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1. 发明申请

US20110183911A1 METHOD FOR IMPROVING NEUROTRANSMISSION FAILURE USING A NOVEL AGENT 审中-公开
标题翻译：使用新型药剂改善神经递质失败的方法
公开(公告)号：US20110183911A1
公开(公告)日：2011-07-28
申请号：US13012545
申请日：2011-01-24
申请人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
发明人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
IPC分类号： A61K38/17 , C07K14/435 , A61P25/00
CPC分类号： A61K38/1709
摘要： A novel medicament for ameliorating neurotransmission dysfunction diseases is provided. A medicament for ameliorating neurotransmission dysfunction diseases comprising as a main active ingredient preferably a selenocysteine-containing protein such as Selenoprotein P or a selenocysteine-containing peptide that consists of said protein or a series of said peptides. A medicament suited for ameliorating neurotransmission dysfunction diseases caused by various pathological conditions is provided.
摘要翻译：提供了用于改善神经传递功能障碍疾病的新型药物。一种用于改善神经传递功能障碍疾病的药物，其包含主要活性成分，优选含有硒代半胱氨酸的蛋白质如硒蛋白P或含有所述蛋白质或一系列所述肽的含硒代胱氨酸的肽。提供了适用于改善由各种病理状况引起的神经传递功能障碍疾病的药物。

2. 发明申请

US20070293431A1 METHOD FOR IMPROVING NEUROTRANSMISSION FAILURE USING A NOVEL AGENT 审中-公开
标题翻译：使用新型药剂改善神经递质失败的方法
公开(公告)号：US20070293431A1
公开(公告)日：2007-12-20
申请号：US11782510
申请日：2007-07-24
申请人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
发明人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
IPC分类号： A61K38/16 , A61K38/00 , A61P25/00
CPC分类号： A61K38/1709
摘要： A novel medicament for ameliorating neurotransmission dysfunction diseases is provided. A medicament for ameliorating neurotransmission dysfunction diseases comprising as a main active ingredient preferably a selenocysteine-containing protein such as Selenoprotein P or a selenocysteine-containing peptide that consists of said protein or a series of said peptides. A medicament suited for ameliorating neurotransmission dysfunction diseases caused by various pathological conditions is provided.
摘要翻译：提供了用于改善神经传递功能障碍疾病的新型药物。一种用于改善神经传递功能障碍疾病的药物，其包含主要活性成分，优选含有硒代半胱氨酸的蛋白质如硒蛋白P或含有所述蛋白质或一系列所述肽的含硒代胱氨酸的肽。提供了适用于改善由各种病理状况引起的神经传递功能障碍疾病的药物。

3. 发明申请

US20060211609A1 Novel agent for improving neurotransmission failure 审中-公开
标题翻译：改善神经传导衰竭的新药
公开(公告)号：US20060211609A1
公开(公告)日：2006-09-21
申请号：US10536963
申请日：2003-11-28
申请人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
发明人： Ryoichi Kawamura , Takeshi Naruse , Masaki Hirashima , Kazuyoshi Kaminaka , Junichi Matsuda , Hiroaki Maeda , Mami Noda , Keiji Wada
IPC分类号： A61K38/17 , A61K38/00
CPC分类号： A61K38/1709
摘要： A novel medicament for ameliorating neurotransmission dysfunction diseases is provided. A medicament for ameliorating neurotransmission dysfunction diseases comprising as a main active ingredient preferably a selenocysteine-containing protein such as Selenoprotein P or a selenocysteine-containing peptide that consists of said protein or a series of said peptides. A medicament suited for ameliorating neurotransmission dysfunction diseases caused by various pathological conditions is provided.
摘要翻译：提供了用于改善神经传递功能障碍疾病的新型药物。一种用于改善神经传递功能障碍疾病的药物，其包含主要活性成分，优选含有硒代半胱氨酸的蛋白质如硒蛋白P或含有所述蛋白质或一系列所述肽的含硒代胱氨酸的肽。提供了适用于改善由各种病理状况引起的神经传递功能障碍疾病的药物。

