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1. 发明申请

US20110183911A1 METHOD FOR IMPROVING NEUROTRANSMISSION FAILURE USING A NOVEL AGENT 审中-公开
标题翻译：使用新型药剂改善神经递质失败的方法
公开(公告)号：US20110183911A1
公开(公告)日：2011-07-28
申请号：US13012545
申请日：2011-01-24
申请人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
发明人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
IPC分类号： A61K38/17 , C07K14/435 , A61P25/00
CPC分类号： A61K38/1709
摘要： A novel medicament for ameliorating neurotransmission dysfunction diseases is provided. A medicament for ameliorating neurotransmission dysfunction diseases comprising as a main active ingredient preferably a selenocysteine-containing protein such as Selenoprotein P or a selenocysteine-containing peptide that consists of said protein or a series of said peptides. A medicament suited for ameliorating neurotransmission dysfunction diseases caused by various pathological conditions is provided.
摘要翻译：提供了用于改善神经传递功能障碍疾病的新型药物。一种用于改善神经传递功能障碍疾病的药物，其包含主要活性成分，优选含有硒代半胱氨酸的蛋白质如硒蛋白P或含有所述蛋白质或一系列所述肽的含硒代胱氨酸的肽。提供了适用于改善由各种病理状况引起的神经传递功能障碍疾病的药物。

2. 发明申请

US20070293431A1 METHOD FOR IMPROVING NEUROTRANSMISSION FAILURE USING A NOVEL AGENT 审中-公开
标题翻译：使用新型药剂改善神经递质失败的方法
公开(公告)号：US20070293431A1
公开(公告)日：2007-12-20
申请号：US11782510
申请日：2007-07-24
申请人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
发明人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
IPC分类号： A61K38/16 , A61K38/00 , A61P25/00
CPC分类号： A61K38/1709
摘要： A novel medicament for ameliorating neurotransmission dysfunction diseases is provided. A medicament for ameliorating neurotransmission dysfunction diseases comprising as a main active ingredient preferably a selenocysteine-containing protein such as Selenoprotein P or a selenocysteine-containing peptide that consists of said protein or a series of said peptides. A medicament suited for ameliorating neurotransmission dysfunction diseases caused by various pathological conditions is provided.
摘要翻译：提供了用于改善神经传递功能障碍疾病的新型药物。一种用于改善神经传递功能障碍疾病的药物，其包含主要活性成分，优选含有硒代半胱氨酸的蛋白质如硒蛋白P或含有所述蛋白质或一系列所述肽的含硒代胱氨酸的肽。提供了适用于改善由各种病理状况引起的神经传递功能障碍疾病的药物。

3. 发明申请

US20060211609A1 Novel agent for improving neurotransmission failure 审中-公开
标题翻译：改善神经传导衰竭的新药
公开(公告)号：US20060211609A1
公开(公告)日：2006-09-21
申请号：US10536963
申请日：2003-11-28
申请人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
发明人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
IPC分类号： A61K38/17 , A61K38/00
CPC分类号： A61K38/1709
摘要： A novel medicament for ameliorating neurotransmission dysfunction diseases is provided. A medicament for ameliorating neurotransmission dysfunction diseases comprising as a main active ingredient preferably a selenocysteine-containing protein such as Selenoprotein P or a selenocysteine-containing peptide that consists of said protein or a series of said peptides. A medicament suited for ameliorating neurotransmission dysfunction diseases caused by various pathological conditions is provided.
摘要翻译：提供了用于改善神经传递功能障碍疾病的新型药物。一种用于改善神经传递功能障碍疾病的药物，其包含主要活性成分，优选含有硒代半胱氨酸的蛋白质如硒蛋白P或含有所述蛋白质或一系列所述肽的含硒代胱氨酸的肽。提供了适用于改善由各种病理状况引起的神经传递功能障碍疾病的药物。

