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1. 发明授权

US09261496B2 Device for high throughput investigations of multi-cellular interactions 有权
标题翻译：用于多细胞相互作用的高通量调查的装置
公开(公告)号：US09261496B2
公开(公告)日：2016-02-16
申请号：US13876293
申请日：2011-09-29
申请人： Roger Dale Kamm , Haruhiko Harry Asada , Waleed Ahmed Farahat , Ioannis K. Zervantonakis , Levi B. Wood , Chandrasekhar Kothapalli , Seok Chung , Jeffrey D. Macklis , Suzanne Tharin , Johanna Varner , Young Kum Park , Kwang Ho Lee , Le Thanh Tu Nguyen , Choong Kim
发明人： Roger Dale Kamm , Haruhiko Harry Asada , Waleed Ahmed Farahat , Ioannis K. Zervantonakis , Levi B. Wood , Chandrasekhar Kothapalli , Seok Chung , Jeffrey D. Macklis , Suzanne Tharin , Johanna Varner , Young Kum Park , Kwang Ho Lee , Le Thanh Tu Nguyen , Choong Kim
IPC分类号： C12M1/34 , C12M3/00 , G01N33/50 , B01L3/00 , C12M3/06 , C12M1/00 , C12M1/12
CPC分类号： G01N33/5008 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , C12M23/16 , C12M23/22 , C12M25/14 , C12M29/04 , G01N33/5011 , G01N33/5029 , G01N33/5058 , G01N33/5064
摘要： Provided herein are microfluidic devices that can be used as a 3D bioassay, e.g., for drug screening, personalized medicine, tissue engineering, wound healing, and other applications. The device has a series of channels {e.g., small fluid channels) in a small polymer block wherein one or more of the channels can be filled with a biologically relevant gel, such as collagen, which is held in place by posts. As shown herein, when the device is plated with cells such as endothelial cells, new blood vessels grow in the gel, which is thick enough for the cells to grow in three dimensions. Other channels, e.g., fluid channels, allow drugs or biological material to be exposed to the 3D cell growth. Cells, such as endothelial cells, can be cultured and observed as they grow on the surface of a 3D gel scaffold, where e.g., rates of angiogenesis can be measured, as well as intervascularization and extravascularization of cancerous cells.
摘要翻译：本文提供的微流体装置可用作3D生物测定，例如用于药物筛选，个性化医学，组织工程，伤口愈合和其它应用。该装置在小聚合物嵌段中具有一系列通道（例如，小的流体通道），其中一个或多个通道可以填充生物相关凝胶，例如通过柱保持在适当位置的胶原。如本文所示，当该装置镀有诸如内皮细胞的细胞时，新的血管在凝胶中生长，其足够厚以使细胞在三维中生长。其他通道，例如流体通道，允许药物或生物材料暴露于3D细胞生长。可以在3D凝胶支架的表面上生长细胞，例如内皮细胞，并且观察细胞，其中例如可以测量血管发生的速率，以及癌细胞的血管间血管形成和血管外再造。

