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    • 1. 发明申请
    • COMPOSITION FOR IMPROVING INTESTINAL MICROFLORA
    • 用于改善肠道微血管的组合物
    • US20110038837A1
    • 2011-02-17
    • US12450113
    • 2008-03-14
    • Satoshi NishidaToshio Fujii
    • Satoshi NishidaToshio Fujii
    • A61K35/74C12N1/20A61P1/00A61P1/14
    • A21D8/045A23C9/1234A23L33/135A23Y2220/63A61K35/747
    • The present invention is to provide a composition for improving the intestinal microflora for maintaining a good intestinal microflora. The present invention consists of a composition for improving the intestinal microflora characterized by containing L. paracasei KW3110 or its variant as an active component. The composition exhibits an excellent intestinal regulation effect, intestinal environment-improving effect, and intestinal microflora-improving effect, enabling to form healthy microflora in human intestine, when being ingested. Especially, a composition for improving the intestinal microflora of the present invention activates lactic acid bacteria such as Bifidobacterium which are beneficial bacteria among the intestinal microflora, and enables substantively the improvement of the intestinal microflora and the maintenance of a good intestinal microflora. In the present invention, it is particularly preferred that the composition is a composition wherein L. paracasei KW3110 or its mutant is combined with probiotics and/or prebiotics.
    • 本发明提供一种用于改善肠道微生物群落以维持肠道微生物群落的组合物。 本发明由用于改善肠道微生物群落的组合物组成,其特征在于含有副干酪乳杆菌KW3110或其变体作为活性成分。 该组合物在摄入时表现出优异的肠调节作用,肠环境改善效果和肠道微生物群落改良效果,能够在人肠中形成健康的微生物群落。 特别地,本发明的肠道微生物群落改良用组合物能够在肠道菌群中活化作为有益细菌的双歧杆菌等乳酸菌,能够实现肠道微生物群落的改善和肠道微生物群落的良好维持。 在本发明中,特别优选组合物是其中副干酪乳杆菌KW3110或其突变体与益生菌和/或益生元组合的组合物。
    • 2. 发明申请
    • Antiallergic composition
    • 抗过敏组合物
    • US20060088513A1
    • 2006-04-27
    • US10504901
    • 2004-02-27
    • Sayo InoueToshio FujiiDaisuke FujiwaraAkira SaikiMinoru TakahashiKoichiro YamauchiMasami GotouSatoshi NishidaKeiji DeuchiHideyuki WakabayashiToshihiro Komeda
    • Sayo InoueToshio FujiiDaisuke FujiwaraAkira SaikiMinoru TakahashiKoichiro YamauchiMasami GotouSatoshi NishidaKeiji DeuchiHideyuki WakabayashiToshihiro Komeda
    • A61K35/74C12N1/20
    • A23C9/1234A23F3/166A23F3/34A23F5/246A23L2/52A23L33/135A23Y2220/67A61K35/747
    • The object of the present invention is to provide an antiallergic composition useful to prevention/treatment of allergy, its preparation method, and its use as foods or drinks or the like. As for means for solving the object, it is to provide an antiallergic composition comprising as active ingredients the lactic acid bacteria showing equal interleukin 12 production level compared to when Lactobacillus paracasei KW 3110 strain is used as the lactic acid bacteria to be tested, or showing 60% or more of interleukin 12 production level compared to when Lactobacillus paracasei KW 3110 strain is used, and showing less than 50% of interleukin 4 production level of a control wherein the lactic acid bacteria are not added, in case lymphocytes derived from mouse spleen sensitized with ovalbumin are suspended in a medium containing ovalbumin, and cultured by adding the lactic acid bacteria to be tested. The present invention encompasses a method for obtaining the lactic acid bacteria with antiallergic activity being the active ingredients of the antiallergic composition of the present invention, and the use of the antiallergic composition of the present invention to foods and beverages and the like, and further by formulation, the use as antiallergic agent administered orally.
    • 本发明的目的是提供一种用于预防/治疗过敏的抗过敏组合物,其制备方法及其作为食品或饮料等的用途。 作为解决目的的方法,提供一种抗过敏组合物,其与作为待测试乳酸菌的副乳酸杆菌KW3110株相比,含有作为活性成分的乳酸菌显示出相等的白细胞介素12的产生水平,或显示出 与使用副干酪乳杆菌KW3110菌株相比,白细胞介素12的产生水平高达60%以上,并且,如果不添加乳酸菌,则显示少于50%的白细胞介素4生产水平,如果来自小鼠脾的淋巴细胞 用卵白蛋白敏化的物质悬浮在含有卵清蛋白的培养基中,并通过加入待测试的乳酸菌进行培养。 本发明包括获得具有抗过敏活性的乳酸菌的方法,其为本发明的抗过敏组合物的活性成分,以及本发明的抗过敏组合物在食品和饮料等中的用途,进一步由 制剂,口服给药作为抗过敏剂。