专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4735959A Carboxylic acid amides and pharmaceutical compositions containing them 失效
标题翻译：羧酸酰胺和含有它们的药物组合物
公开(公告)号：US4735959A
公开(公告)日：1988-04-05
申请号：US734252
申请日：1985-05-14
申请人： Wolfgang Grell , Gerhart Griss , Robert Sauter , Rudolf Hurnaus , Eckhard Rupprecht , Nikolaus Kaubisch , Joachim Kahling , Bernhard Eisele
发明人： Wolfgang Grell , Gerhart Griss , Robert Sauter , Rudolf Hurnaus , Eckhard Rupprecht , Nikolaus Kaubisch , Joachim Kahling , Bernhard Eisele
IPC分类号： C07D207/26 , C07D207/27 , C07D209/44 , C07D211/22 , C07D211/46 , C07D211/70 , C07D211/74 , C07D213/40 , C07D213/80 , C07D217/04 , C07D223/04 , C07D225/02 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D295/192 , C07D317/22 , C07D473/08 , C07D491/10 , A61K31/445 , A61K31/165 , C07C103/82 , C07D295/14
CPC分类号： C07D207/27 , C07D209/44 , C07D211/22 , C07D211/46 , C07D211/70 , C07D211/74 , C07D213/40 , C07D213/80 , C07D217/04 , C07D223/04 , C07D225/02 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D295/192 , C07D317/22 , C07D473/08 , C07D491/10 , Y10S514/866
摘要： There are described novel carboxylic acid derivatives of the formula ##STR1## and derivatives of the formula ##STR2## and the addition salts thereof, which exhibit an effect on the intermediary metabolism. Furthermore, the compounds of Formula Ia as well as the compounds of Formula I possess blood-sugar lowering properties.
摘要翻译：描述了式（I）的新型羧酸衍生物和式（Ia）的衍生物及其加成盐，其对中间代谢具有影响。此外，式Ia化合物以及式I化合物具有降血糖特性。

2. 发明授权

US4343811A 2[3-(4-Chlorophenyl)-1,2-dimethyl-1H-indol-5-yloxy]-2-methyl propanoic acid and hyperlipidemic or atheosclerotic use thereof 失效
标题翻译： 2 [3-（4-氯苯基）-1,2-二甲基-1H-吲哚-5-基氧基] -2-甲基丙酸和其高脂血症或动脉粥样硬化用途
公开(公告)号：US4343811A
公开(公告)日：1982-08-10
申请号：US126006
申请日：1980-02-29
申请人： Rudolf Hurnaus , Gerhart Griss , Wolfgang Grell , Robert Sauter , Bernhard Eisele , Nikolaus Kaubisch , Eckhard Rupprecht , Joachim Kahling
发明人： Rudolf Hurnaus , Gerhart Griss , Wolfgang Grell , Robert Sauter , Bernhard Eisele , Nikolaus Kaubisch , Eckhard Rupprecht , Joachim Kahling
IPC分类号： C07D401/04 , A61K31/40 , A61K31/403 , A61K31/44 , A61K31/4427 , A61P3/06 , A61P9/10 , C07D209/04 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/14 , C07D209/43 , C07D401/06 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/14 , C07D487/04 , Y10S514/824
摘要： This invention relates to novel indole derivatives of formula ##STR1## and the non-toxic, pharmacologically acceptable salts thereof. These compounds exhibit desirable pharmacological properties, especially lipid-level lowering and anti-atherosclerotic activity. The compounds of the invention may be prepared by, for example, alkylation of a corresponding hydroxy indole.
摘要翻译：本发明涉及式IMA的新型吲哚衍生物及其无毒的药理学上可接受的盐。这些化合物显示出所需的药理学性质，特别是脂质降低和抗动脉粥样硬化活性。本发明的化合物可以通过例如相应的羟基吲哚的烷基化来制备。

