient's vasculature.
摘要翻译：部署控制系统提供栓塞保护装置的可控部署，该栓塞保护装置可以包括引导线，在其远端附近附接到导丝的可扩张过滤器，以及将扩张过滤器保持在折叠位置的限制护套。部署控制系统包括扭矩控制装置，该扭矩控制装置允许医师将导丝扭转到患者的解剖结构中，以及用于防止导线在收缩护套以展开可膨胀过滤器时弯曲的机构。用于回收栓塞保护装置的恢复控制系统包括在同轴布置中在外部恢复护套的内腔内延伸的内导管。在将回收系统推进脉管系统期间，内导管的远端部分延伸超过另一恢复护套。恢复护套可以在内导管上推进以使可膨胀过滤器折叠。内导管和恢复护套的近端包括手柄部分，其具有卡扣机构，当回收系统进入患者的脉管系统时，该部件将部件保持在一起。

8. 发明申请

US20090030445A1 DELIVERY SYSEMS FOR EMBOLIC FILTER DEVICES 审中-公开
标题翻译：用于嵌入式过滤装置的交付符号
公开(公告)号：US20090030445A1
公开(公告)日：2009-01-29
申请号：US12187129
申请日：2008-08-06
申请人： William J. Boyle , Benjamin C. Huter , Scott J. Huter
发明人： William J. Boyle , Benjamin C. Huter , Scott J. Huter
IPC分类号： A61F2/01 , A61B17/00
CPC分类号： A61F2/013 , A61F2/95 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008 , A61M25/0668
摘要： A delivery system for an expandable filter device includes a dual lumen delivery sheath which has a lumen for receiving the expandable filter device and a lumen for receiving a primary guide wire. The primary guide wire is utilized to place the delivery sheath and expandable filter into the desired region of the patient's vasculature via an over-the-wire or rapid-exchange arrangement. The delivery sheath can be protracted over the expandable filter device to allow the filter to be deployed within the patient's vasculature at the desired location. The delivery system can be embodied in an alternative design in which the primary guide wire extends through a guide wire lumen located in an obturator which forms part of the expandable filter device. Again, the primary guide wire is utilized to maneuver the filter device into the desired area via an over-the-wire arrangement. A slit extending longitudinally along the length of the sheath facilitates the removal of the guide wire and delivery sheath from the patient's vasculature.
摘要翻译：用于可膨胀过滤器装置的递送系统包括双腔输送护套，其具有用于接收可膨胀过滤器装置的内腔和用于接收主导丝的管腔。主引导线用于通过线上或快速交换布置将输送护套和可扩张过滤器放置在患者血管的期望区域中。输送护套可以延伸在可膨胀的过滤器装置上，以允许过滤器在病人的脉管系统中部署在期望的位置。输送系统可以以替代设计来体现，其中主导丝延伸穿过位于形成可膨胀过滤器装置的一部分的闭孔器中的导丝管腔。再次，主引导线用于通过线上布置来将过滤器装置操纵到期望的区域。沿鞘的长度纵向延伸的狭缝有助于从患者的脉管系统移除导丝和输送鞘。

9. 发明授权

US07972356B2 Flexible and conformable embolic filtering devices 有权
标题翻译：灵活和适应性栓塞过滤装置
公开(公告)号：US07972356B2
公开(公告)日：2011-07-05
申请号：US11767784
申请日：2007-06-25
申请人： William J. Boyle , Benjamin C. Huter , Scott J. Huter , John E. Papp
发明人： William J. Boyle , Benjamin C. Huter , Scott J. Huter , John E. Papp
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0008 , A61F2230/008
摘要： A self-expanding cage for use in conjunction with an embolic filtering device includes one or more circumferential members adapted to expand from an unexpanded position to a expanded position within the patient's body vessel. At least one proximal strut and at least one distal strut are attached to the circumferential member to form the basket. The circumferential member may include a plurality of bending regions which enhance the ability of the circumferential member to move between the unexpanded and expanded positions. The proximal and distal struts can be attached to one of the bending regions. When two or more circumferential members are utilized, each member may be connected by a connecting strut which may be connected at a bending region. The connecting strut can be a straight segment or may have a non-linear shape to provide additional flexibility. The expandable cage can be mounted to a elongated member, such as a guide wire, and can be either permanently mounted or rotatably mounted thereto.
摘要翻译：用于与栓塞过滤装置结合使用的自膨胀笼包括适于从未膨胀位置扩展到患者体内容器内的扩张位置的一个或多个周向构件。至少一个近端支柱和至少一个远端支柱附接到周向构件以形成篮。周向构件可以包括多个弯曲区域，这些弯曲区域增强了圆周构件在未膨胀和膨胀位置之间移动的能力。近端和远端支柱可以附接到一个弯曲区域。当使用两个或更多个周向构件时，每个构件可以通过可在弯曲区域处连接的连接支柱连接。连接支柱可以是直线段，或者可以具有非线性形状以提供额外的灵活性。可扩展的保持架可以安装到诸如导丝的细长构件上，并且可以永久地安装或可旋转地安装在其上。

10. 发明申请

US20100174355A1 DELIVERY AND RECOVERY SHEATHS FOR MEDICAL DEVICES 失效
标题翻译：医疗器械的交付和恢复
公开(公告)号：US20100174355A1
公开(公告)日：2010-07-08
申请号：US12724140
申请日：2010-03-15
申请人： William J. Boyle , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , John E. Papp , Charles R. Peterson , Kent C.B. Stalker
发明人： William J. Boyle , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , John E. Papp , Charles R. Peterson , Kent C.B. Stalker
IPC分类号： A61F2/84
CPC分类号： A61F2/013 , A61F2/95 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： A deployment control system provides controlled deployment of an embolic protection device which may include a guide wire, an expandable filter attached to the guide wire near its distal end, and a restraining sheath that maintains the expanded filter in a collapsed position. The deployment control system includes a torque control device which allows the physician to torque the guide wire into the patient's anatomy and a mechanism for preventing the guide wire from buckling as the restraining sheath is being retracted to deploy the expandable filter. A recovery control system for recovering the embolic protection device includes an inner catheter which extends within a lumen of an outer recovery sheath in a coaxial arrangement. A distal portion of the inner catheter extends beyond another recovery sheath during advancement of the recovery system into the vasculature. The recovery sheath can be advanced over the inner catheter to collapse the expandable filter. The proximal ends of the inner catheter and recovery sheath include handle portions having snap mechanisms which hold the components together as the recovery system is being advanced into the patient's vasculature.
摘要翻译：部署控制系统提供栓塞保护装置的可控部署，该栓塞保护装置可以包括引导线，在其远端附近附接到导丝的可扩张过滤器，以及将扩张过滤器保持在折叠位置的限制护套。部署控制系统包括扭矩控制装置，该扭矩控制装置允许医师将导丝扭转到患者的解剖结构中，以及用于防止导线在收缩护套以展开可膨胀过滤器时弯曲的机构。用于回收栓塞保护装置的恢复控制系统包括在同轴布置中在外部恢复护套的内腔内延伸的内导管。在将回收系统推进脉管系统期间，内导管的远端部分延伸超过另一恢复护套。恢复护套可以在内导管上推进以使可膨胀过滤器折叠。内导管和恢复护套的近端包括手柄部分，其具有卡扣机构，当回收系统进入患者的脉管系统时，该部件将部件保持在一起。

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