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1. 发明申请

US20050258514A1 Microfabricated miniature grids 失效
标题翻译：微型网格
公开(公告)号：US20050258514A1
公开(公告)日：2005-11-24
申请号：US11124424
申请日：2005-05-06
申请人： Rosemary Smith , Scott Collins , Brian Frederick , Lawrence LeGore
发明人： Rosemary Smith , Scott Collins , Brian Frederick , Lawrence LeGore
IPC分类号： H01J9/14 , H01J49/06 , H01L21/46 , H01L23/34
CPC分类号： H01J9/14 , H01J49/0018 , H01J49/061 , H01L2924/0002 , Y10S438/977 , H01L2924/00
摘要： A grid structure and method for manufacturing the same. The grid is used for gating a stream of charged particles in certain types of particle measurement instruments, such as ion mobility spectrometers and the like. The methods include various microfabrication techniques for etching and/or depositing grid structure materials on a silicon substrate.
摘要翻译：一种网格结构及其制造方法。栅格用于在某些类型的粒子测量仪器（例如离子迁移光谱仪等）中选通带电粒子流。这些方法包括用于在硅衬底上蚀刻和/或沉积栅格结构材料的各种微细加工技术。

2. 发明申请

US20070272875A1 Gating grid and method of manufacture 失效
标题翻译：门格栅和制造方法
公开(公告)号：US20070272875A1
公开(公告)日：2007-11-29
申请号：US11714691
申请日：2007-03-06
申请人： Brian Frederick , Lawrence LeGore , Rosemary Smith , Scott Collins , Robert Jackson
发明人： Brian Frederick , Lawrence LeGore , Rosemary Smith , Scott Collins , Robert Jackson
IPC分类号： H01J49/06 , H01R43/00
CPC分类号： H01J49/061 , Y10S438/927 , Y10S438/977 , Y10T29/49046 , Y10T29/49117
摘要： The present invention relates generally to grids for gating a stream of charged particles and methods for manufacturing the same. In one embodiment, the present invention relates to a Bradbury-Nielson gate having transmission line grid elements. In one embodiment is a feed structure for a gating grid where a drive source is coupled to a feeding transmission line with the same geometry as the chopper and continues with the same geometry to a termination transmission line. Also included is a method for fabricating a gate for charged particles which includes micromachining at least two gate elements from at least one wafer, wherein each gate element includes at least one grid element; metalizing the grid elements; and assembling the gate elements such that the grid elements of the gate elements are interleaved, thereby forming a Bradbury Nielson gate.
摘要翻译：本发明一般涉及用于选通带电粒子流的栅格及其制造方法。在一个实施例中，本发明涉及具有传输线网格元件的Bradbury-Nielson门。在一个实施例中是用于门控格栅的馈送结构，其中驱动源耦合到与斩波器具有相同几何形状的馈电传输线，并且以相同的几何形状连续地连接到终端传输线。还包括一种用于制造带电粒子的栅极的方法，其包括从至少一个晶片微加工至少两个栅极元件，其中每个栅极元件包括至少一个栅格元件; 金属化网格元素; 以及组装门元件，使得门元件的栅格元件交错，从而形成Bradbury Nielson门。

