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1. 发明授权

US08168602B2 Compositions, kits and methods for identification, assessment, prevention and therapy of cancer 失效
标题翻译：用于癌症鉴别，评估，预防和治疗的组合物，试剂盒和方法
公开(公告)号：US08168602B2
公开(公告)日：2012-05-01
申请号：US11816601
申请日：2006-02-17
申请人： Ronald A. DePinho , Giovanni Tonon , Kwok-Kin Wong , Lynda Chin
发明人： Ronald A. DePinho , Giovanni Tonon , Kwok-Kin Wong , Lynda Chin
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136
摘要： The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.
摘要翻译：本发明涉及用于检测，表征，预防和治疗人类癌症的组合物，试剂盒和方法。提供了多种染色体区域（MCR）和与之对应的标记物，其中一个或多个MCR的拷贝数和/或一个或多个标记物的量，结构和/或活性的变化的改变与癌症的存在相关。

2. 发明申请

US20130072392A1 Compositions, Kits, and Methods for Identification, Assessment, Prevention, and Therapy of Cancer 有权
标题翻译：癌症鉴定，评估，预防和治疗的组合物，试剂盒和方法
公开(公告)号：US20130072392A1
公开(公告)日：2013-03-21
申请号：US13473969
申请日：2012-05-17
申请人： Ronald A. DePinho , Kenneth C. Anderson , Ruben D. Carrasco , Giovanni Tonon , Cameron Brennan , John D. Shaughnessy, JR. , Lynda Chin
发明人： Ronald A. DePinho , Kenneth C. Anderson , Ruben D. Carrasco , Giovanni Tonon , Cameron Brennan , John D. Shaughnessy, JR. , Lynda Chin
IPC分类号： C40B30/06 , C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6837 , C12Q1/6841 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/178 , C12Q2537/157
摘要： The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.
摘要翻译：本发明涉及用于检测，表征，预防和治疗人类癌症的组合物，试剂盒和方法。提供了多种染色体区域（MCR）和与之对应的标记物，其中一个或多个MCR的拷贝数和/或一个或多个标记物的量，结构和/或活性的变化的改变与癌症的存在相关。

3. 发明授权

US09309564B2 Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer 有权
标题翻译：用于癌症鉴别，评估，预防和治疗的组合物，试剂盒和方法
公开(公告)号：US09309564B2
公开(公告)日：2016-04-12
申请号：US13473969
申请日：2012-05-17
申请人： Ronald A. DePinho , Kenneth C. Anderson , Ruben D. Carrasco , Giovanni Tonon , Cameron Brennan , John D. Shaughnessy, Jr. , Lynda Chin
发明人： Ronald A. DePinho , Kenneth C. Anderson , Ruben D. Carrasco , Giovanni Tonon , Cameron Brennan , John D. Shaughnessy, Jr. , Lynda Chin
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6841 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/178 , C12Q2537/157
摘要： The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.
摘要翻译：本发明涉及用于检测，表征，预防和治疗人类癌症的组合物，试剂盒和方法。提供了多种染色体区域（MCR）和与之对应的标记物，其中一个或多个MCR的拷贝数和/或一个或多个标记物的量，结构和/或活性的变化的改变与癌症的存在相关。

4. 发明授权

US08211634B2 Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer 有权
标题翻译：用于癌症鉴别，评估，预防和治疗的组合物，试剂盒和方法
公开(公告)号：US08211634B2
公开(公告)日：2012-07-03
申请号：US11706155
申请日：2007-02-13
申请人： Ronald A. DePinho , Kenneth C. Anderson , Ruben D. Carrasco , Giovanni Tonon , Cameron W. Brennan , John D. Shaughnessy, Jr. , Lynda Chin
发明人： Ronald A. DePinho , Kenneth C. Anderson , Ruben D. Carrasco , Giovanni Tonon , Cameron W. Brennan , John D. Shaughnessy, Jr. , Lynda Chin
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/6837 , C12Q1/6841 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/178 , C12Q2537/157
摘要： The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.
摘要翻译：本发明涉及用于检测，表征，预防和治疗人类癌症的组合物，试剂盒和方法。提供了多种染色体区域（MCR）和与之对应的标记物，其中一个或多个MCR的拷贝数和/或一个或多个标记物的量，结构和/或活性的变化的改变与癌症的存在相关。

