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1. 发明授权

US06979431B2 Method for labelling technetium or rhenium using borohydride exchange resin 失效
标题翻译：使用硼氢化物交换树脂标记锝或铼的方法
公开(公告)号：US06979431B2
公开(公告)日：2005-12-27
申请号：US10253515
申请日：2002-09-24
申请人： Kyung Bae Park , Sang Hyun Park , Hui Jeong Gwon , Sun Ju Choi , Byung Chul Shin , Young Don Hong , Sang Mu Choi , Woong Woo Park , Kwang Hee Han , Beom Su Jang
发明人： Kyung Bae Park , Sang Hyun Park , Hui Jeong Gwon , Sun Ju Choi , Byung Chul Shin , Young Don Hong , Sang Mu Choi , Woong Woo Park , Kwang Hee Han , Beom Su Jang
IPC分类号： C01B17/20 , C07F13/00 , A61K51/00 , C01G47/00 , C01G57/00
CPC分类号： C07F13/005
摘要： A method for labelling a sulfide compound with technetium or rhenium, comprising the reaction of a disulfide compound with pertechnetate or perrhenate in the presence of borohydride exchange resin to obtain a complex of technetium or rhenium with the sulfide compound. The method can directly label disulfide compounds with technetium or rhenium, can skip the synthetic step of thiol-protected S-precursor, and is useful for high value-added radiopharmaceuticals.
摘要翻译：一种用锝或铼标记硫化物的方法，包括在硼氢化物交换树脂存在下二硫化物与高铁酸盐或高铼酸盐的反应，以获得锝或铼与硫化物的络合物。该方法可以用锝或铼直接标记二硫化物，可以跳过硫醇保护的S-前体的合成步骤，可用于高附加值放射性药物。

2. 发明授权

US06936240B2 Method for the preparation of technetium or rhenium complex for radiopharmaceuticals 失效
标题翻译：用于制备放射性药物的锝或铼络合物的方法
公开(公告)号：US06936240B2
公开(公告)日：2005-08-30
申请号：US10287133
申请日：2002-10-31
申请人： Kyung Bae Park , Sang Hyun Park , Hui Jeong Gwon , Sun Ju Choi , Byung Chul Shin , Young Don Hong , Sang Mu Choi , Woong Woo Park , Kwang Hee Han , Beom Su Jang
发明人： Kyung Bae Park , Sang Hyun Park , Hui Jeong Gwon , Sun Ju Choi , Byung Chul Shin , Young Don Hong , Sang Mu Choi , Woong Woo Park , Kwang Hee Han , Beom Su Jang
IPC分类号： A61K51/00 , A61K51/04 , C07F13/00 , A61M36/14
CPC分类号： C07F13/005 , A61K51/0402 , A61K51/0476 , A61K51/0489
摘要： The present invention relates to a method of preparing technetium or rhenium complex for radiopharmaceuticals, through reaction of pertechnetate or perrhenate with a ligand in the presence of a reducing agent, wherein the reducing agent is a borohydride exchange resin (BER). The borohydride exchange resin of the present invention has advantages of being stable in a wide range of Ph, including acidic or alkaline condition(Ph 2˜14) and thus being applicable to biological materials as well as being easily removable through filtration when being administrated. Also since the radiolabelled complex is produced under conditions milder than those required for the conventional reducing agents as well as has high radiochemical purity and high labeling efficiency, the conventional reducing agents can be replaced by the BER of the present invention.
摘要翻译：本发明涉及在还原剂存在下，通过高锝酸盐或高铼酸盐与配体的反应制备放射性药物的锝或铼络合物的方法，其中还原剂是硼氢化物交换树脂（BER）。本发明的硼氢化物交换树脂具有在广泛的Ph范围内稳定的优点，包括酸性或碱性条件（Ph 2〜14），因此适用于生物材料，并且在施用时易于通过过滤除去。此外，由于放射性标记的复合物在比常规还原剂所需的条件更温和的条件下生产，并且具有高放射化学纯度和高标记效率，所以常规的还原剂可以被本发明的BER代替。

