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1. 发明授权

US4414225A Azepine derivatives and their anti-thrombotic compositions and methods 失效
标题翻译： Azepine衍生物及其抗血栓形成和方法
公开(公告)号：US4414225A
公开(公告)日：1983-11-08
申请号：US348496
申请日：1982-02-12
申请人： Robert Sauter , Gerhart Griss , Wolfgang Grell , Rudolf Hurnaus , Bernhard Eisele , Walter Haarmann , Eckhard Rupprecht
发明人： Robert Sauter , Gerhart Griss , Wolfgang Grell , Rudolf Hurnaus , Bernhard Eisele , Walter Haarmann , Eckhard Rupprecht
IPC分类号： C07D487/02 , A61K31/55 , A61P3/06 , A61P7/02 , C07D223/06 , C07D487/04 , C07D491/02 , C07D491/04 , C07D491/048 , C07D495/04 , A61K31/40
CPC分类号： C07D487/04 , C07D223/06 , C07D491/04 , C07D495/04
摘要： Compounds of the formula ##STR1## wherein n and m are each 1, 2 or 3, and the sum of n+m is 4;R.sub.1 is alkyl; alkenyl; unsubstituted, mono- or di-substituted aralkyl; unsubstituted, mono- or di-substituted benzoyl; alkoxycarbonyl; aralkoxycarbonyl; or, when m and n are each 2 and/or R.sub.2 and R.sub.3 are other than both hydrogen at the same time, also hydrogen;one of R.sub.2 and R.sub.3 is hydrogen or amino, and the other is carboxyl or alkoxycarbonyl; or, when R.sub.3 is hydrogen,R.sub.2 is hydrogen; amino; alkoxycarbonyl-amino; (unsubstituted or mono-substituted phenyl)-aminocarbonyl-; (unsubstituted or mono-substituted phenyl)ethylaminocarbonyl; azidocarbonyl; or hydrazinocarbonyl;X is oxygen, sulfur or ##STR2## where R.sub.4 is hydrogen; alkyl; phenyl-alkyl; or phenyl; non-toxic, pharmacologically acceptable acid addition salts thereof; and, when R.sub.2 or R.sub.3 is carboxyl, non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as antithrombotics.
摘要翻译：其中n和m各自为1,2或3，并且n + m的和为4; R1是烷基; 烯基; 未取代的，单或二取代的芳烷基; 未取代的，单或二取代的苯甲酰基; 烷氧基羰基芳烷氧羰基; 或者当m和n各自为2和/或R 2和R 3不同时为氢时，也为氢; R2和R3之一是氢或氨基，另一个是羧基或烷氧基羰基; 或当R3为氢时，R2为氢; 氨基; 烷氧基羰基 - 氨基; （未取代或单取代的苯基） - 氨基羰基 - ; （未取代或单取代的苯基）乙基氨基羰基; 叠氮羰基; 或肼基羰基; X是氧，硫或者其中R 4是氢; 烷基; 苯基 - 烷基; 或苯基; 无毒，药理学上可接受的酸加成盐; 并且当R 2或R 3为羧基时，与无机或有机碱形成的无毒的药学上可接受的盐。化合物及其盐可用作抗血栓形成剂。

2. 发明授权

US5188940A Method of determining the total fibrinolytic activity in the plasma 失效
标题翻译：确定等离子体中的总纤维素活性的方法
公开(公告)号：US5188940A
公开(公告)日：1993-02-23
申请号：US463177
申请日：1990-01-10
申请人： Jurgen Krause , Walter Haarmann
发明人： Jurgen Krause , Walter Haarmann
IPC分类号： C12Q1/37 , C12Q1/56 , G01N33/86
CPC分类号： G01N33/86 , C12Q1/56 , G01N2333/75 , G01N2333/968 , G01N2333/9726
摘要： A method of determining the total fibrinolytic activity in plasma, is characterized in thata) a quantity of fibrin sufficient to produce turbidity is added to a dilute platelet poor plasma sample or is produced in situ and the time dependent change in turbidity or the time-dependent formation of fibrin cleavage products is measured; orb) a chromogenic plasmin substrate and a quantity of fibrin, fibrinogen cleavage products or an enzyme which produces fibrin in situ, insufficient to produce turbidity, is added to a dilute platelet poor plasma sample and the time dependent color formation is measured.
摘要翻译：确定血浆中总的纤维蛋白溶解活性的方法的特征在于：a）足以产生浊度的纤维蛋白量被加入稀释的血小板贫血血浆样品中，或者原位产生，并且浊度或时间依赖性时间依赖性变化，测量纤维蛋白裂解产物的依赖性形成; 或b）色素性纤溶酶底物和一定量的纤维蛋白，纤维蛋白原裂解产物或原位产生纤维蛋白的酶，不足以产生浊度，加入稀释的血小板不良血浆样品中，并测量时间依赖性色素形成。

