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1. 发明授权

US06979431B2 Method for labelling technetium or rhenium using borohydride exchange resin 失效
标题翻译：使用硼氢化物交换树脂标记锝或铼的方法
公开(公告)号：US06979431B2
公开(公告)日：2005-12-27
申请号：US10253515
申请日：2002-09-24
申请人： Kyung Bae Park , Sang Hyun Park , Hui Jeong Gwon , Sun Ju Choi , Byung Chul Shin , Young Don Hong , Sang Mu Choi , Woong Woo Park , Kwang Hee Han , Beom Su Jang
发明人： Kyung Bae Park , Sang Hyun Park , Hui Jeong Gwon , Sun Ju Choi , Byung Chul Shin , Young Don Hong , Sang Mu Choi , Woong Woo Park , Kwang Hee Han , Beom Su Jang
IPC分类号： C01B17/20 , C07F13/00 , A61K51/00 , C01G47/00 , C01G57/00
CPC分类号： C07F13/005
摘要： A method for labelling a sulfide compound with technetium or rhenium, comprising the reaction of a disulfide compound with pertechnetate or perrhenate in the presence of borohydride exchange resin to obtain a complex of technetium or rhenium with the sulfide compound. The method can directly label disulfide compounds with technetium or rhenium, can skip the synthetic step of thiol-protected S-precursor, and is useful for high value-added radiopharmaceuticals.
摘要翻译：一种用锝或铼标记硫化物的方法，包括在硼氢化物交换树脂存在下二硫化物与高铁酸盐或高铼酸盐的反应，以获得锝或铼与硫化物的络合物。该方法可以用锝或铼直接标记二硫化物，可以跳过硫醇保护的S-前体的合成步骤，可用于高附加值放射性药物。

2. 发明授权

US06936240B2 Method for the preparation of technetium or rhenium complex for radiopharmaceuticals 失效
标题翻译：用于制备放射性药物的锝或铼络合物的方法
公开(公告)号：US06936240B2
公开(公告)日：2005-08-30
申请号：US10287133
申请日：2002-10-31
申请人： Kyung Bae Park , Sang Hyun Park , Hui Jeong Gwon , Sun Ju Choi , Byung Chul Shin , Young Don Hong , Sang Mu Choi , Woong Woo Park , Kwang Hee Han , Beom Su Jang
发明人： Kyung Bae Park , Sang Hyun Park , Hui Jeong Gwon , Sun Ju Choi , Byung Chul Shin , Young Don Hong , Sang Mu Choi , Woong Woo Park , Kwang Hee Han , Beom Su Jang
IPC分类号： A61K51/00 , A61K51/04 , C07F13/00 , A61M36/14
CPC分类号： C07F13/005 , A61K51/0402 , A61K51/0476 , A61K51/0489
摘要： The present invention relates to a method of preparing technetium or rhenium complex for radiopharmaceuticals, through reaction of pertechnetate or perrhenate with a ligand in the presence of a reducing agent, wherein the reducing agent is a borohydride exchange resin (BER). The borohydride exchange resin of the present invention has advantages of being stable in a wide range of Ph, including acidic or alkaline condition(Ph 2˜14) and thus being applicable to biological materials as well as being easily removable through filtration when being administrated. Also since the radiolabelled complex is produced under conditions milder than those required for the conventional reducing agents as well as has high radiochemical purity and high labeling efficiency, the conventional reducing agents can be replaced by the BER of the present invention.
摘要翻译：本发明涉及在还原剂存在下，通过高锝酸盐或高铼酸盐与配体的反应制备放射性药物的锝或铼络合物的方法，其中还原剂是硼氢化物交换树脂（BER）。本发明的硼氢化物交换树脂具有在广泛的Ph范围内稳定的优点，包括酸性或碱性条件（Ph 2〜14），因此适用于生物材料，并且在施用时易于通过过滤除去。此外，由于放射性标记的复合物在比常规还原剂所需的条件更温和的条件下生产，并且具有高放射化学纯度和高标记效率，所以常规的还原剂可以被本发明的BER代替。

