专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120232151A1 Process for the Preparation of Gadobenate Dimeglumine Complex in a Solid Form 审中-公开
标题翻译：以固体形式制备钆酸二甲酚复合物的方法
公开(公告)号：US20120232151A1
公开(公告)日：2012-09-13
申请号：US13510409
申请日：2010-11-23
申请人： Pier Lucio Anelli , Pierfrancesco Morisini , Silvia Ceragioli , Fulvio Uggeri , Luciano Lattuada , Roberta Fretta , Aurelia Ferrigato
发明人： Pier Lucio Anelli , Pierfrancesco Morisini , Silvia Ceragioli , Fulvio Uggeri , Luciano Lattuada , Roberta Fretta , Aurelia Ferrigato
IPC分类号： C07C227/00 , A61K31/197 , C07C229/36
CPC分类号： A61K49/1887 , A61K9/0019 , B29C67/24 , C07C213/10 , C07C227/38 , C07C227/40 , Y10T428/2982 , C07C229/22
摘要： The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.
摘要翻译：本发明公开了一种以固体形式制备钆酸二甲酚络合物的方法。特别地，所述固体形式通过在给定温度和浓度下喷雾干燥相应的液体悬浮液而方便地得到。本发明对于工业规模是特别有利的，因为固体形式可以通过使用水作为溶剂，其是无毒溶剂，易于处理并且基本上不需要麻烦的健康或安全预防措施来获得。

2. 发明申请

US20160297746A1 PROCESS FOR SEPARATION OF DIAMINES AND/OR OMEGA-AMINOACIDS FROM A FEED FIXTURE 审中-公开
标题翻译：从进料装置中分离DIAMINES和/或OMEGA-氨基酸的方法
公开(公告)号：US20160297746A1
公开(公告)日：2016-10-13
申请号：US15094770
申请日：2016-04-08
申请人： INVISTA NORTH AMERICA S.a.r.l.
发明人： Gary Smith , Gregory S Kirby , Paul Pearlman
IPC分类号： C07C227/40 , C07C213/10 , C07C209/86
CPC分类号： B01D15/185 , B01D15/1892 , C07C209/82 , C07C209/86 , C07C211/09 , C07C213/10 , C07C227/38 , C07C227/40 , C12P13/001 , C12P13/005 , C07C211/12 , C07C229/08
摘要： The present disclosure relates to methods for separating at least one amine chosen from diamines and omega-aminoacids from a feed mixture using a simulated moving bed (SMB) adsorptive technology.
摘要翻译：本公开涉及使用模拟移动床（SMB）吸附技术从进料混合物中分离选自二胺和ω-氨基酸的至少一种胺的方法。

3. 发明授权

US06759521B2 Polarization switching to control crystal form 有权
标题翻译：极化切换控制晶体形式
公开(公告)号：US06759521B2
公开(公告)日：2004-07-06
申请号：US09965751
申请日：2001-09-28
申请人： Allan S. Myerson , Bruce A. Garetz
发明人： Allan S. Myerson , Bruce A. Garetz
IPC分类号： B01D902
CPC分类号： B01D9/0036 , C07B61/00 , C07C227/38 , C07K1/306 , C07C229/08
摘要： A method to select and prepare polymorphs of materials by switching the polarization state of light employing non-photochemical laser-induced nucleation.
摘要翻译：通过切换使用非光化学激光诱导成核的光的偏振状态来选择和制备材料的多晶型的方法。

4. 发明授权

US4731476A Process for the separation of L-leucine and L-isoleucine 失效
标题翻译：分离L-亮氨酸和L-异亮氨酸的方法
公开(公告)号：US4731476A
公开(公告)日：1988-03-15
申请号：US32370
申请日：1987-03-31
申请人： Kris Bart de Roos
发明人： Kris Bart de Roos
IPC分类号： C12P13/06 , C07C20060101 , C07C67/00 , C07C227/00 , C07C227/28 , C07C227/40 , C07C229/00 , C07C229/04 , C07C99/12
CPC分类号： C07C227/28 , C07C227/38 , C12P13/06
摘要： The invention relates to a process for the separation of L-leucine and L-isoleucine. The process is carried out by subjecting a mixture of leucine ester, and isoleucine ester, (or a mixture of leucine ester, isoleucine ester and valine ester) to an esterase catalyzed hydrolysis resulting in a selective hydrolysis of the leucine ester. The pure L-leucine can be isolated from the reaction mixture by first removing the non-hydrolyzed esters by extraction with an organic solvent and then crystallizing the L-leucine at its isoelectric point. The recovered L-iso-leucine ester is purified by distillation (if necessary), and hydrolyzed to yield pure crystalline L-isoleucine.

