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1. 发明授权

US07026113B2 EIA vaccine and diagnostic 失效
公开(公告)号：US07026113B2
公开(公告)日：2006-04-11
申请号：US10180626
申请日：2002-06-26
申请人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessy , Karen K. Brown
发明人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessy , Karen K. Brown
IPC分类号： C12Q1/70 , C12Q1/68 , A61K48/00 , G01N33/53 , C12P19/34
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5254 , A61K2039/545 , A61K2039/552 , A61K2039/55555 , C12N7/00 , C12N2740/15021 , C12N2740/15022 , C12N2740/15034 , C12N2740/15061 , Y10S424/82
摘要： The invention provides an equine infectious anemia (EIA) vaccine that provides immunity to mammals, especially equines, from infection with equine infectious anemia virus (EIAV) and which allows differentiation between vaccinated and non-vaccinated, but exposed, mammals or equines. Preferably said vaccine encompasses at least one mutation in an EIAV which produces a non-functional gene in the vaccine virus that is always expressed in disease-producing wild-type EIA viruses. Additionally, said EIA vaccine virus cannot cause clinical disease in mammals or spread or shed to other mammals including equines.

2. 发明授权

US06585978B1 EIA vaccine and diagnostic 失效
标题翻译： EIA疫苗和诊断
公开(公告)号：US06585978B1
公开(公告)日：2003-07-01
申请号：US09658547
申请日：2000-09-09
申请人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessy , Karen K. Brown
发明人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessy , Karen K. Brown
IPC分类号： A61K39193
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5254 , A61K2039/545 , A61K2039/552 , A61K2039/55555 , C12N7/00 , C12N2740/15021 , C12N2740/15022 , C12N2740/15034 , C12N2740/15061 , Y10S424/82
摘要： The invention provides an equine infectious anemia (EIA) vaccine that provides immunity to mammals, especially equines, from infection with equine infectious anemia virus (EIAV) and which allows differentiation between vaccinated and non-vaccinated, but exposed, mammals or equines. Preferably said vaccine encompasses at least one mutation in an EIAV which produces a non-functional gene in the vaccine virus that is always expressed in disease-producing wild-type EIA viruses. Additionally, said EIA vaccine virus cannot cause clinical disease in mammals or spread or shed to other mammals including equines.
摘要翻译：本发明提供了一种马传染性贫血（EIA）疫苗，其能够免受哺乳动物，特别是马感染马传染性贫血病毒（EIAV）的免疫，并且其允许接种疫苗接种但未暴露的哺乳动物或马之间的分化。优选地，所述疫苗包括EIAV中的至少一个突变，其在疫苗病毒中产生总是在产生疾病的野生型EIA病毒中表达的非功能性基因。此外，所述EIA疫苗病毒不能在哺乳动物中引起临床疾病，或传播或流传至包括马的其他哺乳动物。

3. 发明授权

US06528250B1 Equine infectious anemia challenge model for testing vaccines, diagnostics and treatments 失效
标题翻译：用于测试疫苗，诊断和治疗的马传染性贫血挑战模型
公开(公告)号：US06528250B1
公开(公告)日：2003-03-04
申请号：US09659030
申请日：2000-09-09
申请人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessey , Karen K. Brown
发明人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessey , Karen K. Brown
IPC分类号： A61K4800
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N2740/15021 , C12N2740/15022 , C12N2740/15061
摘要： The invention relates to a method for infecting equines with an equine infectious anemia virus (EIAV) in order to reproduce a natural infection challenge model. More specifically, the invention provides a multiple low dose equine EIA challenge model comprising administering at least 1 median horse infective dose to an equine using an intravenous route of administration. It is preferable that the EIAV be administered on a repeated basis. The multiple low dose EIA challenge model described herein can be used for testing efficacy of vaccines, treatments and diagnostic tests.
摘要翻译：本发明涉及用马感染性贫血病毒（EIAV）感染马的方法，以便再现自然感染挑战模型。更具体地，本发明提供多重低剂量马EIA攻击模型，其包括使用静脉内施用途径向马施用至少1个中位数感染剂量。优选地，重复地施用EIAV。本文所述的多重低剂量EIA挑战模型可用于测试疫苗，治疗和诊断测试的功效。

