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1. 发明授权

US11896965B2 Chromium complex and catalyst therefrom 有权
公开(公告)号：US11896965B2
公开(公告)日：2024-02-13
申请号：US17966176
申请日：2022-10-14
申请人： Dow Global Technologies LLC
发明人： Jerzy Klosin , Kara A. Milbrandt , Scott D. Boelter , David R. Wilson , Mari S. Rosen , Dean M. Welsh , Peter M. Margl , Kyoung Moo Koh , David M. Pearson , Rafael Huacuja
IPC分类号： B01J31/24 , B01J31/14 , B01J31/18 , C07C2/36 , C07F9/6568 , C07F9/6584 , C07F11/00 , C07F17/02 , C07F9/6571 , B01J31/22
CPC分类号： B01J31/2433 , B01J31/143 , B01J31/188 , B01J31/2208 , B01J31/2438 , B01J31/2457 , B01J31/2476 , B01J31/2495 , C07C2/36 , C07F9/6568 , C07F9/6571 , C07F9/65683 , C07F9/65685 , C07F9/65842 , C07F9/65844 , C07F9/65846 , C07F9/65848 , C07F9/657154 , C07F11/005 , C07F17/02 , B01J2231/20 , B01J2531/62 , B01J2540/10 , B01J2540/22 , B01J2540/225 , B01J2540/30 , B01J2540/34 , B01J2540/444 , C07C2531/14 , C07C2531/18 , C07C2531/24 , C07C2/36 , C07C11/02 , C07C2/36 , C07C11/107
摘要： The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

2. 发明申请

US20180291048A1 PHOSPHACYCLE COMPOUND AND PROCESS FOR PRODUCTION THEREOF 审中-公开
公开(公告)号：US20180291048A1
公开(公告)日：2018-10-11
申请号：US15557875
申请日：2016-03-10
申请人： Dow Global Technologies LLC
发明人： Jerzy Klosin , Kara A. Milbrandt , Scott D. Boelter , David R. Wilson , Mari S. Rosen , Dean M. Welsh , Peter M. Margl , Kyoung Moo Koh , David M. Pearson , Rafael Huacuja
IPC分类号： C07F9/6568
CPC分类号： B01J31/2433 , B01J31/143 , B01J31/188 , B01J31/2208 , B01J31/2438 , B01J31/2457 , B01J31/2476 , B01J31/2495 , B01J2231/20 , B01J2531/62 , B01J2540/10 , B01J2540/22 , B01J2540/225 , B01J2540/30 , B01J2540/34 , B01J2540/444 , C07C2/36 , C07C2531/14 , C07C2531/18 , C07C2531/24 , C07F9/6568 , C07F9/65683 , C07F9/65685 , C07F9/6571 , C07F9/657154 , C07F9/65842 , C07F9/65844 , C07F9/65846 , C07F9/65848 , C07F11/005 , C07F17/02 , C07C11/02 , C07C11/107
摘要： The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

3. 发明授权

US10016447B2 Pharmaceutical composition having improved content uniformity 有权
公开(公告)号：US10016447B2
公开(公告)日：2018-07-10
申请号：US15512946
申请日：2015-09-25
申请人： Intas Pharmaceuticals Ltd
发明人： Priyank Patel , Mayur Patel , Mahendra Patel , Balvir Singh , Ashish Sehgal
IPC分类号： A61K31/70 , A61K31/675 , A61K31/685 , A61K31/7068 , A61K9/20 , A61K9/24 , C07F9/6584
CPC分类号： A61K31/675 , A61K9/2054 , A61K9/209 , A61K31/7068 , C07F9/65846 , A61K2300/00
摘要： This present invention relates to pharmaceutical compositions comprising cyclophosphamide alone and/or in combination with one or more pharmaceutical active ingredients and one or more pharmaceutically acceptable excipients wherein the cyclophosphamide has D90 particle size less than 100 microns.