3. 发明授权

US4010279A Biphenyloxy derivatives and antihyperlipidemic use 失效
标题翻译：苯二酚衍生物和抗血小板药物使用
公开(公告)号：US4010279A
公开(公告)日：1977-03-01
申请号：US643700
申请日：1975-12-23
申请人： Gerhart Griss , Wolfgang Grell , Rudolf Hurnaus , Robert Sauter , Bernhard Eisele , Nikolaus Kaubisch , Matyas Leitold
发明人： Gerhart Griss , Wolfgang Grell , Rudolf Hurnaus , Robert Sauter , Bernhard Eisele , Nikolaus Kaubisch , Matyas Leitold
IPC分类号： A61K31/165 , A61K31/19 , A61K31/22 , C07C67/00 , C07C217/62 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/17 , C07C233/18 , C07C233/60 , C07C233/68 , C07C235/34 , C07C235/38 , C07D209/48 , C07D213/82 , A61K31/24 , C07C103/84
CPC分类号： C07D209/48 , C07C217/62 , C07D213/82
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is straight or branched alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenylalkyl, phenylalkenyl, pyridyl or ##STR2## where X, Y and Z are each hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms,R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms,R.sub.3 is hydroxymethyl, carboxyl, alkoxycarbonyl of 2 to 7 carbon atoms or cycloalkoxycarbonyl or 4 to 8 carbon atoms,A is --CO--NH-- or --NH--CO--, andn is 1, 2 or 3,And, when R.sub.3 is carboxyl, non-toxic salts thereof formed with an inorganic or organic base; the compounds as well as the salts are useful as antihyperlipidemics.

4. 发明授权

US4042711A Derivatives of biphenyloxy-lower alkanoic acids, salts thereof and their use as antihyperlipidemics 失效
标题翻译：联苯氧基 - 低级链烷酸的衍生物，其盐及其作为抗高脂血症的用途
公开(公告)号：US4042711A
公开(公告)日：1977-08-16
申请号：US740829
申请日：1976-11-11
申请人： Gerhart Griss , Wolfgang Grell , Rudolf Hurnaus , Robert Sauter , Bernhard Eisele , Nikolaus Kaubisch , Matyas Leitold
发明人： Gerhart Griss , Wolfgang Grell , Rudolf Hurnaus , Robert Sauter , Bernhard Eisele , Nikolaus Kaubisch , Matyas Leitold
IPC分类号： C07C217/62 , C07D209/48 , C07D213/82 , C07C103/46 , C07C103/737 , C07C103/84
CPC分类号： C07D209/48 , C07C217/62 , C07D213/82
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is straight or branched alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenylalkyl, phenylalkenyl, pyridyl or ##STR2## where X, Y and Z are each hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms,R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms,A is --CO--NH-- or --NH--CO--, andn is 1, 2 or 3,And non-toxic salts thereof formed with an inorganic or organic base; the compounds as well as the salts are useful as antihyperlipidemics.
摘要翻译：其中R 1为1至6个碳原子的直链或支链烷基，3至6个碳原子的环烷基，苯基烷基，苯基烯基，吡啶基或者其中X，Y和Z各自为氢，卤素， 1至3个碳原子的烷基或1至3个碳原子的烷氧基，R 2是氢或1至4个碳原子的烷基，A是-CO-NH-或-NH-CO-，N IS 1,2或3 ，以及与无机或有机基体形成的非毒性盐; 化合物作为抗生素可用作销售。