3. 发明授权

US4560685A 2-Piperazino-pteridines useful as antithrombotics and antimetastatics 失效
标题翻译： 2-Piperazino-pteridines可用作抗血栓形成和抗转移
公开(公告)号：US4560685A
公开(公告)日：1985-12-24
申请号：US621438
申请日：1984-06-18
申请人： Josef Roch , Josef Nickl , Erich Muller , Berthold Narr , Johannes Weisenberger , Rainer Zimmermann , Walter Haarmann
发明人： Josef Roch , Josef Nickl , Erich Muller , Berthold Narr , Johannes Weisenberger , Rainer Zimmermann , Walter Haarmann
IPC分类号： C07D475/06 , C07D475/08 , A61K31/505
CPC分类号： C07D475/06 , C07D475/08
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is phenylalkylamino, alkylamino, dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-thiomorpholino;R.sub.2 is dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-thiomorpholino; andR.sub.3 is halogen, alkoxy, alkylthio, phenylalkoxy or phenylalkylthio;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antithrombotics and antimetastatics.
摘要翻译：其中R 1是苯基烷基氨基，烷基氨基，二烷基氨基，哌啶子基，吗啉代，硫代吗啉代或1-氧代硫代吗啉代; R2是二烷基氨基，哌啶子基，吗啉代，硫代吗啉代或1-氧代硫代吗啉代; R3是卤素，烷氧基，烷硫基，苯基烷氧基或苯基烷硫基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作抗血栓形成和抗转移酶。

4. 发明授权

US4551464A Antithrombotic sulfoximino carbostyrils 失效
标题翻译：抗血栓形式的磺酰亚胺喹诺酮类
公开(公告)号：US4551464A
公开(公告)日：1985-11-05
申请号：US573964
申请日：1984-01-26
申请人： Erich Muller , Josef Nickl , Berthold Narr , Josef Roch , Walter Haarmann , Johannes M. Weisenberger
发明人： Erich Muller , Josef Nickl , Berthold Narr , Josef Roch , Walter Haarmann , Johannes M. Weisenberger
IPC分类号： A61K31/40 , A61K31/455 , A61K31/47 , C07D209/34 , C07D215/22 , C07D215/227 , C07D401/02 , C07D401/12 , C07D409/02 , C07D409/12
CPC分类号： C07D215/227 , C07D209/34 , C07D401/12 , C07D409/12
摘要： Compounds of the formula ##STR1## wherein n is 0 or 1;A is methylene, vinylene or ethylene optionally substituted by lower alkyl;B is alkylene;R.sub.1 is an optionally substituted alkyl, phenyl or naphthyl group, or a cycloalkyl or pyridyl group; andR.sub.2 is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antithrombotics.
摘要翻译：其中n为0或1的式（I）的化合物; A是任选被低级烷基取代的亚甲基，亚乙烯基或乙烯基; B是亚烷基; R1是任选取代的烷基，苯基或萘基，或环烷基或吡啶基; 并且R 2是氢或酰基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作抗血栓形成剂。

