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1. 发明授权

US08297477B2 Dosing device for medicaments 有权
标题翻译：药剂配药
公开(公告)号：US08297477B2
公开(公告)日：2012-10-30
申请号：US11721002
申请日：2005-12-31
申请人： Rolf-Stefan Brickl , Jürgen Schraivogel
发明人： Rolf-Stefan Brickl , Jürgen Schraivogel
IPC分类号： B65D88/54
CPC分类号： G01F11/24 , B65B1/366
摘要： A dosing device for dispensing small-particulate pharmaceutical preparations has at least one chamber for receiving a larger amount of the preparation and a dosing unit. A rotary valve has at least one dosing chamber for receiving a defined dose of the preparation. The dosing chamber is moveable between a filling position and a dispensing position. The rotary valve rotates about a substantially horizontal axis, and has an adjustment device for setting the volume in the dosing chamber and a twisting device. The twisting device constitutes the actuator for the adjustment device. The device is made of a plastic material carefully selected to assure that no softening agents or other volatile components will be released, which prevents drug contamination.
摘要翻译：用于分配小颗粒药物制剂的计量装置具有用于接收更多量的制剂和剂量单元的至少一个腔室。旋转阀具有用于接收定义剂量的制剂的至少一个计量室。剂量室可以在填充位置和分配位置之间移动。旋转阀围绕基本上水平的轴线旋转，并且具有用于设定剂量室中的体积的调节装置和扭转装置。扭转装置构成用于调节装置的致动器。该装置由精心选择的塑料材料制成，以确保不会释放软化剂或其他挥发性组分，从而防止药物污染。

2. 发明申请

US20100044398A1 DOSING DEVICE, IN PARTICULAR DOSING DEVICE FOR MEDICAMENTS, AND THE USE OF SAID DOSING DEVICE 有权
标题翻译：用于药物的特殊装置的装药装置以及使用装药装置
公开(公告)号：US20100044398A1
公开(公告)日：2010-02-25
申请号：US11721002
申请日：2005-12-31
申请人： Rolf-Stefan Brickl , Jürgen Schraivogel
发明人： Rolf-Stefan Brickl , Jürgen Schraivogel
IPC分类号： G01F11/20
CPC分类号： G01F11/24 , B65B1/366
摘要： The invention relates to a dosing device for dosing small-particulate pharmaceutical preparations with at least one chamber for receiving a larger amount of the preparation and a dosing unit, comprising a rotary valve carrying at least one dosing chamber for receiving a defined partial amount (defined dose) of the preparation, whereby the dosing chamber is moveable between a filling position, in which it is to be filled with a preparation from the chamber, and a dispensing position, in which the preparation is to be dispensed from the dosing chamber. The rotary valve is rotable about a substantially horizontal axis, and assigned an adjustment device for setting the volume in the dosing chamber and a twisting device, whereby the twisting device constitutes the actuator for the adjustment device. The plastic material chosen such, that no softening agents or other volatile components will be released, in order to prevent drug contamination.
摘要翻译：本发明涉及一种用于给小颗粒药物制剂投药的剂量装置，其具有用于接收更大量制剂的至少一个腔室和一个给药单元，该给药单元包括一个带有至少一个剂量室的旋转阀，用于接收限定的部分量剂量），由此计量室可以在其中填充有来自腔室的制剂的填充位置和分配位置之间移动，在该分配位置将从配量室中分配制剂。旋转阀可围绕基本上水平的轴线旋转，并且分配有用于设定剂量室中的体积的调节装置和扭转装置，由此扭转装置构成用于调节装置的致动器。选择这样的塑料材料，即不会释放软化剂或其它挥发性成分，以防止药物污染。

3. 发明申请

US20080176836A1 Use of selected CGRP antagonists for combating menopausal hot flushes 审中-公开
标题翻译：使用选定的CGRP拮抗剂来对抗绝经期的潮红
公开(公告)号：US20080176836A1
公开(公告)日：2008-07-24
申请号：US11774980
申请日：2007-07-09
申请人： Klaus Rudolf , Henri Doods , Stephan Georg Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
发明人： Klaus Rudolf , Henri Doods , Stephan Georg Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
IPC分类号： A61K31/551
CPC分类号： A61K31/517
摘要： The invention relates to the use of selected CGRP antagonists, the physiologically acceptable salts thereof or the hydrates of the hydrates of the salts thereof for combating menopausal hot flushes.
摘要翻译：本发明涉及选择的CGRP拮抗剂，其生理上可接受的盐或其盐的水合物的水合物用于对抗绝经性潮热的用途。