4. 发明授权

US09175295B2 Modified transposon vector and its use 有权
标题翻译：改性转座子载体及其用途
公开(公告)号：US09175295B2
公开(公告)日：2015-11-03
申请号：US11994982
申请日：2006-07-04
申请人： Kazuyoshi Kaminaka , Hiroaki Maeda , Masaki Hirashima , Ryoichi Kawamura , Junichi Matsuda , Takashi Kuwana
发明人： Kazuyoshi Kaminaka , Hiroaki Maeda , Masaki Hirashima , Ryoichi Kawamura , Junichi Matsuda , Takashi Kuwana
IPC分类号： C12N15/79 , C12N5/10 , C12N15/85
CPC分类号： C12N15/79 , A01K2217/05 , A01K2227/30 , C12N15/102 , C12N15/85 , C12N15/90 , C12N2800/30 , C12N2800/90 , C12N2820/00
摘要： A modified transposon vector and a method for introducing a foreign gene into a cell are provided. A modified transposon vector wherein a nucleic acid fragment having the following features (a)-(b) or (a)-(c) is inserted; a cell expressing a foreign gene obtained by introducing said vector into chromosomal DNA of a cell line or an ontogenetic cell and further introducing an expression cassette of a foreign gene into the chromosomal DNA; a genetically recombined animal generated by using said cell (in case of an ontogenetic cell); and a method for producing a foreign protein from said cell and said genetically recombined animal: (a) It consists of 5′- and 3′-TIR sequences of a transposon gene; (b) A sequence where a recombination reaction occurs is inserted between at least either of DR regions present by twos each in 5′- and 3′-TIR sequences of a transposon gene; (c) A restriction enzyme recognition site or an expression cassette of a foreign gene is inserted between 5′- and 3′-TIR sequences of a transposon gene.
摘要翻译：提供了修饰的转座子载体和将外源基因导入细胞的方法。其中插入具有以下特征（a） - （b）或（a） - （c）的核酸片段的修饰的转座子载体; 通过将所述载体导入细胞系或本体细胞的染色体DNA而获得的表达外源基因的细胞，并进一步将外源基因的表达盒导入染色体DNA; 通过使用所述细胞产生的遗传重组的动物（在个体发生细胞的情况下）; 以及从所述细胞和所述遗传重组动物产生外源蛋白的方法：（a）其由转座子基因的5'和3'-TIR序列组成; （b）将重组反应发生的序列插入转座子基因的5'-和3-TIR序列中的两个存在的至少任一个DR区域; （c）将外来基因的限制性内切酶识别位点或表达盒插入转座子基因的5'和3'-TIR序列之间。

5. 发明申请

US20100281551A1 MODIFIED TRANSPOSON VECTOR AND ITS USE 有权
标题翻译：改进的传输矢量及其使用
公开(公告)号：US20100281551A1
公开(公告)日：2010-11-04
申请号：US11994982
申请日：2006-07-04
申请人： Kazuyoshi Kaminaka , Hiroaki Maeda , Masaki Hirashima , Ryoichi Kawamura , Junichi Matsuda , Takashi Kuwana
发明人： Kazuyoshi Kaminaka , Hiroaki Maeda , Masaki Hirashima , Ryoichi Kawamura , Junichi Matsuda , Takashi Kuwana
IPC分类号： A01K67/033 , C12N15/79 , C12P21/00 , C12N5/10
CPC分类号： C12N15/79 , A01K2217/05 , A01K2227/30 , C12N15/102 , C12N15/85 , C12N15/90 , C12N2800/30 , C12N2800/90 , C12N2820/00
摘要： A modified transposon vector and a method for introducing a foreign gene into a cell are provided. A modified transposon vector wherein a nucleic acid fragment having the following features (a)-(b) or (a)-(c) is inserted; a cell expressing a foreign gene obtained by introducing said vector into chromosomal DNA of a cell line or an ontogenetic cell and further introducing an expression cassette of a foreign gene into the chromosomal DNA; a genetically recombined animal generated by using said cell (in case of an ontogenetic cell); and a method for producing a foreign protein from said cell and said genetically recombined animal: (a) It consists of 5′- and 3′-TIR sequences of a transposon gene; (b) A sequence where a recombination reaction occurs is inserted between at least either of DR regions present by twos each in 5′- and 3′-TIR sequences of a transposon gene; (c) A restriction enzyme recognition site or an expression cassette of a foreign gene is inserted between 5′- and 3′-TIR sequences of a transposon gene.
摘要翻译：提供了修饰的转座子载体和将外源基因导入细胞的方法。其中插入具有以下特征（a） - （b）或（a） - （c）的核酸片段的修饰的转座子载体; 通过将所述载体导入细胞系或本体细胞的染色体DNA而获得的表达外源基因的细胞，并进一步将外源基因的表达盒导入染色体DNA; 通过使用所述细胞产生的遗传重组的动物（在个体发生细胞的情况下）; 以及从所述细胞和所述遗传重组动物产生外源蛋白的方法：（a）其由转座子基因的5'和3'-TIR序列组成; （b）将重组反应发生的序列插入转座子基因的5'-和3-TIR序列中的两个存在的至少任一个DR区域; （c）将外来基因的限制性内切酶识别位点或表达盒插入转座子基因的5'和3'-TIR序列之间。

