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1. 发明授权

US5478733A Process for producing L-alanine by fermentation with arthrobacter 失效
标题翻译：用节杆菌发酵生产L-丙氨酸的方法
公开(公告)号：US5478733A
公开(公告)日：1995-12-26
申请号：US90198
申请日：1993-07-16
申请人： Ryoichi Katsumata , Shinichi Hashimoto , Isao Kawamoto , Makoto Suzuki , Hajime Yoshida , Hiroshi Hagino , Kiyoshi Nakayama
发明人： Ryoichi Katsumata , Shinichi Hashimoto , Isao Kawamoto , Makoto Suzuki , Hajime Yoshida , Hiroshi Hagino , Kiyoshi Nakayama
IPC分类号： C12P13/06 , C12N1/20
CPC分类号： C12P13/06 , Y10S435/83
摘要： A process for producing L-alanine, which comprises culturing in a medium a microorganism belonging to the genus Arthrobacter which has L-alanine dehydrogenase activity, but little or no alanine racemase activity, and which is capable of producing L-alanine; allowing L-alanine to accumulate in the culture; and recovering L-alanine from the culture.
摘要翻译：一种生产L-丙氨酸的方法，其包括在培养基中培养具有L-丙氨酸脱氢酶活性但几乎不具有丙氨酸脱水酶活性的节杆菌属的微生物，并且能够产生L-丙氨酸; 允许L-丙氨酸在培养物中积累; 并从培养物中回收L-丙氨酸。

2. 发明授权

US3939042A Process for the production of L-glutamic acid 失效
标题翻译：生产L-谷氨酸的方法
公开(公告)号：US3939042A
公开(公告)日：1976-02-17
申请号：US495272
申请日：1974-08-06
申请人： Kiyoshi Nakayama , Mamoru Kobata , Yoshitake Tanaka , Tadaaki Nomura , Ryoichi Katsumata
发明人： Kiyoshi Nakayama , Mamoru Kobata , Yoshitake Tanaka , Tadaaki Nomura , Ryoichi Katsumata
IPC分类号： C12P13/14 , C12D13/06 , C12K1/02
CPC分类号： C12P13/14 , Y10S435/822 , Y10S435/874
摘要： High yields of L-glutamic acid are produced by culturing mutant strains of microorganisms of the genera Pseudomonas and Protaminobacter in a culture medium containing methanol as the principal source of assimilable carbon. L-glutamic acid is accumulated in the culture liquor and is isolated therefrom.
摘要翻译：通过在含有甲醇作为可同化碳的主要来源的培养基中培养假单胞菌属和Protaminobacter属的微生物的突变菌株来产生高产量的L-谷氨酸。 L-谷氨酸在培养液中积聚并从其中分离出来。

3. 发明授权

US4683220A Novel physiologically active substances K-26, a process for preparation thereof and a pharmaceutical composition containing the same 失效
标题翻译：新型生理活性物质K-26，其制备方法和含有它的药物组合物
公开(公告)号：US4683220A
公开(公告)日：1987-07-28
申请号：US912685
申请日：1986-09-26
申请人： Masayuki Yamato , Hiroshi Kase , Isao Kawamoto , Masaji Kasai , Kunikatsu Shirahata , Takashi Deguchi , Katsuichi Shuto , Akira Karasawa , Ryo Okachi , Kiyoshi Nakayama
发明人： Masayuki Yamato , Hiroshi Kase , Isao Kawamoto , Masaji Kasai , Kunikatsu Shirahata , Takashi Deguchi , Katsuichi Shuto , Akira Karasawa , Ryo Okachi , Kiyoshi Nakayama
IPC分类号： C12P21/00 , A61K35/74 , A61K38/00 , A61P9/12 , C07F9/38 , C07F9/40 , C07K5/06 , C07K14/005 , C07K14/195 , C07K14/41 , C12P21/02 , C12R1/01 , A61K37/64
CPC分类号： C07F9/3808 , C07F9/3882 , C07F9/4006 , C07F9/4056 , C07K5/06191 , A61K38/00
摘要： Disclosed is a novel physiologically active substance, K-26, a process for preparation thereof and a pharmaceutical composition containing the same. The composition of matter, K-26, is useful as a hypotensive agent.
摘要翻译：公开了一种新的生理活性物质K-26，其制备方法和含有该生物活性物质的药物组合物。物质的组成，K-26，作为一种降压剂是有用的。

4. 发明授权

US4522812A Novel physiologically active substance K-4, a process for preparation thereof and a pharmaceutical composition containing the same 失效
标题翻译：新型生理活性物质K-4，其制备方法和含有它的药物组合物
公开(公告)号：US4522812A
公开(公告)日：1985-06-11
申请号：US407082
申请日：1982-08-11
申请人： Toshiro Koguchi , Hiroshi Kase , Isao Kawamoto , Masaji Kasai , Kunikatsu Shirahata , Ryo Okachi , Kiyoshi Nakayama
发明人： Toshiro Koguchi , Hiroshi Kase , Isao Kawamoto , Masaji Kasai , Kunikatsu Shirahata , Ryo Okachi , Kiyoshi Nakayama
IPC分类号： C12N1/20 , A61K35/74 , A61K38/00 , A61P9/12 , C07F9/38 , C07F9/40 , C07G99/00 , C12P1/06 , C12R1/03 , C07C103/52 , A61K37/02
CPC分类号： C07F9/4056 , C07F9/3808 , C07F9/3882 , C07F9/4006 , A61K38/00
摘要： Disclosed is a novel physiologically active substance K-4 which has a hypotensive activity, a process production thereof and a pharmaceutical composition containing the same.
摘要翻译：公开了一种具有低血压活性的新型生理活性物质K-4，其制备方法和含有它们的药物组合物。

