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1. 发明申请

US20110269710A1 PHARMACEUTICAL COMPOSITION OF COMPLEX CARBOHYDRATES AND ESSENTIAL OILS AND METHODS OF USING THE SAME 审中-公开
标题翻译：复合碳酸氢盐和基础油的药物组合物及其使用方法
公开(公告)号：US20110269710A1
公开(公告)日：2011-11-03
申请号：US13183214
申请日：2011-07-14
申请人： Harold G. Brown , Carol A. Cooper , Kristina J. Hennessy , Karen K. Brown
发明人： Harold G. Brown , Carol A. Cooper , Kristina J. Hennessy , Karen K. Brown
IPC分类号： A61K31/715 , A61P35/00 , A61P35/04 , A61K31/702
CPC分类号： A61K31/728 , A23K20/163 , A23L33/10 , A61K9/0014 , A61K31/715 , A61K31/726 , A61K31/727 , A61K31/736 , A61K31/737 , A61K47/44 , Y02A50/406
摘要： The invention discloses the discovery that a pharmaceutical composition containing complex carbohydrates with or without natural or synthetic essential oils can work effectively as a topical, oral or mucosal pharmaceutical composition. Such pharmaceutical compositions reduce inflammation, assist in wound healing, protect against bruising, relieve itching, relieve pain and swelling and treat topical bacterial infections such as acne and decubitus ulcers and prevent and treat numerous other conditions and diseases. Such pharmaceutical compositions can be administered to mammals including humans. Also included in this invention are methods to deliver topically applied macromolecules into the tissue of mammals and methods of blocking the adhesion, metastatic and coronary cascades.
摘要翻译：本发明公开了一种发现，含有或不含天然或合成精油的复合碳水化合物的药物组合物可以有效地作为局部，口服或粘膜药物组合物起作用。这种药物组合物减少炎症，有助于伤口愈合，防止瘀伤，缓解瘙痒，缓解疼痛和肿胀，并治疗局部细菌感染如痤疮和褥疮溃疡，并预防和治疗许多其他病症和疾病。这样的药物组合物可以施用于包括人在内的哺乳动物。本发明还包括将局部施用的大分子递送到哺乳动物的组织中的方法以及阻断粘附，转移和冠状动脉血管的方法。

2. 发明授权

US08003782B1 Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same 有权
标题翻译：复合碳水化合物和精油的药物组合物及其使用方法
公开(公告)号：US08003782B1
公开(公告)日：2011-08-23
申请号：US09890425
申请日：2000-02-01
申请人： Harold G. Brown , Carol A. Cooper , Kristina J. Hennessy , Karen K. Brown
发明人： Harold G. Brown , Carol A. Cooper , Kristina J. Hennessy , Karen K. Brown
IPC分类号： C07H5/04 , C07H5/06
CPC分类号： A23L1/30 , A23K20/163 , A23L33/10 , A61K9/0014 , A61K31/715 , A61K31/726 , A61K31/727 , A61K31/728 , A61K31/736 , A61K31/737 , A61K47/44 , Y02A50/406
摘要： The invention discloses the discovery that a pharmaceutical composition containing complex carbohydrates with or without natural or synthetic essential oils can work effectively as a topical, oral or mucosal pharmaceutical composition. Such pharmaceutical compositions reduce inflammation, assist in wound healing, protect against bruising, relieve itching, relieve pain and swelling and treat topical bacterial infections such as acne and decubitus ulcers and prevent and treat numerous other conditions and diseases. Such pharmaceutical compositions can be administered to mammals including humans. Also included in this invention are methods to deliver topically applied macromolecules into the tissue of mammals and methods of blocking the adhesion, metastatic and coronary cascades.
摘要翻译：本发明公开了一种发现，含有或不含天然或合成精油的复合碳水化合物的药物组合物可以有效地作为局部，口服或粘膜药物组合物起作用。这种药物组合物减少炎症，有助于伤口愈合，防止瘀伤，缓解瘙痒，缓解疼痛和肿胀，并治疗局部细菌感染如痤疮和褥疮溃疡，并预防和治疗许多其他病症和疾病。这样的药物组合物可以施用于包括人在内的哺乳动物。本发明还包括将局部施用的大分子递送到哺乳动物的组织中的方法以及阻断粘附，转移和冠状动脉血管的方法。