3. 发明申请

US20050102829A1 Fabrication of chopper for particle beam instrument 失效
标题翻译：粒子束仪的切碎机制造
公开(公告)号：US20050102829A1
公开(公告)日：2005-05-19
申请号：US10922368
申请日：2004-08-20
申请人： Nicholas LeCursi , Lawrence LeGore , Robert Jackson , C. Crothers , Peter Kleban , Brian Frederick
发明人： Nicholas LeCursi , Lawrence LeGore , Robert Jackson , C. Crothers , Peter Kleban , Brian Frederick
IPC分类号： H01J49/44 , G01N23/05 , G21K1/087 , H01J49/02 , H01J49/04 , H01J49/06 , H01J49/40 , H01L23/48 , H01L29/40 , H05K3/10
CPC分类号： G21K1/087 , G01N23/05 , H01J49/0018 , H01J49/0031 , H01J49/061 , H01J49/446 , H01L2924/0002 , Y10T29/4902 , Y10T29/49082 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156 , H01L2924/00
摘要： A technique for providing a grid for a gate such as utilized in gating a stream of ions or other particles in a spectrometer instrument. The grid of wires may, for example, be a so-called Bradbury-Nielson Gate that consists of a set of two electrically isolated sets of equally spaced wires that lie substantially in the same plane and alternate in potential. The method utilized to provide is to first fabricate a frame of an insulating substrate having a hole and depositing metal film patterns such that conductive portions are formed on either side of the hole. Conductive portions on either side form a series of terminating pads on the portion of the substrate closest to the hole and a bus bar. Grid wires are then formed by stretching a section of wire with desired constant tension across the hole and bonding the ends of the wire to a respective one of the pads on one side and bus bar on the other side. The method provides a rapid, inexpensive way to fabricate such modulating devices.
摘要翻译：提供用于门的栅格的技术，例如用于在光谱仪器中门控离子或其他颗粒物流。电线的网格可以是例如所谓的Bradbury-Nielson门，其由两组基本上位于同一平面中且交替潜在的等间隔的导线的两组电隔离组合组成。用于提供的方法是首先制造具有孔的绝缘基板的框架并沉积金属膜图案，使得导电部分形成在孔的任一侧上。任一侧上的导电部分形成在最靠近该孔的基板部分上的一系列端接焊盘和汇流条。然后通过将所需的恒定张力的一段导线拉伸穿过该孔并且将导线的端部粘合到另一侧的一侧上的焊盘和另一侧的母线上而形成网格线。该方法提供了制造这种调制装置的快速，便宜的方式。

4. 发明申请

US20060178844A1 Spectroscopy instrument using broadband modulation and statistical estimation techniques to account for component artifacts 失效
公开(公告)号：US20060178844A1
公开(公告)日：2006-08-10
申请号：US11386503
申请日：2006-03-22
申请人： Lawrence LeGore , Robert Jackson , Zhong Yang , Linda DeNoyer , Peter Kleban , Brian Frederick
发明人： Lawrence LeGore , Robert Jackson , Zhong Yang , Linda DeNoyer , Peter Kleban , Brian Frederick
IPC分类号： G06F19/00
CPC分类号： G21K1/087 , G01N23/05 , H01J49/0018 , H01J49/0031 , H01J49/061 , H01J49/446 , H01L2924/0002 , Y10T29/4902 , Y10T29/49082 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156 , H01L2924/00
摘要： A spectroscopy instrument that uses spectra produced from random binary sequence modulated data. Statistical estimation techniques are used to achieve resolution enhancement, while properly accounting for the Poisson noise distribution and other artifacts introduced by a modulator or “chopper” or other system components. Indeed, a resolution similar to that of modem spectrometers can be achieved with a dramatic performance advantage over conventional, serial detection analyzers. Both static and dynamic behaviors are theoretically or measured experimentally accounted for in the model as determined. In one embodiment, the finite penetration of the field beyond the plane of the chopper leads to non-ideal chopper response, which is characterized in terms of an “energy corruption” effect and a lead or lag in the time at which the beam responds to the chopper potential.

5. 发明申请

US20050086026A1 Spectroscopy instrument using broadband modulation and statistical estimation techniques to account for component artifacts 失效
标题翻译：光谱仪使用宽带调制和统计估计技术来解决组件工件
公开(公告)号：US20050086026A1
公开(公告)日：2005-04-21
申请号：US10924282
申请日：2004-08-23
申请人： Lawrence LeGore , Robert Jackson , Zhong Yang , Linda DeNoyer , Peter Kleban , Brian Frederick
发明人： Lawrence LeGore , Robert Jackson , Zhong Yang , Linda DeNoyer , Peter Kleban , Brian Frederick
IPC分类号： H01J49/44 , G01N23/05 , G21K1/087 , H01J49/02 , H01J49/04 , H01J49/06 , H01J49/40 , G06F15/00 , G06F17/18
CPC分类号： G21K1/087 , G01N23/05 , H01J49/0018 , H01J49/0031 , H01J49/061 , H01J49/446 , H01L2924/0002 , Y10T29/4902 , Y10T29/49082 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156 , H01L2924/00
摘要： A spectroscopy instrument that uses spectra produced from random binary sequence modulated data. Statistical estimation techniques are used to achieve resolution enhancement, while properly accounting for the Poisson noise distribution and other artifacts introduced by a modulator or “chopper” or other system components. Indeed, a resolution similar to that of modern spectrometers can be achieved with a dramatic performance advantage over conventional, serial detection analyzers. Both static and dynamic behaviors are theoretically or measured experimentally accounted for in the model as determined. In one embodiment, the finite penetration of the field beyond the plane of the chopper leads to non-ideal chopper response, which is characterized in terms of an “energy corruption” effect and a lead or lag in the time at which the beam responds to the chopper potential.
摘要翻译：使用从随机二进制序列调制数据产生的光谱的光谱仪器。统计估计技术用于实现分辨率增强，同时适当地考虑由调制器或“斩波器”或其他系统组件引入的泊松噪声分布和其他伪像。实际上，与传统的串行检测分析仪相比，可以实现与现代光谱仪类似的分辨率，具有显着的性能优势。静态和动态行为在理论上或实验中都经过实验确定。在一个实施例中，场强超过斩波器平面的有限穿透导致非理想的斩波器响应，其特征在于“能量损耗”效应和波束响应时间的引导或滞后砍刀潜力。