5. 再颁专利

USRE28886E Method for preparing cytidine diphosphate choline 失效
标题翻译：胞苷二磷酸胆碱制备方法
公开(公告)号：USRE28886E
公开(公告)日：1976-06-29
申请号：US366263
申请日：1973-06-04
申请人： Kiyoshi Nakayama , Hiroshi Hagino
发明人： Kiyoshi Nakayama , Hiroshi Hagino
IPC分类号： C07H19/10 , C12P19/30
CPC分类号： C07H19/10 , C12P19/305
摘要： Cytidine diphosphate choline is prepared by culturing an aqueous reaction liquor containing (a) at least one of the class consisting of choline or phosphoryl choline; (b) at least one of the class consisting of cytidine, cytidine-5'-monophosphate, cytidine-5'-diphosphate or cytidine-5'triphosphate; (c) enzyme systems of bacteria, yeasts or molds; (d) phosphate ion and (e) at least one of the class consisting of magnesium ion and manganese ion and recovering cytidine diphosphate choline from said culturing liquor.

6. 发明授权

US4086137A Process for the production of L-arginine by fermentation 失效
标题翻译：通过发酵生产L-精氨酸的方法
公开(公告)号：US4086137A
公开(公告)日：1978-04-25
申请号：US766630
申请日：1977-02-08
申请人： Kiyoshi Nakayama , Kazumi Araki , Hajime Yoshida
发明人： Kiyoshi Nakayama , Kazumi Araki , Hajime Yoshida
IPC分类号： C12P13/10 , C12R1/07 , C12D13/06
CPC分类号： C12P13/10 , Y10S435/839
摘要： L-arginine is produced by fermentation of a microorganism belonging to the genus Bacillus capable of producing L-arginine and having a nutritional requirement for at least one compound of the group consisting of methionine, histidine, threonine, proline, isoleucine, lysine, adenine, guanine and uracil or its precursor. L-arginine is accumulated in the culture liquor and may be recovered therefrom.
摘要翻译： L-精氨酸通过发酵能产生L-精氨酸的芽孢杆菌属的微生物产生，并且对至少一种由甲硫氨酸，组氨酸，苏氨酸，脯氨酸，异亮氨酸，赖氨酸，腺嘌呤，鸟嘌呤和尿嘧啶或其前体。 L-精氨酸在培养液中积聚并可从其中回收。

7. 发明申请

US20120287262A1 IN-VEHICLE INFORMATION APPARATUS 有权
标题翻译：车内信息装置
公开(公告)号：US20120287262A1
公开(公告)日：2012-11-15
申请号：US13318376
申请日：2011-01-26
申请人： Kiyoshi Nakayama , Masato Takahashi
发明人： Kiyoshi Nakayama , Masato Takahashi
IPC分类号： H04N7/18
CPC分类号： G01C21/3688 , B60K35/00 , B60K37/06 , B60K2350/1004 , B60K2350/1032 , B60K2350/1096
摘要： An in-vehicle information apparatus according to the invention includes a main unit having a display device, and a navigation unit providing a navigation function to the main unit. The navigation unit includes a navigation processing unit which executes a process concerning the navigation function, a sub unit providing an addition function to the navigation unit, and a navigation unit screen generating unit which generates a navigation unit screen for displaying information concerning a function which the navigation unit provides. The main unit includes an operation unit which receives an input for selecting a function from a user, a main unit screen generating unit which generates a main unit screen for displaying information concerning a function which the main unit provides, and a video selector which selects one of the navigation unit screen and the main unit screen and provides the selected one to the display device. The addition function provided by the sub unit is executed by an interruption process, and the video selector selects one of the navigation unit screen and the main unit screen based on the function inputted to the operation unit and the addition function executed by the interruption process.
摘要翻译：根据本发明的车载信息装置包括具有显示装置的主单元和向主单元提供导航功能的导航单元。导航单元包括执行与导航功能有关的处理的导航处理单元，向导航单元提供加法功能的子单元，以及导航单元画面生成单元，其生成导航单元屏幕，用于显示有关功能的信息，导航单位提供。主单元包括接收用户选择功能的输入的操作单元，产生用于显示与主单元提供的功能有关的信息的主单元屏幕的主单元屏幕生成单元，以及选择一个的导航单元屏幕和主单元屏幕，并将所选择的屏幕提供给显示设备。由子单元提供的附加功能通过中断处理执行，并且视频选择器基于输入到操作单元的功能和通过中断处理执行的加法函数来选择导航单元屏幕和主单元屏幕中的一个。