5. 发明申请

US20100298158A1 Compositions, Kits, and Methods for Identification, Assessment, Prevention, and Therapy of Cancer 审中-公开
标题翻译：癌症鉴定，评估，预防和治疗的组合物，试剂盒和方法
公开(公告)号：US20100298158A1
公开(公告)日：2010-11-25
申请号：US12601161
申请日：2008-05-21
申请人： Ronald A. DePinho , Lynda Chin , Eric S. Martin
发明人： Ronald A. DePinho , Lynda Chin , Eric S. Martin
IPC分类号： C40B30/04 , C12Q1/68 , G01N33/68 , G01N33/574
摘要： The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.
摘要翻译：本发明涉及用于检测，表征，预防和治疗人类癌症的组合物，试剂盒和方法。提供了多种染色体区域（MCR）和与之对应的标记物，其中一个或多个MCR的拷贝数和/或一个或多个标记物的量，结构和/或活性的变化的改变与癌症的存在相关。

6. 发明授权

US09458510B2 Signatures and determinants associated with prostate cancer progression and methods of use thereof 有权
标题翻译：与前列腺癌进展相关的签名和决定因素及其使用方法
公开(公告)号：US09458510B2
公开(公告)日：2016-10-04
申请号：US14127413
申请日：2012-06-26
申请人： Ronald A. DePinho , Zhihu Ding , Chang-Jiun Wu , Lynda Chin
发明人： Ronald A. DePinho , Zhihu Ding , Chang-Jiun Wu , Lynda Chin
IPC分类号： C07K16/00 , C12Q1/68 , G01N33/50 , G01N33/574 , A61N5/10
CPC分类号： G01N33/57434 , A01K67/0276 , A01K2227/105 , A01K2267/0331 , A61N5/10 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5011 , G01N33/57484 , G01N2800/52 , G01N2800/56
摘要： The present invention provides a set of DETERMINANTS (e.g., genes and gene products) that can accurately inform about the risk of cancer progression and recurrence, as well as methods of their use.
摘要翻译：本发明提供了可以准确地通知癌症进展和复发的风险的一组确定因子（例如基因和基因产物）及其使用方法。

7. 发明申请

US20140314765A1 SIGNATURES AND DETERMINANTS ASSOCIATED WITH PROSTATE CANCER PROGRESSION AND METHODS OF USE THEREOF 有权
标题翻译：与前列腺癌进展相关的标志和决定因素及其使用方法
公开(公告)号：US20140314765A1
公开(公告)日：2014-10-23
申请号：US14127413
申请日：2012-06-26
申请人： Ronald A. DePinho , Zhihu Ding , Chang-Jiun Wu , Lynda Chin
发明人： Ronald A. DePinho , Zhihu Ding , Chang-Jiun Wu , Lynda Chin
IPC分类号： C12Q1/68 , G01N33/50 , A61N5/10 , G01N33/574
CPC分类号： G01N33/57434 , A01K67/0276 , A01K2227/105 , A01K2267/0331 , A61N5/10 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5011 , G01N33/57484 , G01N2800/52 , G01N2800/56
摘要： The present invention provides a set of DETERMINANTS (e.g., genes and gene products) that can accurately inform about the risk of cancer progression and recurrence, as well as methods of their use.
摘要翻译：本发明提供了可以准确地通知癌症进展和复发的风险的一组确定因子（例如，基因和基因产物）及其使用方法。

8. 发明授权

US06639121B1 Inducible cancer model to study the molecular basis of host tumor cell interactions in vivo 有权
标题翻译：诱导性癌症模型研究宿主肿瘤细胞相互作用在体内的分子基础
公开(公告)号：US06639121B1
公开(公告)日：2003-10-28
申请号：US09619247
申请日：2000-07-19
申请人： Ronald A. DePinho , Lynda Chin
发明人： Ronald A. DePinho , Lynda Chin
IPC分类号： A01K67033
CPC分类号： A01K67/0275 , A01K67/0271 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/0331 , C07K14/4738 , C07K14/82 , C12N15/8509 , C12N2517/02 , C12N2830/003 , C12N2830/008 , C12N2840/203
摘要： A non-human mammal having incorporated into its genome an expression construct in which nucleic acid encoding an oncogene is operably linked to an inducible promoter; the mammal further has a genetic mutation that causes it to have an increased susceptibility to cancer.
摘要翻译：一种非人哺乳动物，其已经在其基因组中掺入表达构建体，其中编码致癌基因的核酸可操作地连接到诱导型启动子; 哺乳动物还具有导致其对癌症易感性增加的遗传突变。