4. 发明授权

US06727078B2 EIAV p26 deletion vaccine and diagnostic 失效
标题翻译： EIAV p26缺失疫苗和诊断
公开(公告)号：US06727078B2
公开(公告)日：2004-04-27
申请号：US10125087
申请日：2002-04-18
申请人： Ronald Montelaro , Jodi Craigo , Charles Issel , Bridget Puffer , Kristina J. Hennessey , Karen K. Brown
发明人： Ronald Montelaro , Jodi Craigo , Charles Issel , Bridget Puffer , Kristina J. Hennessey , Karen K. Brown
IPC分类号： C12P1500
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5254 , C12N2740/15022
摘要： Disclosed herein is a vaccine which provides immunity to mammals from infection and/or disease caused by a lentivirus, such as equine infectious anemia virus, human immunodeficiency virus (HIV), feline immunodeficiency virus (FIV), bovine immunodeficiency virus (BIV) or simian immunodeficiency virus (SIV) said composition comprising a deletion in a gene that blocks replication of the virus in vivo. Preferably said composition encompasses at least one deletion in a lentivirus which provides protection from exposure to wild-type lentiviruses. It also encompasses a marker vaccine in which a foreign gene is inserted into the gene-deleted region, said inserted gene providing a diagnostic tool for use in vaccinated mammals. The scope of the invention encompasses an EIAV vaccine that allows equines to be safely vaccinated and protected from disease without converting to a seropositive status on the Coggin's Test or any other test wich measures p26.
摘要翻译：本文公开了一种疫苗，其对哺乳动物免受由慢病毒引起的感染和/或疾病，例如马传染性贫血病毒，人免疫缺陷病毒（HIV），猫免疫缺陷病毒（FIV），牛免疫缺陷病毒（BIV）或猿猴免疫缺陷病毒（SIV）所述组合物包含在体内阻断病毒复制的基因中的缺失。优选地，所述组合物包含慢病毒中的至少一种缺失，其提供防止暴露于野生型慢病毒的保护。它还包括其中将外源基因插入基因缺失区域的标记疫苗，所述插入基因提供用于接种哺乳动物的诊断工具。本发明的范围包括EIAV疫苗，其允许马被安全地接种疫苗并免受疾病的侵害，而不会在Coggin's测试或任何其他测试p26的测试中转变为血清阳性状态。

5. 发明申请

US20110269710A1 PHARMACEUTICAL COMPOSITION OF COMPLEX CARBOHYDRATES AND ESSENTIAL OILS AND METHODS OF USING THE SAME 审中-公开
标题翻译：复合碳酸氢盐和基础油的药物组合物及其使用方法
公开(公告)号：US20110269710A1
公开(公告)日：2011-11-03
申请号：US13183214
申请日：2011-07-14
申请人： Harold G. Brown , Carol A. Cooper , Kristina J. Hennessy , Karen K. Brown
发明人： Harold G. Brown , Carol A. Cooper , Kristina J. Hennessy , Karen K. Brown
IPC分类号： A61K31/715 , A61P35/00 , A61P35/04 , A61K31/702
CPC分类号： A61K31/728 , A23K20/163 , A23L33/10 , A61K9/0014 , A61K31/715 , A61K31/726 , A61K31/727 , A61K31/736 , A61K31/737 , A61K47/44 , Y02A50/406
摘要： The invention discloses the discovery that a pharmaceutical composition containing complex carbohydrates with or without natural or synthetic essential oils can work effectively as a topical, oral or mucosal pharmaceutical composition. Such pharmaceutical compositions reduce inflammation, assist in wound healing, protect against bruising, relieve itching, relieve pain and swelling and treat topical bacterial infections such as acne and decubitus ulcers and prevent and treat numerous other conditions and diseases. Such pharmaceutical compositions can be administered to mammals including humans. Also included in this invention are methods to deliver topically applied macromolecules into the tissue of mammals and methods of blocking the adhesion, metastatic and coronary cascades.
摘要翻译：本发明公开了一种发现，含有或不含天然或合成精油的复合碳水化合物的药物组合物可以有效地作为局部，口服或粘膜药物组合物起作用。这种药物组合物减少炎症，有助于伤口愈合，防止瘀伤，缓解瘙痒，缓解疼痛和肿胀，并治疗局部细菌感染如痤疮和褥疮溃疡，并预防和治疗许多其他病症和疾病。这样的药物组合物可以施用于包括人在内的哺乳动物。本发明还包括将局部施用的大分子递送到哺乳动物的组织中的方法以及阻断粘附，转移和冠状动脉血管的方法。

