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1. 发明申请

US20180120338A1 LIQUID-SEALED CARTRIDGE, SPECIMEN ANALYZER, AND SPECIMEN ANALYSIS METHOD 审中-公开
公开(公告)号：US20180120338A1
公开(公告)日：2018-05-03
申请号：US15796224
申请日：2017-10-27
申请人： SYSMEX CORPORATION , ASTI CORPORATION
发明人： Kazuyoshi HORII , Takao FUJIWARA , Noriyuki OGAI , Kenpei ONOZUKA , Yasuhiro TODA
IPC分类号： G01N35/02 , G01N35/08 , B65D83/00
CPC分类号： G01N35/02 , B01L3/502738 , B01L2200/16 , B01L2300/049 , B01L2300/087 , B01L2300/123 , B65D83/00 , G01N35/08 , G01N37/00
摘要： This liquid-sealed cartridge includes: a cartridge body including a plurality of liquid storage portions; a seal body configured to seal an opening of each of the plurality of liquid storage portions; and an elastic body disposed so as to be opposed to the plurality of liquid storage portions, the elastic body being configured to form a passage adjacent to the plurality of liquid storage portions. Each of the plurality of liquid storage portions and the passage are configured to be communicated with each other by the corresponding seal body being pushed to be opened through the elastic body.

2. 发明申请

US20180117583A1 LIQUID-SEALED CARTRIDGE AND LIQUID TRANSFERRING METHOD 审中-公开
公开(公告)号：US20180117583A1
公开(公告)日：2018-05-03
申请号：US15796168
申请日：2017-10-27
申请人： SYSMEX CORPORATION , ASTI CORPORATION
发明人： Kazuyoshi HORII , Takao FUJIWARA , Tomoyuki NOSE , Yasunori MAEKAWA , Noriyuki OGAI , Yasuhiro TODA
IPC分类号： B01L3/00 , G01N33/53 , G01N33/536 , G01N33/576 , G01N35/10
CPC分类号： B01L3/508 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L9/527 , B01L2200/06 , B01L2200/0621 , B01L2200/0684 , B01L2300/047 , B01L2300/0627 , B01L2300/0803 , B01L2300/123 , B01L2300/1805 , B01L2400/0409 , B01L2400/0475 , B01L2400/0638 , F16K1/18 , F16K99/0015 , F16K2099/0084 , G01N21/07 , G01N33/5304 , G01N33/536 , G01N33/5764 , G01N35/10
摘要： Disclosed is a liquid-sealed cartridge in which a liquid is transferred by a centrifugal force generated when the liquid-sealed cartridge is rotated around a rotation shaft, including: a liquid storage portion configured to store the liquid therein; a seal having an outer peripheral portion connected to the liquid storage portion, the seal being configured to seal the liquid storage portion; a flow path connected to the liquid storage portion via the seal, through which the liquid in the liquid storage portion is transferred by the centrifugal force in a direction away from the rotation shaft, wherein, when the seal receives a pressing force, the seal is inclined in a pressing direction, with one portion of the outer peripheral portion thereof remaining connected with the liquid storage portion, and the other portion of the outer peripheral portion being separated from the liquid storage portion.

3. 发明申请

US20200011861A1 METHOD OF DETECTING TEST SUBSTANCE, SAMPLE ANALYSIS CARTRIDGE, AND SAMPLE ANALYZER 审中-公开
公开(公告)号：US20200011861A1
公开(公告)日：2020-01-09
申请号：US16575449
申请日：2019-09-19
申请人： SYSMEX CORPORATION
发明人： Kazuyoshi HORII , Tomoyuki NOSE , Takao FUJIWARA , Tatsuya KOSAKO
IPC分类号： G01N33/543 , B01L3/00 , B01F5/06 , B01F11/00 , B01F13/08
摘要： In a method of detecting a test substance, a test substance is detected using a sample analysis cartridge supplied with a sample. The sample analysis cartridge includes: a passage part having a gas-phase space; and liquid containers communicating with the passage part through openings. The liquid containers include: a first liquid container containing a first liquid containing magnetic particles; and a second liquid container containing a second liquid containing a labeled substance. The magnetic particles are sequentially transported to the liquid containers through the gas-phase space in the passage part. Thus, the magnetic particles carry a complex of the test substance and the labeled substance. The test substance is detected based on the labeled substance in the complex.