5. 发明申请

US20160228583A1 Process for the Preparation of Gadobenate Dimeglumine Complex in a Solid Form 有权
标题翻译：以固体形式制备钆酸二甲酚复合物的方法
公开(公告)号：US20160228583A1
公开(公告)日：2016-08-11
申请号：US15130160
申请日：2016-04-15
申请人： BRACCO IMAGING S.p.A.
发明人： Pier Lucio ANELLI , Pierfrancesco MOROSINI , Silvia CERAGIOLI , Fulvio UGGERI , Luciano LATTUADA , Roberta FRETTA , Aurelia FERRIGATO
IPC分类号： A61K49/18 , C07C213/10 , B29C67/24 , C07C227/40
CPC分类号： A61K49/1887 , A61K9/0019 , B29C67/24 , C07C213/10 , C07C227/38 , C07C227/40 , Y10T428/2982 , C07C229/22
摘要： The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.
摘要翻译：本发明公开了一种以固体形式制备钆酸二甲酚络合物的方法。特别地，所述固体形式通过在给定温度和浓度下喷雾干燥相应的液体悬浮液而方便地得到。本发明对于工业规模是特别有利的，因为固体形式可以通过使用水作为溶剂，其是无毒溶剂，易于处理并且基本上不需要麻烦的健康或安全预防措施来获得。

6. 发明申请

US20140039219A1 Method of Making 6-Aminocaproic Acid As Active Pharmaceutical Ingredient 有权
标题翻译：制备6-氨基己酸作为活性药物成分的方法
公开(公告)号：US20140039219A1
公开(公告)日：2014-02-06
申请号：US13660126
申请日：2012-10-25
申请人： Jien-Heh Tien , Chu-yi Pang
发明人： Jien-Heh Tien , Chu-yi Pang
IPC分类号： C07C227/22
CPC分类号： C07C227/22 , C07C227/38
摘要： The present invention provides a method for making 6-aminocaproic acid as an active pharmaceutical ingredient. The method comprises: performing a hydrolysis procedure to have ε-caprolactam react with acid or base to generate a first reaction mixture, performing a modification procedure to have a solubility regulating agent reacts with 6-aminocaproic acid in the first reaction mixture to form a second reaction mixture including an aminocaproic acid intermediate, performing a separation procedure to have the intermediate separated from the second reaction mixture and performing a hydrogenation procedure to have the aminocaproic acid intermediate hydrogenated to form a 6-aminocaproic acid product.
摘要翻译：本发明提供了制备6-氨基己酸作为活性药物成分的方法。该方法包括：进行水解步骤以使ε-己内酰胺与酸或碱反应以产生第一反应混合物，进行修饰方法以使第一反应混合物中的溶解度调节剂与6-氨基己酸反应形成第二反应混合物反应混合物包括氨基己酸中间体，进行分离步骤以使中间体与第二反应混合物分离，并进行氢化方法使氨基己酸中间体氢化形成6-氨基己酸产物。

7. 发明申请

US20060149099A1 Process for the preparation of amino methyl cyclo alkane acetic acids 有权
公开(公告)号：US20060149099A1
公开(公告)日：2006-07-06
申请号：US10535253
申请日：2006-02-09
申请人： Nagarajan Kuppuswamy , Sivaramakrishman Hariharan , Arulselvan Mariadas
发明人： Nagarajan Kuppuswamy , Sivaramakrishman Hariharan , Arulselvan Mariadas
IPC分类号： C07C227/38
CPC分类号： C07C227/18 , C07C227/38 , C07C2601/14 , C07C229/28
摘要： This invention relates to an improved process for the preparation of amino methyl cyclo alkane acetic acids. This invention particularly relates to an improved process for the preparation of gabapentin (which is chemically known as 1-aminomethyl-1-cyclohexaneacetic acid), which is a very well known agent useful for the treatment of epilepsy and other cerebral disorders. In the chemical series of 1-amino methyl cyclo alkane-1-acetic acids, Gabapentin, which is 1-amino methyl cyclo hexane-1-acetic acid has been developed as a drug having anti convulsive properties.

