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1. 发明授权

US08021361B2 Systems and methods for electrode contact assessment 有权
标题翻译：电极接触评估的系统和方法
公开(公告)号：US08021361B2
公开(公告)日：2011-09-20
申请号：US11553965
申请日：2006-10-27
申请人： Saurav Paul , Troy Tegg , Chou Thao , Hong Cao , Harry A. Puryear , Fos Kuehn , Reed R. Heimbecher
发明人： Saurav Paul , Troy Tegg , Chou Thao , Hong Cao , Harry A. Puryear , Fos Kuehn , Reed R. Heimbecher
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B5/6852 , A61B5/6885 , A61B2090/065
摘要： Systems and methods are disclosed for assessing electrode-tissue contact for tissue ablation. An exemplary electrode contact sensing system comprises an electrode housed within a distal portion of a catheter shaft. At least one electro-mechanical sensor is operatively associated with the electrode within the catheter shaft. The at least one electro-mechanical sensor is responsive to movement of the electrode by generating electrical signals corresponding to the amount of movement. The system may also include an output device electrically connected to the at least one electro-mechanical sensor. The output device receives the electrical signals for assessing a level of contact between the electrode and a tissue.
摘要翻译：公开了用于评估用于组织消融的电极组织接触的系统和方法。示例性电极接触感测系统包括容纳在导管轴的远端部分内的电极。至少一个机电传感器与导管轴内的电极可操作地相关联。所述至少一个机电传感器通过产生对应于移动量的电信号来响应电极的运动。该系统还可以包括电连接到该至少一个机电传感器的输出装置。输出装置接收用于评估电极和组织之间的接触水平的电信号。

2. 发明授权

US08162935B2 Systems and methods for electrode contact assessment 有权
标题翻译：电极接触评估的系统和方法
公开(公告)号：US08162935B2
公开(公告)日：2012-04-24
申请号：US12091151
申请日：2006-10-27
申请人： Saurav Paul , Troy T. Tegg , Chou Thao , Hong Cao , Harry Puryear , Fos Kuehn , Reed R. Heimbecher
发明人： Saurav Paul , Troy T. Tegg , Chou Thao , Hong Cao , Harry Puryear , Fos Kuehn , Reed R. Heimbecher
IPC分类号： A61B18/14 , A61B5/04
CPC分类号： A61B18/1492 , A61B5/6852 , A61B5/6885 , A61B2090/065
摘要： Systems and methods are disclosed for assessing electrode-tissue contact for tissue ablation. An exemplary electrode contact sensing system comprises an electrode 10 housed within a distal portion of a catheter shaft 14. At least one electro-mechanical sensor 20 is operatively associated with the electrode 10 within the catheter shaft 14. The at least one electro-mechanical sensor 20 is responsive to movement of the electrode 10 by generating electrical signals corresponding to the amount of movement. The system may also include an output device electrically connected to the at least one electro-mechanical sensor 20. The output device receives the electrical signals for assessing a level of contact between the electrode 10 and a tissue 12.
摘要翻译：公开了用于评估用于组织消融的电极组织接触的系统和方法。示例性的电极接触感测系统包括容纳在导管轴14的远端部分内的电极10.至少一个电 - 机械传感器20与导管轴14内的电极10可操作地相关联。至少一个电 - 机械传感器 20通过产生对应于移动量的电信号来响应于电极10的运动。该系统还可以包括电连接到至少一个机电传感器20的输出装置。输出装置接收用于评估电极10和组织12之间的接触程度的电信号。