5. 发明授权

US4414225A Azepine derivatives and their anti-thrombotic compositions and methods 失效
标题翻译： Azepine衍生物及其抗血栓形成和方法
公开(公告)号：US4414225A
公开(公告)日：1983-11-08
申请号：US348496
申请日：1982-02-12
申请人： Robert Sauter , Gerhart Griss , Wolfgang Grell , Rudolf Hurnaus , Bernhard Eisele , Walter Haarmann , Eckhard Rupprecht
发明人： Robert Sauter , Gerhart Griss , Wolfgang Grell , Rudolf Hurnaus , Bernhard Eisele , Walter Haarmann , Eckhard Rupprecht
IPC分类号： C07D487/02 , A61K31/55 , A61P3/06 , A61P7/02 , C07D223/06 , C07D487/04 , C07D491/02 , C07D491/04 , C07D491/048 , C07D495/04 , A61K31/40
CPC分类号： C07D487/04 , C07D223/06 , C07D491/04 , C07D495/04
摘要： Compounds of the formula ##STR1## wherein n and m are each 1, 2 or 3, and the sum of n+m is 4;R.sub.1 is alkyl; alkenyl; unsubstituted, mono- or di-substituted aralkyl; unsubstituted, mono- or di-substituted benzoyl; alkoxycarbonyl; aralkoxycarbonyl; or, when m and n are each 2 and/or R.sub.2 and R.sub.3 are other than both hydrogen at the same time, also hydrogen;one of R.sub.2 and R.sub.3 is hydrogen or amino, and the other is carboxyl or alkoxycarbonyl; or, when R.sub.3 is hydrogen,R.sub.2 is hydrogen; amino; alkoxycarbonyl-amino; (unsubstituted or mono-substituted phenyl)-aminocarbonyl-; (unsubstituted or mono-substituted phenyl)ethylaminocarbonyl; azidocarbonyl; or hydrazinocarbonyl;X is oxygen, sulfur or ##STR2## where R.sub.4 is hydrogen; alkyl; phenyl-alkyl; or phenyl; non-toxic, pharmacologically acceptable acid addition salts thereof; and, when R.sub.2 or R.sub.3 is carboxyl, non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as antithrombotics.
摘要翻译：其中n和m各自为1,2或3，并且n + m的和为4; R1是烷基; 烯基; 未取代的，单或二取代的芳烷基; 未取代的，单或二取代的苯甲酰基; 烷氧基羰基芳烷氧羰基; 或者当m和n各自为2和/或R 2和R 3不同时为氢时，也为氢; R2和R3之一是氢或氨基，另一个是羧基或烷氧基羰基; 或当R3为氢时，R2为氢; 氨基; 烷氧基羰基 - 氨基; （未取代或单取代的苯基） - 氨基羰基 - ; （未取代或单取代的苯基）乙基氨基羰基; 叠氮羰基; 或肼基羰基; X是氧，硫或者其中R 4是氢; 烷基; 苯基 - 烷基; 或苯基; 无毒，药理学上可接受的酸加成盐; 并且当R 2或R 3为羧基时，与无机或有机碱形成的无毒的药学上可接受的盐。化合物及其盐可用作抗血栓形成剂。

6. 发明授权

US5455273A N,N-disubstituted arylcycloalkylamines, the salts thereof, pharmaceutical compositions containing these compounds and the use thereof and processes for preparing them 失效
标题翻译： N，N-二取代的芳基环烷基胺，其盐，含有这些化合物的药物组合物及其用途及其制备方法
公开(公告)号：US5455273A
公开(公告)日：1995-10-03
申请号：US154644
申请日：1993-11-19
申请人： Roland Maier , Peter Muller , Eberhard Woitun , Rudolf Hurnaus , Michael Mark , Bernhard Eisele , Ralph-Michael Budzinski , Gerhard Hallermayer
发明人： Roland Maier , Peter Muller , Eberhard Woitun , Rudolf Hurnaus , Michael Mark , Bernhard Eisele , Ralph-Michael Budzinski , Gerhard Hallermayer
IPC分类号： A61K31/18 , A61K31/27 , A61P1/16 , A61P3/06 , C07C211/27 , C07C211/35 , C07C233/41 , C07C233/62 , C07C233/79 , C07C237/06 , C07C255/24 , C07C311/07 , C07C311/20 , C07D333/38 , A61K31/165
CPC分类号： C07C311/20 , C07C233/62 , C07C233/79 , C07C237/06 , C07C255/24 , C07C311/07 , C07D333/38 , C07C2101/02 , C07C2101/14 , C07C2102/04 , C07C2102/10
摘要： The invention relates to N,N-disubstituted arylcycloalkylamines of general formula ##STR1## wherein n, m, A, X and R.sup.1 to R.sup.7 are defined as in claim 1, the isomers, isomer mixtures and salts thereof, which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis.
摘要翻译：本发明涉及通式为（I）的N，N-二取代的芳基环烷基胺，其中n，m，A，X和R 1至R 7如权利要求1所定义，其异构体，异构体混合物和盐具有有价值的特性，特别是对胆固醇生物合成的抑制作用。