3. 发明授权

US08367642B2 Methods of preventing or treating diseases and conditions using complex carbohydrates 有权
公开(公告)号：US08367642B2
公开(公告)日：2013-02-05
申请号：US13006975
申请日：2011-01-14
申请人： Harold G. Brown , Karen K. Brown , Carol A. Cooper
发明人： Harold G. Brown , Karen K. Brown , Carol A. Cooper
IPC分类号： A61K31/70
CPC分类号： A61K31/70 , A61K31/715
摘要： The invention relates to a method of preventing and treating diseases and conditions associated with allergies, autoimmunity, the adhesion cascade, the metastatic cascade or the coronary cascade comprising administering (i) at least one complex carbohydrate as the sole active ingredient, or (ii) at least one pharmaceutical composition which comprises as an active ingredient a pharmacologically effective amount of at least one low purity or cosmetic grade complex carbohydrate selected from the group consisting of oligosaccharides, sialylated oligosaccharides, polysaccharides and glycosaminoglycans, and an effective amount of at least one transdermal or transmucosal carrier in an amount effective to deliver the complex carbohydrate into the blood stream.

4. 发明授权

US07879824B2 Methods of preventing or treating diseases and conditions using complex carbohydrates 有权
标题翻译：使用复合碳水化合物预防或治疗疾病和病症的方法
公开(公告)号：US07879824B2
公开(公告)日：2011-02-01
申请号：US10343240
申请日：2001-07-31
申请人： Harold G. Brown , Karen K. Brown , Carol A. Cooper
发明人： Harold G. Brown , Karen K. Brown , Carol A. Cooper
IPC分类号： A61K31/70
CPC分类号： A61K31/70 , A61K31/715
摘要： The invention relates to a method of preventing and treating diseases and conditions associated with allergies, autoimmunity, the adhesion cascade, the metastatic cascade or the coronary cascade comprising administering (i) at least one complex carbohydrate as the sole active ingredient, or (ii) at least one pharmaceutical composition which comprises as an active ingredient a pharmacologically effective amount of at least one low purity or cosmetic grade complex carbohydrate selected from the group consisting of oligosaccharides, sialylated oligosaccharides, polysaccharides and glycosaminoglycans, and an effective amount of at least one transdermal or transmucosal carrier in an amount effective to deliver the complex carbohydrate into the blood stream.
摘要翻译：本发明涉及一种预防和治疗与过敏，自身免疫，粘附级联，转移性级联或冠状动脉级联相关的疾病和病症的方法，包括给予（i）至少一种复合碳水化合物作为唯一活性成分，或（ii）至少一种药物组合物，其包含作为活性成分的药理学有效量的至少一种选自低聚糖，唾液酸化寡糖，多糖和糖胺聚糖的低纯度或化妆品级复合碳水化合物，以及有效量的至少一种透皮或经粘膜载体以有效将复合碳水化合物递送到血流中的量。

5. 发明授权

US06585978B1 EIA vaccine and diagnostic 失效
标题翻译： EIA疫苗和诊断
公开(公告)号：US06585978B1
公开(公告)日：2003-07-01
申请号：US09658547
申请日：2000-09-09
申请人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessy , Karen K. Brown
发明人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessy , Karen K. Brown
IPC分类号： A61K39193
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5254 , A61K2039/545 , A61K2039/552 , A61K2039/55555 , C12N7/00 , C12N2740/15021 , C12N2740/15022 , C12N2740/15034 , C12N2740/15061 , Y10S424/82
摘要： The invention provides an equine infectious anemia (EIA) vaccine that provides immunity to mammals, especially equines, from infection with equine infectious anemia virus (EIAV) and which allows differentiation between vaccinated and non-vaccinated, but exposed, mammals or equines. Preferably said vaccine encompasses at least one mutation in an EIAV which produces a non-functional gene in the vaccine virus that is always expressed in disease-producing wild-type EIA viruses. Additionally, said EIA vaccine virus cannot cause clinical disease in mammals or spread or shed to other mammals including equines.
摘要翻译：本发明提供了一种马传染性贫血（EIA）疫苗，其能够免受哺乳动物，特别是马感染马传染性贫血病毒（EIAV）的免疫，并且其允许接种疫苗接种但未暴露的哺乳动物或马之间的分化。优选地，所述疫苗包括EIAV中的至少一个突变，其在疫苗病毒中产生总是在产生疾病的野生型EIA病毒中表达的非功能性基因。此外，所述EIA疫苗病毒不能在哺乳动物中引起临床疾病，或传播或流传至包括马的其他哺乳动物。

