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1. 发明授权

US08679425B2 Reagent container and reagent set 有权
标题翻译：试剂容器和试剂组
公开(公告)号：US08679425B2
公开(公告)日：2014-03-25
申请号：US12837869
申请日：2010-07-16
申请人： Sachiko Ueda , Yusuke Mori , Hiroyuki Ohashi , Yuji Itose , Kinya Uchihashi , Yoichi Nakamura , Kohei Sugitani
发明人： Sachiko Ueda , Yusuke Mori , Hiroyuki Ohashi , Yuji Itose , Kinya Uchihashi , Yoichi Nakamura , Kohei Sugitani
IPC分类号： B01L3/00 , B01L9/00 , B01L99/00 , B65D21/02 , B65D1/24 , B65D25/04 , B65D57/00 , B65D85/00 , G01N21/00 , G01N31/00 , G01N33/00 , A47B77/00 , B65D6/28
CPC分类号： B01L3/0293 , B01L3/527 , B01L9/00 , B01L2200/185 , B01L2300/021 , G01N35/1002
摘要： A reagent container set is disclosed which comprises: a first reagent container for accommodating a first reagent to be used in a sample analyzer, the top part of the first reagent container having a first aspiration opening for inserting a first reagent aspirating tube to aspirate the first reagent; a waste fluid container for accommodating the first reagent used in the sample analyzer as a waste fluid, the top of the waste fluid container having a discharge opening for inserting a waste fluid discharging tube to discharge the waste fluid into the waste fluid container; a box for accommodating the first reagent container and the waste fluid container; and a container holding member for holding the first reagent container and the waste fluid container so that the first aspiration opening and the discharge opening are disposed at predetermined positions, the container holding member being maintained at a predetermined position within the box.
摘要翻译：公开了一种试剂容器组，其包括：第一试剂容器，用于容纳待用于样本分析仪的第一试剂，所述第一试剂容器的顶部具有用于插入第一试剂抽吸管的第一抽吸开口，试剂; 用于将用于样品分析器中的第一试剂用作废液的废液容器，废液容器的顶部具有用于插入废液排放管的排出口，以将废液排放到废液容器中; 用于容纳第一试剂容器和废液容器的箱体; 以及容器保持构件，用于保持第一试剂容器和废液容器，使得第一抽吸开口和排出口设置在预定位置，容器保持构件保持在箱内的预定位置。

2. 发明申请

US20110014095A1 REAGENT CONTAINER AND REAGENT SET 有权
标题翻译：试剂容器和试剂组
公开(公告)号：US20110014095A1
公开(公告)日：2011-01-20
申请号：US12837869
申请日：2010-07-16
申请人： Sachiko UEDA , Yusuke Mori , Hiroyuki Ohashi , Yuji Itose , Kinya Uchihashi , Yoichi Nakamura , Kohei Sugitani
发明人： Sachiko UEDA , Yusuke Mori , Hiroyuki Ohashi , Yuji Itose , Kinya Uchihashi , Yoichi Nakamura , Kohei Sugitani
IPC分类号： G01N33/48 , G01N1/28 , B01L3/00
CPC分类号： B01L3/0293 , B01L3/527 , B01L9/00 , B01L2200/185 , B01L2300/021 , G01N35/1002
摘要： A reagent container set is disclosed which comprises: a first reagent container for accommodating a first reagent to be used in a sample analyzer, the top part of the first reagent container having a first aspiration opening for inserting a first reagent aspirating tube to aspirate the first reagent; a waste fluid container for accommodating the first reagent used in the sample analyzer as a waste fluid, the top of the waste fluid container having a discharge opening for inserting a waste fluid discharging tube to discharge the waste fluid into the waste fluid container; a box for accommodating the first reagent container and the waste fluid container; and a container holding member for holding the first reagent container and the waste fluid container so that the first aspiration opening and the discharge opening are disposed at predetermined positions, the container holding member being maintained at a predetermined position within the box.
摘要翻译：公开了一种试剂容器组，其包括：第一试剂容器，用于容纳待用于样本分析仪的第一试剂，所述第一试剂容器的顶部具有用于插入第一试剂抽吸管的第一抽吸开口，试剂; 用于将用于样品分析器中的第一试剂用作废液的废液容器，废液容器的顶部具有用于插入废液排放管的排出口，以将废液排放到废液容器中; 用于容纳第一试剂容器和废液容器的箱体; 以及容器保持构件，用于保持第一试剂容器和废液容器，使得第一抽吸开口和排出口设置在预定位置，容器保持构件保持在箱内的预定位置。

