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1. 发明授权

US07461671B2 Automatic sample collector 失效
标题翻译：自动样品收集器
公开(公告)号：US07461671B2
公开(公告)日：2008-12-09
申请号：US10510485
申请日：2003-03-21
申请人： Rudolf Ehwald , Dietmar Lerche , Holger Woehlecke
发明人： Rudolf Ehwald , Dietmar Lerche , Holger Woehlecke
IPC分类号： B65B1/04 , A61M1/00
CPC分类号： G01N1/2035 , B01D15/247 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2200/146 , B01L2300/0864 , B01L2300/10 , B01L2300/1838 , B01L2400/0406 , B01L2400/0487 , B01L2400/0677 , B01L2400/0688 , B01L2400/0694 , G01N1/18 , G01N1/42 , G01N30/82
摘要： This invention relates to an automatic sample collector for liquids which are discharged from a chromatographic column, a dialysis apparatus, or a reaction container, for example, and are consecutively collected at a give volume division, a method for collecting samples of a liquid in a predefined chronological sequence, and uses of the inventive sample collector. The volume is divided by assigning one or several gas-permeable liquid barriers (4, 5) to each collection container (3). The sample collector can be produced as one piece which is for single use and is made of polypropylene, Teflon, or other suitable materials. The inventive sample collector has the advantage that it requires no source of energy and can be autoclaved and miniaturized, among other things. The design of the inventive sample collector makes it possible to keep the content of the collection containers free from oxygen or immediately freeze the liquid flowing into the collection containers.
摘要翻译：本发明涉及一种用于液体的自动样品收集器，其从色谱柱，透析设备或反应容器排出，并且以给定的体积分数连续收集，用于收集液体样品的方法预定时间顺序，以及本发明的样品收集器的用途。通过为每个收集容器（3）分配一个或多个气体可渗透液体屏障（4,5）来分配体积。样品收集器可以作为单件使用制成，并且由聚丙烯，特氟隆或其他合适的材料制成。本发明的样品收集器具有的优点是，其不需要能量来源，并且可以进行高压灭菌和小型化。本发明的样品收集器的设计使得可以保持收集容器的内容物不含氧气，或立即冷冻流入收集容器的液体。

2. 发明申请

US20050161112A1 Automatic sample collector 失效
标题翻译：自动样品收集器
公开(公告)号：US20050161112A1
公开(公告)日：2005-07-28
申请号：US10510485
申请日：2003-03-21
申请人： Rudolf Ehwald , Dietmar Lerche , Holger Woehlecke
发明人： Rudolf Ehwald , Dietmar Lerche , Holger Woehlecke
IPC分类号： B01D15/24 , B01L3/00 , G01N1/18 , G01N1/20 , G01N1/42 , G01N30/82 , B67C3/00 , B65B43/42
CPC分类号： G01N1/2035 , B01D15/247 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2200/146 , B01L2300/0864 , B01L2300/10 , B01L2300/1838 , B01L2400/0406 , B01L2400/0487 , B01L2400/0677 , B01L2400/0688 , B01L2400/0694 , G01N1/18 , G01N1/42 , G01N30/82
摘要： This invention relates to an automatic sample collector for liquids which are discharged from a chromatographic column, a dialysis apparatus, or a reaction container, for example, and are consecutively collected at a give volume division, a method for collecting samples of a liquid in a predefined chronological sequence, and uses of the inventive sample collector. The volume is divided by assigning one or several gas-permeable liquid barriers (4, 5) to each collection container (3). The sample collector can be produced as one piece which is for single use and is made of polypropylene, Teflon, or other suitable materials. The inventive sample collector has the advantage that it requires no source of energy and can be autoclaved and miniaturized, among other things. The design of the inventive sample collector makes it possible to keep the content of the collection containers free from oxygen or immediately freeze the liquid flowing into the collection containers.
摘要翻译：本发明涉及一种用于液体的自动样品收集器，其从色谱柱，透析设备或反应容器排出，并且以给定的体积分数连续收集，用于收集液体样品的方法预定时间顺序，以及本发明的样品收集器的用途。通过为每个收集容器（3）分配一个或多个气体可渗透液体屏障（4,5）来分配体积。样品收集器可以作为单件使用制成，并且由聚丙烯，特氟隆或其他合适的材料制成。本发明的样品收集器具有的优点是，其不需要能量来源，并且可以进行高压灭菌和小型化。本发明的样品收集器的设计使得可以保持收集容器的内容物不含氧气，或立即冷冻流入收集容器的液体。