4. 发明申请

US20210318297A1 METHOD OF DETECTING TEST SUBSTANCE, SAMPLE ANALYSIS CARTRIDGE, AND SAMPLE ANALYZER 有权
公开(公告)号：US20210318297A1
公开(公告)日：2021-10-14
申请号：US17356597
申请日：2021-06-24
申请人： SYSMEX CORPORATION
发明人： Kazuyoshi HORII , Tomoyuki NOSE , Takao FUJIWARA , Tatsuya KOSAKO
IPC分类号： G01N33/543 , B01L3/00 , B01F5/06 , B01F11/00 , B01F13/08
摘要： In a method of detecting a test substance, a test substance is detected using a sample analysis cartridge supplied with a sample. The sample analysis cartridge includes: a passage part having a gas-phase space; and liquid containers communicating with the passage part through openings. The liquid containers include: a first liquid container containing a first liquid containing magnetic particles; and a second liquid container containing a second liquid containing a labeled substance. The magnetic particles are sequentially transported to the liquid containers through the gas-phase space in the passage part. Thus, the magnetic particles carry a complex of the test substance and the labeled substance. The test substance is detected based on the labeled substance in the complex.

5. 发明申请

US20180003732A1 MEASUREMENT APPARATUS AND MEASUREMENT METHOD 审中-公开
公开(公告)号：US20180003732A1
公开(公告)日：2018-01-04
申请号：US15637992
申请日：2017-06-29
申请人： Sysmex Corporation
发明人： Takao FUJIWARA , Kazuyoshi HORII , Tatsuya KOSAKO , Tomoyuki NOSE , Sayuri TOMODA
IPC分类号： G01N35/10 , G01N21/53 , G01N21/03 , G01N35/00 , G01N21/64 , B01L3/00
CPC分类号： G01N35/1081 , B01L3/5027 , B01L2300/0654 , G01N21/0303 , G01N21/07 , G01N21/532 , G01N21/6456 , G01N35/00069
摘要： Disclosed is a measurement apparatus including: a support mechanism configured to support a cartridge in which a chamber is formed, the chamber being configured to store a measurement sample that generates light an intensity of which varies depending on an amount of a test substance; a photodetector configured to detect the light generated from the measurement sample stored in the chamber; and a reflection member provided between the photodetector and the cartridge supported by the support mechanism, the reflection member having an inner face, the reflection member being configured to reflect, at the inner face, the light generated from the measurement sample stored in the chamber, and guide the light to the photodetector, wherein the reflection member is configured to have an area surrounded by the inner face, the area decreasing from a side where the cartridge supported by the support mechanism is provided toward a side where the photodetector is provided.

6. 发明申请

US20160025611A1 FLOW CYTOMETER, PARTICLE ANALYZER, AND FLOW CYTOMETRIC METHOD 有权
标题翻译：流式细胞仪，颗粒分析仪和流式细胞仪方法
公开(公告)号：US20160025611A1
公开(公告)日：2016-01-28
申请号：US14805009
申请日：2015-07-21
申请人： Sysmex Corporation
发明人： Takao FUJIWARA , Seiichiro TABATA , Fumiya FUTAMATSU
IPC分类号： G01N15/14 , G01J1/04
CPC分类号： G01N15/1434 , G01J1/0422 , G01N15/1459 , G02B3/04 , G02B3/06 , G02B19/0014 , G02B27/0966
摘要： A flow cytometer comprises a flow cell configured to induce a flow of a sample containing object particles, a light source, an irradiating optical system configured to irradiate light from the light source on the flow of particles in the flow cell, a detecting part configured to detect light given off from the flow of particles which are irradiated by light. The irradiating optical system comprises a collective lens having an optical axis symmetric aspherical surface on one surface, and a cylindrical surface on the other surface.
摘要翻译：流式细胞仪包括流动池，其构造成诱导含有物体颗粒的样品的流动，光源，被配置为将来自光源的光照射在流动池中的颗粒流上的照射光学系统，检测部件，被配置为检测从光照射的颗粒流中发出的光。照射光学系统包括在一个表面上具有光轴对称非球面的集体透镜和在另一个表面上的圆柱形表面。