6. 发明授权

US08003782B1 Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same 有权
标题翻译：复合碳水化合物和精油的药物组合物及其使用方法
公开(公告)号：US08003782B1
公开(公告)日：2011-08-23
申请号：US09890425
申请日：2000-02-01
申请人： Harold G. Brown , Carol A. Cooper , Kristina J. Hennessy , Karen K. Brown
发明人： Harold G. Brown , Carol A. Cooper , Kristina J. Hennessy , Karen K. Brown
IPC分类号： C07H5/04 , C07H5/06
CPC分类号： A23L1/30 , A23K20/163 , A23L33/10 , A61K9/0014 , A61K31/715 , A61K31/726 , A61K31/727 , A61K31/728 , A61K31/736 , A61K31/737 , A61K47/44 , Y02A50/406
摘要： The invention discloses the discovery that a pharmaceutical composition containing complex carbohydrates with or without natural or synthetic essential oils can work effectively as a topical, oral or mucosal pharmaceutical composition. Such pharmaceutical compositions reduce inflammation, assist in wound healing, protect against bruising, relieve itching, relieve pain and swelling and treat topical bacterial infections such as acne and decubitus ulcers and prevent and treat numerous other conditions and diseases. Such pharmaceutical compositions can be administered to mammals including humans. Also included in this invention are methods to deliver topically applied macromolecules into the tissue of mammals and methods of blocking the adhesion, metastatic and coronary cascades.
摘要翻译：本发明公开了一种发现，含有或不含天然或合成精油的复合碳水化合物的药物组合物可以有效地作为局部，口服或粘膜药物组合物起作用。这种药物组合物减少炎症，有助于伤口愈合，防止瘀伤，缓解瘙痒，缓解疼痛和肿胀，并治疗局部细菌感染如痤疮和褥疮溃疡，并预防和治疗许多其他病症和疾病。这样的药物组合物可以施用于包括人在内的哺乳动物。本发明还包括将局部施用的大分子递送到哺乳动物的组织中的方法以及阻断粘附，转移和冠状动脉血管的方法。

7. 发明授权

US07482020B2 Process for making an adjuvanted vaccine comprising host albumin 失效
标题翻译：制备包含宿主白蛋白的佐剂疫苗的方法
公开(公告)号：US07482020B2
公开(公告)日：2009-01-27
申请号：US10654534
申请日：2003-09-02
申请人： Kristina J. Hennessy , Karen K. Brown , Jennifer K. Lane , Sandra L. Trump
发明人： Kristina J. Hennessy , Karen K. Brown , Jennifer K. Lane , Sandra L. Trump
IPC分类号： A61K9/00 , A61K9/127 , A61K9/50 , A61K45/00 , A61K47/00 , A61K33/08 , A01N59/06
CPC分类号： A61K39/21 , A61K39/118 , A61K39/12 , A61K39/125 , A61K39/23 , A61K39/265 , A61K39/39 , A61K2039/5252 , A61K2039/552 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55588 , A61K2039/70 , C12N2710/16734 , C12N2740/10034 , C12N2750/14334 , C12N2770/16034
摘要： A process for making an adjuvanted vaccine comprising host albumin. The process comprises mixing host serum or host serum with an antigen, and then mixing the resulting mixture with an adjuvant.
摘要翻译：一种制备包含宿主白蛋白的佐剂疫苗的方法。该方法包括将宿主血清或宿主血清与抗原混合，然后将所得混合物与佐剂混合。