3. 发明申请

US20110098462A1 METHOD AND KIT FOR THE SAMPLE PRESERVATION AND CELL DISRUPTION BEFORE THE EXTRACTION OF NUCLEIC ACIDS 审中-公开
公开(公告)号：US20110098462A1
公开(公告)日：2011-04-28
申请号：US12809468
申请日：2008-12-22
申请人： Rudolf Ehwald , Dietmar Lerche , Holger Woehlecke , Christina Lerche
发明人： Rudolf Ehwald , Dietmar Lerche , Holger Woehlecke , Christina Lerche
IPC分类号： C07H21/00 , C12N5/02 , C12M1/00
CPC分类号： C12N1/063
摘要： The invention relates to a method for preserving samples and disrupting cells which can be employed for the preparation of the extraction of nucleic acids from live cells, cell aggregates and tissue samples, and to a kit for carrying out the method. The method includes the introduction of live cells, cell aggregates or tissue samples whose nucleic acids are to be extracted into an excess of water-miscible and volatile organic liquid. The saturation of the sample with the organic liquid has an advantageous effect on the extraction of the nucleic acids, which is subsequently carried out in an aqueous medium. The mechanical cell disruption is facilitated by the virtually complete removal of the water from the cells. The biomembranes are dissolved in the organic liquid. tRNA and other RNA fractions with a low degree of polymerization, which are capable of permeating across the cell wall, can be extracted selectively without mechanical disruption. Before high-molecular-weight nucleic acids are extracted, the cells, cell aggregates or tissue samples are disrupted in the organic liquid with the aid of mechanical pulses. Since the nucleases are inactive in the dehydrated organic liquid, the biological samples or the homogenates prepared therefrom can be stored at room temperature in the organic liquid as long as desired. After incubation in the largely anhydrous organic liquid, the sample's nucleases are largely denatured. An advantageous kit according to the invention contains a mixed organic/aqueous phase with denaturing properties and, for each sample, a shaped body for dehydration which is adapted to suit the size of the preservation container, and a mixture, adapted to suit the size of the preservation container, of a few large and many small disruption bodies for the disruption in the nonaqueous medium. A considerable advantage of the invention is the fact that cooling and powerful mechanical pulses when disrupting the cells and during the extraction may be dispensed with, and that DNA extraction and cell disruption can be carried out at different times.

4. 发明授权

US09019493B2 Method and device for the characterization of multiple samples of one or various dispersions 有权
标题翻译：用于表征一种或多种分散体的多个样品的方法和装置
公开(公告)号：US09019493B2
公开(公告)日：2015-04-28
申请号：US13565072
申请日：2012-08-02
申请人： Dietmar Lerche , Titus Sobisch , Torsten Detloff , Frank Babick , Michael Stintz
发明人： Dietmar Lerche , Titus Sobisch , Torsten Detloff , Frank Babick , Michael Stintz
IPC分类号： G01J3/28 , G01N15/02 , G01N15/04
CPC分类号： G01N15/0205 , G01N15/042
摘要： A method and a device for the automatic determination of selected physical and colloidal chemistry parameters by determining the attenuation of radiated waves through monodisperse or polydisperse dispersion samples subjected to gravitation or centrifugation, wherein during the segregation by means of centrifugation or gravitation, the instantaneous transmission IT(t, r) characterizing the current segregation status of the waves radiated with the intensity Io(t, r) and/or the instantaneous scattering IS(t, r) as a function of the position within the samples is repeatedly determined and recorded at high resolution at any arbitrary time for one or more wavelengths over the entire length of the sample or in selected partial sections of it, simultaneously for multiple and even concentrated samples with known and/or unknown physical and colloidal chemistry properties.
摘要翻译：通过确定经受重力或离心的单分散或多分散分散样品的辐射波的衰减来自动确定所选物理和胶体化学参数的方法和装置，其中在通过离心或重力分离期间瞬时传输IT （t，r）表征作为样本内的位置的函数的以强度Io（t，r）和/或瞬时散射IS（t，r）辐射的波的当前偏析状态，被重复地确定并记录在在任何时间对于在样品的整个长度上或在其选定的部分切片中的一个或多个波长的高分辨率，同时具有已知和/或未知的物理和胶体化学性质的多个甚至浓缩的样品。