7. 发明授权

US06346545B1 Urethanes, thio and dithio analogues and their use as inhibitors of cholesterol biosynthesis 有权
标题翻译：聚氨酯，硫代和二硫代类似物及其作为胆固醇生物合成抑制剂的用途
公开(公告)号：US06346545B1
公开(公告)日：2002-02-12
申请号：US09275318
申请日：1999-03-24
申请人： Roland Maier , Rudolf Hurnaus , Michael Mark , Bernhard Eisele , Peter Mueller , Gebhard Adelgoss , Gebhard Schilcher
发明人： Roland Maier , Rudolf Hurnaus , Michael Mark , Bernhard Eisele , Peter Mueller , Gebhard Adelgoss , Gebhard Schilcher
IPC分类号： A61K3127
CPC分类号： C07D295/135 , C07C271/24 , C07C271/56 , C07C333/06 , C07C333/24 , C07C2601/14 , Y02P20/55
摘要： The present invention relates to urethanes and the thio and dithio analogues thereof of general formula wherein m, n, A, X, Y and R1 to R8 are defined as in claim 1, the enantiomers, diastereomers and the salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
摘要翻译：本发明涉及聚氨酯，其一般形式的n，A，X，Y和R 1至R 8的硫代和二硫类似物如权利要求1中所定义，其对映异构体，非对映异构体及其盐，特别是生理上可接受的酸加成其具有有价值的性质，特别是对胆固醇生物合成的抑制作用，含有这些化合物的药物组合物，其用途和制备方法。

8. 发明授权

US5466687A Arylidene-1-azacycloalkanes and arylalkyl-1-azacyclo-alkanes, their salts, medicaments containing these compounds and their use, and processes for their preparation 失效
标题翻译：亚芳基-1-氮杂环烷烃和芳基烷基-1-氮杂环烷烃，其盐，含有这些化合物的药物及其用途及其制备方法
公开(公告)号：US5466687A
公开(公告)日：1995-11-14
申请号：US218092
申请日：1994-03-25
申请人： Roland Maier , Peter Muller , Eberhard Woitun , Rudolf Hurnaus , Michael Mark , Bernhard Eisele , Ralph-Michael Budzinski , Gerhard Hallermayer
发明人： Roland Maier , Peter Muller , Eberhard Woitun , Rudolf Hurnaus , Michael Mark , Bernhard Eisele , Ralph-Michael Budzinski , Gerhard Hallermayer
IPC分类号： C07D403/10 , C07D413/10 , C07D413/14 , C07D417/10 , A61K31/55 , A61K31/54 , C07D279/06 , C07D405/10
CPC分类号： C07D403/10 , C07D413/10 , C07D413/14 , C07D417/10
摘要： The invention relates to arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes of the general formula ##STR1## (wherein n, m, p, A, W.sup.1, W.sup.2, X, Y, and R.sup.1 to R.sup.11 are as defined in claim 1) and the isomers, isomer mixtures and salts thereof, which have useful properties, in particular an inhibitory effect on cholesterol biosynthesis.
摘要翻译：本发明涉及通式为（I）（其中n，m，p，A，W 1，W 2，X，Y和R 1至R 11如所定义的亚芳基-1-氮杂环烷烃和芳基烷基-1-氮杂环烷烃权利要求1）及其异构体，异构体混合物和盐，其具有有用的特性，特别是对胆固醇生物合成的抑制作用。