6. 发明申请

US20080118695A1 Method of Joining Two or More Substrates with a Seam 有权
标题翻译：使用接缝连接两个或多个基板的方法
公开(公告)号：US20080118695A1
公开(公告)日：2008-05-22
申请号：US11931971
申请日：2007-10-31
申请人： Christine W. Jarvis , Robert E. Bennett , Brian Frederick
发明人： Christine W. Jarvis , Robert E. Bennett , Brian Frederick
IPC分类号： B32B3/02
CPC分类号： B29C65/5071 , B29C65/04 , B29C65/08 , B29C65/16 , B29C65/18 , B29C65/4815 , B29C65/5021 , B29C65/5085 , B29C65/8215 , B29C65/8253 , B29C66/1122 , B29C66/43 , B29C66/435 , B29C66/71 , B29C66/712 , B29C66/729 , B29C66/73115 , B29C66/73116 , B29C66/83413 , B29C66/91411 , B29C66/919 , B29C66/91931 , B29C66/91933 , B29C66/91935 , B29C66/929 , B29K2007/00 , B29K2021/00 , B29K2021/003 , B29K2101/12 , B29K2105/0836 , B29K2105/0845 , B29K2105/0854 , B29K2311/10 , B29K2313/00 , B29K2711/12 , C09J5/10 , Y10T156/1003 , Y10T156/1051 , Y10T428/19 , Y10T428/192 , Y10T428/2419 , Y10T428/24959 , B29K2077/00 , B29K2075/00 , B29K2067/00 , B29K2023/22 , B29K2023/12 , B29K2023/06
摘要： A method for joining two or more substrates with a seam is provided. The seam is formed with a thermoplastic tape that is capable of forming an adhesive bond and a physical bond with a substrate. For instance, in one embodiment, the thermoplastic tape is formed from a polyurethane film. In addition, the seam can be utilized in a flat configuration or folded into a variety of different shapes, such as in a z-shaped configuration. As a result of the present invention, it has been discovered that a seam can be formed to have improved strength without substantially sacrificing the desired functional properties of the substrate materials.
摘要翻译：提供了一种用于将两个或多个基底与接缝连接的方法。接缝由热塑性带形成，其能够形成粘合剂粘合和与基底的物理结合。例如，在一个实施例中，热塑性带由聚氨酯膜形成。此外，接缝可以以平坦的构造使用或折叠成各种不同的形状，例如z形构型。作为本发明的结果，已经发现，可以形成接缝以具有改善的强度，而基本上不牺牲基底材料的期望的功能特性。