8. 发明申请

US20100130492A1 MORPHOLINOPURINE DERIVATIVES 有权
标题翻译：多环芳烃衍生物
公开(公告)号：US20100130492A1
公开(公告)日：2010-05-27
申请号：US12579175
申请日：2009-10-14
申请人： Kiyoshi Nakayama , Kazuyuki Sugita , Masaki Setoguchi , Yuichi Tominaga , Masanori Saitou , Takashi Odagiri
发明人： Kiyoshi Nakayama , Kazuyuki Sugita , Masaki Setoguchi , Yuichi Tominaga , Masanori Saitou , Takashi Odagiri
IPC分类号： A61K31/5377 , C07D487/04 , A61P43/00 , A61P35/00
CPC分类号： C07D473/34
摘要： There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity: wherein R1, R2, R3, R4, Ra, Rb, Rc, and X each have the same meaning as defined in the specification.
摘要翻译：提供抑制磷脂酰肌醇3-激酶（PI3K）和/或雷帕霉素（mTOR）的哺乳动物靶标并表现出抗肿瘤活性的新型化合物。本发明提供具有抑制PI3K和/或mTOR的各种取代基并表现出抗肿瘤活性的下述式（1）表示的化合物：其中R1，R2，R3，R4，Ra，Rb，Rc和X各自具有与本说明书中定义的含义相同。

9. 发明授权

US06823859B2 Flat heating surface type gas stove 失效
标题翻译：平面加热表面式燃气灶
公开(公告)号：US06823859B2
公开(公告)日：2004-11-30
申请号：US10602723
申请日：2003-06-25
申请人： Yutaka Yamada , Kiyoshi Nakayama
发明人： Yutaka Yamada , Kiyoshi Nakayama
IPC分类号： F24C300
CPC分类号： F24C3/067 , Y02B40/166
摘要： There is disclosed a novel flat heating surface type gas stove which is capable of heating a heating substance across a heat resistance glass at practically applicable heating efficiency, overcoming any inconvenience resulting from the exposure of flame and facilitating the cleaning of the gas stove. This gas stove 10 comprises a heat resistance glass top plate 12 which is disposed over a burner 15, wherein a gas-permeable porous body 40 is disposed below said top plate 12, and a space between said top plate 12 and a surface of said gas-permeable porous body 40 is assigned to a combustion space S. Combustion gas generated is designed to be discharged through said gas-permeable porous body 40. As high-temperature combustion gas passes through said gas-permeable porous body 40, radiant heat B is generated from the surface of said gas-permeable porous body 40. Since the heating substance 4 is heated by both of heat conduction and radiation, high heating efficiency can be achieved.
摘要翻译：公开了一种新颖的平面加热表面式燃气灶，其能够以实际可用的加热效率加热加热物质穿过耐热玻璃，克服了由于火焰的暴露而导致的任何不便，并且便于清洁燃气灶。该气体炉10包括设置在燃烧器15上方的耐热性玻璃顶板12，其中透气性多孔体40设置在所述顶板12的下方，并且所述顶板12与所述气体的表面之间的空间将透气性多孔体40分配给燃烧空间S.产生的燃烧气体被设计成通过所述透气性多孔体40排出。当高温燃烧气体通过所述透气性多孔体40时，辐射热B为从所述透气性多孔体40的表面产生。由于加热物质4被热传导和辐射两者加热，因此可以实现高的加热效率。

10. 发明授权

US5739201A Two-pack crosslinking aqueous adhesive 失效
标题翻译：双组份交联水性胶粘剂
公开(公告)号：US5739201A
公开(公告)日：1998-04-14
申请号：US795309
申请日：1997-02-04
申请人： Masaki Ugai , Kiyoshi Nakayama , Masahito Mori
发明人： Masaki Ugai , Kiyoshi Nakayama , Masahito Mori
IPC分类号： C09J201/02 , C09J11/06 , C09J201/04 , C09J201/08 , C08L83/00
CPC分类号： C09J201/04 , C09J201/08
摘要： A two-pack, crosslinking aqueous adhesive, which comprises (A) an adhesive component comprising an aqueous liquid of a polymer containing at least one of a halogen atom, a carboxyl group or an ester bond in the backbone chain or side chain of the polymer molecule and (B) a curing component comprising an active silyl compound containing at least one of an amino group or an imino group in the molecule, which has excellent emulsion stability after mixing the components, long pot-life and excellent heat resistance and is suitable for adhesion of materials which require heat resistance such as interior automotive trims.
摘要翻译：一种双组分交联水性粘合剂，其包含（A）粘合剂组分，其包含聚合物的水性液体，所述聚合物含有聚合物的主链或侧链中的至少一个卤素原子，羧基或酯键分子和（B）包含在分子中含有氨基或亚氨基中的至少一个的活性甲硅烷基化合物的固化组分，其在混合组分后具有优异的乳液稳定性，长的适用期和优异的耐热性，并且是合适的用于粘附需要耐热性的材料，例如内部汽车饰件。

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