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1. 发明授权

US06614645B1 Matched capacitor array 有权
标题翻译：匹配电容阵列
公开(公告)号：US06614645B1
公开(公告)日：2003-09-02
申请号：US10293628
申请日：2002-11-12
申请人： Satoshi Sakurai , Jason Chin
发明人： Satoshi Sakurai , Jason Chin
IPC分类号： H01G438
CPC分类号： H01G4/38 , H01L27/0805
摘要： A capacitor array of the present invention has a plurality of core capacitors arranged in a plurality of rows and a plurality of columns. A plurality of guard capacitors are arranged such that there is a guard capacitor at the beginning and end of each of the rows and columns of core capacitors. A plurality of fringe capacitors are arranged between the guard capacitors and the core capacitors. The top plates of the core capacitors and the top plates of the fringe capacitors are coupled to a first node of a circuit. The top and bottom plates of the guard capacitors and the bottom plates of the fringe capacitors are coupled to ground. The each of the bottom plates of the core capacitors are independently coupled to a respective independent node of the circuit. The various capacitors of the array and the means for coupling them are uniformly distributed such that each core capacitor is uniformly influenced by its adjacent structure. Thus, each core capacitor in the capacitor array has substantially matched primary and parasitic capacitances.
摘要翻译：本发明的电容器阵列具有以多列排列的多个芯电容器。多个保护电容器布置成使得在芯电容器的每行和列的开始和结束处存在保护电容器。在保护电容器和核心电容器之间布置多个边缘电容器。核心电容器的顶板和条纹电容器的顶板耦合到电路的第一节点。保护电容器的顶板和底板和条纹电容器的底板耦合到地。核心电容器的每个底板独立地耦合到电路的相应独立节点。阵列的各种电容器和用于耦合它们的装置是均匀分布的，使得每个芯电容器均匀地受其相邻结构的影响。因此，电容器阵列中的每个核心电容器具有基本匹配的初级和寄生电容。

2. 发明授权

US08096027B2 Twin buckle assembly with dual release positions 有权
标题翻译：带双释放位置的双扣组件
公开(公告)号：US08096027B2
公开(公告)日：2012-01-17
申请号：US12546914
申请日：2009-08-25
申请人： Marc Jung , Jason Chin
发明人： Marc Jung , Jason Chin
IPC分类号： A44B11/25
CPC分类号： A44B11/2542 , A44B11/2526 , Y10T24/45613 , Y10T24/45644 , Y10T24/45649
摘要： A twin buckle assembly is provided with dual release positions. The buckle assembly can lockingly secure two buckle tongues. The buckle assembly includes a single, pivotal latch mechanism that can separately secure one or both of the buckle tongues. Pivotal movement of the latch occurs upon rotation of the buckle cover. Thus, one tongue is released at a first rotational position of the cover and both tongues are released at a second rotational position of the cover. The buckle assembly, thereby, allows the independent removal of lap and shoulder belts.
摘要翻译：双扣组件提供双释放位置。带扣组件可以锁定两个扣舌。带扣组件包括单独的枢转闩锁机构，其可以单独地固定一个或两个带扣舌。闩锁的枢转运动发生在带扣盖旋转时。因此，一个舌片在盖的第一旋转位置被释放，并且两个舌片在盖子的第二旋转位置被释放。因此，带扣组件可以独立地拆卸搭扣和肩带。

3. 发明申请

US20110027829A1 Methods and Compositions 审中-公开
标题翻译：方法和组成
公开(公告)号：US20110027829A1
公开(公告)日：2011-02-03
申请号：US12739247
申请日：2008-10-27
申请人： Heinz Neumann , Jason Chin
发明人： Heinz Neumann , Jason Chin
IPC分类号： C12P21/00 , C12N9/00 , C07H21/00 , C07K2/00 , C07K14/00 , C12N15/63 , C12N1/00
CPC分类号： C12P21/02 , C12N9/93
摘要： The invention relates to a tRNA synthetase capable of binding N⊂-acetyl lysine, in particular, the invention relates to a tRNA synthetase capable of binding N∈-acetyl lysine wherein said synthetase comprises a polypeptide having at least 90% sequence identity to the amino acid sequence of MbPy1RS. The invention also relates to a method of making a polypeptide comprising N∈-acetyl lysine comprising arranging for the translation of a RNA encoding said polypeptide, wherein said RNA comprises an amber codon, wherein said translation is carried out in the presence of a polypeptide according to any of claims 1 to 11 and in the presence of tRNA capable of being charged with N∈-acetyl lysine, and in the presence of N∈-acetyl lysine.
摘要翻译：本发明涉及能够结合N-乙酰赖氨酸的tRNA合成酶，特别地，本发明涉及能够结合Nε-乙酰赖氨酸的tRNA合成酶，其中所述合成酶包含与氨基具有至少90％序列同一性的多肽 MbPy1RS的酸序列。本发明还涉及一种制备包含Nε-乙酰赖氨酸的多肽的方法，包括安排编码所述多肽的RNA的翻译，其中所述RNA包含琥珀密码子，其中所述翻译在多肽存在下进行，权利要求1至11中任一项，并且在存在能够被Nε-乙酰赖氨酸加载的tRNA存在下，并且在Nε-乙酰赖氨酸存在下。