5. 发明申请

US20110207163A1 METHOD FOR AND MATERIAL OF A SHAPE STANDARD 审中-公开
标题翻译：形状标准方法和材料
公开(公告)号：US20110207163A1
公开(公告)日：2011-08-25
申请号：US12996517
申请日：2009-06-04
申请人： Dietmar Lerche
发明人： Dietmar Lerche
IPC分类号： C12Q1/02 , C12Q1/00 , G01Q60/00
CPC分类号： G01N15/1475 , G01N15/1012 , G01N15/1459 , G01N15/147 , G01N2001/2893 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/0092 , G01N2015/1018 , G01N2015/1477 , G01N2015/1497
摘要： A method is disclosed for the preparation of isomorphic and nonspherical shape standards as isometric as possible and their mixtures for validation of the measurement methods and analyzers for quantification of particle shapes and their characteristics especially in the microscale and nanoscale size range. Furthermore the shape standards also provide quality control and performance qualification can be used at the operator of the corresponding shape measurement devices.
摘要翻译：公开了一种用于制备尽可能等距的同形和非球形形状标准的方法，以及用于验证测量方法和分析器的混合物，用于量化粒子形状及其特征，特别是在微尺度和纳米级尺寸范围内。此外，形状标准还提供质量控制和性能鉴定，可在相应形状测量装置的操作者处使用。

6. 发明申请

US20110282590A9 DETERMINING PARTICLE PROPERTIES BY MEANS OF SUPERIMPOSED FIELDS 失效
标题翻译：通过超声场测定粒子性质
公开(公告)号：US20110282590A9
公开(公告)日：2011-11-17
申请号：US12598405
申请日：2008-04-30
申请人： Dietmar Lerche , Uwe Mertens
发明人： Dietmar Lerche , Uwe Mertens
IPC分类号： G01R33/12 , G06F19/00 , G01N15/06
CPC分类号： G01N15/04 , B82Y25/00 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： The aim of the invention is to model the gravitational field-induced or centrifugal field-induced separation of particles of a dispersion by means of one or more additional force fields that also influence the migration of the particles. Said aim is achieved by detecting and measuring the modified separation behavior with the help of concentration-measuring sensors. The force acting upon the particles can be calculated from the change in velocity of the particles, and the corresponding particle properties can be calculated if the respective field intensities are known.
摘要翻译：本发明的目的是通过一个或多个另外的影响颗粒迁移的附加力场来模拟引力场诱导或离心场诱导的分散颗粒分离。所述目的通过在浓度测量传感器的帮助下检测和测量改进的分离行为来实现。可以根据颗粒的速度变化来计算作用于颗粒的力，并且如果各自的场强是已知的，则可以计算相应的颗粒特性。

7. 发明授权

US06691057B2 Method and device for accelerated stability analysis 有权
标题翻译：加速稳定性分析方法和装置
公开(公告)号：US06691057B2
公开(公告)日：2004-02-10
申请号：US10079812
申请日：2002-02-22
申请人： Dietmar Lerche , Volker Berwald
发明人： Dietmar Lerche , Volker Berwald
IPC分类号： G01N1504
CPC分类号： G01N15/0227 , G01N15/04 , G01N21/03 , G01N21/35 , G01N21/3504 , G01N21/3563 , G01N21/3577 , G01N21/51 , G01N21/59 , G01N2015/0011 , G01N2015/0026 , G01N2015/003 , G01N2015/0053 , G01N2015/0092 , G01N2015/0288 , G01N2021/3181 , G01N2021/5969
摘要： The invention relates to methods and devices for accelerated stability analysis, and in particular to a qualitative and quantitative direct estimation/identification of separation processes of disperse material systems (such as liquid-solid, liquid-liquid or liquid-gaseous). The invention also relates to methods and devices for the classification and quantitative characterization of slow, as well as rapid separation phenomena of disperse material systems of different volume concentration. Exemplary fields of application concern the development, selection and optimization of destabilizers, stabilizers and novel formulations for dispersions, as well as quality and process control (such as in the chemical, pharmaceutical, biotechnological, cosmetic and food industries), as well as in the process technology for separation and treatment processes.
摘要翻译：本发明涉及用于加速稳定性分析的方法和装置，特别涉及分散材料体系（例如液固，液液或液态 - 气体）分离过程的定性和定量的直接估计/鉴定。本发明还涉及用于分级和定量表征不同体积浓度的分散材料体系的缓慢以及快速分离现象的方法和装置。示例性应用领域涉及不稳定剂，稳定剂和用于分散体的新配方以及质量和过程控制（例如在化学，制药，生物技术，化妆品和食品工业）中的开发，选择和优化，以及在分离处理工艺技术。