6. 发明授权

US07026113B2 EIA vaccine and diagnostic 失效
公开(公告)号：US07026113B2
公开(公告)日：2006-04-11
申请号：US10180626
申请日：2002-06-26
申请人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessy , Karen K. Brown
发明人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessy , Karen K. Brown
IPC分类号： C12Q1/70 , C12Q1/68 , A61K48/00 , G01N33/53 , C12P19/34
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5254 , A61K2039/545 , A61K2039/552 , A61K2039/55555 , C12N7/00 , C12N2740/15021 , C12N2740/15022 , C12N2740/15034 , C12N2740/15061 , Y10S424/82
摘要： The invention provides an equine infectious anemia (EIA) vaccine that provides immunity to mammals, especially equines, from infection with equine infectious anemia virus (EIAV) and which allows differentiation between vaccinated and non-vaccinated, but exposed, mammals or equines. Preferably said vaccine encompasses at least one mutation in an EIAV which produces a non-functional gene in the vaccine virus that is always expressed in disease-producing wild-type EIA viruses. Additionally, said EIA vaccine virus cannot cause clinical disease in mammals or spread or shed to other mammals including equines.

7. 发明授权

US07482020B2 Process for making an adjuvanted vaccine comprising host albumin 失效
标题翻译：制备包含宿主白蛋白的佐剂疫苗的方法
公开(公告)号：US07482020B2
公开(公告)日：2009-01-27
申请号：US10654534
申请日：2003-09-02
申请人： Kristina J. Hennessy , Karen K. Brown , Jennifer K. Lane , Sandra L. Trump
发明人： Kristina J. Hennessy , Karen K. Brown , Jennifer K. Lane , Sandra L. Trump
IPC分类号： A61K9/00 , A61K9/127 , A61K9/50 , A61K45/00 , A61K47/00 , A61K33/08 , A01N59/06
CPC分类号： A61K39/21 , A61K39/118 , A61K39/12 , A61K39/125 , A61K39/23 , A61K39/265 , A61K39/39 , A61K2039/5252 , A61K2039/552 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55588 , A61K2039/70 , C12N2710/16734 , C12N2740/10034 , C12N2750/14334 , C12N2770/16034
摘要： A process for making an adjuvanted vaccine comprising host albumin. The process comprises mixing host serum or host serum with an antigen, and then mixing the resulting mixture with an adjuvant.
摘要翻译：一种制备包含宿主白蛋白的佐剂疫苗的方法。该方法包括将宿主血清或宿主血清与抗原混合，然后将所得混合物与佐剂混合。

8. 发明授权

US06682746B2 Adjuvanted vaccine which is substantially free of non-host albumin 失效
标题翻译：基本上不含非宿主白蛋白的佐剂疫苗
公开(公告)号：US06682746B2
公开(公告)日：2004-01-27
申请号：US10099182
申请日：2002-03-14
申请人： Kristina J. Hennessy , Karen K. Brown , Jennifer K. Lane , Sandra L. Trump
发明人： Kristina J. Hennessy , Karen K. Brown , Jennifer K. Lane , Sandra L. Trump
IPC分类号： A61K4500
CPC分类号： A61K39/265 , A61K39/12 , A61K39/125 , A61K39/21 , A61K39/23 , A61K2039/5252 , A61K2039/552 , A61K2039/55555 , A61K2039/70 , C12N2710/16734 , C12N2740/13034 , C12N2750/14334 , C12N2760/18334 , C12N2770/16034
摘要： Disclosed herein is a serum-based adjuvanted vaccine which is substantially free of non-host albumin and the use thereof in reducing or preventing post-vaccination systemic reactions.
摘要翻译：本文公开了基本上不含非宿主白蛋白的血清佐剂疫苗及其在减少或预防接种后全身反应中的用途。