5. 发明授权

US4260621A 3-Amino-4-phenyl-6-piperidino-1H-pyrazolo[3,4-b]-pyridines and salts thereof 失效
标题翻译： 3-氨基-4-苯基-6-哌啶子基-1H-吡唑并[3,4-b] - 吡啶及其盐
公开(公告)号：US4260621A
公开(公告)日：1981-04-07
申请号：US75100
申请日：1979-09-13
申请人： Josef Roch , Erich Muller , Berthold Narr , Josef Nickl , Walter Haarmann
发明人： Josef Roch , Erich Muller , Berthold Narr , Josef Nickl , Walter Haarmann
IPC分类号： A61K31/435 , A61P7/02 , A61P29/00 , C07D213/85 , C07D471/04 , A61K31/445
CPC分类号： C07D471/04 , C07D213/85 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is unsubstituted, mono-substituted or di-substituted piperidino, where the substituents are selected from the group consisting of methyl, hydroxymethyl, hydroxyl, phenyl and benzyl;R.sub.2 is hydrogen, methyl or benzyl; andR.sub.3 is hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antiphlogistics and antithrombotics.
摘要翻译：其中R 1是未取代的，单取代的或二取代的哌啶子基，其中取代基选自甲基，羟甲基，羟基，苯基和苄基; R2是氢，甲基或苄基; R3为氢，卤素，1〜3个碳原子的烷基或1〜3个碳原子的烷氧基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作消炎和抗血栓形成。

6. 发明授权

US4191776A Biphenyl derivatives 失效
标题翻译：联苯衍生物
公开(公告)号：US4191776A
公开(公告)日：1980-03-04
申请号：US852714
申请日：1977-11-18
申请人： Josef Nickl , Erich Muller , Berthold Narr , Walter Haarmann , Wolfgang Schroter , Rudolf Kadatz
发明人： Josef Nickl , Erich Muller , Berthold Narr , Walter Haarmann , Wolfgang Schroter , Rudolf Kadatz
IPC分类号： C07C67/00 , C07C69/76 , C07C313/00 , C07C315/04 , C07C317/10 , C07C317/18 , C07C317/24 , C07C317/44 , C07C323/16 , C07C323/45 , C07C323/52 , C07C323/60 , C07C323/65 , C07D213/30 , C07D295/185 , C07C147/107 , A61K31/235 , A61K31/44 , C07C147/14
CPC分类号： C07D213/30 , C07C317/10 , C07C317/18 , C07C317/24 , C07C317/44 , C07C323/16 , C07C323/45 , C07C323/52 , C07C323/60 , C07C323/65 , C07D295/185 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, methyl, methoxy, methylthio or cyano;R.sub.2 is hydrogen or fluorine;R.sub.3 is carboxyl, (alkoxy of 1 to 6 carbon atoms)-carbonyl, methoxy-(alkoxy of 1 to 6 carbon atoms)-carbonyl, (alkenyloxy of 2 to 6 carbon atoms)-carbonyl, (aralkoxy of 7 to 12 carbon atoms)-carbonyl, phenoxy-carbonyl or pyridyl-methoxy-carbonyl,A is (alkyl of 1 to 3 carbon atoms)-methylene,m is 1 or 2; andn is 0, 1, 2 or 3;and, when R.sub.3 is carboxyl, non-toxic salts thereof formed with an inorganic or organic base. The compounds as well as the salts are useful as antithrombotics, anticholesteremics and anticoagulants.
摘要翻译：其中R 1是氢，氟，氯，溴，甲基，甲氧基，甲硫基或氰基的式 R2是氢或氟; R 3为羧基，（碳原子数1〜6的烷氧基） - 羰基，甲氧基 - （1〜6个碳原子的烷氧基） - 羰基，（2〜6个碳原子的烯氧基） - 羰基，（碳原子数为7〜12）） - 羰基，苯氧基 - 羰基或吡啶基 - 甲氧基 - 羰基，A是（1至3个碳原子的烷基） - 亚甲基，m是1或2; 并且n为0,1,2或3; 并且当R 3为羧基时，其无毒盐与无机或有机碱形成。化合物以及盐可用作抗血栓形成剂，抗胆固醇剂和抗凝剂。

