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1. 发明授权

US08679109B2 Dynamic contact assessment for electrode catheters 有权
标题翻译：电极导管的动态接触评估
公开(公告)号：US08679109B2
公开(公告)日：2014-03-25
申请号：US11549100
申请日：2006-10-12
申请人： Saurav Paul , Chou Thao , Kedar Ravindra Belhe , Reed R. Heimbecher
发明人： Saurav Paul , Chou Thao , Kedar Ravindra Belhe , Reed R. Heimbecher
IPC分类号： A61B18/18
CPC分类号： A61B5/036 , A61B5/061 , A61B5/6885 , A61B18/1492 , A61B2018/00351 , A61B2090/065
摘要： An electrode catheter and a method for assessing catheter-tissue contact for tissue ablation are disclosed. An exemplary electrode catheter comprises a flexible catheter shaft. At least one piezoelectric sensor is oriented coaxial to the flexible catheter shaft. The at least one piezoelectric sensor is responsive to movement of the flexible catheter shaft by generating electrical signals corresponding to the amount of movement. The system may also include an output device electrically connected to the at least one piezoelectric sensor. The output device receives the electrical signals for dynamically assessing a level of contact between the flexible catheter shaft and a moving tissue. In another exemplary embodiment, the system may be implemented in a hydrodynamic environment.
摘要翻译：公开了电极导管和用于评估用于组织消融的导管 - 组织接触的方法。示例性电极导管包括柔性导管轴。至少一个压电传感器与柔性导管轴同轴地定向。至少一个压电传感器通过产生对应于移动量的电信号来响应柔性导管轴的移动。该系统还可以包括电连接到至少一个压电传感器的输出装置。输出装置接收用于动态评估柔性导管轴和移动组织之间的接触程度的电信号。在另一个示例性实施例中，系统可以在流体动力学环境中实现。

2. 发明授权

US09283025B2 Assessment of electrode coupling for tissue ablation 有权
公开(公告)号：US09283025B2
公开(公告)日：2016-03-15
申请号：US12095701
申请日：2006-12-06
申请人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao
发明人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao
IPC分类号： A61B18/12 , A61B18/14 , A61B19/00 , A61B18/00
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.

3. 发明授权

US08449537B2 Ablation catheter with thermally mediated catheter body for mitigating blood coagulation and creating larger lesion 有权
标题翻译：消融导管与热介导的导管体减轻血液凝固和创造更大的病变
公开(公告)号：US08449537B2
公开(公告)日：2013-05-28
申请号：US11618692
申请日：2006-12-29
申请人： Hong Cao , Xiaoping Guo , Isaac Shai , Michael Yang , Kedar Ravindra Belhe , Saurav Paul , Chou Thao
发明人： Hong Cao , Xiaoping Guo , Isaac Shai , Michael Yang , Kedar Ravindra Belhe , Saurav Paul , Chou Thao
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00005 , A61B2018/00357
摘要： An ablation catheter is provided for ablating internal tissue of a patient. The catheter includes a distal end that is adapted to be inserted into a body cavity relative to a desired location therein (e.g., within the heart). An ablation electrode is connected relative to the distal end of the catheter for providing ablation energy to patient tissue. A heat sink is provided that is in thermal contact with the ablation electrode. The heat sink, in addition to being in thermal contact with the ablation electrode, is electrically isolated from the ablation electrode. This allows the heat sink to conduct heat away from the ablation electrode without dissipating electrical energy from the electrode. In this regard, the heat sink may prevent build-up of excess heat within the electrode that may result in blood coagulation and/or tissue charring.
摘要翻译：提供消融导管以消融患者的内部组织。该导管包括适于相对于其中的期望位置（例如，在心脏内）插入体腔内的远端。消融电极相对于导管的远端连接，以向患者组织提供消融能量。提供与消融电极热接触的散热器。除了与消融电极热接触之外，散热器与消融电极电隔离。这允许散热器将热量从消融电极导出，而不会从电极中消耗电能。在这方面，散热器可以防止在电极内积聚多余的热量，从而导致血液凝固和/或组织烧焦。

