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1. 发明申请

US20140051604A1 MICROFLUIDIC DROPLET QUEUING NETWORK 审中-公开
标题翻译：微型流体排队网络
公开(公告)号：US20140051604A1
公开(公告)日：2014-02-20
申请号：US14057301
申请日：2013-10-18
申请人： STOKES BIO LIMITED
发明人： Mark Davies , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01F13/0071 , B01F15/0201 , B01F15/0232 , B01J2219/00313 , B01J2219/00353 , B01J2219/00479 , B01J2219/00587 , B01J2219/00608 , B01L3/5025 , B01L3/502784 , B01L2200/0673 , B01L2300/0829 , B01L2400/0487 , Y10T436/25
摘要： A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow. The phase of the inlet flow (from the droplet inlet port (5) and the draft inlet port (4) is used to determine the outlet port (6) flow phase.
摘要翻译：多端口液体桥（1）将包含油相载体液体（11）中的水相液滴（10）加入到通风道（4,6）。室（3）连接四个端口，在使用时永久充满油（11）。油相在进气口（4）的进料流中进料，并通过排气口（6）和补偿流通口（7）排出。油载体和样品液滴（“水相”）以相当的流体流通过入口端口（5）流过补偿口（7）。桥梁（1）的端口由保持在塑料壳体中的位置的毛细管的端部形成。这些阶段是密度匹配的，以创造引力几乎可忽略的环境。这导致当从毛细管尖端悬浮时，液滴（10）采用球形。此外，质量流量的相等性等于体积流量的相等。入口流（从液滴入口端口5和进气口4）的相位用于确定出口（6）的流动相位。

2. 发明申请

US20150352513A1 Microfluidic Droplet Queuing Network 审中-公开
标题翻译：微流控液滴排队网络
公开(公告)号：US20150352513A1
公开(公告)日：2015-12-10
申请号：US14828336
申请日：2015-08-17
申请人： STOKES BIO LIMITED
发明人： Mark Davies , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01F13/0071 , B01F15/0201 , B01F15/0232 , B01J2219/00313 , B01J2219/00353 , B01J2219/00479 , B01J2219/00587 , B01J2219/00608 , B01L3/5025 , B01L3/502784 , B01L2200/0673 , B01L2300/0829 , B01L2400/0487 , Y10T436/25
摘要： A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries help in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow. The phase of the inlet flow from the droplet inlet port (5) and the draft inlet port (4) is used to determine the outlet port (6) flow phase.
摘要翻译：多端口液体桥（1）将包含油相载体液体（11）中的水相液滴（10）加入到通风道（4,6）。室（3）连接四个端口，在使用时永久充满油（11）。油相在进气口（4）的进料流中进料，并通过排气口（6）和补偿流通口（7）排出。油载体和样品液滴（“水相”）以相当的流体流通过入口端口（5）流过补偿口（7）。桥（1）的端口由毛细管的端部形成在塑料外壳中的位置。这些阶段是密度匹配的，以创造引力几乎可忽略的环境。这导致当从毛细管尖端悬浮时，液滴（10）采用球形。此外，质量流量的相等性等于体积流量的相等。来自液滴入口（5）和进气口（4）的入口流的相位用于确定出口（6）流动相。

3. 发明授权

US09108177B2 Microfluidic droplet queuing network 有权
标题翻译：微流控液滴排队网络
公开(公告)号：US09108177B2
公开(公告)日：2015-08-18
申请号：US14057301
申请日：2013-10-18
申请人： STOKES BIO LIMITED
发明人： Mark Davies , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
IPC分类号： C12M1/34 , B01J19/00 , B01F13/00 , B01F15/02 , B01L3/00
CPC分类号： B01J19/0046 , B01F13/0071 , B01F15/0201 , B01F15/0232 , B01J2219/00313 , B01J2219/00353 , B01J2219/00479 , B01J2219/00587 , B01J2219/00608 , B01L3/5025 , B01L3/502784 , B01L2200/0673 , B01L2300/0829 , B01L2400/0487 , Y10T436/25
摘要： A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow. The phase of the inlet flow (from the droplet inlet port (5) and the draft inlet port (4) is used to determine the outlet port (6) flow phase.
摘要翻译：多端口液体桥（1）将包含油相载体液体（11）中的水相液滴（10）加入到通风道（4,6）。室（3）连接四个端口，在使用时永久充满油（11）。油相在进气口（4）的进料流中进料，并通过排气口（6）和补偿流通口（7）排出。油载体和样品液滴（“水相”）以相当的流体流通过入口端口（5）流过补偿口（7）。桥梁（1）的端口由保持在塑料壳体中的位置的毛细管的端部形成。这些阶段是密度匹配的，以创造引力几乎可忽略的环境。这导致当从毛细管尖端悬浮时，液滴（10）采用球形。此外，质量流量的相等性等于体积流量的相等。入口流（从液滴入口端口5和进气口4）的相位用于确定出口（6）的流动相位。

4. 发明申请

US20140308671A1 Sampling Device 审中-公开
标题翻译：取样装置
公开(公告)号：US20140308671A1
公开(公告)日：2014-10-16
申请号：US14250776
申请日：2014-04-11
申请人： STOKES BIO LIMITED
发明人： David McGuire , Kieran Curran , Julie Garvey , Damian Curtin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , B01L3/021 , B01L3/0293 , B01L7/52 , B01L2200/0642 , C12Q1/686
摘要： The present invention generally relates to devices, systems, and methods for acquiring and/or dispensing a sample without introducing a gas into a microfluidic system, such as a liquid bridge system. An exemplary embodiment provides a sampling device including: a sampling member for acquiring or dispensing a sample; and a supply of a fluid that is immiscible with the sample; in which the device is configured to provide a continuous flow of immiscible fluid enveloping the sampling member.
摘要翻译：本发明一般涉及用于获取和/或分配样品而不将气体引入诸如液体桥系统的微流体系统中的装置，系统和方法。示例性实施例提供一种采样装置，包括：用于获取或分配样本的采样部件; 和与样品不混溶的流体供应; 其中所述装置被配置为提供包围所述采样构件的不混溶流体的连续流。

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