3. 发明申请

US20060223137A1 Reagent for partially lysing a cell membrane of a red blood cell, a reagent for detecting malaria infected red blood cells, and a sample analyzing method for detecting malaria infected red blood cells 有权
标题翻译：用于部分裂解红细胞的细胞膜的试剂，用于检测疟疾感染的红细胞的试剂和用于检测疟疾感染的红细胞的样品分析方法
公开(公告)号：US20060223137A1
公开(公告)日：2006-10-05
申请号：US11390298
申请日：2006-03-28
申请人： Ayumu Yoshida , Kinya Uchihashi , Yuji Itose , Aya Konishi , Hiromitsu Iizuka
发明人： Ayumu Yoshida , Kinya Uchihashi , Yuji Itose , Aya Konishi , Hiromitsu Iizuka
IPC分类号： C12Q1/04
CPC分类号： G01N33/80 , G01N33/56905 , Y02A50/58
摘要： A reagent for partially lysing a cell membrane of a red blood cell infected with a malaria parasite, comprising: a first surfactant which has predetermined lysing ability for the red blood cell membrane; and a second surfactant which has weaker lysing ability than that of the first surfactant; wherein the reagent has pH of 5 to 7 and osmotic pressure of 200 to 300 mOsm/kg·H2O; and wherein the reagent partially lyses the malaria infected red blood cell membrane such that a malaria parasite is retained in the red blood cell and fluorescent dye passes through the cell membrane, is disclosed. A reagent for detecting malaria infected red blood cells, and a sample analyzing method for detecting malaria infected red blood cells, are also disclosed.
摘要翻译：一种用于部分溶解感染疟原虫的红细胞的细胞膜的试剂，其包含：对红细胞膜具有预定的裂解能力的第一表面活性剂; 和具有比第一表面活性剂弱的裂解能力的第二表面活性剂; 其中所述试剂的pH为5至7，渗透压为200至300mOsm / kg.H 2 O; 并且其中所述试剂部分地裂解疟疾感染的红细胞膜，使得疟原虫被保留在红细胞中，荧光染料通过细胞膜。还公开了用于检测疟疾感染的红细胞的试剂和用于检测疟疾感染的红细胞的样品分析方法。

4. 发明授权

US08808624B2 Blood analyzer, blood analysis method and hemolytic agent 有权
标题翻译：血液分析仪，血液分析法和溶血剂
公开(公告)号：US08808624B2
公开(公告)日：2014-08-19
申请号：US12942561
申请日：2010-11-09
申请人： Hideaki Matsumoto , Kinya Uchihashi , Yuji Itose , Aya Konishi
发明人： Hideaki Matsumoto , Kinya Uchihashi , Yuji Itose , Aya Konishi
IPC分类号： G01N33/00
CPC分类号： G01N33/4915 , G01N21/05 , G01N21/47 , G01N21/51 , G01N21/6428 , G01N21/6486 , G01N33/49 , G01N2021/4726 , G01N2021/6439 , G01N2021/6482 , G01N2021/6493 , Y10T436/10 , Y10T436/101666 , Y10T436/11 , Y10T436/117497
摘要： This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement sample and a control portion performing a first classification of white blood cells in the measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of the fluorescent information and the two types of scattered light information.
摘要翻译：该血液分析装置包括准备没有来自血液试样的标记物质的测定试样和不含标记物质的溶血剂的样品制备部，产生荧光信息的光信息生成部和来自所述荧光信息的至少2种散射光信息测量样品和控制部分，其基于荧光信息和两种类型的散射光信息，将测量样品中的白血球的第一分类进行至少四组单核细胞，嗜中性粒细胞，嗜酸性粒细胞等。

5. 发明申请

US20110053212A1 BLOOD ANALYZER, BLOOD ANALYSIS METHOD, HEMOLYTIC AGENT AND STAINING AGENT 有权
标题翻译：血液分析仪，血液分析方法，HEMOLYTIC AGENT AND STAINING AGENT
公开(公告)号：US20110053212A1
公开(公告)日：2011-03-03
申请号：US12942752
申请日：2010-11-09
申请人： Hideaki Matsumoto , Kinya Uchihashi , Yuji Itose , Aya Konishi , Ayumu Yoshida
发明人： Hideaki Matsumoto , Kinya Uchihashi , Yuji Itose , Aya Konishi , Ayumu Yoshida
IPC分类号： C12Q1/04 , C12M1/34
CPC分类号： C12Q1/68 , G01N33/5094 , G01N33/56905 , G01N2333/44 , Y02A50/58
摘要： This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion.
摘要翻译：该血液分析装置具备准备含有血液试样和溶血剂的第一测定试样和含有血液试样的第二测定试样，与溶血剂相同的溶血剂和染色剂的试样调制部以及白血病分级对照部基于荧光信息和由光信息生成部生成的两种类型的散射光信息将第一测量样品中的细胞分成至少四组单核细胞，嗜中性粒细胞，嗜酸性粒细胞等，并将第二测量样品中的血细胞分类为基于由光信息生成部生成的荧光信息和散射光信息，最少疟疾感染的红细胞等。