4. 发明授权

US07311704B2 Spring-tip, flexible electrode catheter for tissue ablation 有权
标题翻译：弹簧尖端，柔性电极导管用于组织消融
公开(公告)号：US07311704B2
公开(公告)日：2007-12-25
申请号：US10856904
申请日：2004-05-27
申请人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , John Avi Roop , Chou Thao
发明人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , John Avi Roop , Chou Thao
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/143 , A61B2018/1435
摘要： A spring-tip, flexible electrode, and a method for using that electrode for tissue ablation, are disclosed. The spring-tip, flexible electrode comprises an enshrouded flexible electrode (e.g., an enshrouded plurality of flexible brush filaments or bristles) for applying ablative energy (e.g., RF energy) to target tissue during the formation of spot or continuous linear lesions. The spring of the spring tip may comprise compressible coils, compressible mesh, or compressible bellows, among other things. The spring provides axial suspension and is capable of axial compression and extension, and is flexible enough for deflection and bending. The axial suspension of the spring tip facilitates the desired contact between the electrode and the tissue surface. A shielded, spring-tip, flexible electrode is also disclosed, and includes a flexible nipple or shield. The spring-tip, flexible electrode facilitates enhanced tissue contact in difficult environments (e.g., during ablation of a contoured or trabeculated surface inside a beating heart) since the flexible electrode readily conforms to surface contours while the bending stress of the spring enhances the contract pressure on the tissue.
摘要翻译：公开了一种弹簧尖端，柔性电极和用于组织消融使用该电极的方法。弹簧尖端的柔性电极包括用于在形成斑点或连续的线性损伤期间向目标组织施加消融能量（例如，RF能量）的带有屏蔽的柔性电极（例如，被包围的多个柔性刷丝或刷毛）。弹簧尖端的弹簧可以包括可压缩线圈，可压缩网或可压缩波纹管等等。弹簧提供轴向悬挂并且能够轴向压缩和伸展，并且具有足够的挠性和弯曲性。弹簧顶端的轴向悬挂有助于电极和组织表面之间的所需接触。还公开了屏蔽的弹簧尖端柔性电极，并且包括柔性接头或屏蔽。弹簧尖端的柔性电极有助于在困难的环境中（例如在跳动心脏内的轮廓或小梁表面的消融期间）增强组织接触，因为柔性电极容易符合表面轮廓，同时弹簧的弯曲应力增加了收缩压力在纸巾上。

5. 发明申请

US20120323237A1 ASSESSMENT OF ELECTRODE COUPLING FOR TISSUE ABLATION 有权
标题翻译：电器联合电击组织评估
公开(公告)号：US20120323237A1
公开(公告)日：2012-12-20
申请号：US13593676
申请日：2012-08-24
申请人： Saurav Paul , Hong Cao , Kedar Ravindra Belhe , Chou Thao
发明人： Saurav Paul , Hong Cao , Kedar Ravindra Belhe , Chou Thao
IPC分类号： A61B18/14
CPC分类号： A61B18/1206 , A61B5/0538 , A61B18/1492 , A61B2018/00357 , A61B2018/00577 , A61B2018/00732 , A61B2018/00869 , A61B2018/00875 , A61B2018/124 , A61B2018/128
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.
摘要翻译：公开了电极导管和用于评估电极组织接触和耦合的方法。示例性电极导管包括适于施加电能的电极。测量电路适于在电极接近目标组织时测量电极和地面之间的阻抗。处理器至少部分地基于由测量电路测量的阻抗的电抗来确定目标组织的接触和耦合条件。在另一示例性实施例中，电极导管至少部分地基于阻抗的相位角确定接触和耦合条件。

6. 发明授权

US07955326B2 Pressure-sensitive conductive composite electrode and method for ablation 有权
标题翻译：压敏导电复合电极及其消融方法
公开(公告)号：US07955326B2
公开(公告)日：2011-06-07
申请号：US11647316
申请日：2006-12-29
申请人： Saurav Paul , Kedar Ravindra Belhe , Chou Thao , Hong Cao
发明人： Saurav Paul , Kedar Ravindra Belhe , Chou Thao , Hong Cao
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00791 , A61B2018/1437 , A61B2090/064 , A61B2090/065 , A61B2218/002
摘要： The present invention is directed to ablation devices and methods utilizing pressure sensitive conductive composites, such as quantum tunneling composites, or other contact-sensitive, conductive polymers. The materials provide for electrodes and methods capable of differentiating between a soft and a hard push. The present invention thus provides an electrode for delivering selective electrical energy for ablation that may be varied based upon the pressure exerted on the surface area of the targeted tissue.
摘要翻译：本发明涉及使用压敏导电复合材料如量子隧道复合材料或其它接触敏感的导电聚合物的消融装置和方法。这些材料提供了能够区分软推和硬推的电极和方法。因此，本发明提供了一种用于输送用于消融的选择性电能的电极，其可以基于施加在目标组织的表面积上的压力而变化。

