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1. 发明授权

US07026113B2 EIA vaccine and diagnostic 失效
公开(公告)号：US07026113B2
公开(公告)日：2006-04-11
申请号：US10180626
申请日：2002-06-26
申请人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessy , Karen K. Brown
发明人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessy , Karen K. Brown
IPC分类号： C12Q1/70 , C12Q1/68 , A61K48/00 , G01N33/53 , C12P19/34
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5254 , A61K2039/545 , A61K2039/552 , A61K2039/55555 , C12N7/00 , C12N2740/15021 , C12N2740/15022 , C12N2740/15034 , C12N2740/15061 , Y10S424/82
摘要： The invention provides an equine infectious anemia (EIA) vaccine that provides immunity to mammals, especially equines, from infection with equine infectious anemia virus (EIAV) and which allows differentiation between vaccinated and non-vaccinated, but exposed, mammals or equines. Preferably said vaccine encompasses at least one mutation in an EIAV which produces a non-functional gene in the vaccine virus that is always expressed in disease-producing wild-type EIA viruses. Additionally, said EIA vaccine virus cannot cause clinical disease in mammals or spread or shed to other mammals including equines.

2. 发明授权

US06585978B1 EIA vaccine and diagnostic 失效
标题翻译： EIA疫苗和诊断
公开(公告)号：US06585978B1
公开(公告)日：2003-07-01
申请号：US09658547
申请日：2000-09-09
申请人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessy , Karen K. Brown
发明人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessy , Karen K. Brown
IPC分类号： A61K39193
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5254 , A61K2039/545 , A61K2039/552 , A61K2039/55555 , C12N7/00 , C12N2740/15021 , C12N2740/15022 , C12N2740/15034 , C12N2740/15061 , Y10S424/82
摘要： The invention provides an equine infectious anemia (EIA) vaccine that provides immunity to mammals, especially equines, from infection with equine infectious anemia virus (EIAV) and which allows differentiation between vaccinated and non-vaccinated, but exposed, mammals or equines. Preferably said vaccine encompasses at least one mutation in an EIAV which produces a non-functional gene in the vaccine virus that is always expressed in disease-producing wild-type EIA viruses. Additionally, said EIA vaccine virus cannot cause clinical disease in mammals or spread or shed to other mammals including equines.
摘要翻译：本发明提供了一种马传染性贫血（EIA）疫苗，其能够免受哺乳动物，特别是马感染马传染性贫血病毒（EIAV）的免疫，并且其允许接种疫苗接种但未暴露的哺乳动物或马之间的分化。优选地，所述疫苗包括EIAV中的至少一个突变，其在疫苗病毒中产生总是在产生疾病的野生型EIA病毒中表达的非功能性基因。此外，所述EIA疫苗病毒不能在哺乳动物中引起临床疾病，或传播或流传至包括马的其他哺乳动物。

3. 发明授权

US06461616B1 EIAV p26 deletion vaccine and diagnostic 失效
标题翻译： EIAV p26缺失疫苗和诊断
公开(公告)号：US06461616B1
公开(公告)日：2002-10-08
申请号：US09659026
申请日：2000-09-09
申请人： Ronald Montelaro , Jodi Craigo , Charles Issel , Bridget Puffer , Kristina J. Hennessy , Karen K Brown
发明人： Ronald Montelaro , Jodi Craigo , Charles Issel , Bridget Puffer , Kristina J. Hennessy , Karen K Brown
IPC分类号： A61K39193
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5254 , C12N2740/15022
摘要： Disclosed herein is a vaccine which provides immunity to mammals from infection and/or disease caused by a lentivirus, such as equine infectious anemia virus, human immunodeficiency virus (HIV), feline immunodeficiency virus (FIV), bovine immunodeficiency virus (BIV) or simian immunodeficiency virus (SIV) said composition comprising a deletion in a gene that blocks replication of the virus in vivo. Preferably said composition encompasses at least one deletion in a lentivirus which provides protection from exposure to wild-type lentiviruses. It also encompasses a marker vaccine in which a foreign gene is inserted into the gene-deleted region, said inserted gene providing a diagnostic tool for use in vaccinated mammals. The scope of the invention encompasses an EIAV vaccine that allows equines to be safely vaccinated and protected from disease without converting to a seropositive status on the Coggin's Test or any other test which measures p26.
摘要翻译：本文公开了一种疫苗，其对哺乳动物免受由慢病毒引起的感染和/或疾病，例如马传染性贫血病毒，人免疫缺陷病毒（HIV），猫免疫缺陷病毒（FIV），牛免疫缺陷病毒（BIV）或猿猴免疫缺陷病毒（SIV）所述组合物包含在体内阻断病毒复制的基因中的缺失。优选地，所述组合物包含慢病毒中的至少一种缺失，其提供防止暴露于野生型慢病毒的保护。它还包括其中将外源基因插入基因缺失区域的标记疫苗，所述插入基因提供用于接种哺乳动物的诊断工具。本发明的范围包括EIAV疫苗，其允许马被安全地接种疫苗并免受疾病的侵害，而不会在Coggin's Test或任何其他测量p26的测试中转变为血清阳性状态。