7. 发明申请

US20080090760A2 Compositions and Methods for Inhibiting Cellular Proliferation 审中-公开
标题翻译：抑制细胞增殖的组合物和方法
公开(公告)号：US20080090760A2
公开(公告)日：2008-04-17
申请号：US11636353
申请日：2006-12-08
申请人： Todd Hembrough , Christopher Holmes , Qun Yin , Genet Zemede , Yvonne Angell , Brian Frederick , Caiding Xu
发明人： Todd Hembrough , Christopher Holmes , Qun Yin , Genet Zemede , Yvonne Angell , Brian Frederick , Caiding Xu
IPC分类号： A61K38/10 , A61K38/08 , C07K7/08 , C07K7/06
CPC分类号： A61K38/08 , A61K38/10 , A61K47/55 , A61K47/60 , A61K47/62 , C07K7/08 , C07K14/001
摘要： Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise peptide molecules, optionally containing one or more individual peptide chains covalently linked, and optionally modified with polyethylene glycol (PEG). The methods involve administering to a human or animal the composition described herein in a dosage sufficient to inhibit cell proliferation, particularly endothelial cell proliferation. The methods are useful for treating diseases and processes mediated by undesired and uncontrolled cell proliferation, such as cancer, particularly by inhibiting angiogenesis. Administration of the composition to a human or animal having prevascularized, metastasized tumors is useful for preventing the growth or expansion of such tumors.
摘要翻译：提供了有效抑制异常或不期望的细胞增殖，特别是与新生血管形成和肿瘤生长相关的内皮细胞增殖和血管发生的组合物和方法。组合物包含肽分子，任选地含有一个或多个共价连接并且任选地用聚乙二醇（PEG）修饰的单个肽链。所述方法包括以足以抑制细胞增殖，特别是内皮细胞增殖的剂量向人或动物施用本文所述的组合物。该方法可用于治疗由不期望的和不受控制的细胞增殖如癌症介导的疾病和过程，特别是通过抑制血管发生。将组合物给予具有血运重建的转移性肿瘤的人或动物可用于预防这些肿瘤的生长或扩张。

8. 发明授权

US08361582B2 Method of joining two or more substrates with a seam 有权
公开(公告)号：US08361582B2
公开(公告)日：2013-01-29
申请号：US11931971
申请日：2007-10-31
申请人： Christine W Jarvis , Robert E Bennett , Brian Frederick
发明人： Christine W Jarvis , Robert E Bennett , Brian Frederick
IPC分类号： B32B3/00
CPC分类号： B29C65/5071 , B29C65/04 , B29C65/08 , B29C65/16 , B29C65/18 , B29C65/4815 , B29C65/5021 , B29C65/5085 , B29C65/8215 , B29C65/8253 , B29C66/1122 , B29C66/43 , B29C66/435 , B29C66/71 , B29C66/712 , B29C66/729 , B29C66/73115 , B29C66/73116 , B29C66/83413 , B29C66/91411 , B29C66/919 , B29C66/91931 , B29C66/91933 , B29C66/91935 , B29C66/929 , B29K2007/00 , B29K2021/00 , B29K2021/003 , B29K2101/12 , B29K2105/0836 , B29K2105/0845 , B29K2105/0854 , B29K2311/10 , B29K2313/00 , B29K2711/12 , C09J5/10 , Y10T156/1003 , Y10T156/1051 , Y10T428/19 , Y10T428/192 , Y10T428/2419 , Y10T428/24959 , B29K2077/00 , B29K2075/00 , B29K2067/00 , B29K2023/22 , B29K2023/12 , B29K2023/06
摘要： A method for joining two or more substrates with a seam is provided. The seam is formed with a thermoplastic tape that is capable of forming an adhesive bond and a physical bond with a substrate. For instance, in one embodiment, the thermoplastic tape is formed from a polyurethane film. In addition, the seam can be utilized in a flat configuration or folded into a variety of different shapes, such as in a z-shaped configuration. As a result of the present invention, it has been discovered that a seam can be formed to have improved strength without substantially sacrificing the desired functional properties of the substrate materials.