7. 发明授权

US07883508B2 Contact-sensitive pressure-sensitive conductive composite electrode and method for ablation 有权
标题翻译：接触敏感的压敏导电复合电极及其消融方法
公开(公告)号：US07883508B2
公开(公告)日：2011-02-08
申请号：US11647294
申请日：2006-12-29
申请人： Chou Thao , Saurav Paul , Kedar Ravindra Belhe , Hong Cao
发明人： Chou Thao , Saurav Paul , Kedar Ravindra Belhe , Hong Cao
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00577 , A61B2018/00702 , A61B2090/064
摘要： A catheter assembly for pressure-sensitive control of ablation treatment is disclosed. The assembly includes a conductive element, an electrode, and a pressure sensitive conductive composite member positioned between the conductive element and the electrode. At least one of the conductive pin, the pressure sensitive conductive composite element and the ablation electrode are moveable to create an engagement position and a non-engagement position. In the engagement position, the elements are electrically coupled such that ablation energy may be delivered from the conductive pin to the ablation electrode via the pressure sensitive conductive composite element. In the non-engagement position, the elements are electrically decoupled such that ablation energy is not delivered to the ablation electrode. A related method for pressure-sensitive control of ablation is also disclosed.
摘要翻译：公开了一种用于消融治疗的压敏控制的导管组件。组件包括导电元件，电极和位于导电元件和电极之间的压敏导电复合元件。导电针，压敏导电复合元件和消融电极中的至少一个可移动以产生接合位置和非接合位置。在接合位置，元件被电耦合，使得消融能量可以经由压敏导电复合元件从导电引脚传送到消融电极。在非接合位置，元件被电去耦合，使得消融能量不被输送到消融电极。还公开了一种用于消融的压敏控制的相关方法。

8. 发明授权

US07326204B2 Brush electrode and method for ablation 有权
公开(公告)号：US07326204B2
公开(公告)日：2008-02-05
申请号：US10808919
申请日：2004-03-24
申请人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao
发明人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao
IPC分类号： A61B18/18
CPC分类号： A61B18/1402 , A61B2018/143 , A61B2018/1472
摘要： A brush electrode and a method for using the brush electrode for tissue ablation are disclosed. The brush electrode comprises a plurality of flexible filaments or bristles for applying ablative energy (e.g., RF energy) to target tissue during the formation of spot or continuous linear lesions. Interstitial spaces are defined among the filaments of the brush electrode, and the interstitial spaces are adapted to direct conductive or nonconductive fluid, when present, toward the distal ends of the brush filaments. The brush electrode facilitates electrode-tissue contact in target tissue having flat or contoured surfaces. The flexible filaments may be selectively trimmed to give a desired tip configuration or a desired standoff distance between the tissue and the conductive filaments in the brush electrode. Also, the filaments may be grouped into clusters. A shielded-tip brush electrode, including a flexible boot, is also disclosed.

9. 发明授权

US09254163B2 Assessment of electrode coupling for tissue ablation 有权
公开(公告)号：US09254163B2
公开(公告)日：2016-02-09
申请号：US13593676
申请日：2012-08-24
申请人： Saurav Paul , Hong Cao , Kedar Ravindra Belhe , Chou Thao
发明人： Saurav Paul , Hong Cao , Kedar Ravindra Belhe , Chou Thao
IPC分类号： A61B18/12 , A61B5/053 , A61B18/14 , A61B18/00
CPC分类号： A61B18/1206 , A61B5/0538 , A61B18/1492 , A61B2018/00357 , A61B2018/00577 , A61B2018/00732 , A61B2018/00869 , A61B2018/00875 , A61B2018/124 , A61B2018/128
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.

10. 发明授权

US08728077B2 Handle set for ablation catheter with indicators of catheter and tissue parameters 有权
标题翻译：用于消融导管的手柄，其具有导管和组织参数指示
公开(公告)号：US08728077B2
公开(公告)日：2014-05-20
申请号：US12096069
申请日：2006-12-06
申请人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao , James A. Hassett
发明人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao , James A. Hassett
IPC分类号： A61B18/18 , A61B5/05
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode coupling output system provides indication to the physician, via electrode guidance instrumentation, concerning the electrical coupling of an electrode, such as an ablative or mapping electrode, with a patient. The output can be provided to the physician via an output device incorporated into the handle set of the electrode catheter. For example, a visual, audio or mechanical output can be provided via the handle set. Additionally or alternatively, the output can be provided to the physician via a navigation system. The indication may be provided by changing the color or other display characteristics of the electrode on the navigation system display or by way of providing a waveform indicating the electrode coupling. In this manner, electrode coupling information is provided to a physician in a manner that minimizes physician distraction.
摘要翻译：电极耦合输出系统通过电极引导仪器向医师提供关于电极（例如烧蚀或映射电极）与患者的电耦合的指示。输出可以通过结合到电极导管的手柄组中的输出装置提供给医师。例如，可以通过手柄组提供视觉，音频或机械输出。另外或替代地，输出可以经由导航系统提供给医师。可以通过改变导航系统显示器上的电极的颜色或其他显示特性或通过提供指示电极耦合的波形来提供指示。以这种方式，电极耦合信息以最小化医师分心的方式提供给医师。

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