6. 发明授权

US07354775B2 Reagent for partially lysing a cell membrane of a red blood cell, a reagent for detecting malaria infected red blood cells, and a sample analyzing method for detecting malaria infected red blood cells 有权
标题翻译：用于部分裂解红细胞的细胞膜的试剂，用于检测疟疾感染的红细胞的试剂和用于检测疟疾感染的红细胞的样品分析方法
公开(公告)号：US07354775B2
公开(公告)日：2008-04-08
申请号：US11390298
申请日：2006-03-28
申请人： Ayumu Yoshida , Kinya Uchihashi , Yuji Itose , Aya Konishi , Hiromitsu Iizuka
发明人： Ayumu Yoshida , Kinya Uchihashi , Yuji Itose , Aya Konishi , Hiromitsu Iizuka
IPC分类号： G01N33/555
CPC分类号： G01N33/80 , G01N33/56905 , Y02A50/58
摘要： A reagent for partially lysing a cell membrane of a red blood cell infected with a malaria parasite, comprising: a first surfactant which has predetermined lysing ability for the red blood cell membrane; and a second surfactant which has weaker lysing ability than that of the first surfactant; wherein the reagent has pH of 5 to 7 and osmotic pressure of 200 to 300 mOsm/kg·H2O; and wherein the reagent partially lyses the malaria infected red blood cell membrane such that a malaria parasite is retained in the red blood cell and fluorescent dye passes through the cell membrane, is disclosed. A reagent for detecting malaria infected red blood cells, and a sample analyzing method for detecting malaria infected red blood cells, are also disclosed.
摘要翻译：一种用于部分溶解感染疟原虫的红细胞的细胞膜的试剂，其包含：对红细胞膜具有预定的裂解能力的第一表面活性剂; 和具有比第一表面活性剂弱的裂解能力的第二表面活性剂; 其中所述试剂的pH为5至7，渗透压为200至300mOsm / kg.H 2 O; 并且其中所述试剂部分地裂解疟疾感染的红细胞膜，使得疟原虫被保留在红细胞中，荧光染料通过细胞膜。还公开了用于检测疟疾感染的红细胞的试剂和用于检测疟疾感染的红细胞的样品分析方法。

7. 发明申请

US20070020721A1 Blood analyzing method and blood analyzer 审中-公开
标题翻译：血液分析方法和血液分析仪
公开(公告)号：US20070020721A1
公开(公告)日：2007-01-25
申请号：US11491352
申请日：2006-07-21
申请人： Ayumu Yoshida , Yuji Itose , Kinya Uchihashi
发明人： Ayumu Yoshida , Yuji Itose , Kinya Uchihashi
IPC分类号： C12Q1/04
CPC分类号： G01N15/1459 , G01N2015/008 , G01N2015/0088 , G01N2015/1486
摘要： A blood analyzing method is described that includes steps of: preparing a measurement sample by hemolyzing red blood cells in a blood specimen, the measurement sample containing particles; irradiating a light on the measurement sample to detect two or more types of optical information reflecting characters of the particles in the measurement sample, thereby acquiring data indicating light intensities of the respective optical information as a particle data associated with each of the particles; counting white blood cells based on the particle data; outputting the result of counting white blood cells; determining whether malarial parasites are present or not based on the particle data; and outputting the result of determining. A blood analyzer also described.
摘要翻译：描述了一种血液分析方法，其包括以下步骤：通过溶血血样中的红细胞来制备测量样品，所述测量样品含有颗粒; 在测量样品上照射光以检测反映测量样本中的颗粒的字符的两种或更多种类型的光学信息，从而获取指示各个光学信息的光强度的数据，作为与每个颗粒相关联的粒子数据; 基于粒子数据计数白细胞; 输出白细胞计数结果; 基于粒子数据确定疟疾寄生虫是否存在; 并输出确定结果。血液分析仪也有描述。