3. 发明授权

US07264791B2 Method for preparing technetium-labeled antimony sulfide nanocolloid 有权
标题翻译：制备锝标记的硫化锑纳米胶体的方法
公开(公告)号：US07264791B2
公开(公告)日：2007-09-04
申请号：US11065524
申请日：2005-02-23
申请人： Sang Hyun Park , Kyung Bae Park , Byung Chul Shin
发明人： Sang Hyun Park , Kyung Bae Park , Byung Chul Shin
IPC分类号： A61K51/00
CPC分类号： A61K51/025 , A61K51/1217
摘要： The present invention relates to a preparation method for technetium-antimony trisulfide nanocolloid, more precisely, a preparation method for technetium-antimony trisulfide nanocolloid which is characterized by the processes of mixing and stirring or irradiating of pertechnetate and antimony sulfide nanocolloid in the presence of borohydride exchange resin to obtain the technetium-antimony trisulfide nanocolloid radioactive complex.
摘要翻译：本发明涉及锑 - 锑三硫化物纳米胶体的制备方法，更确切地说，涉及锑 - 锑三硫化物纳米胶体的制备方法，其特征在于在硼氢化钠存在下混合并搅拌或辐照高锝酸盐和硫化锑纳米胶体交换树脂获得锑 - 锑三硫化物纳米胶体放射性复合物。

4. 发明授权

US06888019B1 Method of preparing rhenium complex using borohydride exchange resin 有权
标题翻译：使用硼氢化物交换树脂制备铼配合物的方法
公开(公告)号：US06888019B1
公开(公告)日：2005-05-03
申请号：US10838805
申请日：2004-05-04
申请人： Sang Hyun Park , Kyung Bae Park , Sun Ju Choi
发明人： Sang Hyun Park , Kyung Bae Park , Sun Ju Choi
IPC分类号： C07F13/00 , A61K51/00
CPC分类号： C07F13/005 , A61K51/0478
摘要： Disclosed is a method of preparing a rhenium complex by use of a borohydride exchange resin, including dissolving perrhenic acid in a solution containing ethylenediamine tetraacetate, mannitol and stannous chloride to obtain a perrhenic acid solution (step 1), which is then mixed with disulfide in the presence of a borohydride exchange resin and reacts at room temperature, to obtain a rhenium complex (step 2). The preparation method of the current invention is characterized in that rhenium is reduced to have a desired oxidation number through the dissolving of the step 1, whereby the reaction of the step 2 can occur at room temperature. In addition, use of the borohydride exchange resin as a reducing agent results in direct formation of the rhenium complex of sulfide from disulfide, without the need of synthesis of thiol-protected S-precursor. Therefore, radioactive pharmaceuticals having high values can be economically and efficiently produced.
摘要翻译：公开了使用硼氢化物交换树脂制备铼络合物的方法，包括将高铼酸溶解在含有乙二胺四乙酸酯，甘露糖醇和氯化亚锡的溶液中以获得高铼酸溶液（步骤1），然后将其与二硫化物混合硼氢化物交换树脂的存在并在室温下反应，得到铼络合物（步骤2）。本发明的制备方法的特征在于，通过步骤1的溶解将铼还原成具有所需的氧化数，由此步骤2的反应可以在室温下进行。此外，使用硼氢化物交换树脂作为还原剂导致硫化物从二硫化物直接形成铼络合物，而不需要合成硫醇保护的S-前体。因此，具有高价值的放射性药物可以经济有效地产生。

5. 发明授权

US08247538B2 Preparation method of radioisotope labeling compound using carbon nanotube 有权
标题翻译：使用碳纳米管的放射性同位素标记化合物的制备方法
公开(公告)号：US08247538B2
公开(公告)日：2012-08-21
申请号：US11788801
申请日：2007-04-20
申请人： Sang Hyun Park , Hui Jeong Gwon , Myung Woo Byun
发明人： Sang Hyun Park , Hui Jeong Gwon , Myung Woo Byun
IPC分类号： C07F13/00 , C07C279/02
CPC分类号： C07F13/005 , C07C277/00 , C07C279/06
摘要： Disclosed herein is a method for the preparation of radioisotope-labeled compounds using CNT. It comprises filling the carbon nanotube with a radioisotope; and labeling a physiologically active material with the radioisotope charged in the carbon nanotube. Taking advantage of CNT, the method can prepare a radioisotope-labeled compound invention at a high yield and in a simple manner. Also, the radioisotope, when remaining unreacted, can be recovered by the filtration of the CNT, thereby achieving the prevention of radioactive contamination and the reduction of radioactive waste. Further, the radioisotope-labeled compound is useful as a contrast medium for imaging the hepatobiliary system.
摘要翻译：本文公开了使用CNT制备放射性同位素标记化合物的方法。它包括用放射性同位素填充碳纳米管; 并用放入碳纳米管的放射性同位素标记生理活性物质。利用CNT，该方法可以以高产率和简单的方式制备放射性同位素标记的化合物。此外，当保留未反应时，放射性同位素可以通过过滤CNT来回收，从而实现放射性污染的防止和放射性废物的减少。此外，放射性同位素标记的化合物可用作成像肝胆系统的造影剂。