4. 发明申请

US20180086780A1 METHOD OF PRODUCTION OF N,N-BIS(2-CHLOROETHYL)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE-2-AMINE 2-OXIDE 审中-公开
公开(公告)号：US20180086780A1
公开(公告)日：2018-03-29
申请号：US15562655
申请日：2015-04-02
申请人： PRZEDSIEBIORSTWO PRODUKCY JNO-WDROZENIOWE IFOTAM Sp. z o.o.
发明人： Bogdan UZNANSKI , Tomasz DYMITRUK
IPC分类号： C07F9/6584 , C07B47/00 , B01D9/00
CPC分类号： C07F9/65846 , B01D9/0018 , C07B47/00
摘要： The invention relates to a method of production of N,N-bis(2-chloroethyl)amino)-2-oxo-1,3,2-oxazaphosphorinane in a reaction of phosphorous oxychloride POCl3, N,N-bis(2-chloroethyl)amine, and 3-aminopropan-1-ol in a single reaction vessel, characterized by the fact that phosphorous oxychloride and N,N-bis(2-chloroethyl)amine hydrochloride are added to an inert aprotic organic solvent placed in a closed reaction vessel, in a slight molar excess in relation to phosphorous oxychloride, whereupon the mixture is cooled to temperature in the range of −15 to −10° C., and with the temperature maintained within this range and continuous stirring, the solution of 3-aminopropan-1-ol and the first portion of the auxiliary base is slowly added in an amount of 1 mole calculated as per 1 mole of 3-aminopropan-1-ol in an inert aprotic organic solvent, and subsequently, while maintaining the reaction mixture temperature in the range of −7 to −3° C. the second portion of the auxiliary base is added dropwise, in an amount required for binding of HCl released during the cyclisation reaction, and after the mixture reaches temperature in the range of 15 to 20° C. it is stirred in this temperature for a period of 5 to 25 hours, whereupon, while continuously stirring, the remaining portion of the auxiliary base is added dropwise, in an amount of 2-2.3 moles, calculated per a theoretical amount of hydrochloride released from bis(2-chloroethyl)amine hydrochloride and released in the reaction of substitution of chlorine at the phosphorous atom in 2-chloro-tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, and without stopping the stirring, the temperature is gradually increased from 20 to 40° C., the reaction being conducted until the conversion of the substrates is complete.

5. 发明申请

US20180016288A1 COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
公开(公告)号：US20180016288A1
公开(公告)日：2018-01-18
申请号：US15548533
申请日：2017-01-13
申请人： LES LABORATOIRES SERVIER
发明人： Philippe GLOANEC , Arnaud-Pierre SCHAFFNER , Patricia SANSILVESTRI-MOREL , Alain RUPIN , Philippe MENNECIER , Marie-Odile VALLEZ
IPC分类号： C07F9/6568 , A61K45/06 , A61K31/675 , A61K31/66 , C07F9/6584 , A61K9/00
CPC分类号： C07F9/6568 , A61K9/0019 , A61K31/66 , A61K31/675 , A61K45/06 , C07F9/6584 , C07F9/65846
摘要： Compounds of formula (I) wherein: Ak1 represents an alkyl chain, X represents —(CH2)m—, —CH(R)—, —N(R)—, —CH2—N(R)—, —N(R)—CH2— or —CH2—N(R)—CH2—, m and R are as defined in the description, R1 and R2 each represent H when X represents —(CH2)m—, —CH(R)—, —N(R)—, —CH2—N(R)— or —N(R)—CH2—, or together form a bond when X represents —CH2—N(R)—CH2—, R3 represents NH2, Cy-NH2, Cy-Ak3-NH2 or piperidin-4-yl, Cy and Ak3 are as defined in the description, R4 and R5, which may be identical or different, each represent H or F, their optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful in treating conditions requiring a TAFIa inhibitor.

