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1. 发明申请

US20130005019A1 GENETICALLY ENCODED PHOTO CONTROL 审中-公开
标题翻译：基本编码照片控制
公开(公告)号：US20130005019A1
公开(公告)日：2013-01-03
申请号：US13582703
申请日：2011-03-04
申请人： Jason Chin , Duy P. Nguyen , Arnaud Gautier , Alexander Dieters
发明人： Jason Chin , Duy P. Nguyen , Arnaud Gautier , Alexander Dieters
IPC分类号： C07D317/62 , C12N9/00 , C12N9/12
CPC分类号： C12N9/1205 , C07D317/50 , C07K14/805 , C12N9/93 , C12Y207/12002 , C12Y601/01026
摘要： The invention relates to a caged lysine, wherein the caged lysine is according to Formula (I): or salts thereof. The invention further relates to polypeptides comprising a caged lysine, and to methods of making same. The invention further relates to tRNA synthetases capable of charging tRNA with caged lysine.
摘要翻译：本发明涉及笼状赖氨酸，其中笼养的赖氨酸是根据式（I）：或其盐。本发明进一步涉及包含笼养赖氨酸的多肽及其制备方法。本发明还涉及能够将tRNA与笼养的赖氨酸一起加入的tRNA合成酶。

2. 发明申请

US20120237961A1 Labelling of Fusion Proteins with Synthetic Probes 有权
标题翻译：用合成探针标记融合蛋白
公开(公告)号：US20120237961A1
公开(公告)日：2012-09-20
申请号：US13484954
申请日：2012-05-31
申请人： Arnaud Gautier , Kai Johnsson , Maik Kindermann , Alexandre Juillerat , Florent Beaufils
发明人： Arnaud Gautier , Kai Johnsson , Maik Kindermann , Alexandre Juillerat , Florent Beaufils
IPC分类号： G01N21/64 , C12N9/10
CPC分类号： G01N33/581 , C07D239/47 , C07D403/14 , C07D405/12 , C07D487/04 , C12N9/12 , C12Q1/48
摘要： The invention relates to new proteins called alkylcytosine transferases (ACTs) derived from O6-alkylguanine-DNA alkyltransferase, and to substrates for ACTs specifically transferring a label to these ACTs and to fusion proteins comprising these. The substrates according of the invention are substituted cytosines of formula (I) wherein R1 is an aromatic or a heteroaromatic group, or an optionally substituted unsaturated alkyl, cycloalkyl or heterocyclyl group with the double bond connected to OCH2—; R2 is a linker; and L is a label or a plurality of same or different labels. The invention further relates to methods of transferring label L from these substrates of formula (I) to ACTs and ACT fusion proteins. The system of ACT-compound of formula (I) is particularly suitable for double labelling studies together with the known system O6-alkylguanine-DNA alkyltransferase (AGT)-benzylguanines.
摘要翻译：本发明涉及从O6-烷基鸟嘌呤-DNA烷基转移酶衍生的称为烷基胞嘧啶转移酶（ACT）的新蛋白质，以及将这些ACT特异性转移标记物的ACT和包含这些酶的融合蛋白质的底物。根据本发明的底物是其中R 1是芳族或杂芳族基团的式（I）的取代的胞嘧啶或具有与OCH 2连接的双键的任选取代的不饱和烷基，环烷基或杂环基; R2是连接体; L是标签或多个相同或不同的标签。本发明还涉及将标记L从这些式（I）底物转移到ACT和ACT融合蛋白的方法。式（I）的ACT-化合物的系统特别适用于已知的系统O6-烷基鸟嘌呤-DNA烷基转移酶（AGT） - 苄基胍的双重标记研究。

3. 发明授权

US08227602B2 Labelling of fusion proteins with synthetic probes 有权
标题翻译：用合成探针标记融合蛋白
公开(公告)号：US08227602B2
公开(公告)日：2012-07-24
申请号：US12309554
申请日：2007-07-24
申请人： Arnaud Gautier , Kai Johnsson , Maik Kindermann , Alexandre Juillerat , Florent Beaufils
发明人： Arnaud Gautier , Kai Johnsson , Maik Kindermann , Alexandre Juillerat , Florent Beaufils
IPC分类号： C07D239/02
CPC分类号： G01N33/581 , C07D239/47 , C07D403/14 , C07D405/12 , C07D487/04 , C12N9/12 , C12Q1/48
摘要： The invention relates to new proteins called alkylcytosine transferases (ACTs) derived from O6-alkylguanine-DNA alkyltransferase, and to substrates for ACTs specifically transferring a label to these ACTs and to fusion proteins comprising these. The substrates according of the invention are substituted cytosines of formula (I) wherein R1 is an aromatic or a heteroaromatic group, or an optionally substituted unsaturated alkyl, cycloalkyl or heterocyclyl group with the double bond connected to OCH2—; R2 is a linker; and L is a label or a plurality of same or different labels. The invention further relates to methods of transferring label L from these substrates of formula (I) to ACTs and ACT fusion proteins. The system of ACT-compound of formula (I) is particularly suitable for double labelling studies together with the known system O6-alkylguanine-DNA alkyltransferase (AGT)-benzylguanines.
摘要翻译：本发明涉及从O6-烷基鸟嘌呤-DNA烷基转移酶衍生的称为烷基胞嘧啶转移酶（ACT）的新蛋白质，以及特异性将标记转移至这些ACT的ACT的底物和包含它们的融合蛋白。根据本发明的底物是其中R 1是芳族或杂芳族基团的式（I）的取代的胞嘧啶或具有与OCH 2连接的双键的任选取代的不饱和烷基，环烷基或杂环基; R2是连接体; L是标签或多个相同或不同的标签。本发明还涉及将标记L从这些式（I）底物转移到ACT和ACT融合蛋白的方法。式（I）的ACT-化合物的系统特别适用于已知的系统O6-烷基鸟嘌呤-DNA烷基转移酶（AGT） - 苄基胍的双重标记研究。

