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1. 发明授权

US08409531B2 Method and apparatus for storing and dispensing reagent beads 有权
标题翻译：用于存储和分配试剂珠的方法和装置
公开(公告)号：US08409531B2
公开(公告)日：2013-04-02
申请号：US12512926
申请日：2009-07-30
申请人： Ronald Chang , Douglas B. Dority , Steve Montgomery
发明人： Ronald Chang , Douglas B. Dority , Steve Montgomery
IPC分类号： B01L3/00 , G01N31/00 , G01N33/543 , B65G47/14 , B23Q7/04 , B65H3/06 , B65H3/24 , B65H3/44 , B65H1/08 , B65H3/00 , G01N1/00 , G07F9/00 , G07F11/16 , B65G59/00
CPC分类号： B01L3/527 , B01J19/0046 , B01J2219/00468 , B01J2219/005 , B01J2219/00657 , B01L3/0289 , B01L2200/0647 , B01L2200/16 , G01N2035/00574 , Y10T436/25
摘要： Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads.
摘要翻译：本发明的实施方案提供了用于存储和分配试剂珠的有效和有效的技术。在一些实施例中，提供了一种用于分配包含在珠子存储装置中的试剂珠粒的装置，其包括具有多个孔的珠粒载体; 设置在所述孔中的多个试剂珠; 以及可剥离地附接到胎圈载体以覆盖孔并将试剂珠保持在孔中的覆盖带。该装置包括一个通道，在该通道中，珠子存放装置使胎圈承载件面向通道的支撑壁，盖带面向通道的剥离壁。剥离壁包括设置在剥离边缘和相对边缘之间的剥离间隙，以及在剥离壁的与剥离边缘相对的一侧上邻近相对边缘设置的分配开口。覆盖带可以通过剥离间隙被插入以被拉靠在剥离边缘上，以从胎圈载体上剥离覆盖带，以将通道内的胎圈载体的孔移动到分配开口，并单独暴露孔以分配试剂珠。

2. 发明授权

US08409530B2 Apparatus for storing and dispensing reagent beads 有权
标题翻译：用于存储和分配试剂珠的装置
公开(公告)号：US08409530B2
公开(公告)日：2013-04-02
申请号：US12512833
申请日：2009-07-30
申请人： Ronald Chang , Douglas B. Dority , Steve Montgomery
发明人： Ronald Chang , Douglas B. Dority , Steve Montgomery
IPC分类号： B01L9/00 , B23Q7/04 , G07F11/16 , B65H5/00 , B65H1/08 , B65H3/00
CPC分类号： B01L3/527 , B01J19/0046 , B01J2219/00468 , B01J2219/005 , B01J2219/00657 , B01L3/0289 , B01L2200/0647 , B01L2200/16 , G01N2035/00574 , Y10T436/25
摘要： Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads.
摘要翻译：本发明的实施方案提供了用于存储和分配试剂珠的有效和有效的技术。在一些实施例中，提供了一种用于分配包含在珠子存储装置中的试剂珠粒的装置，其包括具有多个孔的珠粒载体; 设置在孔中的多个试剂珠; 以及可剥离地附接到胎圈载体以覆盖孔并将试剂珠保持在孔中的覆盖带。该装置包括一个通道，在该通道中，珠子存放装置使胎圈承载件面向通道的支撑壁，盖带面向通道的剥离壁。剥离壁包括设置在剥离边缘和相对边缘之间的剥离间隙，以及在剥离壁的与剥离边缘相对的一侧上邻近相对边缘设置的分配开口。覆盖带可以通过剥离间隙被插入以被拉靠在剥离边缘上，以从胎圈载体上剥离覆盖带，以将通道内的胎圈载体的孔移动到分配开口，并单独暴露孔以分配试剂珠。

3. 发明授权

US10247646B2 Self-contained sample processing cartridge with preloaded reagent 有权
公开(公告)号：US10247646B2
公开(公告)日：2019-04-02
申请号：US14642698
申请日：2015-03-09
申请人： Shazi S Iqbal , Steven M Montgomery , Ronald Chang , Gregory E Mote , Douglas B Dority , Jeffrey S Ross
发明人： Shazi S Iqbal , Steven M Montgomery , Ronald Chang , Gregory E Mote , Douglas B Dority , Jeffrey S Ross
IPC分类号： G01N1/31 , G01N1/30 , B01L3/00 , B01L9/00 , G01N35/00 , G01N1/38
摘要： A self-contained biological sample processing cartridge includes top and bottom portions that close together to form a sealed chamber therein. The chamber is configured to enable one of one or more biological sample staining procedures appropriate for a biological sample. The top portion includes a chamber top section and valve control elements. The bottom portion includes a chamber bottom section and fluidic valves. One of the fluid valves evacuates the contents of the chamber. One of the valve control elements couples to a respective fluidic valve to control fluid flow for the chamber. The cartridge includes a preloaded reagent component to supply the chamber with the reagent component appropriate for a particular biological sample staining procedure. A user desiring to conduct a particular biological sample staining procedure may select a particular cartridge that is preloaded with the preloaded reagent fluidic valves component appropriate for the particular biological sample staining procedure.

