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1. 发明申请

US20060142274A1 Use of selected CGRP antagonists for combating menopausal hot flushes 审中-公开
标题翻译：使用选定的CGRP拮抗剂来对抗绝经期的潮红
公开(公告)号：US20060142274A1
公开(公告)日：2006-06-29
申请号：US11301446
申请日：2005-12-13
申请人： Klaus Rudolf , Henri Doods , Stephan Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
发明人： Klaus Rudolf , Henri Doods , Stephan Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
IPC分类号： A61K31/5513 , A61K31/517
CPC分类号： A61K31/517
摘要： The invention relates to the use of selected CGRP antagonists, the physiologically acceptable salts thereof or the hydrates of the hydrates of the salts thereof for combating menopausal hot flushes.
摘要翻译：本发明涉及选择的CGRP拮抗剂，其生理上可接受的盐或其盐的水合物的水合物用于对抗绝经性潮热的用途。

2. 发明申请

US20070249592A1 Use of selected CGRP antagonists in treatment and prevention of hot flushes in prostate cancer patients 审中-公开
标题翻译：使用选定的CGRP拮抗剂治疗和预防前列腺癌患者的热潮红
公开(公告)号：US20070249592A1
公开(公告)日：2007-10-25
申请号：US11774995
申请日：2007-07-09
申请人： Klaus Rudolf , Henri Doods , Stephan Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
发明人： Klaus Rudolf , Henri Doods , Stephan Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
IPC分类号： A61K31/517 , A61K31/5513
CPC分类号： A61K31/517
摘要： The invention relates to a method of treatment or prevention of hot flushes in men who underwent castration, e.g. due to androgen ablation treatment in prostate cancer therapy, comprising administration of an effective amount of a selected CGRP antagonist to the patient, and to the use of said active compounds for the manufacture of a pharmaceutical composition intended to be used in this method.
摘要翻译：本发明涉及一种治疗或预防接受阉割的男性热潮红的方法，例如，由于前列腺癌治疗中的雄激素消除治疗，包括向患者施用有效量的选择的CGRP拮抗剂，以及使用所述活性化合物来制造预期用于该方法的药物组合物。

3. 发明申请

US20060154921A1 Use of CGRP antagonists in treatment and prevention of hot flushes in prostate cancer patients 审中-公开
标题翻译：使用CGRP拮抗剂治疗和预防前列腺癌患者的热潮红
公开(公告)号：US20060154921A1
公开(公告)日：2006-07-13
申请号：US11301422
申请日：2005-12-13
申请人： Klaus Rudolf , Henri Doods , Stephan Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
发明人： Klaus Rudolf , Henri Doods , Stephan Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
IPC分类号： A61K31/5513
CPC分类号： A61K31/517
摘要： The invention relates to a method of treatment or prevention of hot flushes in men who underwent castration, e.g. due to androgen ablation treatment in prostate cancer therapy, comprising administration of an effective amount of a selected CGRP antagonist to the patient, and to the use of said active compounds for the manufacture of a pharmaceutical composition intended to be used in this method.
摘要翻译：本发明涉及一种治疗或预防接受阉割的男性热潮红的方法，例如，由于前列腺癌治疗中的雄激素消除治疗，包括向患者施用有效量的选择的CGRP拮抗剂，以及使用所述活性化合物来制造预期用于该方法的药物组合物。

4. 发明申请

US20080103134A1 Use of selected CGRP-antagonists in combination with other antimigraine drugs for the treatment of migraine 审中-公开
标题翻译：选择的CGRP拮抗剂与其他抗偏头痛药物组合用于治疗偏头痛
公开(公告)号：US20080103134A1
公开(公告)日：2008-05-01
申请号：US11962633
申请日：2007-12-21
申请人： Klaus Rudolf , Henri Doods , Stephan Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
发明人： Klaus Rudolf , Henri Doods , Stephan Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
IPC分类号： A61K31/551 , A61P25/06
CPC分类号： A61K45/06 , A61K31/4545 , A61K31/5513 , A61K2300/00
摘要： The present invention relates to a process for the treatment or prevention of indications which are selected from among the group comprising headaches, migraine and cluster headaches, this process comprising the joint administration of a therapeutically effective amount of a selected CGRP antagonist (A), a physiologically acceptable salt thereof or a hydrate of the salt and a therapeutically effective amount of a second or third active anti-migraine medicament (B), particularly sumatriptan, zolmitriptan or dihydroergotamine or a physiologically acceptable salt thereof, and to the corresponding pharmaceutical compositions and the preparation thereof.
摘要翻译：本发明涉及治疗或预防选自包括头痛，偏头痛和丛集性头痛的组的适应症的方法，该方法包括联合施用治疗有效量的选择的CGRP拮抗剂（A），其生理上可接受的盐或盐的水合物和治疗有效量的第二或第三活性抗偏头痛药物（B），特别是舒马曲坦，佐米曲坦或二氢麦角胺或其生理学上可接受的盐，以及相应的药物组合物和的制备。