9. 发明申请

US20130040853A1 Context Specific Genetic Screen Platform to Aid in Gene Discovery and Target Validation 审中-公开
标题翻译：背景特异性基因筛选平台，用于基因发现和目标验证
公开(公告)号：US20130040853A1
公开(公告)日：2013-02-14
申请号：US13521882
申请日：2011-01-21
申请人： Lynda Chin , Timothy P. Heffernan , Ronald A. DePinho
发明人： Lynda Chin , Timothy P. Heffernan , Ronald A. DePinho
IPC分类号： C40B30/06
CPC分类号： C12N15/1079
摘要： The present invention relates to a context-specific forward genetic screen designed to systematically assign relative weight of biological evidence to a library of high-probability driver genetic elements in a genetically defined cancer-sensitized model system whose constellation of engineered mutations reflects a particular clinically relevant genetic subclass of a given tumor type. The screen may be formed in vivo or ex vivo. The screen allows for the formulation of clinical path hypotheses for targeting driver genetic elements and, in parallel, the rapid functional validation of the role of the driver genetic element(s) in the cancer. In this manner, the context-specific genetic screen can systematically assign the biological relevance of a library of genetic elements to a clinically-definable genetic and disease context, as well as inform combinations of drugs in the clinic such one uses one drug that targets the newly discovered genetic element or its protein and another drug that targets those genetic elements or its associated proteins which have been engineered into the primary cell model.
摘要翻译：本发明涉及一种上下文特异性前向遗传屏幕，其设计用于系统地将生物学证据的相对权重分配给遗传定义的癌症致敏模型系统中的高概率驱动因子遗传图谱库，其中所设计突变的星座反映特定的临床相关性给定肿瘤类型的遗传亚类。屏幕可以在体内或离体形成。屏幕允许制定针对驾驶员遗传元件的临床路径假设，并且同时，快速功能验证驾驶员遗传元件在癌症中的作用。以这种方式，上下文特异性遗传屏幕可以系统地将遗传元件库的生物相关性分配给临床上可定义的遗传和疾病背景，并且通知临床中药物的组合，例如使用一种靶向新发现的遗传元件或其蛋白质和另一种靶向已被设计成原代细胞模型的遗传元件或其相关蛋白质的药物。

10. 发明授权

US08999633B2 Compositions, kits, and methods for identification, assessment, prevention and treatment of pancreatic adenocarcinoma in humans 有权
标题翻译：用于人类胰腺腺癌鉴定，评估，预防和治疗的组合物，试剂盒和方法
公开(公告)号：US08999633B2
公开(公告)日：2015-04-07
申请号：US11597825
申请日：2005-05-27
申请人： Lynda Chin , Cameron W. Brennan , Ronald A. DePinho , Andrew J. Aguirre
发明人： Lynda Chin , Cameron W. Brennan , Ronald A. DePinho , Andrew J. Aguirre
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/154
摘要： The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human pancreatic adenocarcinoma. A variety of chromosomal regions (MCRs) and markers in the MCRs, are provided that are correlated with cancer. In particular, chromosomal regions and markers in the MCR 50.06-62.89 Mb of human chromosome 19, are provided, wherein alterations in the copy number of the MCR and/or alterations in the amount, structure, and/or activity of one or more of the markers in the MCR is correlated with the presence of pancreatic adenocarcinoma.
摘要翻译：本发明涉及用于检测，表征，预防和治疗人胰腺腺癌的组合物，试剂盒和方法。提供与癌症相关的MCR中的多种染色体区（MCR）和标记。特别地，提供了染色体区域和人类染色体19的MCR 50.06-62.89Mb中的标记，其中MCR的拷贝数的改变和/或其中一个或多个的数量，结构和/或活性的改变 MCR中的标记与胰腺腺癌的存在相关。

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