3. 发明申请

US20080275442A1 Systems and Methods for Electrode Contact Assessment 有权
标题翻译：电极接触评估系统与方法
公开(公告)号：US20080275442A1
公开(公告)日：2008-11-06
申请号：US12091151
申请日：2006-10-27
申请人： Saurav Paul , Troy T. Tegg , Chou Thao , Hong Cao , Harry Puryear , Fos Kuehn , Reed R. Heimbecher
发明人： Saurav Paul , Troy T. Tegg , Chou Thao , Hong Cao , Harry Puryear , Fos Kuehn , Reed R. Heimbecher
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B5/6852 , A61B5/6885 , A61B2090/065
摘要： Systems and methods are disclosed for assessing electrode-tissue contact for tissue ablation. An exemplary electrode contact sensing system comprises an electrode 10 housed within a distal portion of a catheter shaft 14. At least one electromechanical sensor 20 is operatively associated with the electrode 10 within the catheter shaft 14. The at least one electromechanical sensor 20 is responsive to movement of the electrode 10 by generating electrical signals corresponding to the amount of movement. The system may also include an output device electrically connected to the at least one electromechanical sensor 20. The output device receives the electrical signals for assessing a level of contact between the electrode 10 and a tissue 12.
摘要翻译：公开了用于评估用于组织消融的电极组织接触的系统和方法。示例性电极接触感测系统包括容纳在导管轴14的远端部分内的电极10。至少一个机电传感器20与导管轴14内的电极10可操作地相关联。至少一个机电传感器20通过产生对应于移动量的电信号来响应电极10的运动。该系统还可以包括电连接到至少一个机电传感器20的输出装置。输出装置接收用于评估电极10和组织12之间的接触水平的电信号。

4. 发明申请

US20070100332A1 Systems and methods for electrode contact assessment 有权
标题翻译：电极接触评估的系统和方法
公开(公告)号：US20070100332A1
公开(公告)日：2007-05-03
申请号：US11553965
申请日：2006-10-27
申请人： Saurav Paul , Troy Tegg , Chou Thao , Hong Cao , Harry Puryear , Fos Kuehn , Reed Heimbecher
发明人： Saurav Paul , Troy Tegg , Chou Thao , Hong Cao , Harry Puryear , Fos Kuehn , Reed Heimbecher
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B5/6852 , A61B5/6885 , A61B2090/065
摘要： Systems and methods are disclosed for assessing electrode-tissue contact for tissue ablation. An exemplary electrode contact sensing system comprises an electrode housed within a distal portion of a catheter shaft. At least one electro-mechanical sensor is operatively associated with the electrode within the catheter shaft. The at least one electro-mechanical sensor is responsive to movement of the electrode by generating electrical signals corresponding to the amount of movement. The system may also include an output device electrically connected to the at least one electro-mechanical sensor. The output device receives the electrical signals for assessing a level of contact between the electrode and a tissue.
摘要翻译：公开了用于评估用于组织消融的电极组织接触的系统和方法。示例性电极接触感测系统包括容纳在导管轴的远端部分内的电极。至少一个机电传感器与导管轴内的电极可操作地相关联。所述至少一个机电传感器通过产生对应于移动量的电信号来响应电极的运动。该系统还可以包括电连接到该至少一个机电传感器的输出装置。输出装置接收用于评估电极和组织之间的接触水平的电信号。

5. 发明授权

US08679109B2 Dynamic contact assessment for electrode catheters 有权
标题翻译：电极导管的动态接触评估
公开(公告)号：US08679109B2
公开(公告)日：2014-03-25
申请号：US11549100
申请日：2006-10-12
申请人： Saurav Paul , Chou Thao , Kedar Ravindra Belhe , Reed R. Heimbecher
发明人： Saurav Paul , Chou Thao , Kedar Ravindra Belhe , Reed R. Heimbecher
IPC分类号： A61B18/18
CPC分类号： A61B5/036 , A61B5/061 , A61B5/6885 , A61B18/1492 , A61B2018/00351 , A61B2090/065
摘要： An electrode catheter and a method for assessing catheter-tissue contact for tissue ablation are disclosed. An exemplary electrode catheter comprises a flexible catheter shaft. At least one piezoelectric sensor is oriented coaxial to the flexible catheter shaft. The at least one piezoelectric sensor is responsive to movement of the flexible catheter shaft by generating electrical signals corresponding to the amount of movement. The system may also include an output device electrically connected to the at least one piezoelectric sensor. The output device receives the electrical signals for dynamically assessing a level of contact between the flexible catheter shaft and a moving tissue. In another exemplary embodiment, the system may be implemented in a hydrodynamic environment.
摘要翻译：公开了电极导管和用于评估用于组织消融的导管 - 组织接触的方法。示例性电极导管包括柔性导管轴。至少一个压电传感器与柔性导管轴同轴地定向。至少一个压电传感器通过产生对应于移动量的电信号来响应柔性导管轴的移动。该系统还可以包括电连接到至少一个压电传感器的输出装置。输出装置接收用于动态评估柔性导管轴和移动组织之间的接触程度的电信号。在另一个示例性实施例中，系统可以在流体动力学环境中实现。