5. 发明申请

US20060142273A1 Use of selected CGRP-antagonists in combination with other antimigraine drugs for the treatment of migraine 审中-公开
标题翻译：选择的CGRP拮抗剂与其他抗偏头痛药物组合用于治疗偏头痛
公开(公告)号：US20060142273A1
公开(公告)日：2006-06-29
申请号：US11275169
申请日：2005-12-16
申请人： Klaus RUDOLF , Henri DOODS , Stephan MUELLER , Annette ZAMPONI , Philipp LUSTENBERGER , Kirsten ARNDT , Gerhard SCHAENZLE , Dirk STENKAMP , Rolf-Stefan Brickl
发明人： Klaus RUDOLF , Henri DOODS , Stephan MUELLER , Annette ZAMPONI , Philipp LUSTENBERGER , Kirsten ARNDT , Gerhard SCHAENZLE , Dirk STENKAMP , Rolf-Stefan Brickl
IPC分类号： A61K31/5513
CPC分类号： A61K45/06 , A61K31/4545 , A61K31/5513 , A61K2300/00
摘要： The present invention relates to a process for the treatment or prevention of indications which are selected from among the group comprising headaches, migraine and cluster headaches, this process comprising the joint administration of a therapeutically effective amount of a selected CGRP antagonist (A), a physiologically acceptable salt thereof or a hydrate of the salt and a therapeutically effective amount of a second or third active anti-migraine medicament (B), particularly sumatriptan, zolmitriptan or dihydroergotamine or a physiologically acceptable salt thereof, and to the corresponding pharmaceutical compositions and the preparation thereof.
摘要翻译：本发明涉及治疗或预防选自包括头痛，偏头痛和丛集性头痛的组的适应症的方法，该方法包括联合施用治疗有效量的选择的CGRP拮抗剂（A），其生理上可接受的盐或盐的水合物和治疗有效量的第二或第三活性抗偏头痛药物（B），特别是舒马曲坦，佐米曲坦或二氢麦角胺或其生理学上可接受的盐，以及相应的药物组合物和的制备。

6. 发明申请

US20080176836A1 Use of selected CGRP antagonists for combating menopausal hot flushes 审中-公开
标题翻译：使用选定的CGRP拮抗剂来对抗绝经期的潮红
公开(公告)号：US20080176836A1
公开(公告)日：2008-07-24
申请号：US11774980
申请日：2007-07-09
申请人： Klaus Rudolf , Henri Doods , Stephan Georg Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
发明人： Klaus Rudolf , Henri Doods , Stephan Georg Mueller , Annette Zamponi , Philipp Lustenberger , Kirsten Arndt , Gerhard Schaenzle , Dirk Stenkamp , Rolf-Stefan Brickl
IPC分类号： A61K31/551
CPC分类号： A61K31/517
摘要： The invention relates to the use of selected CGRP antagonists, the physiologically acceptable salts thereof or the hydrates of the hydrates of the salts thereof for combating menopausal hot flushes.
摘要翻译：本发明涉及选择的CGRP拮抗剂，其生理上可接受的盐或其盐的水合物的水合物用于对抗绝经性潮热的用途。