9. 发明授权

US06339096B1 Urethanes derived from azacycloalkanes, the thio and dithio analogues thereof and their use as cholesterol biosynthesis inhibitors 有权
标题翻译：衍生自氮杂环烷烃的聚氨酯，其硫代和二硫类似物及其作为胆固醇生物合成抑制剂的用途
公开(公告)号：US06339096B1
公开(公告)日：2002-01-15
申请号：US09275317
申请日：1999-03-24
申请人： Roland Maier , Rudolf Hurnaus , Michael Mark , Bernhard Eisele , Peter Mueller , Gebhard Schilcher , Gebhard Adelgoss
发明人： Roland Maier , Rudolf Hurnaus , Michael Mark , Bernhard Eisele , Peter Mueller , Gebhard Schilcher , Gebhard Adelgoss
IPC分类号： A61K31445
CPC分类号： C07D211/70 , C07D211/26 , C07D211/32 , C07D211/54
摘要： The present invention relates to urethanes derived from azacycloalkanes and the thio and dithio analogues thereof of general formula wherein m, n, A, X, Y, E and R1 to R8 are defined as in claim 1, the enantiomers, diastereomers and the salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
摘要翻译：本发明涉及衍生自氮杂环烷烃的氨基甲酸酯及其一般形式的n，A，X，Y，E和R 1至R 8的硫代和二硫代类似物，如权利要求1中所定义，其对映异构体，非对映体及其盐，特别是其生理上可接受的酸加成盐，其具有有价值的性质，特别是对胆固醇生物合成的抑制作用，含有这些化合物的药物组合物，其用途和制备方法。

10. 发明申请

US20080217076A1 Method and Device for Bidirectional Single-Wire Data Transmission 有权
标题翻译：双向单线数据传输方法与装置
公开(公告)号：US20080217076A1
公开(公告)日：2008-09-11
申请号：US10566916
申请日：2004-07-01
申请人： Rolf Kraemer , Ulrich Bentel , Bernhard Eisele , Markus Ketterer , Uwe Schiller , Juergen Stein
发明人： Rolf Kraemer , Ulrich Bentel , Bernhard Eisele , Markus Ketterer , Uwe Schiller , Juergen Stein
IPC分类号： H04L5/14 , H04L25/49
CPC分类号： H04L25/4902 , H04L5/1423 , Y10T307/826
摘要： A device and a method for bidirectional single-wire data transmission of data information between an electronic control unit and at least one peripheral unit. A predefined constant voltage and/or a predefined constant current is applied to a driver device of the electronic control unit to produce voltage-coded and/or current-coded information. The voltage-coded and/or current-coded information is transmitted from the driver device of the electronic control unit to a driver device 30 of the peripheral unit via a single-wire line. At least the driver logic of the driver device and/or the communication logic of the peripheral unit are triggered and powered through the current flow. Information occurring on the peripheral unit is current-coded and/or voltage coded due to the triggering thereof. The current-coded and/or voltage-coded information are uploaded from the driver device of the peripheral unit to the driver device of the electronic control unit during the triggering of the peripheral unit via the same single-wire line.
摘要翻译：一种用于在电子控制单元和至少一个外围单元之间的数据信息的双向单线数据传输的装置和方法。将预定义的恒定电压和/或预定义的恒定电流施加到电子控制单元的驱动器装置以产生电压编码和/或电流编码信息。电压编码和/或电流编码信息经由单线线路从电子控制单元的驱动器装置发送到外围单元的驱动器装置30。至少驱动器装置的驱动器逻辑和/或外围单元的通信逻辑被触发并通过电流进行供电。在外围单元上发生的信息由于其触发而被电流编码和/或电压编码。在通过相同的单线线路触发外围单元期间，将电流编码和/或电压编码信息从外围单元的驱动器装置上传到电子控制单元的驱动器装置。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式