3. 发明授权

US06888019B1 Method of preparing rhenium complex using borohydride exchange resin 有权
标题翻译：使用硼氢化物交换树脂制备铼配合物的方法
公开(公告)号：US06888019B1
公开(公告)日：2005-05-03
申请号：US10838805
申请日：2004-05-04
申请人： Sang Hyun Park , Kyung Bae Park , Sun Ju Choi
发明人： Sang Hyun Park , Kyung Bae Park , Sun Ju Choi
IPC分类号： C07F13/00 , A61K51/00
CPC分类号： C07F13/005 , A61K51/0478
摘要： Disclosed is a method of preparing a rhenium complex by use of a borohydride exchange resin, including dissolving perrhenic acid in a solution containing ethylenediamine tetraacetate, mannitol and stannous chloride to obtain a perrhenic acid solution (step 1), which is then mixed with disulfide in the presence of a borohydride exchange resin and reacts at room temperature, to obtain a rhenium complex (step 2). The preparation method of the current invention is characterized in that rhenium is reduced to have a desired oxidation number through the dissolving of the step 1, whereby the reaction of the step 2 can occur at room temperature. In addition, use of the borohydride exchange resin as a reducing agent results in direct formation of the rhenium complex of sulfide from disulfide, without the need of synthesis of thiol-protected S-precursor. Therefore, radioactive pharmaceuticals having high values can be economically and efficiently produced.
摘要翻译：公开了使用硼氢化物交换树脂制备铼络合物的方法，包括将高铼酸溶解在含有乙二胺四乙酸酯，甘露糖醇和氯化亚锡的溶液中以获得高铼酸溶液（步骤1），然后将其与二硫化物混合硼氢化物交换树脂的存在并在室温下反应，得到铼络合物（步骤2）。本发明的制备方法的特征在于，通过步骤1的溶解将铼还原成具有所需的氧化数，由此步骤2的反应可以在室温下进行。此外，使用硼氢化物交换树脂作为还原剂导致硫化物从二硫化物直接形成铼络合物，而不需要合成硫醇保护的S-前体。因此，具有高价值的放射性药物可以经济有效地产生。

4. 发明授权

US09421282B2 Method of preparing iodine seed for treating eye disease or cancer, and iodine seed prepared thereby 有权
标题翻译：制备碘晶种治疗眼病或癌症的方法及由此制备的碘种子
公开(公告)号：US09421282B2
公开(公告)日：2016-08-23
申请号：US13765072
申请日：2013-02-12
申请人： Kang Hyuk Choi , Kwang Jae Son , Jin-Hee Lee , Sung-Soo Nam , Sun Ju Choi
发明人： Kang Hyuk Choi , Kwang Jae Son , Jin-Hee Lee , Sung-Soo Nam , Sun Ju Choi
IPC分类号： A61M36/14 , A61K51/00 , A61K51/02 , A61K51/12
CPC分类号： A61K51/00 , A61K51/02 , A61K51/1282
摘要： The present invention provides a technique for adsorbing I-125 on a support for treating cancer and a method of preparing an I-125 seed using the same. Since a method of preparing iodine according to the present invention uses an intermediate having phosphate-based, oxalate-based, or arsenate-based anions introduced thereinto, the intermediate has a substitution effect of iodine 3 to 5 times higher than that of a typically used intermediate having chlorine anions introduced thereinto. According to the substitution effect, control of a radiation dose may be possible during the manufacturing of an iodine seed and an iodine seed may be prepared within a shorter period of time. Also, since an amount of residual radioactive iodine may be decreased as a result of a large amount of adsorption, an amount of radioactive iodine (I-125) waste may be decreased, and the effect thereof may be also high environmentally.
摘要翻译：本发明提供了用于将I-125吸附在用于治疗癌症的支持体上的技术，以及使用该技术制备I-125种子的方法。由于根据本发明的制备碘的方法使用引入其中含有基于磷酸盐，草酸盐或砷酸盐的阴离子的中间体，所以中间体具有碘的替代效应，比通常使用的碘的比例高3至5倍带有氯阴离子的中间体。根据替代效果，在制造碘种子期间可以控制辐射剂量，并且可以在更短的时间内制备碘种子。另外，由于吸附量大，残留的放射性碘量可能会降低，因此放射性碘（I-125）废物的量可能会降低，其效果也可能较高。

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