6. 发明申请

US20170018720A1 SPIRO COMPOUND HAVING AZAFLUORENE RING STRUCTURE, LIGHT-EMITTING MATERIAL, AND ORGANIC ELECTROLUMINESCENT DEVICE 审中-公开
标题翻译：具有AZAFUENENE环结构，发光材料和有机电致发光器件的螺旋化合物
公开(公告)号：US20170018720A1
公开(公告)日：2017-01-19
申请号：US15124840
申请日：2015-03-02
申请人： Hodogaya Chemical Co., Ltd. , Kyushu University, National University Corporation
发明人： Chihaya Adachi , Takuma Yasuda , Tetsuya Nakagawa , Katsuyuki Shizu , Hiroshi Ookuma
IPC分类号： H01L51/00 , C07D471/20 , C09K11/02 , C07F9/6584 , C07D471/10 , C09K11/06 , C07F11/00
CPC分类号： H01L51/0072 , C07D403/12 , C07D403/14 , C07D413/14 , C07D471/10 , C07D471/20 , C07D487/04 , C07F9/6584 , C07F9/65846 , C07F11/00 , C09K11/02 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1033 , C09K2211/1037 , C09K2211/104 , C09K2211/1044 , C09K2211/1088 , C09K2211/1092 , C09K2211/188 , H01L51/0052 , H01L51/0058 , H01L51/0059 , H01L51/006 , H01L51/0061 , H01L51/0065 , H01L51/0068 , H01L51/0071 , H01L51/0073 , H01L51/0077 , H01L51/5012 , H01L51/5056 , H01L51/5096
摘要： A compound that emits fluorescence and delayed fluorescence is provided as a material for an organic electroluminescent device of high efficiency, and an organic photoluminescent device and an organic electroluminescent device of high efficiency and high luminance are provided using this compound. The spiro compound of a general formula (1) having an azafluorene ring structure is used as a constituent material of at least one organic layer in an organic electroluminescent device that includes a pair of electrodes, and one or more organic layers sandwiched between the pair of electrodes.
摘要翻译： [问题]提供发出荧光和延迟荧光作为高效有机电致发光元件的材料的化合物; 并且使用该化合物提供有机光致发光元件和高效率和高亮度的有机电致发光元件。 [溶液]具有由通式（1）表示的氮杂芴环结构的螺环化合物; 以及具有一对电极和夹在其间的一个或多个有机层的有机电致发光元件，其特征在于，所述化合物用作至少一个有机层作为构成材料。

7. 发明申请

US20160333038A1 NOVEL DERIVATIVES OF OXAZAPHOSPHORINES THAT ARE PRE-ACTIVATED, USE AND METHOD OF PREPARATION 审中-公开
公开(公告)号：US20160333038A1
公开(公告)日：2016-11-17
申请号：US15222316
申请日：2016-07-28
申请人： INSTITUT GUSTAVE ROUSSY
发明人： ANGELO PACI , THIERRY MARTENS , MICHAEL RIVARD , PATRICK COUVREUR , DIDIER DESMAELE , JOACHIM CARON
IPC分类号： C07F9/6584 , C07K16/30 , A61K47/48
CPC分类号： C07F9/65846 , A61K47/6851 , C07K16/30
摘要： The present invention relates to novel derivatives of oxazaphosphorines that are pre-activated, to the methods for preparing same, to the pharmaceutical compositions containing same and to the therapeutic use thereof, in particular for treating cancer.