4. 发明授权

US09175295B2 Modified transposon vector and its use 有权
标题翻译：改性转座子载体及其用途
公开(公告)号：US09175295B2
公开(公告)日：2015-11-03
申请号：US11994982
申请日：2006-07-04
申请人： Kazuyoshi Kaminaka , Hiroaki Maeda , Masaki Hirashima , Ryoichi Kawamura , Junichi Matsuda , Takashi Kuwana
发明人： Kazuyoshi Kaminaka , Hiroaki Maeda , Masaki Hirashima , Ryoichi Kawamura , Junichi Matsuda , Takashi Kuwana
IPC分类号： C12N15/79 , C12N5/10 , C12N15/85
CPC分类号： C12N15/79 , A01K2217/05 , A01K2227/30 , C12N15/102 , C12N15/85 , C12N15/90 , C12N2800/30 , C12N2800/90 , C12N2820/00
摘要： A modified transposon vector and a method for introducing a foreign gene into a cell are provided. A modified transposon vector wherein a nucleic acid fragment having the following features (a)-(b) or (a)-(c) is inserted; a cell expressing a foreign gene obtained by introducing said vector into chromosomal DNA of a cell line or an ontogenetic cell and further introducing an expression cassette of a foreign gene into the chromosomal DNA; a genetically recombined animal generated by using said cell (in case of an ontogenetic cell); and a method for producing a foreign protein from said cell and said genetically recombined animal: (a) It consists of 5′- and 3′-TIR sequences of a transposon gene; (b) A sequence where a recombination reaction occurs is inserted between at least either of DR regions present by twos each in 5′- and 3′-TIR sequences of a transposon gene; (c) A restriction enzyme recognition site or an expression cassette of a foreign gene is inserted between 5′- and 3′-TIR sequences of a transposon gene.
摘要翻译：提供了修饰的转座子载体和将外源基因导入细胞的方法。其中插入具有以下特征（a） - （b）或（a） - （c）的核酸片段的修饰的转座子载体; 通过将所述载体导入细胞系或本体细胞的染色体DNA而获得的表达外源基因的细胞，并进一步将外源基因的表达盒导入染色体DNA; 通过使用所述细胞产生的遗传重组的动物（在个体发生细胞的情况下）; 以及从所述细胞和所述遗传重组动物产生外源蛋白的方法：（a）其由转座子基因的5'和3'-TIR序列组成; （b）将重组反应发生的序列插入转座子基因的5'-和3-TIR序列中的两个存在的至少任一个DR区域; （c）将外来基因的限制性内切酶识别位点或表达盒插入转座子基因的5'和3'-TIR序列之间。

5. 发明申请

US20100281551A1 MODIFIED TRANSPOSON VECTOR AND ITS USE 有权
标题翻译：改进的传输矢量及其使用
公开(公告)号：US20100281551A1
公开(公告)日：2010-11-04
申请号：US11994982
申请日：2006-07-04
申请人： Kazuyoshi Kaminaka , Hiroaki Maeda , Masaki Hirashima , Ryoichi Kawamura , Junichi Matsuda , Takashi Kuwana
发明人： Kazuyoshi Kaminaka , Hiroaki Maeda , Masaki Hirashima , Ryoichi Kawamura , Junichi Matsuda , Takashi Kuwana
IPC分类号： A01K67/033 , C12N15/79 , C12P21/00 , C12N5/10
CPC分类号： C12N15/79 , A01K2217/05 , A01K2227/30 , C12N15/102 , C12N15/85 , C12N15/90 , C12N2800/30 , C12N2800/90 , C12N2820/00
摘要： A modified transposon vector and a method for introducing a foreign gene into a cell are provided. A modified transposon vector wherein a nucleic acid fragment having the following features (a)-(b) or (a)-(c) is inserted; a cell expressing a foreign gene obtained by introducing said vector into chromosomal DNA of a cell line or an ontogenetic cell and further introducing an expression cassette of a foreign gene into the chromosomal DNA; a genetically recombined animal generated by using said cell (in case of an ontogenetic cell); and a method for producing a foreign protein from said cell and said genetically recombined animal: (a) It consists of 5′- and 3′-TIR sequences of a transposon gene; (b) A sequence where a recombination reaction occurs is inserted between at least either of DR regions present by twos each in 5′- and 3′-TIR sequences of a transposon gene; (c) A restriction enzyme recognition site or an expression cassette of a foreign gene is inserted between 5′- and 3′-TIR sequences of a transposon gene.
摘要翻译：提供了修饰的转座子载体和将外源基因导入细胞的方法。其中插入具有以下特征（a） - （b）或（a） - （c）的核酸片段的修饰的转座子载体; 通过将所述载体导入细胞系或本体细胞的染色体DNA而获得的表达外源基因的细胞，并进一步将外源基因的表达盒导入染色体DNA; 通过使用所述细胞产生的遗传重组的动物（在个体发生细胞的情况下）; 以及从所述细胞和所述遗传重组动物产生外源蛋白的方法：（a）其由转座子基因的5'和3'-TIR序列组成; （b）将重组反应发生的序列插入转座子基因的5'-和3-TIR序列中的两个存在的至少任一个DR区域; （c）将外来基因的限制性内切酶识别位点或表达盒插入转座子基因的5'和3'-TIR序列之间。