8. 发明申请

US20080046193A1 Method and Device for Characterisation of Multiple Samples of One or Various Dispersions 有权
标题翻译：用于表征一种或多种分散体的多个样品的方法和装置
公开(公告)号：US20080046193A1
公开(公告)日：2008-02-21
申请号：US10591701
申请日：2005-03-04
申请人： Dietmar Lerche , Titus Sobisch , Torsten Detloff , Frank Babick , Michael Stintz
发明人： Dietmar Lerche , Titus Sobisch , Torsten Detloff , Frank Babick , Michael Stintz
IPC分类号： G06F19/00 , G01J3/30
CPC分类号： G01N15/0205 , G01N15/042
摘要： The invention relates to a method and a device for the automatic determination of selected physical and colloidal chemistry parameters (for example, the grain size, the distribution of grain sizes, the hindrance function and indices of structural stability) by means of the determination of the attenuation of radiated waves through monodisperse or polydisperse dispersion samples subjected to gravitation or centrifugation, characterised in that during the segregation by means of centrifugation or gravitation, the instantaneous transmission IT(t, r) characterising the current segregation status of the waves radiated with the intensity Io(t, r) and/or the instantaneous scattering IS(t, r) as a function of the position within the samples is repeatedly determined and recorded at high resolution at any arbitrary time for one or more wavelengths over the entire length of the sample or in selected partial sections of it, simultaneously for multiple and even concentrated samples with known and/or unknown physical and colloidal chemistry properties.
摘要翻译：本发明涉及一种用于通过确定所选择的物理和胶体化学参数（例如，粒度，粒度分布，阻碍功能和结构稳定性指标）自动确定方法和装置。通过经过重力或离心的单分散或多分散分散样品衰减辐射波，其特征在于，在通过离心或重力分离期间，表征当前分离的瞬时传递I T（t，r）随着强度I （t，r）和/或瞬时散射I S（t，r）辐射的波的状态作为内部位置的函数在样品的整个长度上或其选定的部分部分中，对于一个或多个波长在任意任意时间重复地确定和记录样品，同时对于多个和均匀的浓度具有已知和/或未知物理和胶体化学性质的带入样品。

9. 发明授权

US08370081B2 Determining particle properties by means of superimposed fields 失效
标题翻译：通过叠加场确定粒子特性
公开(公告)号：US08370081B2
公开(公告)日：2013-02-05
申请号：US12598405
申请日：2008-04-30
申请人： Dietmar Lerche , Uwe Mertens
发明人： Dietmar Lerche , Uwe Mertens
IPC分类号： G01N31/00 , G06F19/00
CPC分类号： G01N15/04 , B82Y25/00 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： Modeling the gravitational field-induced or centrifugal field-induced separation of particles of a dispersion by use of one or more additional force fields that also influence the migration of the particles. A method includes detecting and measuring the modified separation behavior with the help of concentration-measuring sensors. The force acting upon the particles can be calculated from the change in velocity of the particles, and the corresponding particle properties can be calculated if the respective field intensities are known.
摘要翻译：通过使用还影响颗粒迁移的一个或多个额外的力场来模拟引力场诱导或离心场诱导的分散体颗粒的分离。一种方法包括在浓度测量传感器的帮助下检测和测量改进的分离行为。可以根据颗粒的速度变化来计算作用于颗粒的力，并且如果各自的场强是已知的，则可以计算相应的颗粒特性。

10. 发明授权

US08265882B2 Method and device for characterisation of multiple samples of one or various dispersions 有权
标题翻译：用于表征一种或多种分散体的多个样品的方法和装置
公开(公告)号：US08265882B2
公开(公告)日：2012-09-11
申请号：US10591701
申请日：2005-03-04
申请人： Dietmar Lerche , Titus Sobisch , Torsten Detloff , Frank Babick , Michael Stintz
发明人： Dietmar Lerche , Titus Sobisch , Torsten Detloff , Frank Babick , Michael Stintz
IPC分类号： G01N33/00
CPC分类号： G01N15/0205 , G01N15/042
摘要： A method and a device for the automatic determination of selected physical and colloidal chemistry parameters by determining the attenuation of radiated waves through monodisperse or polydisperse dispersion samples subjected to gravitation or centrifugation, wherein during the segregation by means of centrifugation or gravitation, the instantaneous transmission IT(t, r) characterizing the current segregation status of the waves radiated with the intensity Io(t, r) and/or the instantaneous scattering IS(t, r) as a function of the position within the samples is repeatedly determined and recorded at high resolution at any arbitrary time for one or more wavelengths over the entire length of the sample or in selected partial sections of it, simultaneously for multiple and even concentrated samples with known and/or unknown physical and colloidal chemistry properties.
摘要翻译：通过确定经受重力或离心的单分散或多分散分散样品的辐射波的衰减来自动确定所选物理和胶体化学参数的方法和装置，其中在通过离心或重力分离期间瞬时传输IT （t，r）表征作为样本内的位置的函数的以强度Io（t，r）和/或瞬时散射IS（t，r）辐射的波的当前偏析状态，被重复地确定并记录在在任何时间对于在样品的整个长度上或在其选定的部分切片中的一个或多个波长的高分辨率，同时具有已知和/或未知的物理和胶体化学性质的多个甚至浓缩的样品。

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