8. 发明申请

US20160218301A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT USING SAME 审中-公开
公开(公告)号：US20160218301A1
公开(公告)日：2016-07-28
申请号：US15025046
申请日：2014-09-29
申请人： LG CHEM, LTD.
发明人： Minyoung KANG , Dong Hoon LEE , Boonjae JANG , Jungi JANG , Seong So KIM
IPC分类号： H01L51/00 , C07D487/06 , C07D471/06 , C07F9/6561 , C09K11/02 , C09K11/06
CPC分类号： H01L51/0072 , C07D471/06 , C07D487/06 , C07D498/06 , C07D513/06 , C07F9/6561 , C07F9/65846 , C09K11/025 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1044 , C09K2211/1092 , C09K2211/185 , C09K2211/188 , H01L51/0051 , H01L51/0052 , H01L51/0054 , H01L51/0055 , H01L51/0056 , H01L51/0058 , H01L51/0067 , H01L51/0068 , H01L51/0071 , H01L51/0077 , H01L51/0085 , H01L51/5012 , H01L51/5016 , H01L51/5056 , H01L51/5072 , H01L51/5076 , H01L51/5088 , H01L51/5092 , H01L51/5096 , H01L51/5203 , H05B33/20
摘要： The present specification provides a heterocyclic compound and an organic light emitting device using the same.

9. 发明授权

US09278987B2 Functionally-modified oligonucleotides and subunits thereof 有权
标题翻译：功能修饰的寡核苷酸及其亚基
公开(公告)号：US09278987B2
公开(公告)日：2016-03-08
申请号：US14358992
申请日：2012-11-15
申请人： Sarepta Therapeutics, Inc.
发明人： Gunnar J. Hanson , Dwight D. Weller , Bao Zhong Cai , Ming Zhou
IPC分类号： C07F9/6558 , C07F9/6584 , C07F9/6561 , C07H21/00
CPC分类号： C12N15/113 , C07F9/65583 , C07F9/65586 , C07F9/65616 , C07F9/65846 , C07H21/00 , C12N15/1131 , C12N2310/11 , C12N2310/314 , C12N2310/3233 , C12N2310/346 , C12N2310/351 , C12N2310/3513 , C12N2310/353
摘要： Functionally-modified oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.
摘要翻译：提供包含修饰的亚单位间键和/或修饰的3'和/或5'-端基的功能修饰的寡核苷酸类似物。所公开的化合物可用于治疗其中抑制蛋白质表达或修正异常mRNA剪接产物产生有益治疗效果的疾病。

10. 发明申请

US20150097162A1 MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENTS, ORGANIC ELECTROLUMINESCENT ELEMENT, DISPLAY DEVICE, AND LIGHTING DEVICE 审中-公开
标题翻译：有机电致发光元件，有机电致发光元件，显示器件和照明器件的材料
公开(公告)号：US20150097162A1
公开(公告)日：2015-04-09
申请号：US14386153
申请日：2013-09-11
申请人： JNC Corporation , Kyoto University
发明人： Yohei Ono , Kazushi Shiren , Toshiaki Ikuta , Jingping Ni , Takeshi Matsushita , Takuji Hatakeyama , Masaharu Nakamura , Shiguma Hashimoto
IPC分类号： H01L51/00 , H01L51/50
CPC分类号： H01L51/0071 , C07F5/02 , C07F7/22 , C07F9/65846 , C09K11/06 , C09K2211/1007 , C09K2211/1014 , C09K2211/1029 , C09K2211/104 , H01L51/0052 , H01L51/0054 , H01L51/0059 , H01L51/0067 , H01L51/0072 , H01L51/0077 , H01L51/008 , H01L51/0094 , H01L51/5012 , H01L51/5016 , H01L51/5056 , H01L51/5072 , H01L51/508 , H01L51/5088 , H01L51/5092 , H01L51/5096 , H05B33/14
摘要： Provided is an organic electroluminescent element which has improved driving voltage and improved current efficiency. An organic electroluminescent element having the above-mentioned improved characteristics is provided by using, as a material for organic electroluminescent elements, a polycyclic aromatic compound in which a nitrogen atom and another heteroatom or a metal atom (X) are adjacent to each other in a non-aromatic ring.
摘要翻译：提供了具有改善的驱动电压和改善的电流效率的有机电致发光元件。通过使用其中氮原子和其它杂原子或金属原子（X）彼此相邻的多环芳族化合物作为有机电致发光元件的材料，提供具有上述改进特性的有机电致发光元件非芳香环。

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