2. 发明申请

US20140057311A1 Device For High Throughput Investigations Of Multi-Cellular Interactions 有权
标题翻译：多通道相互作用的高通量调查装置
公开(公告)号：US20140057311A1
公开(公告)日：2014-02-27
申请号：US13876293
申请日：2011-09-29
申请人： Roger Dale Kamm , Haruhiko Harry Asada , Waleed Ahmed Farahat , Ioannis K. Zervantonakis , Levi B. Wood , Chandrasekhar Kothapalli , Seok Chung , Jeffrey D. Macklis , Suzanne Tharin , Johanna Varner , Young Kum Park , Kwang Ho Lee , Le Thanh Tu Nguyen , Choong Kim
发明人： Roger Dale Kamm , Haruhiko Harry Asada , Waleed Ahmed Farahat , Ioannis K. Zervantonakis , Levi B. Wood , Chandrasekhar Kothapalli , Seok Chung , Jeffrey D. Macklis , Suzanne Tharin , Johanna Varner , Young Kum Park , Kwang Ho Lee , Le Thanh Tu Nguyen , Choong Kim
IPC分类号： G01N33/50
CPC分类号： G01N33/5008 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , C12M23/16 , C12M23/22 , C12M25/14 , C12M29/04 , G01N33/5011 , G01N33/5029 , G01N33/5058 , G01N33/5064
摘要： Provided herein are microfluidic devices that can be used as a 3D bioassay, e.g., for drug screening, personalized medicine, tissue engineering, wound healing, and other applications. The device has a series of channels {e.g., small fluid channels) in a small polymer block wherein one or more of the channels can be filled with a biologically relevant gel, such as collagen, which is held in place by posts. As shown herein, when the device is plated with cells such as endothelial cells, new blood vessels grow in the gel, which is thick enough for the cells to grow in three dimensions. Other channels, e.g., fluid channels, allow drugs or biological material to be exposed to the 3D cell growth. Cells, such as endothelial cells, can be cultured and observed as they grow on the surface of a 3D gel scaffold, where e.g., rates of angiogenesis can be measured, as well as intervascularization and extravascularization of cancerous cells.
摘要翻译：本文提供的微流体装置可用作3D生物测定，例如用于药物筛选，个性化医学，组织工程，伤口愈合和其它应用。该装置在小聚合物嵌段中具有一系列通道（例如，小的流体通道），其中一个或多个通道可以填充生物相关凝胶，例如通过柱保持在适当位置的胶原。如本文所示，当装置镀有诸如内皮细胞的细胞时，新的血管在凝胶中生长，其足够厚以使细胞在三维中生长。其他通道，例如流体通道，允许药物或生物材料暴露于3D细胞生长。可以在3D凝胶支架的表面上生长细胞，例如内皮细胞，并且观察细胞，其中例如可以测量血管发生的速率，以及癌细胞的血管间血管形成和血管外再造。

3. 发明申请

US20070131312A1 IN-SITU DUCTILE METAL/BULK METALLIC GLASS MATRIX COMPOSITES FORMED BY CHEMICAL PARTITIONING 有权
标题翻译：通过化学分离形成的原位金属/块状金属玻璃基体复合材料
公开(公告)号：US20070131312A1
公开(公告)日：2007-06-14
申请号：US10735148
申请日：2003-12-12
申请人： Choong Kim , Charles Hays , William Johnson
发明人： Choong Kim , Charles Hays , William Johnson
IPC分类号： C22C45/10
CPC分类号： C22C16/00 , C22C1/002 , C22C45/10
摘要： A composite metal object comprises ductile crystalline metal particles in an amorphous metal matrix. An alloy is heated above its liquidus temperature. Upon cooling from the high temperature melt, the alloy chemically partitions, forming dendrites in the melt. Upon cooling the remaining liquid below the glass transition temperature it freezes to the amorphous state, producing a two-phase microstructure containing crystalline particles in an amorphous metal matrix. The ductile metal particles have a size in the range of from 0.1 to 15 micrometers and spacing in the range of from 0.1 to 20 micrometers. Preferably, the particle size is in the range of from 0.5 to 8 micrometers and spacing is in the range of from 1 to 10 micrometers. The volume proportion of particles is in the range of from 5 to 50% and preferably 15 to 35%. Differential cooling can produce oriented dendrites of ductile metal phase in an amorphous matrix. Examples are given in the Zr—Ti—Cu—Ni—Be alloy bulk glass forming system with added niobium.
摘要翻译：复合金属物体包括无定形金属基质中的延性结晶金属颗粒。将合金加热至液相线温度以上。在从高温熔体冷却时，合金化学分隔，在熔体中形成枝晶。将剩余的液体冷却至低于玻璃化转变温度时，将其冻结至非晶状态，产生在非晶态金属基质中含有结晶颗粒的两相微结构。延性金属颗粒的尺寸范围为0.1至15微米，间距为0.1-20微米。优选地，粒度在0.5至8微米的范围内，并且间距在1至10微米的范围内。颗粒的体积比例在5至50％，优选15至35％的范围内。差分冷却可以在无定形基质中产生延性金属相的取向树枝状晶体。在具有添加铌的Zr-Ti-Cu-Ni-Be合金块状玻璃形成系统中给出了实施例。