4. 发明申请

US20100105565A1 Evolved Orthogonal Ribosomes 失效
标题翻译：进化正交核糖体
公开(公告)号：US20100105565A1
公开(公告)日：2010-04-29
申请号：US12516230
申请日：2007-11-28
申请人： Jason Chin , Kaihang Wang , Heinz Neumann
发明人： Jason Chin , Kaihang Wang , Heinz Neumann
IPC分类号： C40B30/00 , C07H21/02 , C12P21/06 , C12N1/21
CPC分类号： C12N15/11 , C12N15/111 , C12N2320/13 , C12P21/02 , C40B10/00 , C40B40/08
摘要： There is provided a method for evolving an orthogonal rRNA molecule, comprising the steps of: providing one or more libraries of mutant orthogonal rRNA molecules and introducing the libraries into cells such that the orthogonal rRNA is incorporated into ribosomes to provide orthogonal ribosomes; providing one or more orthogonal mRNA molecules which (i) are not translated by natural ribosomes, and (ii) comprise one or more orthogonal mRNA codons; assaying the translation of the of the orthogonal mRNA and selecting the orthogonal rRNA molecules which translate the orthogonal mRNA, wherein the assay in step (c) requires translation of one or more orthogonal mRNA codons in the orthogonal mRNA; and orthogonal ribosomes incorporating such rRNA molecules.
摘要翻译：提供了用于进化正交rRNA分子的方法，包括以下步骤：提供一个或多个突变正交rRNA分子文库，并将文库引入细胞，使得正交rRNA被并入核糖体中以提供正交核糖体; 提供（i）不被天然核糖体翻译的一个或多个正交mRNA分子，和（ii）包含一个或多个正交mRNA密码子; 测定正交mRNA的翻译并选择翻译正交mRNA的正交rRNA分子，其中步骤（c）中的测定需要在正交mRNA中翻译一个或多个正交mRNA密码子; 并结合这样的rRNA分子的正交核糖体。

5. 发明授权

US09868956B2 Methods 有权
公开(公告)号：US09868956B2
公开(公告)日：2018-01-16
申请号：US13376068
申请日：2010-06-02
申请人： Duy P. Nguyen , Heinz Neumann , Alexander Deiters , Jason Chin , Hrvoje Lusic
发明人： Duy P. Nguyen , Heinz Neumann , Alexander Deiters , Jason Chin , Hrvoje Lusic
IPC分类号： C12P21/06 , C12N15/67 , C07C233/49 , C07C271/22 , C12N9/00 , C12P21/02
CPC分类号： C12N15/67 , C07C233/49 , C07C271/22 , C12N9/93 , C12P21/02
摘要： The invention relates to a method of making a polypeptide comprising an orthogonal functional group, said orthogonal functional group being comprised by an aliphatic amino acid or amino acid derivative, said method comprising providing a host cell; providing a nucleic acid encoding the polypeptide of interest; providing a tRNA-tRNA synthetase pair orthogonal to said host cell; adding an amino acid or amino acid derivative comprising the orthogonal functional group of interest, wherein said amino acid or amino acid derivative is a substrate for said orthogonal tRNA synthetase, wherein said amino acid or amino acid derivative has an aliphatic carbon backbone; and incubating to allow incorporation of said amino acid or amino acid derivative into the polypeptide of interest via the orthogonal tRNA-tRNA synthetase pair. The invention also relates to certain amino acids, and to polypeptides comprising same.

6. 发明申请

US20140148576A1 Traceless Ubiquitination 审中-公开
标题翻译：无痕泛素化
公开(公告)号：US20140148576A1
公开(公告)日：2014-05-29
申请号：US14129028
申请日：2012-06-22
申请人： Jason Chin , Satpal Virdee
发明人： Jason Chin , Satpal Virdee
IPC分类号： C12P21/00 , C07C271/22 , C07C323/59 , C12N9/10
CPC分类号： C12P21/00 , C07C271/22 , C07C323/59 , C07K2319/95 , C12N9/104 , C12N9/93 , C12Y601/01026
摘要： The invention related to a tRNA synthetase capable of binding delta-substituted lysine, wherein said tRNA synthetase comprises amino acid sequence corresponding to the amino acid sequence of at least L271 to Y349 of MbPyIRS, wherein said sequence comprises 5 or fewer substitutions within the amino acid sequence corresponding to the amino acid sequence of at least L271 to Y349 of MbPyIRS; and wherein said synthetase comprises W at amino acid position 349 relative to MbPyIRS.
摘要翻译：本发明涉及能够结合δ-取代的赖氨酸的tRNA合成酶，其中所述tRNA合成酶包含对应于MbPyIRS的至少L271至Y349的氨基酸序列的氨基酸序列，其中所述序列在氨基酸内包含5个或更少个取代对应于MbPyIRS的至少L271至Y349的氨基酸序列的序列; 并且其中所述合成酶在相对于MbPyIRS的氨基酸位置349处包含W。