7. 发明申请

US20140094523A1 SOLID AMBROXOL-CONTAINING PREPARATION 有权
标题翻译：固体含甲醛制备
公开(公告)号：US20140094523A1
公开(公告)日：2014-04-03
申请号：US14006183
申请日：2012-03-15
申请人： Rolf-Stefan Brickl , Herrad-Odilia Krenkel
发明人： Rolf-Stefan Brickl , Herrad-Odilia Krenkel
IPC分类号： A61K31/137
CPC分类号： A61K31/137 , A61K9/1617 , A61K9/1694
摘要： The present invention relates to solid preparations containing ambroxol which are obtainable by melt extrusion of the mixture consisting of a) 30 to 80% by weight of ambroxol hydrochloride, b) 2 to 68% by weight of at least one hydrogenated vegetable oil, c) 2 to 68% by weight of at least one mixture containing fatty acid ester and/or hydroxy fatty acid ester and d) 0 to 66% by weight of one or more pharmaceutical adjuvants, based in each case on the total amount of the preparation and its use for secretolytic treatment in acute and chronic bronchopulmonary diseases.
摘要翻译：本发明涉及含有氨溴索的固体制剂，其可通过熔融挤出由a）30至80重量％的盐酸氨溴索组成的混合物，b）2至68重量％的至少一种氢化植物油，c） 2至68重量％的至少一种含有脂肪酸酯和/或羟基脂肪酸酯的混合物和d）0至66重量％的一种或多种药物佐剂，基于每种情况下所述制剂的总量和其用于急性和慢性支气管肺疾病中的溶解性治疗。

8. 发明授权

US08297477B2 Dosing device for medicaments 有权
标题翻译：药剂配药
公开(公告)号：US08297477B2
公开(公告)日：2012-10-30
申请号：US11721002
申请日：2005-12-31
申请人： Rolf-Stefan Brickl , Jürgen Schraivogel
发明人： Rolf-Stefan Brickl , Jürgen Schraivogel
IPC分类号： B65D88/54
CPC分类号： G01F11/24 , B65B1/366
摘要： A dosing device for dispensing small-particulate pharmaceutical preparations has at least one chamber for receiving a larger amount of the preparation and a dosing unit. A rotary valve has at least one dosing chamber for receiving a defined dose of the preparation. The dosing chamber is moveable between a filling position and a dispensing position. The rotary valve rotates about a substantially horizontal axis, and has an adjustment device for setting the volume in the dosing chamber and a twisting device. The twisting device constitutes the actuator for the adjustment device. The device is made of a plastic material carefully selected to assure that no softening agents or other volatile components will be released, which prevents drug contamination.
摘要翻译：用于分配小颗粒药物制剂的计量装置具有用于接收更多量的制剂和剂量单元的至少一个腔室。旋转阀具有用于接收定义剂量的制剂的至少一个计量室。剂量室可以在填充位置和分配位置之间移动。旋转阀围绕基本上水平的轴线旋转，并且具有用于设定剂量室中的体积的调节装置和扭转装置。扭转装置构成用于调节装置的致动器。该装置由精心选择的塑料材料制成，以确保不会释放软化剂或其他挥发性组分，从而防止药物污染。

9. 发明授权

US09782365B2 Solid ambroxol-containing preparation 有权
公开(公告)号：US09782365B2
公开(公告)日：2017-10-10
申请号：US14006183
申请日：2012-03-15
申请人： Rolf-Stefan Brickl , Herrad-Odilia Krenkel
发明人： Rolf-Stefan Brickl , Herrad-Odilia Krenkel
IPC分类号： A61K31/137 , A61K9/16
CPC分类号： A61K31/137 , A61K9/1617 , A61K9/1694
摘要： The present invention relates to solid preparations containing ambroxol which are obtainable by melt extrusion of the mixture consisting of a) 30 to 80% by weight of ambroxol hydrochloride, b) 2 to 68% by weight of at least one hydrogenated vegetable oil, c) 2 to 68% by weight of at least one mixture containing fatty acid ester and/or hydroxy fatty acid ester and d) 0 to 66% by weight of one or more pharmaceutical adjuvants, based in each case on the total amount of the preparation and its use for secretolytic treatment in acute and chronic bronchopulmonary diseases.

10. 发明授权

US08715728B2 Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof 失效
标题翻译：含有普拉克索或其药学上可接受的盐的延长释放丸剂制剂
公开(公告)号：US08715728B2
公开(公告)日：2014-05-06
申请号：US12630271
申请日：2009-12-03
申请人： Thomas Friedl , Rolf-Stefan Brickl
发明人： Thomas Friedl , Rolf-Stefan Brickl
IPC分类号： A61K9/22 , A61K9/62 , A61K9/58 , A61K9/16 , A61K9/50 , A61K31/425
CPC分类号： A61K9/5078
摘要： An extended release pellet comprising an active ingredient selected from pramipexole and the pharmaceutically acceptable salts thereof, and at least one release-modifying excipient.
摘要翻译：包含选自普拉克索及其药学上可接受的盐的活性成分和至少一种释放调节赋形剂的延长释放丸剂。

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