4. 发明申请

US20140094523A1 SOLID AMBROXOL-CONTAINING PREPARATION 有权
标题翻译：固体含甲醛制备
公开(公告)号：US20140094523A1
公开(公告)日：2014-04-03
申请号：US14006183
申请日：2012-03-15
申请人： Rolf-Stefan Brickl , Herrad-Odilia Krenkel
发明人： Rolf-Stefan Brickl , Herrad-Odilia Krenkel
IPC分类号： A61K31/137
CPC分类号： A61K31/137 , A61K9/1617 , A61K9/1694
摘要： The present invention relates to solid preparations containing ambroxol which are obtainable by melt extrusion of the mixture consisting of a) 30 to 80% by weight of ambroxol hydrochloride, b) 2 to 68% by weight of at least one hydrogenated vegetable oil, c) 2 to 68% by weight of at least one mixture containing fatty acid ester and/or hydroxy fatty acid ester and d) 0 to 66% by weight of one or more pharmaceutical adjuvants, based in each case on the total amount of the preparation and its use for secretolytic treatment in acute and chronic bronchopulmonary diseases.
摘要翻译：本发明涉及含有氨溴索的固体制剂，其可通过熔融挤出由a）30至80重量％的盐酸氨溴索组成的混合物，b）2至68重量％的至少一种氢化植物油，c） 2至68重量％的至少一种含有脂肪酸酯和/或羟基脂肪酸酯的混合物和d）0至66重量％的一种或多种药物佐剂，基于每种情况下所述制剂的总量和其用于急性和慢性支气管肺疾病中的溶解性治疗。

5. 发明申请

US20060142274A1 Use of selected CGRP antagonists for combating menopausal hot flushes 审中-公开
标题翻译：使用选定的CGRP拮抗剂来对抗绝经期的潮红
公开(公告)号：US20060142274A1
公开(公告)日：2006-06-29
申请号：US11301446
申请日：2005-12-13
申请人： Klaus Rudolf , Henri Doods , Stephan Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
发明人： Klaus Rudolf , Henri Doods , Stephan Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
IPC分类号： A61K31/5513 , A61K31/517
CPC分类号： A61K31/517
摘要： The invention relates to the use of selected CGRP antagonists, the physiologically acceptable salts thereof or the hydrates of the hydrates of the salts thereof for combating menopausal hot flushes.
摘要翻译：本发明涉及选择的CGRP拮抗剂，其生理上可接受的盐或其盐的水合物的水合物用于对抗绝经性潮热的用途。

6. 发明授权

US09782365B2 Solid ambroxol-containing preparation 有权
公开(公告)号：US09782365B2
公开(公告)日：2017-10-10
申请号：US14006183
申请日：2012-03-15
申请人： Rolf-Stefan Brickl , Herrad-Odilia Krenkel
发明人： Rolf-Stefan Brickl , Herrad-Odilia Krenkel
IPC分类号： A61K31/137 , A61K9/16
CPC分类号： A61K31/137 , A61K9/1617 , A61K9/1694
摘要： The present invention relates to solid preparations containing ambroxol which are obtainable by melt extrusion of the mixture consisting of a) 30 to 80% by weight of ambroxol hydrochloride, b) 2 to 68% by weight of at least one hydrogenated vegetable oil, c) 2 to 68% by weight of at least one mixture containing fatty acid ester and/or hydroxy fatty acid ester and d) 0 to 66% by weight of one or more pharmaceutical adjuvants, based in each case on the total amount of the preparation and its use for secretolytic treatment in acute and chronic bronchopulmonary diseases.

7. 发明授权

US08715728B2 Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof 失效
标题翻译：含有普拉克索或其药学上可接受的盐的延长释放丸剂制剂
公开(公告)号：US08715728B2
公开(公告)日：2014-05-06
申请号：US12630271
申请日：2009-12-03
申请人： Thomas Friedl , Rolf-Stefan Brickl
发明人： Thomas Friedl , Rolf-Stefan Brickl
IPC分类号： A61K9/22 , A61K9/62 , A61K9/58 , A61K9/16 , A61K9/50 , A61K31/425
CPC分类号： A61K9/5078
摘要： An extended release pellet comprising an active ingredient selected from pramipexole and the pharmaceutically acceptable salts thereof, and at least one release-modifying excipient.
摘要翻译：包含选自普拉克索及其药学上可接受的盐的活性成分和至少一种释放调节赋形剂的延长释放丸剂。