7. 发明授权

US3993683A Biphenylyl derivatives 失效
标题翻译：联苯衍生物
公开(公告)号：US3993683A
公开(公告)日：1976-11-23
申请号：US577169
申请日：1975-05-14
申请人： Josef Nickl , Erich Muller , Berthold Narr , Walter Haarmann , Wolfgang Schroter , Rudolf Kadatz
发明人： Josef Nickl , Erich Muller , Berthold Narr , Walter Haarmann , Wolfgang Schroter , Rudolf Kadatz
IPC分类号： C07C67/00 , C07C69/76 , C07C313/00 , C07C315/04 , C07C317/10 , C07C317/18 , C07C317/24 , C07C317/44 , C07C323/16 , C07C323/45 , C07C323/52 , C07C323/60 , C07C323/65 , C07D213/30 , C07D295/185 , C07C149/40
CPC分类号： C07D213/30 , C07C317/10 , C07C317/18 , C07C317/24 , C07C317/44 , C07C323/16 , C07C323/45 , C07C323/52 , C07C323/60 , C07C323/65 , C07D295/185 , Y10S514/822
摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 is hydrogen, fluorine, bromine, methyl, methoxy, methylthio, nitro, cyano or, when A is other than methylene, R.sub.2 is hydrogen, R.sub.3 is carboxyl, m is 2 and n is 0, also chlorine;R.sub.2 is hydrogen or fluorine;R.sub.3 is hydrogen, methyl, hydroxymethyl, carboxyl, (alkoxy of 1 to 6 carbon atoms)-carbonyl, methoxy-(alkoxy of 1 to 6 carbon atoms)-carbonyl, (alkenyloxy of 2 to 6 carbon atoms)-carbonyl, (aralkoxy of 7 to 12 carbon atoms)-carbonyl, phenoxy-carbonyl, pyridylmethoxy-carbonyl, amino-carbonyl, (alkyl of 1 to 3 carbon atoms-amino)-carbonyl, (dialkyl of 1 to 3 carbon atoms-amino)-carbonyl, phenylamino-carbonyl, morpholino-carbonyl, piperidino-carbonyl, thiomorpholino-carbonyl, (1-oxidothiomorpholino)-carbonyl or (1,1-dioxido-thiomorpholino)-carbonyl;A is methylene, (alkyl of 1 to 3 carbon atoms)-methylene, di-(alkyl of 1 to 3 carbon atoms)-methylene, hydroxymethyl-methylene, hydroxymethylene or carbonyl;m is 1 or 2; andn is 0, 1, 2 or 3;And, when R.sub.3 is carboxyl, non-toxic salts thereof formed with an inorganic or organic base. The compounds as well as the salts are useful as antithrombotics, anticholesteremics and anticoagulants.
摘要翻译：式A的化合物是氢，氟，溴，甲基，甲氧基，甲硫基，硝基，氰基，或当A不是亚甲基时，R 2是氢，R 3是羧基，m是2，n是0，也是氯; R2是氢或氟; R 3是氢，甲基，羟甲基，羧基，（1至6个碳原子的烷氧基） - 羰基，甲氧基 - （1至6个碳原子的烷氧基） - 羰基，（2至6个碳原子的链烯氧基） - 羰基 7至12个碳原子的羰基，苯氧基 - 羰基，吡啶基甲氧羰基，氨基 - 羰基，（1至3个碳原子的烷基 - 氨基） - 羰基，（1至3个碳原子的二烷基 - 氨基） - 羰基，苯基氨基羰基，吗啉代羰基，哌啶子基 - 羰基，硫代吗啉代羰基，（1-氧硫基吗啉代）羰基或（1,1-二氧化硫代吗啉代）羰基。 A是亚甲基，（1至3个碳原子的烷基） - 亚甲基，二（1至3个碳原子的烷基） - 亚甲基，羟甲基 - 亚甲基，羟基亚甲基或羰基; M IS 1 OR 2; 和N是0,1,2或3; 当R 3为羧基时，其无机盐与无机或有机碱形成。化合物以及盐可用作抗血栓形成剂，抗胆固醇剂和抗凝剂。