4. 发明授权

US08975039B2 Automatic sample staining method 有权
标题翻译：自动样品染色法
公开(公告)号：US08975039B2
公开(公告)日：2015-03-10
申请号：US12135925
申请日：2008-06-09
申请人： Shazi Iqbal , Steven M. Montgomery , Ronald Chang , Gregory Mote , Douglas B Dority , Jeffrey S. Ross
发明人： Shazi Iqbal , Steven M. Montgomery , Ronald Chang , Gregory Mote , Douglas B Dority , Jeffrey S. Ross
IPC分类号： G01N1/30 , G01N35/00 , G01N1/31 , C12M1/02 , G01N1/38
CPC分类号： G01N1/312 , G01N1/30 , G01N1/38 , G01N35/00029 , G01N35/0092 , G01N2001/386 , G01N2035/00534 , G01N2035/00792 , G01N2035/00811 , Y10T436/112499 , Y10T436/25 , Y10T436/2525
摘要： Provided is a system and method for staining of one or more samples, including providing one or more self-contained sample processing receptacles, each of the one or more self-contained sample processing receptacles configured to be inserted into an auto-staining instrument; and enabling one of one or more staining procedures appropriate for the one or more samples as a function of a choice of self-contained sample processing receptacle, each of the one or more self-contained sample processing receptacles configured to process each inserted sample of the one or more samples within the self-contained sample processing receptacle.
摘要翻译：提供了一种用于染色一个或多个样品的系统和方法，包括提供一个或多个独立的样品处理容器，所述一个或多个独立样品处理容器中的每一个被配置为插入自动染色仪器中; 以及使得适合于所述一个或多个样品的一个或多个染色程序中的一个作为自选样品处理容器的选择的功能，所述一个或多个独立样品处理容器中的每一个被配置成处理每个插入的样品独立样品处理容器内的一个或多个样品。

5. 发明申请

US20120288924A1 CARTRIDGE FOR CONDUCTING A CHEMICAL REACTION 有权
标题翻译：用于进行化学反应的墨盒
公开(公告)号：US20120288924A1
公开(公告)日：2012-11-15
申请号：US13436475
申请日：2012-03-30
申请人： Kurt E. Peterson , William A. McMillan , Farzad Pourahmadi , Ronald Chang , Douglas B. Dority
发明人： Kurt E. Peterson , William A. McMillan , Farzad Pourahmadi , Ronald Chang , Douglas B. Dority
IPC分类号： G01N21/59 , C12M1/34 , G01N33/48
CPC分类号： B01L7/52 , B01L3/502 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0858 , B01L2300/087 , B01L2300/123 , B01L2300/14 , B01L2300/168 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12Q1/6844 , G01N33/5302 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： A cartridge for conducting a chemical reaction includes a body having at least one flow path formed therein. The cartridge also includes a reaction vessel extending from the body for holding a reaction mixture for chemical reaction and optical detection. The vessel comprises a rigid frame defining the side walls of a reaction chamber. The frame includes at least one channel connecting the flow path to the chamber. The vessel also includes flexible films or sheets attached to opposite sides of the rigid frame to form opposing major walls of the chamber. In addition, at least two of the side walls are optically transmissive and angularly offset from each to permit real-time optical detection of analyte in the reaction chamber.
摘要翻译：用于进行化学反应的药筒包括具有形成在其中的至少一个流路的主体。药筒还包括从身体延伸的反应容器，用于保持用于化学反应和光学检测的反应混合物。容器包括限定反应室侧壁的刚性框架。该框架包括连接到该腔室的流动路径的至少一个通道。容器还包括附接到刚性框架的相对侧的柔性膜或片，以形成腔室的相对的主壁。此外，至少两个侧壁是光学透射的并且与每个侧壁成角度地偏移以允许对反应室中的分析物的实时光学检测。