8. 发明授权

US06682746B2 Adjuvanted vaccine which is substantially free of non-host albumin 失效
标题翻译：基本上不含非宿主白蛋白的佐剂疫苗
公开(公告)号：US06682746B2
公开(公告)日：2004-01-27
申请号：US10099182
申请日：2002-03-14
申请人： Kristina J. Hennessy , Karen K. Brown , Jennifer K. Lane , Sandra L. Trump
发明人： Kristina J. Hennessy , Karen K. Brown , Jennifer K. Lane , Sandra L. Trump
IPC分类号： A61K4500
CPC分类号： A61K39/265 , A61K39/12 , A61K39/125 , A61K39/21 , A61K39/23 , A61K2039/5252 , A61K2039/552 , A61K2039/55555 , A61K2039/70 , C12N2710/16734 , C12N2740/13034 , C12N2750/14334 , C12N2760/18334 , C12N2770/16034
摘要： Disclosed herein is a serum-based adjuvanted vaccine which is substantially free of non-host albumin and the use thereof in reducing or preventing post-vaccination systemic reactions.
摘要翻译：本文公开了基本上不含非宿主白蛋白的血清佐剂疫苗及其在减少或预防接种后全身反应中的用途。

9. 发明授权

US09913906B2 Hyaluronic acid stabilizer 有权
公开(公告)号：US09913906B2
公开(公告)日：2018-03-13
申请号：US14995325
申请日：2016-01-14
申请人： Karen K. Brown
发明人： Karen K. Brown
IPC分类号： A61K31/728 , A61K47/12 , C08B37/08 , A61K9/00 , A61K47/02 , A61K9/06 , C08L5/08 , A61K8/04 , A61K8/365 , A61K8/73 , A61K9/08 , A61Q11/00 , A61Q19/00 , A61K47/22 , A61K47/46
CPC分类号： A61K47/12 , A61K8/042 , A61K8/365 , A61K8/735 , A61K9/0014 , A61K9/06 , A61K9/08 , A61K31/728 , A61K47/02 , A61K47/22 , A61K47/46 , A61K2800/524 , A61Q11/00 , A61Q19/00 , C08B37/0072 , C08L5/08
摘要： An embodiment of the present disclosure provides a composition that comprises hyaluronic acid, or its salt or derivative thereof, and an antimicrobial agent, such as zinc citrate, that does not degrade the hyaluronic acid molecule.

10. 发明授权

US07462359B2 Neospora vaccines 失效
标题翻译：新孢子虫疫苗
公开(公告)号：US07462359B2
公开(公告)日：2008-12-09
申请号：US11119474
申请日：2005-04-28
申请人： Leszek J. Choromanski , Karen K. Brown
发明人： Leszek J. Choromanski , Karen K. Brown
IPC分类号： A61K39/02
CPC分类号： C12R1/90 , A61K39/002
摘要： A Neospora caninum vaccine comprising tissue culture grown Neospora and methods of making and using said vaccines. Neospora caninum vaccines described include those containing whole Neospora tachyzoites, extracts of Neospora tachyzoites and protective antigen subunits of Neospora tachyzoites. The vaccines of this invention may be in a liquid or lyophilized form.
摘要翻译：包含组织培养生长的新孢子虫的新孢子虫疫苗以及制备和使用所述疫苗的方法。描述的新孢子虫疫苗包括含有全新孢子虫速殖子，新孢子虫速殖子的提取物和新孢子虫速殖子的保护性抗原亚单位的疫苗。本发明的疫苗可以是液体或冻干形式。

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