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    • 4. 发明授权
    • Process for preparing lipid vesicles by vaporisation of solvents
    • 通过溶剂蒸发制备脂质囊泡的方法
    • US4608211A
    • 1986-08-26
    • US587653
    • 1984-03-08
    • Rose-Marie HandjaniAlain RibierManlio M. Maurelli
    • Rose-Marie HandjaniAlain RibierManlio M. Maurelli
    • A61K9/133A61K9/127B01J13/02A61K9/50A61K9/64
    • A61K9/1277Y10S436/829Y10T428/2984
    • A process for preparing large unilamellar lipid vesicles is disclosed which process comprises preparing unilamellar lipid vesicles having an average diameter of at least 1,000 .ANG., each of these vesicles consisting of a spheroidal lipid lamella containing a substance to be encapsulated, which process comprises dissolving one or more lipids intended to form the lamella of the vesicles in at least one water-insoluble solvent, conditioning the resulting lipid solution at a pressure P.sub.1 and at a temperature .theta..sub.1, dissolving the substance to be encapsulated in water to obtain an aqueous phase, conditioning said aqueous phase at a pressure P.sub.2 and a temperature .theta..sub.2, injecting the lipid solution into the aqueous phase at a low flow rate so as initially to form droplets and so that solvent of the lipid solution vaporises on coming into contact with the said aqueous phase, the pressure P.sub.2 being less than P.sub.1 and less than the vapor pressure of the solvent in the said droplets at the temperature .theta..sub.2.
    • 公开了一种制备大单层脂质囊泡的方法,该方法包括制备平均直径至少为1000的单层脂质小泡,这些囊泡由包含待包被物质的球状脂质薄片组成,该方法包括将一个或多个 更多的脂质旨在在至少一种水不溶性溶剂中形成泡囊的薄片,在压力P1和温度θ下调节所得脂质溶液,将待包封的物质溶解在水中以获得水相,调理 所述水相在压力P2和温度θ2下,以低流速将脂质溶液注入水相中,以便最初形成液滴,使得脂质溶液的溶剂在与所述水相接触时蒸发 压力P2小于P1且小于t处所述液滴中溶剂的蒸气压 温度θ2。