6. 发明申请

US20100029507A1 THE BIOCHIP FOR THE DETECTION OF PHOSPHORYLATION AND THE DETECTION METHOD USING THE SAME 审中-公开
标题翻译：用于检测磷酸化的生物技术和使用其的检测方法
公开(公告)号：US20100029507A1
公开(公告)日：2010-02-04
申请号：US11776969
申请日：2007-07-12
申请人： Sang Hyun Park , Hui Jeong Gwon , Kyong Cheol Ko , Myung Woo Byun
发明人： Sang Hyun Park , Hui Jeong Gwon , Kyong Cheol Ko , Myung Woo Byun
IPC分类号： C40B30/08 , C40B40/10
CPC分类号： C12Q1/485 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , G01N33/54353 , G01N2500/00
摘要： The present invention relates to a biochip for the detection of phosphorylation and a method for measuring phosphorylation using the same, more precisely a biochip integrated with the substrate of kinase and a kit for measuring phosphorylation comprising the biochip and a radio-labeled co-factor, and a method for measuring phosphorylation using the same. The kit for the detection of phosphorylation of the present invention facilitates simple and fast measurement of phosphorylation with a minimum amount of a sample, compared with the conventional method using an antibody, because it uses a radioisotope. This chip and kit can be effectively used for the analysis of kinase activity since this method favors fast mass analysis.
摘要翻译：本发明涉及用于检测磷酸化的生物芯片和使用其的磷酸化测定方法，更确切地说，与激酶底物整合的生物芯片和用于测量磷酸化的试剂盒包括生物芯片和放射性标记的辅因子，以及使用其测定磷酸化的方法。与使用抗体的常规方法相比，本发明的用于检测本发明的磷酸化的试剂盒由于使用放射性同位素，与使用抗体的常规方法相比，促进了用最少量的样品简单且快速地测量磷酸化。该芯片和试剂盒可以有效地用于激酶活性的分析，因为该方法有利于快速质量分析。

7. 发明授权

US07851496B2 Ionic liquid type crown ether derivatives, method for preparing the same and method for isolating metal ions using the same 有权
标题翻译：离子液体型冠醚衍生物，其制备方法以及使用该衍生物分离金属离子的方法
公开(公告)号：US07851496B2
公开(公告)日：2010-12-14
申请号：US11473751
申请日：2006-06-23
申请人： Sang Hyun Park , Seung Ho Jang , Hui Jeong Gwon , Myung Woo Byun
发明人： Sang Hyun Park , Seung Ho Jang , Hui Jeong Gwon , Myung Woo Byun
IPC分类号： A61K31/4188 , A61K51/04 , C07D273/00
CPC分类号： C07D491/14 , Y02P20/582
摘要： Disclosed relates to an ionic liquid type crown ether derivative, expressed by Chemical Formula 1 below, for isolating metal ions, a method for preparing the same and a method for isolating selectively the metal ions using the cycle size of the same. The present invention can provide the ionic liquid type crown ether and isolate metal ions including radioactive isotopes efficiently using the same. Furthermore, the prevent invention provides crown ether valuably used as a recyclable and environment-friendly isolating medium by preparing crown ether of ionic liquid type. wherein m, n, X− and R are identical with those in the description.
摘要翻译：本发明涉及离子液体型冠醚衍生物，由下述化学式1表示，用于分离金属离子，其制备方法以及使用其周期尺寸选择性地分离金属离子的方法。本发明可以提供离子液体型冠醚，并且使用它们有效地分离包括放射性同位素的金属离子。此外，本发明提供了通过制备离子液体型冠醚可贵地用作可回收和环境友好的隔离介质的冠醚。其中m，n，X和R与说明书中的相同。