4. 发明授权

US09045747B2 Apparatus and method for fabricating micro-capsule 有权
标题翻译：微胶囊制造装置及方法
公开(公告)号：US09045747B2
公开(公告)日：2015-06-02
申请号：US12154409
申请日：2008-05-21
申请人： Choong Kim , Ji Yoon Kang , Tae Song Kim
发明人： Choong Kim , Ji Yoon Kang , Tae Song Kim
IPC分类号： C12N11/04 , C12M1/12 , B01F3/08
CPC分类号： C12N11/04 , B01F3/0865 , C12M25/16
摘要： The present invention relates to an apparatus and a method for fabricating a microcapsule, more particularly to an apparatus and a method for fabricating a microcapsule, which enable to encapsulate uniform cell number in a microcapsule through cell distribution, improve cell viability in the microcapsule through fluid exchange, and ensure uniform microcapsule size. The apparatus for fabricating a microcapsule according to the present invention uses a plurality of microchannels which are spatially connected with one another and are designed such that fluid flows through them in a particular direction, and comprises a cell supply unit which supplies a fluid mixture of cells and a cell dropletizing material; and a droplet forming unit in which a dropletization inducing fluid supplied from one of the plurality of microchannels joins with the fluid mixture of the cells and the cell dropletizing material to form a droplet.
摘要翻译：本发明涉及一种用于制造微胶囊的装置和方法，更具体地涉及一种用于制造微胶囊的装置和方法，其能够通过细胞分布将微胶囊中的均匀细胞数量包封，通过流体提高微胶囊中的细胞活力交换，确保微胶囊尺寸均匀。根据本发明的用于制造微胶囊的装置使用多个彼此空间连接的微通道，并且被设计成使得流体沿着特定方向流过它们，并且包括供应单元的流体混合物的单元供应单元和细胞液滴化材料; 以及液滴形成单元，其中从所述多个微通道中的一个提供的液滴诱导流体与所述单元和所述单元液滴化材料的流体混合物结合以形成液滴。

5. 发明申请

US20080254541A1 Chip having microchannels and a method for continuous dilution of solution 审中-公开
标题翻译：具有微通道的芯片和连续稀释溶液的方法
公开(公告)号：US20080254541A1
公开(公告)日：2008-10-16
申请号：US11891228
申请日：2007-08-09
申请人： Ji Yoon Kang , Choong Kim , Kang Sun Lee , Sung Shin Ryu , Tae Song Kim
发明人： Ji Yoon Kang , Choong Kim , Kang Sun Lee , Sung Shin Ryu , Tae Song Kim
IPC分类号： G01N31/00 , G01N15/06
CPC分类号： G01N1/38 , Y10T436/10
摘要： A microchannel chip and a dilution method using the same capable of continuously diluting the diverse concentrations of solution by one time fluid injection using the microfluid technology are provided. The microchannels are formed in a plastic chip using the microfluid technology, and a width, a sectional area, or a length of the microchannel is regulated so that the flow rate of a diluted solution (e.g., buffer solution) and a sample (e.g., chemicals or medicament) is controlled. The diluted solution and the specimen are mixed in the mixing channel according to the flow rate, thereby diluting the sample. Such a diluted solution is mixed again with a diluted solution, carrying out the dilution. With the repeated dilution processes, continuously diluted solution is obtained.
摘要翻译：提供了使用该微通道芯片的微通道芯片和使用该微流体技术通过一次流体注入连续稀释不同浓度的溶液的稀释方法。使用微流体技术在塑料芯片中形成微通道，调节微通道的宽度，截面面积或长度，使得稀释溶液（例如缓冲溶液）和样品（例如，化学品或药物）被控制。将稀释的溶液和样品根据流速在混合通道中混合，由此稀释样品。将这种稀释溶液再次与稀释溶液混合，进行稀释。通过重复稀释过程，获得连续稀释的溶液。

6. 发明申请

US20090269824A1 Apparatus and method for fabricating Micro-Capsule 有权
标题翻译：微胶囊制造装置及方法
公开(公告)号：US20090269824A1
公开(公告)日：2009-10-29
申请号：US12154409
申请日：2008-05-21
申请人： Choong Kim , Ji Yoon Kang , Tae Song Kim
发明人： Choong Kim , Ji Yoon Kang , Tae Song Kim
IPC分类号： C12N11/04
CPC分类号： C12N11/04 , B01F3/0865 , C12M25/16
摘要： The present invention relates to an apparatus and a method for fabricating a microcapsule, more particularly to an apparatus and a method for fabricating a microcapsule, which enable to encapsulate uniform cell number in a microcapsule through cell distribution, improve cell viability in the microcapsule through fluid exchange, and ensure uniform microcapsule size.The apparatus for fabricating a microcapsule according to the present invention uses a plurality of microchannels which are spatially connected with one another and are designed such that fluid flows through them in a particular direction, and comprises a cell supply unit which supplies a fluid mixture of cells and a cell dropletizing material; and a droplet forming unit in which a dropletization inducing fluid supplied from one of the plurality of microchannels joins with the fluid mixture of the cells and the cell dropletizing material to form a droplet.
摘要翻译：本发明涉及一种用于制造微胶囊的装置和方法，更具体地涉及一种用于制造微胶囊的装置和方法，其能够通过细胞分布将微胶囊中的均匀细胞数量包封，通过流体提高微胶囊中的细胞活力交换，确保微胶囊尺寸均匀。根据本发明的用于制造微胶囊的装置使用多个彼此空间连接的微通道，并且被设计成使得流体沿着特定方向流过它们，并且包括供应单元的流体混合物的单元供应单元和细胞液滴化材料; 以及液滴形成单元，其中从所述多个微通道中的一个提供的液滴诱导流体与所述单元和所述单元液滴化材料的流体混合物结合以形成液滴。