8. 发明申请

US20020120105A1 Polarization switching to control crystal form 有权
标题翻译：极化切换控制晶体形式
公开(公告)号：US20020120105A1
公开(公告)日：2002-08-29
申请号：US09965751
申请日：2001-09-28
发明人： Allan S. Myerson , Bruce A. Garetz
IPC分类号： C07K014/00
CPC分类号： B01D9/0036 , C07B61/00 , C07C227/38 , C07K1/306 , C07C229/08
摘要： A method to select and prepare polymorphs of materials by switching the polarization state of light employing non-photochemical laser-induced nucleation.
摘要翻译：通过切换使用非光化学激光诱导成核的光的偏振状态来选择和制备材料的多晶型的方法。

9. 发明申请

US20180093200A1 PROCESS FOR SEPARATION OF DIAMINES AND/OR OMEGA-AMINOACIDS FROM A FEED MIXTURE 审中-公开
公开(公告)号：US20180093200A1
公开(公告)日：2018-04-05
申请号：US15564895
申请日：2016-04-08
申请人： INVISTA NORTH AMERICA S.A.R.L.
发明人： Paul Pearlman , Gary Smith , Gregory S. Kirby
IPC分类号： B01D15/18 , C07C209/86 , C07C227/40 , C07C211/09
CPC分类号： B01D15/185 , B01D15/1892 , C07C209/82 , C07C209/86 , C07C211/09 , C07C213/10 , C07C227/38 , C07C227/40 , C12P13/001 , C12P13/005 , C07C211/12 , C07C229/08
摘要： The present disclosure relates to methods for separating at least one amine chosen from diamines and omega-aminoacids from a feed mixture using a simulated moving bed (SMB) adsorptive technology.

10. 发明申请

US20070213559A1 Method Of Separately Collecting Optically Active Amino Acid Amide And Optically Active Amino Acid 有权
标题翻译：分开收集光活性氨基酸酰胺和光活性氨基酸的方法
公开(公告)号：US20070213559A1
公开(公告)日：2007-09-13
申请号：US11587006
申请日：2005-04-22
申请人： Atsushi Inoue , Akinori Tanaka , Satoshi Nanba
发明人： Atsushi Inoue , Akinori Tanaka , Satoshi Nanba
IPC分类号： C07C227/40
CPC分类号： C07C227/38 , C07C231/24 , C12P13/04 , C07C229/08 , C07C237/06
摘要： The present invention is a method for separately collecting an optically active amino acid amide and an optically active amino acid from an aqueous solution containing the optically active amino acid amide and the optically active amino acid together with at least one member selected from the group consisting of an acid, a base and a salt: comprising a neutralization step of neutralizing an acid or a base when the aqueous solution contains the acid or the base; a desalting step of removing a salt contained in the aqueous solution and/or formed in the neutralization step; and a step of collecting the optically active amino acid amide and the optically active amino acid separately from the aqueous solution which has been desalted in the desalting step, by a process which takes advantage of a difference in solubility between the two components in an organic solvent. The desalting step is preferably performed by an electrodialysis process optionally in the state where ammonia is added to the aqueous solution. According to the present invention, an optically active amino acid amide and an optically active amino acid, which are important as intermediates in the production of pharmaceuticals, agricultural chemicals, and various industrial chemicals, can be separately collected with high efficiency by use of an organic solvent.
摘要翻译：本发明是从含有光学活性氨基酸酰胺和光学活性氨基酸的水溶液中分别收集光学活性氨基酸酰胺和光学活性氨基酸的方法，以及选自以下的至少一种：酸，碱和盐：包含当水溶液含有酸或碱时中和酸或碱的中和步骤; 去除水溶液中含有的盐和/或在中和步骤中形成的脱盐步骤; 以及通过利用有机溶剂中的两种成分之间的溶解度差异的方法，在脱盐步骤中从脱盐的水溶液中分离收集光学活性氨基酸酰胺和光学活性氨基酸的步骤。脱盐步骤优选通过电渗析方法进行，任选地在向水溶液中加入氨的状态下进行。根据本发明，可以通过使用有机物以高效率单独收集作为药物，农药和各种工业化学品生产中的中间体的光学活性氨基酸酰胺和光学活性氨基酸溶剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式