6. 发明授权

US09114098B2 Method for using inactivated Japanese encephalitis virus particles as adjuvant 有权
标题翻译：使用灭活的日本脑炎病毒颗粒作为佐剂的方法
公开(公告)号：US09114098B2
公开(公告)日：2015-08-25
申请号：US12996236
申请日：2009-05-27
申请人： Makoto Moriyama , Kazuyoshi Kaminaka , Junichi Matsuda , Chikateru Nozaki
发明人： Makoto Moriyama , Kazuyoshi Kaminaka , Junichi Matsuda , Chikateru Nozaki
IPC分类号： C07K14/18 , A61K39/00
CPC分类号： A61K39/00 , A61K2039/5252 , A61K2039/55588 , Y02A50/388 , Y02A50/39 , Y02A50/464 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要： A method for using inactivated Japanese encephalitis virus particles as an adjuvant of a vaccine is provided. A method for using inactivated Japanese encephalitis virus (JEV) particles as an adjuvant of various vaccines or a mixed vaccine, said JEV particles being obtained by inoculating JEV Beijing-1 strain to Vero cells, culturing said JEV-infected cells to give cultured cells or culture supernatant, purifying JEV particles from said cultured cells or culture supernatant and inactivating said JEV particles with formalin, a method for preparing a (mixed) vaccine which comprises a step of letting inactivated Japanese encephalitis virus be contained, and a mixed vaccine prepared by said method.
摘要翻译：提供了使用灭活的日本脑炎病毒颗粒作为疫苗佐剂的方法。使用灭活的日本脑炎病毒（JEV）颗粒作为各种疫苗或混合疫苗的佐剂的方法，所述JEV颗粒通过将JEV Beijing-1菌株接种到Vero细胞获得，培养所述JEV感染的细胞以产生培养的细胞或培养上清液，从所述培养细胞或培养上清液中纯化JEV颗粒，并用福尔马林灭活所述JEV颗粒，制备包含使灭活的日本脑炎病毒的步骤的（混合）疫苗的方法，以及由所述方法。

7. 发明授权

US08106015B2 Method for enhancing immune response with peptide 有权
标题翻译：用肽增强免疫应答的方法
公开(公告)号：US08106015B2
公开(公告)日：2012-01-31
申请号：US12596741
申请日：2008-04-18
申请人： Junichi Matsuda , Kazuyoshi Kaminaka , Chikateru Nozaki
发明人： Junichi Matsuda , Kazuyoshi Kaminaka , Chikateru Nozaki
IPC分类号： A61K38/17 , A61K39/00 , A61P25/00 , A61P37/04 , C07K14/435
CPC分类号： A61K39/0007 , A61K31/711 , C07K14/4711
摘要： An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid β peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.
摘要翻译：本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默氏病的药物，其包括淀粉样蛋白诱导增强的免疫应答的肽。淀粉样蛋白肽或其部分，其中加入或插入半胱氨酸，以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。一种用于预防或治疗阿尔茨海默病的药物，其包含淀粉样蛋白肽或其部分诱导增强的免疫应答。可能具有相同作用的DNA疫苗，其包含编码淀粉样蛋白的基因; 肽或其部分，其通过加入或插入半胱氨酸诱导增强的免疫应答。

