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    • 9. 发明授权
    • Detection of digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer by gene expression profiling
    • 通过基因表达谱检测消化器官癌,胃癌,结肠直肠癌,胰腺癌和胆道癌
    • US08932990B2
    • 2015-01-13
    • US13391858
    • 2010-08-03
    • Shuichi KanekoMasao HondaYoshio SakaiTaro Yamashita
    • Shuichi KanekoMasao HondaYoshio SakaiTaro Yamashita
    • C40B30/04C12Q1/68C40B40/06
    • C12Q1/6886C12Q2600/158C12Q2600/16
    • The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects. The reagent for detecting digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer contains nucleotides or partial sequences thereof consisting of the nucleotide sequence of at least one gene selected from the group consisting of probes with expression levels that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer, or nucleotides containing sequences complementary thereto.
    • 本发明提供了通过分析与消化器官癌相关的变化的表达水平(外周血)的基因来检测消化器官癌,胃癌,结肠直肠癌,胰腺癌或胆道癌患者的方法和试剂, 胃癌,结肠直肠癌,胰腺癌或胆道癌,与正常健康人相比。 具体地,基于表达谱,检测消化器官癌,胃癌,结肠直肠癌,胰腺癌或胆道癌患者的方法包括获得至少一种基因的表达谱,所述基因选自对应于具有 与正常健康受试者相比,消化器官癌,胃癌,结肠直肠癌,胰腺癌和胆道癌患者的表达水平(外周血)差异不大。 用于检测消化器官癌,胃癌,结肠直肠癌,胰腺癌或胆道癌的试剂含有由至少一种基因的核苷酸序列组成的核苷酸或其部分序列,所述核苷酸序列选自下组的探针:表达水平在 消化器官癌,胃癌,结肠直肠癌,胰腺癌或胆道癌,或含有与其互补的序列的核苷酸。
    • 10. 发明申请
    • SEMICONDUCTOR DEVICE AND MANUFACTURING METHOD THEREOF
    • 半导体器件及其制造方法
    • US20120001226A1
    • 2012-01-05
    • US13233392
    • 2011-09-15
    • Akio IWABUCHIShuichi Kaneko
    • Akio IWABUCHIShuichi Kaneko
    • H01L29/739
    • H01L29/7395H01L29/0653H01L29/66333
    • A manufacturing method of a semiconductor device 10 includes forming a plurality of second conductive second semiconductor regions at specific intervals on one main surface of a first conductive first semiconductor region, the plurality of second conductive second semiconductor regions being opposite to the first conductive first semiconductor region, forming a plurality of the first conductive third semiconductor regions on a main surface of the second semiconductor region, the plurality of the first conductive third regions being separated from each other, forming a plurality of holes at specific intervals on an another main surface which faces the one main surface of the first semiconductor region, the plurality of holes being separated from each other, forming a pair of adjacent second conductive fourth semiconductor regions which are alternately connected at a bottom part of the hole within the first semiconductor region, and burying an electrode within the hole.
    • 半导体器件10的制造方法包括在第一导电第一半导体区域的一个主表面上以特定间隔形成多个第二导电第二半导体区域,所述多个第二导电第二半导体区域与第一导电第一半导体区域相对 在所述第二半导体区域的主表面上形成多个所述第一导电第三半导体区域,所述多个所述第一导电第三区域彼此分离,在另一个主表面上以特定间隔形成多个孔,所述另一个主表面 第一半导体区域的一个主表面,多个孔彼此分离,形成一对相邻的第二导电第四半导体区域,其在第一半导体区域内的孔的底部交替连接,并且将 电极内孔。