8. 发明授权

US3975384A 2,4,5,6-Tetrasubstituted pyrimidines and salts thereof 失效
标题翻译： 2,4,5,6-四取代嘧啶及其盐
公开(公告)号：US3975384A
公开(公告)日：1976-08-17
申请号：US497459
申请日：1974-08-14
申请人： Berthold Narr , Josef Roch , Erich Muller , Walter Haarmann
发明人： Berthold Narr , Josef Roch , Erich Muller , Walter Haarmann
IPC分类号： C07D239/30 , C07D239/34 , C07D239/38 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/557 , C07D239/56 , C07D239/60 , C07D417/14
CPC分类号： C07D239/30 , C07D239/34 , C07D239/38 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/52 , C07D239/545 , C07D239/557 , C07D239/56 , C07D239/60
摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 is alkoxy of 1 to 3 carbon atoms, morpholino, thiomorpholino, 1-oxido-thiomorpholino, 1,1-dioxido-thiomorpholino, or ##EQU1## where A is hydrogen, alkanoyl of 1 to 4 carbon atoms, alkenoyl of 2 to 4 carbon atoms, methoxy-(alkanoyl of 1 to 4 carbon atoms), carboxyl-(alkanoyl of 1 to 4 carbon atoms), acetyl-(alkanoyl of 1 to 4 carbon atoms), methoxy-(alkenoyl of 2 to 4 carbon atoms), carboxyl-(alkenoyl of 2 to 4 carbon atoms), acetyl-(alkenoyl of 2 to 4 carbon atoms), aminocarbonyl, mono(alkyl of 1 to 4 carbon atoms)-aminocarbonyl, di-(alkyl of 1 to 4 carbon atoms)-aminocarbonyl, methoxymethylaminocarbonyl, pyridinoyl, salicyloyl, furanoyl, or (alkyl of 1 to 3 carbon atoms)-sulfonyl,R.sub.2 is morpholino, thiomorpholino, 1-oxido-thiomorpholino, 1,1-dioxido-thiomorpholino, piperazino or N'-[acetyl-(alkanoyl of 1 to 3 arbon atoms)]-piperazino,R.sub.3 is hydrogen, chlorine, bromine, nitro, cyano, formyl, acetyl or carbalkoxy of 2 to 4 carbon atoms, andR.sub.4 is hydrogen, chlorine, bromine, cyano, carbalkoxy of 2 to 4 carbon atoms, alkyl of 1 to 6 carbon atoms, mono(carbalkoxy of 2 to 4 carbon atoms)-alkyl of 1 to 6 carbon atoms, di(carbalkoxy of 2 to 4 carbon atoms)-alkyl of 1 to 6 carbon atoms, hydroxyl, allyloxy, alkoxy of 1 to 6 carbon atoms, mercapto, allylmercapto, (alkyl of 1 to 6 carbon atoms)-mercapto, 1-oxidothiomorpholino, or--NHBwhereB is hydrogen, alkyl of 1 to 3 carbon atoms, cyclohexyl, phenyl, chloro-phenyl, carboxy-phenyl, carbomethoxy-phenyl or pyridyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as antithrombotics.
摘要翻译：式WHERE R1的化合物是1至3个碳原子的烷氧基，吗啉代，硫代吗啉代，1-氧代硫代吗啉代，1,1-二氧化硫代吗啉代或-NN-A，其中A是氢，1至4个碳原子的烷酰基，2至4个碳原子的烯酰基，1至4个碳原子的甲氧基 - （烷酰基），1至4个碳原子的羧基 - （烷酰基），1至4个碳原子的乙酰基 - （烷酰基），甲氧基 - 2至4个碳原子），羧基（2-4个碳原子的烯酰基），乙酰基（2至4个碳原子的烯酰基），氨基羰基，单（1-4个碳原子的烷基） - 氨基羰基，二 - （烷基 1至4个碳原子） - 氨基羰基，甲氧基甲基氨基羰基，哒嗪基，水杨酰基，呋喃酰基或（1至3个碳原子的烷基） - 磺酰基，R2是吗啉代，硫代吗啉代，1-氧代硫代吗啉代，1,1-二氧化硫代吗啉，哌嗪基或N' - [乙酰基（1至3个碳原子的烷酰基）] - 哌嗪基，R 3为氢，氯，溴，硝基，氰基，甲酰基，乙酰基或碳原子数2〜4的烷氧基，R4为氢 n，氯，溴，氰基，碳原子数为2〜4的烷氧基，碳原子数为1〜6的烷基，碳原子数2〜4的单（碳烷氧基） - 碳原子数为1〜6的烷基，二（碳数2〜4的烷氧基）碳原子数1〜6的烷基，羟基，烯丙氧基，1〜6个碳原子的烷氧基，巯基，烯丙基巯基，（1〜6个碳原子的烷基） - 巯基，1-氧硫基吗啉代或-NHB，其中B为氢，1至3个碳原子的烷基，环己基，苯基，氯 - 苯基，羧基 - 苯基，甲酯基 - 苯基或吡啶基，和非毒性，药理学上可接受的酸添加物; 化合物作为抗菌药物有用的方法。