6. 发明申请

US20050143310A1 Novel remedies for neurodegenerative disease 审中-公开
标题翻译：神经退行性疾病的新方法
公开(公告)号：US20050143310A1
公开(公告)日：2005-06-30
申请号：US10477216
申请日：2002-05-10
申请人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Hidenao Fukushima
发明人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Hidenao Fukushima
IPC分类号： A61K38/17 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61K38/10
CPC分类号： A61K38/1709
摘要： A medicament for treating neurodegenerative diseases, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from the C-terminal of selenoprotein P. An excellent medicament for treating neurodegenerative diseases, especially suitable for treating neurodegenerative diseases with ataxia as a principal symptom is provided.
摘要翻译：一种用于治疗神经变性疾病的药物，其包含作为活性成分的硒蛋白P和/或肽片段或一系列衍生自硒蛋白P的C末端的肽片段。用于治疗神经变性疾病的优异药物，特别适用于治疗神经变性疾病提供共济失调作为主要症状。

7. 发明申请

US20070249534A1 Novel medicament for treating neurodegenerative diseases 审中-公开
标题翻译：用于治疗神经变性疾病的新型药物
公开(公告)号：US20070249534A1
公开(公告)日：2007-10-25
申请号：US11707942
申请日：2007-02-20
申请人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Hidenao Fukushima
发明人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Hidenao Fukushima
IPC分类号： A61K38/16
CPC分类号： A61K38/1709
摘要： A medicament for treating neurodegenerative diseases, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from the C-terminal of selenoprotein P. An excellent medicament for treating neurodegenerative diseases, especially suitable for treating neurodegenerative diseases with ataxia as a principal symptom is provided.
摘要翻译：一种用于治疗神经变性疾病的药物，其包含作为活性成分的硒蛋白P和/或肽片段或一系列衍生自硒蛋白P的C末端的肽片段。用于治疗神经变性疾病的优异药物，特别适用于治疗神经变性疾病提供共济失调作为主要症状。

8. 发明申请

US20050037954A1 Novel agents for ameliorating motor disorder 审中-公开
标题翻译：用于改善运动障碍的新型药剂
公开(公告)号：US20050037954A1
公开(公告)日：2005-02-17
申请号：US10472444
申请日：2001-08-31
申请人： Masaki Hirashima , Takumi Sasaki , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki
发明人： Masaki Hirashima , Takumi Sasaki , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki
IPC分类号： A61K38/17 , A61P25/00 , A61P25/08 , A61P25/28
CPC分类号： A61K38/1709
摘要： A novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from said protein is provided. The novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, according to the present invention is suitably applicable to diseases with decrease in motor function.
摘要翻译：提供了用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物，其包含作为活性成分的硒蛋白P和/或肽片段或一系列源自所述蛋白质的肽片段。根据本发明的用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物适用于运动功能降低的疾病。

9. 发明授权

US07960508B2 Peptide having cytotoxicity inhibitory activity and method of screening these peptide having cytotoxicity inhibitory activity 失效
标题翻译：具有细胞毒性抑制活性的肽和筛选具有细胞毒性抑制活性的肽的方法
公开(公告)号：US07960508B2
公开(公告)日：2011-06-14
申请号：US10477101
申请日：2002-05-10
申请人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Wataru Hattori
发明人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Wataru Hattori
IPC分类号： A61K38/00 , A61K38/04 , A61K38/16 , A61K38/10 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/4747 , C07K14/47 , G01N33/5014
摘要： A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.
摘要翻译：含有一种或多种硒代半胱氨酸的肽片段或一系列肽片段，其毒性低于硒代胱氨酸并且具有细胞毒性抑制活性。根据本发明的肽片段或一系列肽片段优选具有来自硒蛋白P的C末端的第260至第362位氨基酸残基的氨基酸序列，或其中具有一个或几个氨基酸残基的所述氨基酸序列是缺失，取代或添加，或上述氨基酸序列中的任一个的部分序列，或包含作为上述氨基酸序列之一的氨基酸序列。还提供了具有细胞毒性抑制活性的肽片段的筛选方法。

10. 发明授权

US07704951B2 Method for ameliorating dyskinesia 失效
标题翻译：改善运动障碍的方法
公开(公告)号：US07704951B2
公开(公告)日：2010-04-27
申请号：US12081991
申请日：2008-04-24
申请人： Masaki Hirashima , Takumi Sasaki , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki
发明人： Masaki Hirashima , Takumi Sasaki , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki
IPC分类号： A61K38/02 , A61K38/18 , A61K31/095
CPC分类号： A61K38/1709
摘要： A novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from said protein is provided. The novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, according to the present invention is suitably applicable to diseases with decrease in motor function.
摘要翻译：提供了用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物，其包含作为活性成分的硒蛋白P和/或肽片段或一系列源自所述蛋白质的肽片段。根据本发明的用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物适用于运动功能降低的疾病。

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