6. 发明申请

US20090305337A1 SAMPLE PROCESSING SYSTEM AND METHOD 有权
标题翻译：样本处理系统和方法
公开(公告)号：US20090305337A1
公开(公告)日：2009-12-10
申请号：US12135925
申请日：2008-06-09
申请人： Shazi Iqbal , Steven M. Montgomery , Ronald Chang , Gregory Mote , Douglas B. Dority , Jeffrey S. Ross
发明人： Shazi Iqbal , Steven M. Montgomery , Ronald Chang , Gregory Mote , Douglas B. Dority , Jeffrey S. Ross
IPC分类号： G01N1/30 , G01N1/31 , C12M1/00 , C12M1/36 , C12M1/02
CPC分类号： G01N1/312 , G01N1/30 , G01N1/38 , G01N35/00029 , G01N35/0092 , G01N2001/386 , G01N2035/00534 , G01N2035/00792 , G01N2035/00811 , Y10T436/112499 , Y10T436/25 , Y10T436/2525
摘要： Provided is a system and method for staining of one or more samples, including providing one or more self-contained sample processing receptacles, each of the one or more self-contained sample processing receptacles configured to be inserted into an auto-staining instrument; and enabling one of one or more staining procedures appropriate for the one or more samples as a function of a choice of self-contained sample processing receptacle, each of the one or more self-contained sample processing receptacles configured to process each inserted sample of the one or more samples within the self-contained sample processing receptacle.
摘要翻译：提供了一种用于染色一个或多个样品的系统和方法，包括提供一个或多个独立的样品处理容器，所述一个或多个独立样品处理容器中的每一个被配置为插入自动染色仪器中; 以及使得适合于所述一个或多个样品的一个或多个染色程序中的一个作为自选样品处理容器的选择的功能，所述一个或多个独立样品处理容器中的每一个被配置成处理每个插入的样品独立样品处理容器内的一个或多个样品。

7. 发明授权

US06940598B2 Multi-channel optical detection system 有权
标题翻译：多通道光学检测系统
公开(公告)号：US06940598B2
公开(公告)日：2005-09-06
申请号：US10119228
申请日：2002-04-08
申请人： Lee A. Christel , M. Allen Northrup , Kurt E. Petersen , William A. McMillan , Gregory T. A. Kovacs , Steven J. Young , Ronald Chang , Douglas B. Dority , Raymond T. Hebert , Gregory J. Kintz
发明人： Lee A. Christel , M. Allen Northrup , Kurt E. Petersen , William A. McMillan , Gregory T. A. Kovacs , Steven J. Young , Ronald Chang , Douglas B. Dority , Raymond T. Hebert , Gregory J. Kintz
IPC分类号： B01J19/00 , B01L3/00 , B01L3/14 , B01L7/00 , F28F3/12 , F28F21/04 , G01N21/03 , G01N35/00 , G01N21/64
CPC分类号： B01L3/508 , B01J19/0093 , B01L3/5082 , B01L7/52 , B01L2300/042 , B01L2300/0809 , B01L2300/0858 , B01L2300/168 , B01L2300/1805 , F28D2021/0077 , F28F3/12 , F28F21/04 , F28F2280/10 , G01N21/0303 , G01N21/0332 , G01N2035/00326
摘要： An apparatus for thermally controlling and optically interrogating a reaction mixture includes a vessel [2] having a chamber [10] for holding the mixture. The apparatus also includes a heat-exchanging module [37] having a pair of opposing thermal plates [34A, 34B] for receiving the vessel [2] between them and for heating/and or cooling the mixture contained in the vessel. The module [37] also includes optical excitation and detection assemblies [46,48] positioned to optically interrogate the mixture. The excitation assembly [46] includes multiple light sources [100] and a set of filters for sequentially illuminating labeled analytes in the mixture with excitation beams in multiple excitation wavelength ranges. The detection assembly [48] includes multiple detectors [102] and a second set of filters for detecting light emitted from the chamber [10] in multiple emission wavelength ranges. The optics assemblies [46,48] thus provide a multi-channel system for detecting a plurality of different target analytes in the mixture.
摘要翻译：用于热控制和光学询问反应混合物的装置包括具有用于保持混合物的室[10]的容器[2]。该装置还包括具有一对相对的热板[34A，34B]的热交换模块[37]，用于在它们之间接收容器[2]并用于加热和/或冷却容器中所含的混合物。模块[37]还包括定位成光学询问混合物的光学激发和检测组件[46,48]。激发组件[46]包括多个光源[100]和一组用于在多个激发波长范围内用激发光束顺序地照射混合物中的标记分析物的滤光器。检测组件[48]包括多个检测器[102]和第二组滤波器，用于在多个发射波长范围内检测从腔室[10]发射的光。因此，光学组件[46,48]提供用于检测混合物中的多个不同目标分析物的多通道系统。