8. 发明授权

US08598183B2 Solid state forms of a potent HCV inhibitor 有权
标题翻译：固态形式的有效的HCV抑制剂
公开(公告)号：US08598183B2
公开(公告)日：2013-12-03
申请号：US13241551
申请日：2011-09-23
申请人： Rolf-Stefan Brickl , Shirlynn Chen , Jihchin Chung , Mayur Suryakant Dudhedia , Danping Li , Zhi-Hui Lu , Siddharthya Mujumdar , Chitra Telang , Richard J. Varsolona , Zeren Wang
发明人： Rolf-Stefan Brickl , Shirlynn Chen , Jihchin Chung , Mayur Suryakant Dudhedia , Danping Li , Zhi-Hui Lu , Siddharthya Mujumdar , Chitra Telang , Richard J. Varsolona , Zeren Wang
IPC分类号： C07D235/04
CPC分类号： C07D403/14
摘要： This invention relates to novel sodium salt forms of the following Compound (1), and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in the treatment of Hepatitis C Viral (HCV) infection:
摘要翻译：本发明涉及以下化合物（1）的新型钠盐形式及其制备方法，其药物组合物及其在治疗丙型肝炎病毒（HCV）感染中的用途：

9. 发明申请

US20080103134A1 Use of selected CGRP-antagonists in combination with other antimigraine drugs for the treatment of migraine 审中-公开
标题翻译：选择的CGRP拮抗剂与其他抗偏头痛药物组合用于治疗偏头痛
公开(公告)号：US20080103134A1
公开(公告)日：2008-05-01
申请号：US11962633
申请日：2007-12-21
申请人： Klaus Rudolf , Henri Doods , Stephan Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
发明人： Klaus Rudolf , Henri Doods , Stephan Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
IPC分类号： A61K31/551 , A61P25/06
CPC分类号： A61K45/06 , A61K31/4545 , A61K31/5513 , A61K2300/00
摘要： The present invention relates to a process for the treatment or prevention of indications which are selected from among the group comprising headaches, migraine and cluster headaches, this process comprising the joint administration of a therapeutically effective amount of a selected CGRP antagonist (A), a physiologically acceptable salt thereof or a hydrate of the salt and a therapeutically effective amount of a second or third active anti-migraine medicament (B), particularly sumatriptan, zolmitriptan or dihydroergotamine or a physiologically acceptable salt thereof, and to the corresponding pharmaceutical compositions and the preparation thereof.
摘要翻译：本发明涉及治疗或预防选自包括头痛，偏头痛和丛集性头痛的组的适应症的方法，该方法包括联合施用治疗有效量的选择的CGRP拮抗剂（A），其生理上可接受的盐或盐的水合物和治疗有效量的第二或第三活性抗偏头痛药物（B），特别是舒马曲坦，佐米曲坦或二氢麦角胺或其生理学上可接受的盐，以及相应的药物组合物和的制备。

10. 发明申请

US20060142273A1 Use of selected CGRP-antagonists in combination with other antimigraine drugs for the treatment of migraine 审中-公开
标题翻译：选择的CGRP拮抗剂与其他抗偏头痛药物组合用于治疗偏头痛
公开(公告)号：US20060142273A1
公开(公告)日：2006-06-29
申请号：US11275169
申请日：2005-12-16
申请人： Klaus RUDOLF , Henri DOODS , Stephan MUELLER , Annette ZAMPONI , Philipp LUSTENBERGER , Kirsten ARNDT , Gerhard SCHAENZLE , Dirk STENKAMP , Rolf-Stefan Brickl
发明人： Klaus RUDOLF , Henri DOODS , Stephan MUELLER , Annette ZAMPONI , Philipp LUSTENBERGER , Kirsten ARNDT , Gerhard SCHAENZLE , Dirk STENKAMP , Rolf-Stefan Brickl
IPC分类号： A61K31/5513
CPC分类号： A61K45/06 , A61K31/4545 , A61K31/5513 , A61K2300/00
摘要： The present invention relates to a process for the treatment or prevention of indications which are selected from among the group comprising headaches, migraine and cluster headaches, this process comprising the joint administration of a therapeutically effective amount of a selected CGRP antagonist (A), a physiologically acceptable salt thereof or a hydrate of the salt and a therapeutically effective amount of a second or third active anti-migraine medicament (B), particularly sumatriptan, zolmitriptan or dihydroergotamine or a physiologically acceptable salt thereof, and to the corresponding pharmaceutical compositions and the preparation thereof.
摘要翻译：本发明涉及治疗或预防选自包括头痛，偏头痛和丛集性头痛的组的适应症的方法，该方法包括联合施用治疗有效量的选择的CGRP拮抗剂（A），其生理上可接受的盐或盐的水合物和治疗有效量的第二或第三活性抗偏头痛药物（B），特别是舒马曲坦，佐米曲坦或二氢麦角胺或其生理学上可接受的盐，以及相应的药物组合物和的制备。

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