8. 发明授权

US08920726B2 Blood analyzer, blood analysis method, hemolytic agent and staining agent 有权
标题翻译：血液分析仪，血液分析法，溶血剂和染色剂
公开(公告)号：US08920726B2
公开(公告)日：2014-12-30
申请号：US12942752
申请日：2010-11-09
申请人： Hideaki Matsumoto , Kinya Uchihashi , Yuji Itose , Aya Konishi , Ayumu Yoshida
发明人： Hideaki Matsumoto , Kinya Uchihashi , Yuji Itose , Aya Konishi , Ayumu Yoshida
IPC分类号： G01N33/00 , G01N1/00 , G01N33/569 , G01N33/50 , B01L3/00
CPC分类号： C12Q1/68 , G01N33/5094 , G01N33/56905 , G01N2333/44 , Y02A50/58
摘要： This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion.
摘要翻译：该血液分析装置具备准备含有血液试样和溶血剂的第一测定试样和含有血液试样的第二测定试样，与溶血剂相同的溶血剂和染色剂的试样调制部以及白血病分级对照部基于荧光信息和由光信息生成部生成的两种类型的散射光信息将第一测量样品中的细胞分成至少四组单核细胞，嗜中性粒细胞，嗜酸性粒细胞等，并将第二测量样品中的血细胞分类为基于由光信息生成部生成的荧光信息和散射光信息，最少疟疾感染的红细胞等。

9. 发明申请

US20110053210A1 BLOOD ANALYZER, BLOOD ANALYSIS METHOD AND HEMOLYTIC AGENT 有权
标题翻译：血液分析仪，血液分析方法和HEMOLYTIC AGENT
公开(公告)号：US20110053210A1
公开(公告)日：2011-03-03
申请号：US12942561
申请日：2010-11-09
申请人： Hideaki MATSUMOTO , Kinya Uchihashi , Yuji Itose , Aya Konishi
发明人： Hideaki MATSUMOTO , Kinya Uchihashi , Yuji Itose , Aya Konishi
IPC分类号： C12Q1/24 , C12M1/34
CPC分类号： G01N33/4915 , G01N21/05 , G01N21/47 , G01N21/51 , G01N21/6428 , G01N21/6486 , G01N33/49 , G01N2021/4726 , G01N2021/6439 , G01N2021/6482 , G01N2021/6493 , Y10T436/10 , Y10T436/101666 , Y10T436/11 , Y10T436/117497
摘要： This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement sample and a control portion performing a first classification of white blood cells in the measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of the fluorescent information and the two types of scattered light information.
摘要翻译：该血液分析装置包括准备没有来自血液试样的标记物质的测定试样和不含标记物质的溶血剂的样品制备部，产生荧光信息的光信息生成部和来自所述荧光信息的至少2种散射光信息测量样品和控制部分，其基于荧光信息和两种类型的散射光信息，将测量样品中的白血球的第一分类进行至少四组单核细胞，嗜中性粒细胞，嗜酸性粒细胞等。

10. 发明申请

US20100330565A1 REAGENT KIT FOR SAMPLE ANALYSIS AND SAMPLE ANALYSIS METHOD 有权
标题翻译：用于样品分析和样品分析方法的试剂盒
公开(公告)号：US20100330565A1
公开(公告)日：2010-12-30
申请号：US12677250
申请日：2008-09-26
申请人： Tatsuya Narikawa , Tomohiro Tsuji , Keiko Moriyama , Yuji Itose , Shinichiro Oguni , Ayumu Yoshida , Saori Suzuki , Toshihiro Mizukami
发明人： Tatsuya Narikawa , Tomohiro Tsuji , Keiko Moriyama , Yuji Itose , Shinichiro Oguni , Ayumu Yoshida , Saori Suzuki , Toshihiro Mizukami
IPC分类号： C12Q1/68
CPC分类号： G01N33/582 , G01N15/1459 , G01N21/6428 , G01N2015/1006 , G01N2015/1402
摘要： The present invention provides a reagent kit for analyzing a sample comprising a first reagent containing a cationic surfactant, a nonionic surfactant and an aromatic carboxylic acid and a second reagent containing a fluorescent dye capable of staining nucleic acid, and a method for analyzing a sample using the kit.
摘要翻译：本发明提供了一种用于分析样品的试剂盒，其包含含有阳离子表面活性剂，非离子表面活性剂和芳香族羧酸的第一试剂和含有能够染色核酸的荧光染料的第二试剂，以及使用该套件。

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