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1. 发明授权

US09115160B2 Solvent-free process for the preparation of cyclophosphamide 有权
标题翻译：无溶剂方法制备环磷酰胺
公开(公告)号：US09115160B2
公开(公告)日：2015-08-25
申请号：US14013211
申请日：2013-08-29
申请人： Sunny Pharmtech Inc.
发明人： Jien-Heh Tien , Pi-Shan Chiang
IPC分类号： C07F9/6584
CPC分类号： C07F9/65846
摘要： This invention discloses a solvent-free process for the preparation of cyclophosphamide. According to this invention, there is no solvent used during the reaction step for preparing cyclophosphamide, so that the total volume of the reaction for preparing cyclophosphamide can be reduced and the manufacture of cyclophosphamide can become more efficient. Furthermore, the above solvent-free process for the preparation of cyclophosphamide is more simply operated, more economic, and more environmental friendly than the preparation of cyclophosphamide in the prior art.
摘要翻译：本发明公开了一种无溶剂的制备环磷酰胺的方法。根据本发明，在用于制备环磷酰胺的反应步骤期间没有使用溶剂，从而可以减少制备环磷酰胺的反应的总体积，并且环磷酰胺的制备可以变得更有效。此外，用于制备环磷酰胺的上述无溶剂方法比现有技术中环磷酰胺的制备更简单地操作，更经济，更环保。

2. 发明授权

US10144692B2 Method of making vitamin K1 有权
公开(公告)号：US10144692B2
公开(公告)日：2018-12-04
申请号：US15312328
申请日：2014-10-16
申请人： Sunny Pharmtech Inc.
发明人： Jien-Heh Tien , Chu-Yi Pang , Nai-Hsuan Hsu
IPC分类号： C07C46/06 , C07C46/00
摘要： This invention discloses a method of making vitamin K1. The mentioned method of making vitamin K1 comprises performing a first one-pot synthesis with base catalyst, performing a first hydrolysis, performing a substitution, and performing a second one-pot synthesis without metal oxidant. The starting material of this invention is stable 2-methyl-1,4-naphthoquinone. Preferably, this invention provides a method of making vitamin K1 efficiently on simplifying the operation and decreasing the side-product. More preferably, without metal residue, the vitamin K1 of this invention is without metal residue and more safety for clinical application.

3. 发明授权

US08809581B2 Method of making 6-aminocaproic acid as active pharmaceutical ingredient 有权
标题翻译：制备6-氨基己酸作为活性药物成分的方法
公开(公告)号：US08809581B2
公开(公告)日：2014-08-19
申请号：US13660126
申请日：2012-10-25
申请人： Sunny pharmtech Inc.
发明人： Jien-Heh Tien , Chu-yi Pang
IPC分类号： C07C205/00
CPC分类号： C07C227/22 , C07C227/38
摘要： The present invention provides a method for making 6-aminocaproic acid as an active pharmaceutical ingredient. The method comprises: performing a hydrolysis procedure to have ε-caprolactam react with acid or base to generate a first reaction mixture, performing a modification procedure to have a solubility regulating agent reacts with 6-aminocaproic acid in the first reaction mixture to form a second reaction mixture including an aminocaproic acid intermediate, performing a separation procedure to have the intermediate separated from the second reaction mixture and performing a hydrogenation procedure to have the aminocaproic acid intermediate hydrogenated to form a 6-aminocaproic acid product.
摘要翻译：本发明提供了制备6-氨基己酸作为活性药物成分的方法。该方法包括：进行水解步骤以使ε-己内酰胺与酸或碱反应以产生第一反应混合物，进行改性步骤以使溶解调节剂与第一反应混合物中的6-氨基己酸反应形成第二反应混合物，包括氨基己酸中间体，进行分离步骤以使中间体与第二反应混合物分离，并进行氢化方法使氨基己酸中间体氢化形成6-氨基己酸产物。

4. 发明申请

US20170260117A1 Method of Making Vitamin K1 审中-公开
公开(公告)号：US20170260117A1
公开(公告)日：2017-09-14
申请号：US15312328
申请日：2014-10-16
申请人： SUNNY PHARMTECH INC.
发明人： Jien-Heh Tien , Chu-Yi Pang , Nai-Hsuan Hsu
IPC分类号： C07C46/06
CPC分类号： C07C46/06 , C07C46/00 , C07C50/14
摘要： This invention discloses a method of making vitamin K1. The mentioned method of making vitamin K1 comprises performing a first one-pot synthesis with base catalyst, performing a first hydrolysis, performing a substitution, and performing a second one-pot synthesis without metal oxidant. The starting material of this invention is stable 2-methyl-1,4-naphthoquinone. Preferably, this invention provides a method of making vitamin K1 efficiently on simplifying the operation and decreasing the side-product. More preferably, without metal residue, the vitamin K1 of this invention is without metal residue and more safety for clinical application.

5. 发明申请

US20140066654A1 Solvent-Free Process for the Preparation of Cyclophosphamide 有权
标题翻译：无溶剂制备环磷酰胺的方法
公开(公告)号：US20140066654A1
公开(公告)日：2014-03-06
申请号：US14013211
申请日：2013-08-29
申请人： Sunny Pharmtech Inc.
发明人： Jien-Heh Tien , Pi-Shan Chiang
IPC分类号： C07F9/6584
CPC分类号： C07F9/65846
摘要： This invention discloses a solvent-free process for the preparation of cyclophosphamide. According to this invention, there is no solvent used during the reaction step for preparing cyclophosphamide, so that the total volume of the reaction for preparing cyclophosphamide can be reduced and the manufacture of cyclophosphamide can become more efficient. Furthermore, the above solvent-free process for the preparation of cyclophosphamide is more simply operated, more economic, and more environmental friendly than the preparation of cyclophosphamide in the prior art.
摘要翻译：本发明公开了一种无溶剂的制备环磷酰胺的方法。根据本发明，在用于制备环磷酰胺的反应步骤期间没有使用溶剂，从而可以减少制备环磷酰胺的反应的总体积，并且环磷酰胺的制备可以变得更有效。此外，用于制备环磷酰胺的上述无溶剂方法比现有技术中环磷酰胺的制备更简单地操作，更经济，更环保。

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