8. 发明授权

US06403037B1 Reaction vessel and temperature control system 有权
标题翻译：反应容器和温度控制系统
公开(公告)号：US06403037B1
公开(公告)日：2002-06-11
申请号：US09497848
申请日：2000-02-04
申请人： Ronald Chang , Douglas B. Dority , Lee A. Christel , Kurt E. Petersen
发明人： Ronald Chang , Douglas B. Dority , Lee A. Christel , Kurt E. Petersen
IPC分类号： G01N1506
CPC分类号： B01L3/502 , B01L3/50825 , B01L7/52 , B01L2200/026 , B01L2200/0642 , B01L2200/0684 , B01L2300/0654 , B01L2300/14 , B01L2400/049 , B01L2400/0644 , G01N2035/0405 , Y10T436/2575
摘要： The invention provides a reaction vessel and temperature control system for performing heat-exchanging chemical reactions, such as nucleic acid amplification. The vessel has a body defining a reaction chamber, and a loading structure extending from the body for loading a sample into the chamber. The loading structure has a loading reservoir, an aspiration port, and respective fluid channels connecting the loading reservoir and aspiration port to the chamber. To load the sample into the vessel, the sample is first dispensed into the loading reservoir and then drawn into the chamber by application of a vacuum to the aspiration port. The vessel also includes a seal aperture extending over the outer ends of the loading reservoir and aspiration port. A plug is inserted into the aperture after loading the sample into the chamber to simultaneously seal the chamber, loading reservoir, and aspiration port from the external environment. The temperature of the sample is controlled by opposing plates positioned to contact opposite sides of the vessel. The system also,includes thermal elements for heating or cooling the plates and optics for detecting one or more analytes in the sample.
摘要翻译：本发明提供了用于进行热交换化学反应如核酸扩增的反应容器和温度控制系统。容器具有限定反应室的主体和从主体延伸以将样品装载到室中的装载结构。装载结构具有装载储存器，抽吸端口和将装载储存器和抽吸端口连接到室的各个流体通道。为了将样品装载到容器中，首先将样品分配到装载容器中，然后通过向抽吸端口施加真空而将其抽吸到室中。容器还包括在装载容器和抽吸端口的外端上延伸的密封孔。将样品装入室后，将插头插入孔中，以同时将腔室，装载储存器和抽吸端口从外部环境密封。样品的温度由位于容器相对侧的相对板控制。该系统还包括用于加热或冷却板的热元件和用于检测样品中的一种或多种分析物的光学元件。

9. 发明授权

US08431413B2 Fluid processing and control 有权
标题翻译：流体加工和控制
公开(公告)号：US08431413B2
公开(公告)日：2013-04-30
申请号：US13245572
申请日：2011-09-26
申请人： Douglas B. Dority , Ronald Chang
发明人： Douglas B. Dority , Ronald Chang
IPC分类号： G01N33/53
CPC分类号： B01L3/502715 , B01L3/502 , B01L3/50273 , B01L3/502738 , B01L2200/06 , B01L2200/10 , B01L2200/16 , B01L2300/06 , B01L2300/0645 , B01L2300/0681 , B01L2300/0848 , B01L2300/0861 , B01L2300/0877 , B01L2300/123 , B01L2300/14 , B01L2400/0421 , B01L2400/0478 , B01L2400/0487 , B01L2400/0644 , G01N1/18 , G01N1/28 , G01N1/405 , Y10T436/255 , Y10T436/2575
摘要： A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.
摘要翻译：用于控制多个室之间的流体流动的流体控制和处理系统包括主体，其包括与流体位移区域流体连续耦合的流体处理区域。流体位移区域是可减压的，以将流体吸入流体移动区域并且可加压以从流体位移区域排出流体。身体至少包括一个外部端口。流体处理区域与至少一个外部端口流体耦合。流体位移区域与主体的至少一个外部端口流体耦合。主体相对于多个室可调节以将至少一个外部端口选择性地与多个室流体连通。

10. 发明申请

US20120171758A1 Device for extracting nucleic acid from a sample 有权
标题翻译：从样品中提取核酸的装置
公开(公告)号：US20120171758A1
公开(公告)日：2012-07-05
申请号：US11977615
申请日：2007-10-24
申请人： Kurt E. Petersen , Michael T. Taylor , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching , Douglas B. Dority , Phillip Belgrader , M. Allen Northrup
发明人： Kurt E. Petersen , Michael T. Taylor , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching , Douglas B. Dority , Phillip Belgrader , M. Allen Northrup
IPC分类号： C12M1/34 , C12M1/00
CPC分类号： B01L3/502 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0809 , B01L2300/087 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12N1/066 , C12N13/00 , Y10S435/81 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809 , Y10S436/829 , Y10T137/87716 , Y10T137/88046 , Y10T436/255
摘要： The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and/or detection of the analyte. The cartridge is useful in a variety of diagnostic, life science research, environmental, or forensic applications for determining the presence or absence of one or more analytes in a sample.
摘要翻译：本发明提供一种用于分析流体样品的盒。盒提供用于有效分离样品中的细胞或病毒与剩余的样品流体，裂解细胞或病毒以从其中分离分析物（例如核酸），以及任选地分析物的化学反应和/或检测。墨盒可用于各种诊断，生命科学研究，环境或法医应用，用于确定样品中一种或多种分析物的存在或不存在。

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