9. 发明授权

US06308356B1 Substantially environmental-pollution-free cleaning method and device employing electric energy and surface physical properties 失效
标题翻译：基本无环境污染的清洁方法和使用电能和表面物理性能的装置
公开(公告)号：US06308356B1
公开(公告)日：2001-10-30
申请号：US09053103
申请日：1998-04-01
申请人： Max B. Frederick , Brian Frederick
发明人： Max B. Frederick , Brian Frederick
IPC分类号： D06F3902
CPC分类号： D06F35/00 , D06F39/007
摘要： A washing method and apparatus characterized by employment of the electric form of energy in addition to the traditional three forms of energy (kinetic energy, thermal energy, and chemical energy) to do the work of cleaning, thereby reducing the requirement for and dependency on the traditional three forms of energy. Electric charge is employed to do work of cleaning by various physical phenomena. The phenomena include, but are not limited to effecting the physical characteristics of surface chemistry, the physical characteristics of water, and the chemical characteristics of water, Such characteristics include but are not limited to surface tension, agitation, hydrolization, and adhesion. Such effects of the physical or chemical characteristics are temporary, and are not detectable after the washing water is discarded so as to have minimal polluting effect on the environment. After the cleaning work is done, this temporary energy effect of the physical or chemical characteristics is just as transient, undetectable and non-polluting as is the thermal energy of hot water that has been cooled or the kinetic energy of moving water that has been stopped. Previous to this invention, the work of cleaning was done by three forms of energy: Thermal energy, kinetic energy, and chemical energy. This invention adds electric energy to the forms of energy that do the work of cleaning. Of the four forms of energy, the only one that remains in the waste water is chemical energy. Adding this additional form of energy allows the reduction of requirement for work to be done by any or all of the other forms of energy. The net result is the transfer of the work load from chemical energy, thus resulting in less dependence on the one form of energy that pollutes the environment.
摘要翻译：一种洗涤方法和装置，除了传统的三种形式的能量（动能，热能和化学能）之外，还采用电能形式进行清洁工作，从而减少对清洁能力的要求和依赖性传统的三种形式的能量。用电充电可以通过各种物理现象进行清洁工作。这些现象包括但不限于实现表面化学的物理特性，水的物理特性和水的化学特性。这些特征包括但不限于表面张力，搅拌，水解和粘附。物理或化学特性的这种影响是暂时性的，并且在洗涤水被丢弃以便对环境的污染影响最小的情况下是不可检测的。清洁工作完成后，物理或化学特性的这种临时能量效应与已冷却的热水的热能或已停止的动水的动能一样短暂，不可检测和无污染。在本发明之前，通过三种形式的能量来进行清洁工作：热能，动能和化学能。本发明将电能添加到进行清洁工作的能量形式中。在四种形式的能源中，唯一留在废水中的是化学能。添加这种额外形式的能量可以减少任何或所有其他能量形式的工作需求。最终的结果是工作负荷从化学能的转移，从而减少对污染环境的一种能量的依赖。

10. 发明申请

US20070203066A1 Compositions and methods for inhibiting cellular proliferation 审中-公开
标题翻译：抑制细胞增殖的组合物和方法
公开(公告)号：US20070203066A1
公开(公告)日：2007-08-30
申请号：US11636353
申请日：2006-12-08
申请人： Christopher Holmes , Qun Yin , Genet Zemede , Yvonne Angell , Brian Frederick , Caiding Xu
发明人： Christopher Holmes , Qun Yin , Genet Zemede , Yvonne Angell , Brian Frederick , Caiding Xu
IPC分类号： A61K38/10 , A61K38/08 , C07K7/08 , C07K7/06
CPC分类号： A61K38/08 , A61K38/10 , A61K47/55 , A61K47/60 , A61K47/62 , C07K7/08 , C07K14/001
摘要： Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise peptide molecules, optionally containing one or more individual peptide chains covalently linked, and optionally modified with polyethylene glycol (PEG). The methods involve administering to a human or animal the composition described herein in a dosage sufficient to inhibit cell proliferation, particularly endothelial cell proliferation. The methods are useful for treating diseases and processes mediated by undesired and uncontrolled cell proliferation, such as cancer, particularly by inhibiting angiogenesis. Administration of the composition to a human or animal having prevascularized, metastasized tumors is useful for preventing the growth or expansion of such tumors.
摘要翻译：提供了有效抑制异常或不期望的细胞增殖，特别是与新生血管形成和肿瘤生长相关的内皮细胞增殖和血管发生的组合物和方法。组合物包含肽分子，任选地含有一个或多个共价连接并且任选地用聚乙二醇（PEG）修饰的单个肽链。所述方法包括以足以抑制细胞增殖，特别是内皮细胞增殖的剂量向人或动物施用本文所述的组合物。该方法可用于治疗由不期望的和不受控制的细胞增殖如癌症介导的疾病和过程，特别是通过抑制血管发生。将组合物给予具有血运重建的转移性肿瘤的人或动物可用于预防这些肿瘤的生长或扩张。

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