7. 发明申请

US20180126377A1 LIQUID SEALED CARTRIDGE, METHOD FOR PRODUCING LIQUID SEALED CARTRIDGE, AND LIQUID SENDING METHOD 审中-公开
公开(公告)号：US20180126377A1
公开(公告)日：2018-05-10
申请号：US15801580
申请日：2017-11-02
申请人： SYSMEX CORPORATION
发明人： Kazuyoshi HORII , Takao FUJIWARA , Tomoyuki NOSE
IPC分类号： B01L3/00 , G01N33/49
CPC分类号： B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2200/16 , B01L2300/0803 , B01L2300/0887 , B01L2400/0409 , B01L2400/0475 , B01L2400/0683 , B01L2400/0688 , B65B3/12 , G01N21/76 , G01N33/491 , G01N35/00069 , G01N35/0098 , G01N2035/00089 , G01N2035/00495
摘要： Disclosed is a liquid sealed cartridge in which a liquid injected through an inlet is previously sealed, and the liquid is transferred by a centrifugal force being applied by rotation, and the liquid sealed cartridge includes: a liquid storage portion configured to store the liquid; a bypass flow path having one end and the other end connected to the liquid storage portion, the bypass flow path having the inlet; and a transfer flow path into which the liquid is transferred from the liquid storage portion when the centrifugal force is applied.

8. 发明申请

US20180003704A1 DETECTION APPARATUS AND DETECTION METHOD 审中-公开
公开(公告)号：US20180003704A1
公开(公告)日：2018-01-04
申请号：US15637957
申请日：2017-06-29
申请人： Sysmex Corporation
发明人： Kazuyoshi HORII , Tomoyuki NOSE , Takao FUJIWARA , Sayuri TOMODA , Yusuke MIIDA , Yasunori MAEKAWA , Noriaki SASAKI
IPC分类号： G01N33/543 , G01N35/00 , G01N21/76 , B01L3/00 , G01N21/69 , B03C1/28 , G01N35/10 , G01N33/58
CPC分类号： G01N33/54326 , B01L3/502761 , B01L2200/0668 , B01L2300/0803 , B01L2300/0858 , B01L2300/0864 , B01L2300/087 , B01L2400/0409 , B01L2400/043 , B03C1/284 , G01N21/69 , G01N21/76 , G01N33/582 , G01N35/00069 , G01N35/0098 , G01N35/10 , G01N2035/00495 , G01N2035/00574
摘要： Disclosed is a detection apparatus that transfers magnetic particles through a plurality of chambers in a cartridge which includes the plurality of chambers and a channel connecting between the plurality of chambers, and that causes the magnetic particles to carry a complex of a test substance and a labelling substance, to detect the test substance on the basis of the labelling substance in the complex. The detection apparatus includes: a rotation mechanism configured to rotate the cartridge about a rotation shaft; a magnet configured to collect the magnetic particles in the chambers; a movement mechanism configured to move the magnet in a direction different from a circumferential direction of a circle in which the rotation shaft is centered; a detector configured to detect the test substance; and a controller programmed to control the rotation mechanism and the movement mechanism so as to transfer the magnetic particles from one of the chambers to another one of the chambers.

9. 发明申请

US20160320375A1 METHOD OF DETECTING TEST SUBSTANCE, SAMPLE ANALYSIS CARTRIDGE, AND SAMPLE ANALYZER 审中-公开
标题翻译：检测测试物质的方法，样品分析盒和样品分析仪
公开(公告)号：US20160320375A1
公开(公告)日：2016-11-03
申请号：US15081070
申请日：2016-03-25
申请人： SYSMEX CORPORATION
发明人： Kazuyoshi HORII , Tomoyuki NOSE , Takao FUJIWARA , Tatsuya KOSAKO
IPC分类号： G01N33/543 , B01L3/00
摘要： In a method of detecting a test substance, a test substance is detected using a sample analysis cartridge supplied with a sample. The sample analysis cartridge includes: a passage part having a gas-phase space; and liquid containers communicating with the passage part through openings. The liquid containers include: a first liquid container containing a first liquid containing magnetic particles; and a second liquid container containing a second liquid containing a labeled substance 42. The magnetic particles are sequentially transported to the liquid containers through the gas-phase space in the passage part. Thus, the magnetic particles carry a complex of the test substance and the labeled substance. The test substance is detected based on the labeled substance in the complex.
摘要翻译：在检测被检物质的方法中，使用供给有试样的样品分析盒来检测被检物质。样品分析盒包括：具有气相空间的通道部分; 以及通过开口与通道部分连通的液体容器。液体容器包括：含有含有磁性颗粒的第一液体的第一液体容器; 和含有含有标记物质42的第二液体的第二液体容器。磁性颗粒通过通道部分中的气相空间依次传送到液体容器。因此，磁性颗粒携带被检物质和标记物质的复合物。基于复合物中的标记物质检测测试物质。

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