8. 发明授权

US09381242B2 Adjuvant composition containing citrulline 有权
标题翻译：含有瓜氨酸的佐剂组合物
公开(公告)号：US09381242B2
公开(公告)日：2016-07-05
申请号：US14004308
申请日：2012-03-09
申请人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda
发明人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda
IPC分类号： A61K45/00 , A61K39/145 , A61K39/39 , A61K39/12 , A61K39/00
CPC分类号： A61K39/39 , A61K39/0007 , A61K39/12 , A61K39/145 , A61K2039/55511 , A61K2039/55516 , A61K2039/575 , C12N2760/16134 , C12N2760/16171
摘要： A novel adjuvant composition is provided that is excellent in safety and convenience as compared to the conventional adjuvant such as Alum. An adjuvant composition comprising citrullines, which are water soluble substance present in the living body, and/or a salt thereof; a vaccine composition comprising said adjuvant composition and an antigen; a process for preparing said adjuvant composition and said vaccine composition; and a method for administering said adjuvant composition and said vaccine composition are provided.
摘要翻译：提供与常规佐剂如Alum相比，安全性和便利性优异的新型佐剂组合物。包含作为存在于生物体中的水溶性物质的瓜氨酸的佐剂组合物和/或其盐; 包含所述佐剂组合物和抗原的疫苗组合物; 一种制备所述佐剂组合物和所述疫苗组合物的方法; 并提供了用于施用所述佐剂组合物和所述疫苗组合物的方法。

9. 发明授权

US09028463B2 Microneedle device, and method for enhancing the efficacy of influenza vaccine by using microneedle device 有权
标题翻译：微针装置以及通过使用微针装置增强流感疫苗的功效的方法
公开(公告)号：US09028463B2
公开(公告)日：2015-05-12
申请号：US13001995
申请日：2009-05-22
申请人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda , Takaaki Terahara , Tetsuji Kuwahara , Seiji Tokumoto
发明人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda , Takaaki Terahara , Tetsuji Kuwahara , Seiji Tokumoto
IPC分类号： A61M31/00 , A61K39/145 , A61B17/20 , A61M37/00 , A61K39/00
CPC分类号： A61K39/145 , A61B17/205 , A61K39/12 , A61K2039/5252 , A61K2039/541 , A61K2039/545 , A61K2039/55511 , A61K2039/70 , A61M37/0015 , A61M2037/0046 , A61M2037/0061 , C12N2760/16134 , C12N2760/16234
摘要： The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.
摘要翻译：本发明提供使用能够增强流感疫苗的免疫原性的微针装置增强免疫原性的方法。根据使用本发明的微针装置的增强免疫原性的方法，将具有由聚乳酸制成的微针的微针装置涂敷于A型菌株（H1N1），A型菌株（H3N2）和A型菌株作为活性成分的B菌株与皮肤直接接触，以便经皮施用上述流感疫苗。在经皮给药之后，将月桂醇施用于已经与微针装置直接接触的皮肤部位。

10. 发明申请

US20120107334A1 METHOD FOR ENHANCING IMMUNE RESPONSE WITH PEPTIDE 有权
标题翻译：用于增强与肽的免疫应答的方法
公开(公告)号：US20120107334A1
公开(公告)日：2012-05-03
申请号：US13220452
申请日：2011-08-29
申请人： Junichi Matsuda , Kazuyoshi Kaminaka , Chikateru Nozaki
发明人： Junichi Matsuda , Kazuyoshi Kaminaka , Chikateru Nozaki
IPC分类号： A61K39/00 , A61P25/28 , A61P37/04 , C07K14/435
CPC分类号： A61K39/0007 , A61K31/711 , C07K14/4711
摘要： An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.
摘要翻译：本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默氏病的药物，其包括淀粉样蛋白诱导增强的免疫应答的肽。淀粉样蛋白肽或其部分，其中加入或插入半胱氨酸，以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。一种用于预防或治疗阿尔茨海默病的药物，其包含淀粉样蛋白肽或其部分诱导增强的免疫应答。可以具有相同效果的DNA疫苗，其包含编码淀粉样肽或其部分的基因，其通过加入或插入半胱氨酸诱导增强的免疫应答。

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