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    • 1. 发明授权
    • Composition for treating hepatitis C
    • 用于治疗丙型肝炎的组合物
    • US07381435B2
    • 2008-06-03
    • US10547548
    • 2004-03-04
    • Satoshi YoshidaShuichi Kaneko
    • Satoshi YoshidaShuichi Kaneko
    • A61K36/42A61K36/286A61K36/68A61K36/355
    • A61K36/286A61K36/355A61K36/42A61K36/68A61K2300/00
    • By administering a composition comprising pumpkin seed, safflower, plantain and honeysuckle, subjective symptoms (for example, general malaise and abdominal swelling) of a patient with chronic hepatitis C can be eliminated and, moreover, objective symptoms diagnosed by a medical doctor (for example, liver enlargement and palm erythema) can be relieved or eliminated. From 1 to 3 months after the administration of the composition, a significant decrease in hepatitis C virus RNA level is gradually observed. Therefore, the above composition is useful at least as a composition for treating chronic hepatitis C. In particular, it is advantageous in treating a chronic hepatitis C patient showing a high chronic hepatitis C virus RNA level.
    • 通过施用包含南瓜籽,红花,车前草和金银花的组合物,可以消除患有慢性丙型肝炎患者的主观症状(例如,一般不适和腹部肿胀),此外,由医生诊断的客观症状(例如, ,肝肿大和棕红斑)可以缓解或消除。 在组合物施用后1至3个月,逐渐观察到丙型肝炎病毒RNA水平的显着降低。 因此,上述组合物至少可用作治疗慢性丙型肝炎的组合物。特别是,治疗显示高的慢性丙型肝炎病毒RNA水平的慢性丙型肝炎患者是有利的。
    • 2. 发明申请
    • Composition for treating hepatitis c
    • 治疗丙型肝炎的组合物
    • US20070020348A1
    • 2007-01-25
    • US10547548
    • 2004-03-04
    • Satoshi YoshidaShuichi Kaneko
    • Satoshi YoshidaShuichi Kaneko
    • A61K36/54A61K36/42A61K36/28
    • A61K36/286A61K36/355A61K36/42A61K36/68A61K2300/00
    • By administering a composition comprising pumpkin seed, safflower, plantain and honeysuckle, subjective symptoms (for example, general malaise and abdominal swelling) of a patient with chronic hepatitis C can be eliminated and, moreover, objective symptoms diagnosed by a medical doctor (for example, liver enlargement and palm erythema) can be relieved or eliminated. From 1 to 3 months after the administration of the composition, a significant decrease in hepatitis C virus RNA level is gradually observed. Therefore, the above composition is useful at least as a composition for treating chronic hepatitis C. In particular, it is advantageous in treating a chronic hepatitis C patient showing a high chronic hepatitis C virus RNA level.
    • 通过施用包含南瓜籽,红花,车前草和金银花的组合物,可以消除患有慢性丙型肝炎患者的主观症状(例如,一般不适和腹部肿胀),此外,由医生诊断的客观症状(例如, ,肝肿大和棕红斑)可以缓解或消除。 在组合物施用后1至3个月,逐渐观察到丙型肝炎病毒RNA水平的显着降低。 因此,上述组合物至少可用作治疗慢性丙型肝炎的组合物。特别是,治疗显示高的慢性丙型肝炎病毒RNA水平的慢性丙型肝炎患者是有利的。
    • 10. 发明申请
    • DETECTION OF DIGESTIVE ORGAN CANCER, GASTRIC CANCER, COLORECTAL CANCER, PANCREATIC CANCER, AND BILIARY TRACT CANCER BY GENE EXPRESSION PROFILING
    • 根据基因表达分析检测消化性癌,胃癌,色素性癌,胰腺癌和胆汁性肝癌
    • US20120157341A1
    • 2012-06-21
    • US13391858
    • 2010-08-03
    • Shuichi KanekoMasao HondaYoshio SakaiTaro Yamashita
    • Shuichi KanekoMasao HondaYoshio SakaiTaro Yamashita
    • C40B30/04C40B40/06
    • C12Q1/6886C12Q2600/158C12Q2600/16
    • The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects. The reagent for detecting digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer contains nucleotides or partial sequences thereof consisting of the nucleotide sequence of at least one gene selected from the group consisting of probes with expression levels that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer, or nucleotides containing sequences complementary thereto.
    • 本发明提供了通过分析与消化器官癌相关的变化的表达水平(外周血)的基因来检测消化器官癌,胃癌,结肠直肠癌,胰腺癌或胆道癌患者的方法和试剂, 胃癌,结肠直肠癌,胰腺癌或胆道癌,与正常健康人相比。 具体地,基于表达谱,检测消化器官癌,胃癌,结肠直肠癌,胰腺癌或胆道癌患者的方法包括获得至少一种基因的表达谱,所述基因选自对应于具有 与正常健康受试者相比,消化器官癌,胃癌,结肠直肠癌,胰腺癌和胆道癌患者的表达水平(外周血)差异不大。 用于检测消化器官癌,胃癌,结肠直肠癌,胰腺癌或胆道癌的试剂含有由至少一种基因的核苷酸序列组成的核苷酸或其部分序列,所述核苷酸序列选自下组的探针:表达水平在 消化器官癌,胃癌,结肠直肠癌,胰腺癌或胆道癌,或含有与其互补的序列的核苷酸。