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1. 发明授权

US07960508B2 Peptide having cytotoxicity inhibitory activity and method of screening these peptide having cytotoxicity inhibitory activity 失效
标题翻译：具有细胞毒性抑制活性的肽和筛选具有细胞毒性抑制活性的肽的方法
公开(公告)号：US07960508B2
公开(公告)日：2011-06-14
申请号：US10477101
申请日：2002-05-10
申请人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Wataru Hattori
发明人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Wataru Hattori
IPC分类号： A61K38/00 , A61K38/04 , A61K38/16 , A61K38/10 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/4747 , C07K14/47 , G01N33/5014
摘要： A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.
摘要翻译：含有一种或多种硒代半胱氨酸的肽片段或一系列肽片段，其毒性低于硒代胱氨酸并且具有细胞毒性抑制活性。根据本发明的肽片段或一系列肽片段优选具有来自硒蛋白P的C末端的第260至第362位氨基酸残基的氨基酸序列，或其中具有一个或几个氨基酸残基的所述氨基酸序列是缺失，取代或添加，或上述氨基酸序列中的任一个的部分序列，或包含作为上述氨基酸序列之一的氨基酸序列。还提供了具有细胞毒性抑制活性的肽片段的筛选方法。

2. 发明申请

US20050143311A1 Peptide having cytotoxicity inhibitory activity and method of screening these peptide having cytotoxicity inhibitory activity 失效
标题翻译：具有细胞毒性抑制活性的肽和筛选具有细胞毒性抑制活性的肽的方法
公开(公告)号：US20050143311A1
公开(公告)日：2005-06-30
申请号：US10477101
申请日：2002-05-10
申请人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Wataru Hattori
发明人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Wataru Hattori
IPC分类号： C07K14/47 , G01N33/50 , A61K38/08 , C07K7/08
CPC分类号： C07K14/4747 , C07K14/47 , G01N33/5014
摘要： A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.
摘要翻译：含有一种或多种硒代半胱氨酸的肽片段或一系列肽片段，其毒性低于硒代胱氨酸并且具有细胞毒性抑制活性。根据本发明的肽片段或一系列肽片段优选具有来自硒蛋白P的C末端的第260至第362位氨基酸残基的氨基酸序列，或其中具有一个或几个氨基酸残基的所述氨基酸序列是缺失，取代或添加，或上述氨基酸序列中的任一个的部分序列，或包含作为上述氨基酸序列之一的氨基酸序列。还提供了具有细胞毒性抑制活性的肽片段的筛选方法。

3. 发明申请

US20050143310A1 Novel remedies for neurodegenerative disease 审中-公开
标题翻译：神经退行性疾病的新方法
公开(公告)号：US20050143310A1
公开(公告)日：2005-06-30
申请号：US10477216
申请日：2002-05-10
申请人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Hidenao Fukushima
发明人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Hidenao Fukushima
IPC分类号： A61K38/17 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61K38/10
CPC分类号： A61K38/1709
摘要： A medicament for treating neurodegenerative diseases, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from the C-terminal of selenoprotein P. An excellent medicament for treating neurodegenerative diseases, especially suitable for treating neurodegenerative diseases with ataxia as a principal symptom is provided.
摘要翻译：一种用于治疗神经变性疾病的药物，其包含作为活性成分的硒蛋白P和/或肽片段或一系列衍生自硒蛋白P的C末端的肽片段。用于治疗神经变性疾病的优异药物，特别适用于治疗神经变性疾病提供共济失调作为主要症状。

4. 发明申请

US20070249534A1 Novel medicament for treating neurodegenerative diseases 审中-公开
标题翻译：用于治疗神经变性疾病的新型药物
公开(公告)号：US20070249534A1
公开(公告)日：2007-10-25
申请号：US11707942
申请日：2007-02-20
申请人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Hidenao Fukushima
发明人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Hidenao Fukushima
IPC分类号： A61K38/16
CPC分类号： A61K38/1709
摘要： A medicament for treating neurodegenerative diseases, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from the C-terminal of selenoprotein P. An excellent medicament for treating neurodegenerative diseases, especially suitable for treating neurodegenerative diseases with ataxia as a principal symptom is provided.
摘要翻译：一种用于治疗神经变性疾病的药物，其包含作为活性成分的硒蛋白P和/或肽片段或一系列衍生自硒蛋白P的C末端的肽片段。用于治疗神经变性疾病的优异药物，特别适用于治疗神经变性疾病提供共济失调作为主要症状。