9. 发明授权

US4678792A Quaternary 3,4-dihydro-isoquinolinium salts 失效
标题翻译：第四纪3,4-二氢 - 异喹啉鎓盐
公开(公告)号：US4678792A
公开(公告)日：1987-07-07
申请号：US706579
申请日：1985-02-28
申请人： Josef Nickl , Erich Muller , Benthold Narr , Helmut Ballhause , Walter Haarmann
发明人： Josef Nickl , Erich Muller , Benthold Narr , Helmut Ballhause , Walter Haarmann
IPC分类号： A61K31/47 , A61K31/472 , A61P7/02 , C07D217/02 , C07D217/04
CPC分类号： C07D217/02 , C07D217/04 , Y10S514/824
摘要： This invention relates to a compound of formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy; and R.sub.3 is a C.sub.7 -C.sub.9 aralkyl, the phenyl nucleus of which can be mono-, di-, or trisubstituted by halogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy, and nontoxic, pharmaceutically acceptable salts thereof. The compounds have useful antithrombic properties.
摘要翻译：本发明涉及式（I）化合物：其中R 1和R 2各自独立地为氢，C 1 -C 3烷基或C 1 -C 3烷氧基; 并且R 3是C 7 -C 9芳烷基，其苯基基团可以被卤素，C 1 -C 3烷基或C 1 -C 3烷氧基单，二或三取代，和其无毒的药学上可接受的盐。该化合物具有有用的抗血栓性质。

10. 发明授权

US4442111A Antithrombotic sulfimino and sulfoximino indolinones-2 失效
标题翻译：抗血栓形成亚硫酰亚氨基和磺酰肟基吲哚啉酮-2
公开(公告)号：US4442111A
公开(公告)日：1984-04-10
申请号：US395631
申请日：1982-07-06
申请人： Erich Muller , Josef Nickl , Berthold Narr , Josef Roch , Walter Haarmann , Johannes M. Weisenberger
发明人： Erich Muller , Josef Nickl , Berthold Narr , Josef Roch , Walter Haarmann , Johannes M. Weisenberger
IPC分类号： A61K31/40 , A61K31/455 , A61K31/47 , C07D209/34 , C07D215/22 , C07D215/227 , C07D401/02 , C07D401/12 , C07D409/02 , C07D409/12
CPC分类号： C07D215/227 , C07D209/34 , C07D401/12 , C07D409/12
摘要： Compounds of the formula ##STR1## wherein n is 0 or 1;A is methylene, vinylene or ethylene optionally substituted by lower alkyl;B is alkylene;R.sub.1 is an optionally substituted alkyl, phenyl or naphthyl group, or a cycloalkyl or pyridyl group; andR.sub.2 is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antithrombotics.
摘要翻译：其中n为0或1的式（I）的化合物; A是任选被低级烷基取代的亚甲基，亚乙烯基或乙烯基; B是亚烷基; R1是任选取代的烷基，苯基或萘基，或环烷基或吡啶基; 并且R 2是氢或酰基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作抗血栓形成剂。

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