4. 发明授权

US06528250B1 Equine infectious anemia challenge model for testing vaccines, diagnostics and treatments 失效
标题翻译：用于测试疫苗，诊断和治疗的马传染性贫血挑战模型
公开(公告)号：US06528250B1
公开(公告)日：2003-03-04
申请号：US09659030
申请日：2000-09-09
申请人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessey , Karen K. Brown
发明人： Ronald Montelaro , Bridget Puffer , Feng Li , Charles Issel , Kristina J. Hennessey , Karen K. Brown
IPC分类号： A61K4800
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N2740/15021 , C12N2740/15022 , C12N2740/15061
摘要： The invention relates to a method for infecting equines with an equine infectious anemia virus (EIAV) in order to reproduce a natural infection challenge model. More specifically, the invention provides a multiple low dose equine EIA challenge model comprising administering at least 1 median horse infective dose to an equine using an intravenous route of administration. It is preferable that the EIAV be administered on a repeated basis. The multiple low dose EIA challenge model described herein can be used for testing efficacy of vaccines, treatments and diagnostic tests.
摘要翻译：本发明涉及用马感染性贫血病毒（EIAV）感染马的方法，以便再现自然感染挑战模型。更具体地，本发明提供多重低剂量马EIA攻击模型，其包括使用静脉内施用途径向马施用至少1个中位数感染剂量。优选地，重复地施用EIAV。本文所述的多重低剂量EIA挑战模型可用于测试疫苗，治疗和诊断测试的功效。

5. 发明授权

US06727078B2 EIAV p26 deletion vaccine and diagnostic 失效
标题翻译： EIAV p26缺失疫苗和诊断
公开(公告)号：US06727078B2
公开(公告)日：2004-04-27
申请号：US10125087
申请日：2002-04-18
申请人： Ronald Montelaro , Jodi Craigo , Charles Issel , Bridget Puffer , Kristina J. Hennessey , Karen K. Brown
发明人： Ronald Montelaro , Jodi Craigo , Charles Issel , Bridget Puffer , Kristina J. Hennessey , Karen K. Brown
IPC分类号： C12P1500
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5254 , C12N2740/15022
摘要： Disclosed herein is a vaccine which provides immunity to mammals from infection and/or disease caused by a lentivirus, such as equine infectious anemia virus, human immunodeficiency virus (HIV), feline immunodeficiency virus (FIV), bovine immunodeficiency virus (BIV) or simian immunodeficiency virus (SIV) said composition comprising a deletion in a gene that blocks replication of the virus in vivo. Preferably said composition encompasses at least one deletion in a lentivirus which provides protection from exposure to wild-type lentiviruses. It also encompasses a marker vaccine in which a foreign gene is inserted into the gene-deleted region, said inserted gene providing a diagnostic tool for use in vaccinated mammals. The scope of the invention encompasses an EIAV vaccine that allows equines to be safely vaccinated and protected from disease without converting to a seropositive status on the Coggin's Test or any other test wich measures p26.
摘要翻译：本文公开了一种疫苗，其对哺乳动物免受由慢病毒引起的感染和/或疾病，例如马传染性贫血病毒，人免疫缺陷病毒（HIV），猫免疫缺陷病毒（FIV），牛免疫缺陷病毒（BIV）或猿猴免疫缺陷病毒（SIV）所述组合物包含在体内阻断病毒复制的基因中的缺失。优选地，所述组合物包含慢病毒中的至少一种缺失，其提供防止暴露于野生型慢病毒的保护。它还包括其中将外源基因插入基因缺失区域的标记疫苗，所述插入基因提供用于接种哺乳动物的诊断工具。本发明的范围包括EIAV疫苗，其允许马被安全地接种疫苗并免受疾病的侵害，而不会在Coggin's测试或任何其他测试p26的测试中转变为血清阳性状态。

6. 发明申请

US20050287524A1 Differential serological diagnosis of equine infectious anemia virus infected and vaccinated horses using recombinant S2 protein 审中-公开
标题翻译：使用重组S2蛋白的马传染性贫血病毒感染和接种马的差异血清学诊断
公开(公告)号：US20050287524A1
公开(公告)日：2005-12-29
申请号：US11210358
申请日：2005-08-24
申请人： Ronald Montelaro , Charles Issel , Sha Jin
发明人： Ronald Montelaro , Charles Issel , Sha Jin
IPC分类号： C12Q1/70 , G01N33/569
CPC分类号： G01N33/56983 , G01N2333/155 , G01N2469/20
摘要： We describe here the development and optimization of an embodiment of a new serologic EIAV diagnostic ELISA assay to detect serum antibodies to the EIAV S2 protein that are produced in infected horses, but not in horses inoculated with the EIAVUKΔS2 vaccine virus. An embodiment of the test S2 protein antigen was developed using the S2 gene sequence from the EIAVUK strain of virus and a series of modifications to facilitate production and purification of the diagnostic antigen, designated HS2G. Using this embodiment of an HS2G as antigen, we describe the development of an affinity ELISA (NN-ELISA) that provides a sensitive and specific detection of S2-specific serum antibodies in experimentally and field infected horses (22/24), without detectable reactivity with immune serum from uninfected (12/12) or vaccinated (29/29) horses.
摘要翻译：我们在这里描述开发和优化新的血清学EIAV诊断ELISA测定的实施方案，以检测在感染的马中产生的EIAV S2蛋白的血清抗体，但不是用EIAV UK接种的马。 DeltaS2疫苗病毒。使用来自EIAV UK UK病毒株的S2基因序列开发了测试S2蛋白抗原的一个实施方案，并进行了一系列修饰，以促进命名为HS2G的诊断抗原的产生和纯化。使用HS2G的这个实施方案作为抗原，我们描述了在实验和田间感染的马（22/24）中提供对S2特异性血清抗体的敏感和特异性检测的亲和ELISA（NN-ELISA）的开发，而没有可检测的反应性来自未感染（12/12）或接种疫苗（29/29）的马的免疫血清。

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