5. 发明授权

US07704951B2 Method for ameliorating dyskinesia 失效
标题翻译：改善运动障碍的方法
公开(公告)号：US07704951B2
公开(公告)日：2010-04-27
申请号：US12081991
申请日：2008-04-24
申请人： Masaki Hirashima , Takumi Sasaki , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki
发明人： Masaki Hirashima , Takumi Sasaki , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki
IPC分类号： A61K38/02 , A61K38/18 , A61K31/095
CPC分类号： A61K38/1709
摘要： A novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from said protein is provided. The novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, according to the present invention is suitably applicable to diseases with decrease in motor function.
摘要翻译：提供了用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物，其包含作为活性成分的硒蛋白P和/或肽片段或一系列源自所述蛋白质的肽片段。根据本发明的用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物适用于运动功能降低的疾病。

6. 发明申请

US20090075865A1 Novel medicament for ameliorating dyskinesia 失效
标题翻译：用于改善运动障碍的新型药物
公开(公告)号：US20090075865A1
公开(公告)日：2009-03-19
申请号：US12081991
申请日：2008-04-24
申请人： Masaki Hirashima , Takumi Sasaki , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki
发明人： Masaki Hirashima , Takumi Sasaki , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki
IPC分类号： A61K38/16 , A61P25/14
CPC分类号： A61K38/1709
摘要： A novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from said protein is provided. The novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, according to the present invention is suitably applicable to diseases with decrease in motor function.
摘要翻译：提供了用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物，其包含作为活性成分的硒蛋白P和/或肽片段或一系列源自所述蛋白质的肽片段。根据本发明的用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物适用于运动功能降低的疾病。

7. 发明申请

US20050037954A1 Novel agents for ameliorating motor disorder 审中-公开
标题翻译：用于改善运动障碍的新型药剂
公开(公告)号：US20050037954A1
公开(公告)日：2005-02-17
申请号：US10472444
申请日：2001-08-31
申请人： Masaki Hirashima , Takumi Sasaki , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki
发明人： Masaki Hirashima , Takumi Sasaki , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki
IPC分类号： A61K38/17 , A61P25/00 , A61P25/08 , A61P25/28
CPC分类号： A61K38/1709
摘要： A novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from said protein is provided. The novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, according to the present invention is suitably applicable to diseases with decrease in motor function.
摘要翻译：提供了用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物，其包含作为活性成分的硒蛋白P和/或肽片段或一系列源自所述蛋白质的肽片段。根据本发明的用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物适用于运动功能降低的疾病。

8. 发明申请

US20060051851A1 Novel selenocysteine-containing protein 审中-公开
标题翻译：新型含硒半胱氨酸的蛋白质
公开(公告)号：US20060051851A1
公开(公告)日：2006-03-09
申请号：US10489716
申请日：2002-09-12
申请人： Sara Kaminaka , Kazuyoshio Kaminaka , Masaki Hirashima , Hiroaki Maeda , Chikateru Nozaki , Kazuhiko Takahashi
发明人： Sara Kaminaka , Kazuyoshio Kaminaka , Masaki Hirashima , Hiroaki Maeda , Chikateru Nozaki , Kazuhiko Takahashi
IPC分类号： C12N9/02 , C07H21/04 , C12P21/06
CPC分类号： C12N9/0065 , C07K14/765 , C07K2319/00
摘要： A novel selenocysteine-containing protein is provided which is a substantial entity having an enzymatic activity, typically an activity to reduce peroxide phospholipids. There are provided a gene consisting of a coding sequence for a protein not containing selenocysteine in which the codon for selenocysteine is introduced at a desired position and a selenocysteine insertion sequence resided at the 3′-end of said coding sequence and a protein expressed therefrom, typically a selenocysteine-containing protein having an activity to reduce peroxide phospholipids which is prepared by introducing selenocysteine into albumin and as well as a gene encoding said protein. A novel anti-oxidative substance is provided which can be applied for prevention of worsening, prophylaxis or treatment of various diseases associated with oxidative stress.
摘要翻译：提供了一种新型含硒代半胱氨酸的蛋白质，其是具有酶活性的实质实体，通常是减少过氧化物磷脂的活性。提供了由不含硒代半胱氨酸的蛋白质的编码序列组成的基因，其中在期望的位置引入硒代半胱氨酸的密码子，并且存在位于所述编码序列的3'端的硒代半胱氨酸插入序列和由其表达的蛋白质，通常是含有硒代半胱氨酸的蛋白质，其具有通过将硒代半胱氨酸引入白蛋白而制备的过氧化物磷脂的活性，以及编码所述蛋白质的基因。提供了一种新的抗氧化物质，其可用于预防与氧化应激相关的各种疾病的恶化，预防或治疗。

