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    • 3. 发明授权
    • Methods and devices for rotator cuff repair
    • 肩袖修复方法及装置
    • US08016883B2
    • 2011-09-13
    • US11671102
    • 2007-02-05
    • Struan ColemanDavid P. MartinSaid RizkAjay AhujaSimon F. Williams
    • Struan ColemanDavid P. MartinSaid RizkAjay AhujaSimon F. Williams
    • A61F2/08
    • A61F2/08A61B17/0401A61B17/0469A61B17/064A61B17/0642A61B2017/00893A61L27/18A61L2430/10C08L67/04
    • Interposition and augmentation devices for tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using arthroscopic methods. The devices are preferably derived from biocompatible polyhydroxyalkanoates, and preferably from copolymers or homopolymers of 4-hydroxybutyrate. The devices may be delivered arthroscopically, and offer additional benefits such as support for the surgical repair, high initial strength, prolonged strength retention in vivo, flexibility, anti-adhesion properties, improved biocompatibility, an ability to remodel in vivo to healthy tissue, minimal risk for disease transmission or to potentiate infection, options for fixation including sufficiently high strength to prevent suture pull out or other detachment of the implanted device, eventual absorption eliminating future risk of foreign body reactions or interference with subsequent procedures, competitive cost, and long-term mechanical stability. The devices are also particularly suitable for use in pediatric populations where their eventual absorption should not hinder growth.
    • 已经开发了用于肌腱和韧带修复的包括肩袖修复的插入和增大装置以及使用关节镜方法进行递送的方法。 所述装置优选衍生自生物相容性聚羟基链烷酸酯,优选衍生自4-羟基丁酸酯的共聚物或均聚物。 这些装置可以关节镜地传送,并且提供额外的益处,例如支持手术修复,高初始强度,在体内延长的强度保持力,柔韧性,抗粘连性,改善的生物相容性,体内重塑健康组织的能力,最小化 疾病传播的风险或增强感染的选择,包括足够高的强度的选项,以防止缝合线拔出或植入装置的其他脱离,最终吸收消除异物反应的未来风险或干扰后续程序,竞争性成本, 长期机械稳定性。 这些装置还特别适用于儿科人群,其最终吸收不应阻碍生长。
    • 4. 发明授权
    • Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
    • 包含聚-4-羟基丁酸取代膜和共聚物的医疗器械
    • US07943683B2
    • 2011-05-17
    • US11931850
    • 2007-10-31
    • Said RizkDavid P. MartinKicherl HoSimon F. Williams
    • Said RizkDavid P. MartinKicherl HoSimon F. Williams
    • C08G63/06B29C47/00
    • A61L27/34A61L27/18A61L31/10B29C55/005B29C55/04B29C55/12B29K2067/00B29K2067/046B29K2995/006C08L67/04
    • Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 μm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm2, tensile modulus less than 181 kgf/mm2, and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film's original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.
    • 用于制造具有以下特性中的一种或多种的可吸收聚合物膜的连续加工方法:高韧性,低模量,高拉伸强度和小于10mm,更优选小于1mm,更优选小于100μm的厚度具有 已经开发 在优选的实施方案中,聚合物是聚羟基链烷酸酯,并且在最优选的实施方案中,聚合物包含4-羟基丁酸酯。 特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的膜,其中所述膜的拉伸强度大于5.5kgf / mm 2,拉伸模量小于181kgf / mm 2,断裂伸长率为10-500% 其中所述膜通过连续方法如熔体挤出或溶剂浇铸得到,然后在一个或多个方向上定向至超过膜的原始长度的25%。 这些可以用于各种目的,包括制造医疗器械。
    • 8. 发明申请
    • Methods and Devices for Rotator Cuff Repair
    • 旋转器袖带修复的方法和装置
    • US20070198087A1
    • 2007-08-23
    • US11671102
    • 2007-02-05
    • Struan ColemanDavid P. MartinSaid RizkAjay AhujaSimon F. Williams
    • Struan ColemanDavid P. MartinSaid RizkAjay AhujaSimon F. Williams
    • A61F2/08A61F5/00A61B17/04
    • A61F2/08A61B17/0401A61B17/0469A61B17/064A61B17/0642A61B2017/00893A61L27/18A61L2430/10C08L67/04
    • Interposition and augmentation devices for tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using arthroscopic methods. The devices are preferably derived from biocompatible polyhydroxyalkanoates, and preferably from copolymers or homopolymers of 4-hydroxybutyrate. The devices may be delivered arthroscipiclly, and offer additional benefits such as support for the surgical repair, high initial strength, prolonged strength retention in vivo, flexibility, anti-adhesion properties, improved biocompatibility, an ability to remodel in vivo to healthy tissue, minimal risk for disease transmission or to potentiate infection, options for fixation including sufficiently high strength to prevent suture pull out or other detachment of the implanted device, eventual absorption eliminating future risk of foreign body reactions or interference with subsequent procedures, competitive cost, and long-term mechanical stability. The device are also particularly suitable for use in pediatric populations where their eventual absorption should not hinder growth.
    • 已经开发了用于肌腱和韧带修复的包括肩袖修复的插入和增大装置以及使用关节镜方法进行递送的方法。 所述装置优选衍生自生物相容性聚羟基链烷酸酯,优选衍生自4-羟基丁酸酯的共聚物或均聚物。 这些装置可以被关节镜递送,并提供额外的益处,例如支持手术修复,高初始强度,在体内延长的强度保持力,柔韧性,抗粘连性,改善的生物相容性,体内重塑健康组织的能力,最小化 疾病传播的风险或增强感染的选择,包括足够高的强度的选项,以防止缝合线拔出或植入装置的其他脱离,最终吸收消除异物反应的未来风险或干扰后续程序,竞争性成本, 长期机械稳定性。 该装置还特别适用于儿科人群,其最终吸收不应阻碍生长。