6. 发明授权

US09283025B2 Assessment of electrode coupling for tissue ablation 有权
公开(公告)号：US09283025B2
公开(公告)日：2016-03-15
申请号：US12095701
申请日：2006-12-06
申请人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao
发明人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao
IPC分类号： A61B18/12 , A61B18/14 , A61B19/00 , A61B18/00
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.

7. 发明授权

US08449537B2 Ablation catheter with thermally mediated catheter body for mitigating blood coagulation and creating larger lesion 有权
标题翻译：消融导管与热介导的导管体减轻血液凝固和创造更大的病变
公开(公告)号：US08449537B2
公开(公告)日：2013-05-28
申请号：US11618692
申请日：2006-12-29
申请人： Hong Cao , Xiaoping Guo , Isaac Shai , Michael Yang , Kedar Ravindra Belhe , Saurav Paul , Chou Thao
发明人： Hong Cao , Xiaoping Guo , Isaac Shai , Michael Yang , Kedar Ravindra Belhe , Saurav Paul , Chou Thao
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00005 , A61B2018/00357
摘要： An ablation catheter is provided for ablating internal tissue of a patient. The catheter includes a distal end that is adapted to be inserted into a body cavity relative to a desired location therein (e.g., within the heart). An ablation electrode is connected relative to the distal end of the catheter for providing ablation energy to patient tissue. A heat sink is provided that is in thermal contact with the ablation electrode. The heat sink, in addition to being in thermal contact with the ablation electrode, is electrically isolated from the ablation electrode. This allows the heat sink to conduct heat away from the ablation electrode without dissipating electrical energy from the electrode. In this regard, the heat sink may prevent build-up of excess heat within the electrode that may result in blood coagulation and/or tissue charring.
摘要翻译：提供消融导管以消融患者的内部组织。该导管包括适于相对于其中的期望位置（例如，在心脏内）插入体腔内的远端。消融电极相对于导管的远端连接，以向患者组织提供消融能量。提供与消融电极热接触的散热器。除了与消融电极热接触之外，散热器与消融电极电隔离。这允许散热器将热量从消融电极导出，而不会从电极中消耗电能。在这方面，散热器可以防止在电极内积聚多余的热量，从而导致血液凝固和/或组织烧焦。

8. 发明申请

US20090163916A1 Flexible Conductive Polymer Electrode and Method for Ablation 有权
标题翻译：柔性导电聚合物电极和消融方法
公开(公告)号：US20090163916A1
公开(公告)日：2009-06-25
申请号：US11963430
申请日：2007-12-21
申请人： Saurav Paul , Hong Cao , Chou Thao
发明人： Saurav Paul , Hong Cao , Chou Thao
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00005 , A61B2018/00023 , A61B2018/00029 , A61B2018/00077 , A61B2018/00136 , A61B2018/00148 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821
摘要： An electrode for ablation therapy includes a flexible conductive element for conducting electrical energy and a flexible conductive polymer member in electrically conductive contact with the conductive element. A catheter shaft may be coupled to the conductive element and/or the flexible conductive polymer member. The flexible conductive element may be formed as a helical coil, a mesh coating or wrap, or any other suitable form, and may surround (wholly or partially) a flexible electrically insulative, and optionally thermally conductive, member. A heat sink may be thermally coupled to at least one of the flexible conductive polymer member and the flexible electrically insulative member. The flexible electrically insulative member may include a passageway for coolant fluid to cool the electrode during ablation. The passageway may include at least one efflux hole to permit coolant fluid to flow from the passageway, or may define a closed loop.
摘要翻译：用于消融治疗的电极包括用于传导电能的柔性导电元件和与导电元件导电接触的柔性导电聚合物构件。导管轴可以联接到导电元件和/或柔性导电聚合物构件。柔性导电元件可以形成为螺旋线圈，网状涂层或包裹物或任何其它合适的形式，并且可以围绕（全部或部分地）柔性电绝缘和任选地导热的构件。散热器可以热耦合到柔性导电聚合物构件和柔性电绝缘构件中的至少一个。柔性电绝缘构件可以包括用于在消融期间冷却电极的冷却剂流体的通道。通道可以包括至少一个排出孔，以允许冷却剂流体从通道流出，或者可以限定闭环。