8. 发明申请

US20080214797A1 Preparation method of radioisotope labeling compound using carbon nanotube 有权
标题翻译：使用碳纳米管的放射性同位素标记化合物的制备方法
公开(公告)号：US20080214797A1
公开(公告)日：2008-09-04
申请号：US11788801
申请日：2007-04-20
申请人： Sang Hyun Park , Hui Jeong Gwon , Myung Woo Byun
发明人： Sang Hyun Park , Hui Jeong Gwon , Myung Woo Byun
IPC分类号： C07F13/00 , C07C279/02
CPC分类号： C07F13/005 , C07C277/00 , C07C279/06
摘要： Disclosed herein is a method for the preparation of radioisotope-labeled compounds using CNT. It comprises filling the carbon nanotube with a radioisotope; and labeling a physiologically active material with the radioisotope charged in the carbon nanotube. Taking advantage of CNT, the method can prepare a radioisotope-labeled compound invention at a high yield and in a simple manner. Also, the radioisotope, when remaining unreacted, can be recovered by the filtration of the CNT, thereby achieving the prevention of radioactive contamination and the reduction of radioactive waste. Further, the radioisotope-labeled compound is useful as a contrast medium for imaging the hepatobiliary system.
摘要翻译：本文公开了使用CNT制备放射性同位素标记化合物的方法。它包括用放射性同位素填充碳纳米管; 并用放入碳纳米管的放射性同位素标记生理活性物质。利用CNT，该方法可以以高产率和简单的方式制备放射性同位素标记的化合物。此外，当保留未反应时，放射性同位素可以通过过滤CNT来回收，从而实现放射性污染的防止和放射性废物的减少。此外，放射性同位素标记的化合物可用作成像肝胆系统的造影剂。

9. 发明授权

US07459141B2 Technetium-99m-labeled organic germanium nanocolloids, method of preparing the same and use thereof 有权
标题翻译：锝-99m标记的有机锗纳米胶体及其制备方法及其应用
公开(公告)号：US07459141B2
公开(公告)日：2008-12-02
申请号：US11474717
申请日：2006-06-26
申请人： Sang Hyun Park , Hui Jeong Gwon , Myung Woo Byun
发明人： Sang Hyun Park , Hui Jeong Gwon , Myung Woo Byun
IPC分类号： A61K51/00 , C07J13/00
CPC分类号： C07F13/005 , A61K51/0478 , A61K51/1217
摘要： Disclosed relates to organic germanium nanocolloids, to which technetium-99m (99mTc), a radionuclide, is labeled, method of the same, and a spleen-imaging agent including the same. According to the invention, 99mTc-labeled organic germanium nanocolloids having high labeling efficiency and stability can be provided. Moreover, since the 99mTc-labeled organic germanium nanocolloids of the invention are accumulated in the spleen considerably higher than the conventional spleen-imaging agent, it is possible to use the 99mTc-labeled organic germanium nanocolloids of the present invention as a therapeutic radiopharmaceutical for the spleen imaging.
摘要翻译：涉及有机锗纳米胶体，锝-99m（99mTc），放射性核素被标记，其方法和包括其的脾显像剂。根据本发明，可以提供具有高标记效率和稳定性的99mTc标记的有机锗纳米胶体。此外，由于本发明的99mTc标记的有机锗纳米胶体在脾脏中积累显着高于常规脾显像剂，因此可以使用本发明的99mTc标记的有机锗纳米胶体作为治疗性放射性药物脾脏成像。

10. 发明授权

US09448003B2 Refrigerator having ice making compartment with refrigerant pipe support structure 有权
标题翻译：冰箱具有制冷隔室和制冷剂管支撑结构
公开(公告)号：US09448003B2
公开(公告)日：2016-09-20
申请号：US12929108
申请日：2010-12-30
申请人： Young Shik Shin , Chang Hak Lim , Jin Jeong , Sang Hyun Park
发明人： Young Shik Shin , Chang Hak Lim , Jin Jeong , Sang Hyun Park
IPC分类号： F25D17/06 , F25D21/14 , F25C1/24 , F25D23/00
CPC分类号： F25D21/14 , F25C1/24 , F25D23/006 , F25D2317/061 , F25D2321/1441
摘要： A refrigerator including a refrigeration cycle including a refrigerant pipe to supply cooling energy to an ice making compartment, an ice making tray, on which at least a portion of the refrigerant pipe is seated, a drainage duct to collect condensed water falling from the ice making tray or from at least a portion of the refrigerant pipe, and to drain the collected water, and at least one fixer to fix at least a portion of the refrigerant pipe to the ice making tray. The fixer is protruded from the drainage duct.
摘要翻译：一种制冷机，包括制冷循环，该制冷循环包括向制冰室供应冷却能的制冷剂管，制冰盘，至少一部分制冷剂管所在的制冰盘，用于收集从制冰中排出的冷凝水的排水管托盘或来自制冷剂管道的至少一部分，并且排出收集的水，以及至少一个定影器，以将制冷剂管道的至少一部分固定到制冰托盘。定位器从排水管突出。

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