4. 发明申请

US20110207157A1 Labelling of Fusion Proteins With Synthetic Probes 有权
标题翻译：用合成探针标记融合蛋白
公开(公告)号：US20110207157A1
公开(公告)日：2011-08-25
申请号：US12309554
申请日：2007-07-24
申请人： Arnaud Gautier , Kai Johnsson , Maik Kindermann , Alexandrc Juillerat , Florent Beaufils
发明人： Arnaud Gautier , Kai Johnsson , Maik Kindermann , Alexandrc Juillerat , Florent Beaufils
IPC分类号： C12Q1/48 , C12N9/10 , C40B30/00 , C07D239/47 , C07D405/12 , C07D403/14 , C07D495/04 , C07D493/10 , C12N9/96
CPC分类号： G01N33/581 , C07D239/47 , C07D403/14 , C07D405/12 , C07D487/04 , C12N9/12 , C12Q1/48
摘要： The invention relates to new proteins called alkylcytosine transferases (ACTs) derived from O6-alkylguanine-DNA alkyltransferase, and to substrates for ACTs specifically transferring a label to these ACTs and to fusion proteins comprising these. The substrates according of the invention are substituted cytosines of formula (I) wherein R1 is an aromatic or a heteroaromatic group, or an optionally substituted unsaturated alkyl, cycloalkyl or heterocyclyl group with the double bond connected to OCH2—; R2 is a linker; and L is a label or a plurality of same or different labels. The invention further relates to methods of transferring label L from these substrates of formula (I) to ACTs and ACT fusion proteins. The system of ACT-compound of formula (I) is particularly suitable for double labelling studies together with the known system O6-alkylguanine-DNA alkyltransferase (AGT)-benzylguanines.
摘要翻译：本发明涉及从O6-烷基鸟嘌呤-DNA烷基转移酶衍生的称为烷基胞嘧啶转移酶（ACT）的新蛋白质，以及将这些ACT特异性转移标记物的ACT和包含这些酶的融合蛋白质的底物。根据本发明的底物是其中R 1是芳族或杂芳族基团的式（I）的取代的胞嘧啶或具有与OCH 2连接的双键的任选取代的不饱和烷基，环烷基或杂环基; R2是连接体; L是标签或多个相同或不同的标签。本发明还涉及将标记L从这些式（I）底物转移到ACT和ACT融合蛋白的方法。式（I）的ACT-化合物的系统特别适用于已知的系统O6-烷基鸟嘌呤-DNA烷基转移酶（AGT） - 苄基胍的双重标记研究。

5. 发明授权

US08623627B2 Labelling of fusion proteins with synthetic probes 有权
标题翻译：用合成探针标记融合蛋白
公开(公告)号：US08623627B2
公开(公告)日：2014-01-07
申请号：US13484954
申请日：2012-05-31
申请人： Arnaud Gautier , Kai Johnsson , Maik Kindermann , Alexandre Juillerat , Florent Beaufils
发明人： Arnaud Gautier , Kai Johnsson , Maik Kindermann , Alexandre Juillerat , Florent Beaufils
IPC分类号： C12N9/12 , C07D239/47
CPC分类号： G01N33/581 , C07D239/47 , C07D403/14 , C07D405/12 , C07D487/04 , C12N9/12 , C12Q1/48
摘要： The invention relates to new proteins called alkylcytosine transferases (ACTs) derived from O6-alkylguanine-DNA alkyltransferase, and to substrates for ACTs specifically transferring a label to these ACTs and to fusion proteins comprising these. The substrates according of the invention are substituted cytosines of formula (I) wherein R1 is an aromatic or a heteroaromatic group, or an optionally substituted unsaturated alkyl, cycloalkyl or heterocyclyl group with the double bond connected to OCH2—; R2 is a linker; and L is a label or a plurality of same or different labels. The invention further relates to methods of transferring label L from these substrates of formula (I) to ACTs and ACT fusion proteins. The system of ACT-compound of formula (I) is particularly suitable for double labelling studies together with the known system O6-alkylguanine-DNA alkyltransferase (AGT)-benzylguanines.
摘要翻译：本发明涉及从O6-烷基鸟嘌呤-DNA烷基转移酶衍生的称为烷基胞嘧啶转移酶（ACT）的新蛋白质，以及将这些ACT特异性转移标记物的ACT和包含这些酶的融合蛋白质的底物。根据本发明的底物是其中R 1是芳族或杂芳族基团的式（I）的取代的胞嘧啶或具有与OCH 2连接的双键的任选取代的不饱和烷基，环烷基或杂环基; R2是连接体; L是标签或多个相同或不同的标签。本发明还涉及将标记L从这些式（I）底物转移到ACT和ACT融合蛋白的方法。式（I）的ACT-化合物的系统特别适用于已知的系统O6-烷基鸟嘌呤-DNA烷基转移酶（AGT） - 苄基胍的双重标记研究。

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