9. 发明申请

US20080161796A1 Design of ablation electrode with tactile sensor 审中-公开
标题翻译：消融电极与触觉传感器的设计
公开(公告)号：US20080161796A1
公开(公告)日：2008-07-03
申请号：US11647279
申请日：2006-12-29
申请人： Hong Cao , Chou Thao , Saurav Paul
发明人： Hong Cao , Chou Thao , Saurav Paul
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/6852 , A61B5/6885 , A61B2090/065
摘要： A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. The assembly includes a catheter shaft and a pressure sensitive conductive composite member whose electrical resistance varies with pressure applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive conductive composite member. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive conductive composites.
摘要翻译：公开了一种用于评估导管组件和组织之间的接触的导管组件。组件包括导管轴和压力敏感的导电复合构件，其电阻随着施加到导管组件的压力而变化。组件还包括至少一个测量端子，以允许测量压敏导电复合构件的电特性的变化。组件可以可选地包括测量电阻，阻抗和/或其他电特性的测量装置。组件可以利用固定到患者组织的参考电极，其允许测量装置测量参考电极和至少一个测量终端之间的变化。可选地，组件可以包括导电外层。还公开了传感器组件，接触传感器，接触感测方法以及与使用压敏导电复合材料有关的制造方法。

10. 发明申请

US20080091192A1 Brush electrode and method for ablation 审中-公开
标题翻译：刷电极和消融方法
公开(公告)号：US20080091192A1
公开(公告)日：2008-04-17
申请号：US11953151
申请日：2007-12-10
申请人： Saurav Paul , Kedar Belhe , Hong Cao , Chou Thao
发明人： Saurav Paul , Kedar Belhe , Hong Cao , Chou Thao
IPC分类号： A61B18/14
CPC分类号： A61B18/1402 , A61B2018/143 , A61B2018/1472
摘要： A brush electrode and a method for using the brush electrode for tissue ablation are disclosed. The brush electrode comprises a plurality of flexible filaments or bristles for applying ablative energy (e.g., RF energy) to target tissue during the formation of spot or continuous linear lesions. Interstitial spaces are defined among the filaments of the brush electrode, and the interstitial spaces are adapted to direct conductive or nonconductive fluid, when present, toward the distal ends of the brush filaments. The brush electrode facilitates electrode-tissue contact in target tissue having flat or contoured surfaces. The flexible filaments may be selectively trimmed to give a desired tip configuration or a desired standoff distance between the tissue and the conductive filaments in the brush electrode. Also, the filaments may be grouped into clusters. A shielded-tip brush electrode, including a flexible boot, is also disclosed.
摘要翻译：公开了一种刷电极和使用刷电极进行组织消融的方法。刷电极包括多个柔性细丝或刷毛，用于在形成斑点或连续线性损伤期间向靶组织施加消融能量（例如RF能量）。间隙空间被限定在刷电极的细丝之间，并且间隙空间适于将导电或非导电流体（当存在时）引向刷丝的远端。刷电极促进具有平坦或轮廓表面的靶组织中的电极组织接触。可以选择性地修剪柔性细丝以给出组织和刷电极中的导电细丝之间的期望的尖端构型或期望的间隔距离。此外，丝可以分组成簇。还公开了一种包括柔性护罩的屏蔽尖刷电极。

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