9. 发明授权

US07598349B2 Antibodies to peptide fragments having cell death-inhibitory activity 失效
标题翻译：具有细胞死亡抑制活性的肽片段的抗体
公开(公告)号：US07598349B2
公开(公告)日：2009-10-06
申请号：US11185859
申请日：2005-07-21
申请人： Masaki Hirashima , Hiroaki Maeda , Chikateru Nozaki
发明人： Masaki Hirashima , Hiroaki Maeda , Chikateru Nozaki
IPC分类号： C07K16/00
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention provides a peptide fragment or a series of peptide fragments having a cell death-inhibitory activity, having the amino acid sequence consisting of 103 amino acid residues at the C-terminal of selenoprotein P, or having said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or having a partial sequence of either of the above amino acid sequences, a medicament for treatment comprising said peptide fragment or a series of peptide fragments, an antibody to said peptide fragment or a series of peptide fragments, and a method for screening a cell death-inhibitory activity using said peptide fragment or a series of peptide fragments. The preferable peptide fragment or a series of peptide fragments of the present invention has the amino acid sequences shown in SEQ ID NO: 1 and/or SEQ ID NO: 2 or has a partial sequence thereof.
摘要翻译：本发明提供具有细胞死亡抑制活性的肽片段或一系列肽片段，其具有在硒蛋白P的C末端由103个氨基酸残基组成的氨基酸序列，或者具有所述氨基酸序列与一个或多个其中缺少，取代或添加的几个氨基酸残基，或具有上述氨基酸序列之一的部分序列，包含所述肽片段或一系列肽片段的治疗药物，所述肽片段的抗体或一系列的肽片段，以及使用所述肽片段或一系列肽片段筛选细胞死亡抑制活性的方法。本发明优选的肽片段或一系列肽片段具有SEQ ID NO：1和/或SEQ ID NO：2所示的氨基酸序列或其部分序列。

10. 发明授权

US07199097B1 Peptide fragments having cell death inhibitory activity 失效
标题翻译：具有细胞死亡抑制活性的肽片段
公开(公告)号：US07199097B1
公开(公告)日：2007-04-03
申请号：US09856199
申请日：1999-11-12
申请人： Masaki Hirashima , Hiroaki Maeda , Chikateru Nozaki
发明人： Masaki Hirashima , Hiroaki Maeda , Chikateru Nozaki
IPC分类号： A01N37/18 , G01N33/48
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention provides a peptide fragment or a series of peptide fragments having a cell death-inhibitory activity, having the amino acid sequence consisting of 103 amino acid residues at the C-terminal of selenoprotein P, or having said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or having a partial sequence of either of the above amino acid sequences, a medicament for treatment comprising said peptide fragment or a series of peptide fragments, an antibody to said peptide fragment or a series of peptide fragments, and a method for screening a cell death-inhibitory activity using said peptide fragment or a series of peptide fragments. The preferable peptide fragment or a series of peptide fragments of the present invention has the amino acid sequences shown in SEQ ID NO: 1 and/or SEQ ID NO: 2 or has a partial sequence thereof.
摘要翻译：本发明提供具有细胞死亡抑制活性的肽片段或一系列肽片段，其具有在硒蛋白P的C末端由103个氨基酸残基组成的氨基酸序列，或者具有所述氨基酸序列与一个或多个其中缺少，取代或添加的几个氨基酸残基，或具有上述氨基酸序列之一的部分序列，包含所述肽片段或一系列肽片段的治疗药物，所述肽片段的抗体或一系列的肽片段，以及使用所述肽片段或一系列肽片段筛选细胞死亡抑制活性的方法。本发明优选的肽片段或一系列肽片段具有SEQ ID NO：1和/或SEQ ID NO：2所示的氨基酸序列或其部分序列。

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