9. 发明授权

US06911436B2 Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same 失效
标题翻译：复合碳水化合物和精油的药物组合物及其使用方法
公开(公告)号：US06911436B2
公开(公告)日：2005-06-28
申请号：US09880907
申请日：2001-06-15
申请人： Harold G. Brown , Karen K. Brown
发明人： Harold G. Brown , Karen K. Brown
IPC分类号： A61K8/73 , A61K8/92 , A61K9/00 , A61K31/715 , A61K31/727 , A61K31/728 , A61K31/737 , A61K36/15 , A61K36/185 , A61K36/23 , A61K36/45 , A61K36/53 , A61K36/534 , A61K36/537 , A61K36/54 , A61K36/57 , A61K36/61 , A61K36/736 , A61K36/752 , A61K36/886 , A61K36/9064 , A61K36/9066 , A61K47/44 , A61Q19/00 , A61K31/725 , A61K31/70 , C08B37/00
CPC分类号： A61K47/44 , A61K8/73 , A61K8/735 , A61K8/922 , A61K9/0014 , A61K9/0019 , A61K31/715 , A61K31/727 , A61K31/728 , A61K31/737 , A61K36/15 , A61K36/185 , A61K36/23 , A61K36/45 , A61K36/53 , A61K36/534 , A61K36/537 , A61K36/54 , A61K36/57 , A61K36/61 , A61K36/736 , A61K36/752 , A61K36/886 , A61K36/9064 , A61K36/9066 , A61Q19/00 , Y10S424/13 , Y10S514/825 , Y10S514/859 , Y10S514/862 , Y10S514/865 , Y10S514/885 , Y10S514/886 , Y10S514/887 , A61K2300/00
摘要： The invention discloses the discovery that a pharmaceutical composition containing complex carbohydrates and natural or synthetic essential oils can work effectively as a topical pharmaceutical composition. Such pharmaceutical compositions reduce inflammation, assist in wound healing, protect against bruising, relieve itching, relieve pain and swelling and treat topical bacterial infections such as acne and decubitus ulcers. Such pharmaceutical compositions can be administered to mammals including humans. Also included in this invention are methods to deliver topically applied macromolecules into the tissue of mammals and methods of blocking the adhesion cascade.
摘要翻译：本发明公开了一种发现，含有复合碳水化合物和天然或合成精油的药物组合物可以作为局部药物组合物有效地起作用。这样的药物组合物减少炎症，有助于伤口愈合，防止瘀伤，缓解瘙痒，缓解疼痛和肿胀以及治疗局部细菌感染如痤疮和褥疮溃疡。这样的药物组合物可以施用于包括人在内的哺乳动物。本发明还包括将局部施用的大分子递送到哺乳动物的组织中的方法和阻断粘附级联的方法。

10. 发明授权

US09913906B2 Hyaluronic acid stabilizer 有权
公开(公告)号：US09913906B2
公开(公告)日：2018-03-13
申请号：US14995325
申请日：2016-01-14
申请人： Karen K. Brown
发明人： Karen K. Brown
IPC分类号： A61K31/728 , A61K47/12 , C08B37/08 , A61K9/00 , A61K47/02 , A61K9/06 , C08L5/08 , A61K8/04 , A61K8/365 , A61K8/73 , A61K9/08 , A61Q11/00 , A61Q19/00 , A61K47/22 , A61K47/46
CPC分类号： A61K47/12 , A61K8/042 , A61K8/365 , A61K8/735 , A61K9/0014 , A61K9/06 , A61K9/08 , A61K31/728 , A61K47/02 , A61K47/22 , A61K47/46 , A61K2800/524 , A61Q11/00 , A61Q19/00 , C08B37/0072 , C08L5/08
摘要： An embodiment of the present disclosure provides a composition that comprises hyaluronic acid, or its salt or derivative thereof, and an antimicrobial agent, such as zinc citrate, that does not degrade the hyaluronic acid molecule.

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