7. 发明申请

US20130005019A1 GENETICALLY ENCODED PHOTO CONTROL 审中-公开
标题翻译：基本编码照片控制
公开(公告)号：US20130005019A1
公开(公告)日：2013-01-03
申请号：US13582703
申请日：2011-03-04
申请人： Jason Chin , Duy P. Nguyen , Arnaud Gautier , Alexander Dieters
发明人： Jason Chin , Duy P. Nguyen , Arnaud Gautier , Alexander Dieters
IPC分类号： C07D317/62 , C12N9/00 , C12N9/12
CPC分类号： C12N9/1205 , C07D317/50 , C07K14/805 , C12N9/93 , C12Y207/12002 , C12Y601/01026
摘要： The invention relates to a caged lysine, wherein the caged lysine is according to Formula (I): or salts thereof. The invention further relates to polypeptides comprising a caged lysine, and to methods of making same. The invention further relates to tRNA synthetases capable of charging tRNA with caged lysine.
摘要翻译：本发明涉及笼状赖氨酸，其中笼养的赖氨酸是根据式（I）：或其盐。本发明进一步涉及包含笼养赖氨酸的多肽及其制备方法。本发明还涉及能够将tRNA与笼养的赖氨酸一起加入的tRNA合成酶。

8. 发明申请

US20070166791A1 Expanding the eukaryotic genetic code 有权
公开(公告)号：US20070166791A1
公开(公告)日：2007-07-19
申请号：US11710672
申请日：2007-02-22
申请人： Jason Chin , T. Cropp , J. Anderson , Peter Schultz
发明人： Jason Chin , T. Cropp , J. Anderson , Peter Schultz
IPC分类号： C12P21/06
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.

9. 发明申请

US20060246509A1 Unnatural reactive amino acid genetic code additions 有权
标题翻译：非天然的反应性氨基酸遗传密码添加
公开(公告)号：US20060246509A1
公开(公告)日：2006-11-02
申请号：US10561121
申请日：2004-04-16
申请人： Alexander Deiters , T. Cropp , Jason Chin , J. Anderson , Peter Schultz
发明人： Alexander Deiters , T. Cropp , Jason Chin , J. Anderson , Peter Schultz
IPC分类号： G01N33/53 , C07K14/195 , C12N1/21 , C12N15/74 , C07H21/02 , C12P21/06
CPC分类号： G01N33/583 , C07C227/22 , C07C229/36 , C07C269/06 , C07C311/41 , C07K1/1072 , C07K1/13 , C07K14/001 , C07K16/18 , C09B11/08 , C09B57/00 , C12N9/93 , C12N15/67 , C12N2510/02 , C12P17/04 , C12P21/02 , G01N33/532 , G01N33/582 , C07C271/22
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsyn-thetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译：本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。组分包括正交tRNA，正交氨酰-tRNAsyn-tt，tRNA /合成酶和非天然氨基酸对。还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。

10. 发明申请

US20050287542A1 Protein binding miniature proteins 有权
标题翻译：蛋白结合微型蛋白
公开(公告)号：US20050287542A1
公开(公告)日：2005-12-29
申请号：US10982727
申请日：2004-11-04
申请人： Alanna Shrader , Jason Chin , Reena Zutshi , Stacey Rutledge , Tanya Schneider , Heather Volkman
发明人： Alanna Shrader , Jason Chin , Reena Zutshi , Stacey Rutledge , Tanya Schneider , Heather Volkman
IPC分类号： A61K38/00 , A61K38/28 , C07H21/04 , C07K14/465 , C07K14/575 , C12N5/06 , C12Q1/68
CPC分类号： C07K14/465 , A61K38/00 , C07K14/00 , C07K2319/00 , C12N15/1037 , C12N15/62 , C40B40/02
摘要： The present invention provides a protein scaffold, such as an avian pancreatic polypeptide, that can be modified by substitution of two or more amino acid residues that are exposed on the alpha helix domain of the polypeptide when the polypeptide is in a tertiary form.
摘要翻译：本发明提供蛋白质支架，例如禽胰腺多肽，当多肽处于三级形式时，可通过取代暴露于多肽的α螺旋结构域上的两个或更多个氨基酸残基来修饰。

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