7. 发明申请

US20050277706A1 Highly functional dental adhesive composition 失效
标题翻译：高功能牙科粘合剂组合物
公开(公告)号：US20050277706A1
公开(公告)日：2005-12-15
申请号：US11025337
申请日：2004-12-29
申请人： Dong Han , Kyu Baek , Min Kim , Sang Park , Hyun Goo , Choong Kim
发明人： Dong Han , Kyu Baek , Min Kim , Sang Park , Hyun Goo , Choong Kim
IPC分类号： A61K6/08 , A61K6/00 , A61K6/02 , A61K6/083
CPC分类号： A61K6/0023 , Y10S522/908 , C08L33/00
摘要： There is provided a highly functional one-step light-curing dental adhesive composition i) based on a multifunctional prepolymer mixture of 2,2-bis-[4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl]propane (“Bis-GMA”) and a multifunctional prepolymer formed by substitiuting hydrogen atoms of hydroxyl groups present in Bis-GMA molecules with methacrylate groups, in which the Bis-GMA is used as a base prepolymer of conventional dental adhesive compositions; and ii) comprising and acidic monomer for removing a portion of smear layer, which is allowed to be bonded without separate treatment of acid etchant, an adhesive monomer having both hydrophobic and hydrophilic properties, a hydrophilic monomer which is allowed to be bonded in the present of moisture, an inorganic filler for improving mechanical properties, diluent, water for demineralization, a photoinitiation system and other additives.
摘要翻译：提供了基于2,2-双 - [4-（2-羟基-3-甲基丙烯酰氧基丙氧基）苯基]丙烷（“Bis-GMA”）的多官能预聚物混合物的高功能性一步光固化牙科粘合剂组合物 “）和通过将Bis-GMA分子中存在的羟基的氢原子与甲基丙烯酸酯基团取代形成的多官能预聚物，其中Bis-GMA用作常规牙科粘合剂组合物的基础预聚物; 和ii）包含和酸性单体，用于除去涂覆层的一部分，其在酸性蚀刻剂单独处理的情况下允许粘合，具有疏水性和亲水性两者的粘合剂单体，在本发明中允许结合的亲水性单体的水分，用于改善机械性能的无机填料，稀释剂，用于脱矿质的水，光引发体系和其它添加剂。

8. 发明授权

US08273311B2 Apparatus and method for separating biological particles using difference between gravity and magnetic force 有权
标题翻译：使用重力和磁力之间的差异分离生物颗粒的装置和方法
公开(公告)号：US08273311B2
公开(公告)日：2012-09-25
申请号：US12160242
申请日：2007-01-11
申请人： Kang Sun Lee , Ji Yoon Kang , Sung Shin Ryu , In Hye Lee , Choong Kim , Su Kyoung Chae , Jin Woo Lee
发明人： Kang Sun Lee , Ji Yoon Kang , Sung Shin Ryu , In Hye Lee , Choong Kim , Su Kyoung Chae , Jin Woo Lee
IPC分类号： B01D21/00
CPC分类号： B03C1/288 , B03C1/30
摘要： Disclosed is an apparatus and method for injecting liquid-drops of particle mixture liquid including a mixture of biological particles, affecting magnetic field, and having only positive particles, which are combined with magnetic responsive material, separated by magnetic force, and having negative particles, which are not combined with magnetic responsive material, precipitated by gravity.
摘要翻译：本发明涉及一种装置和方法，用于将包括影响磁场的生物颗粒的混合物的粒子混合液体的液滴注入，并且仅具有正磁性颗粒，其与通过磁力分离并具有负性颗粒的磁响应材料组合，其不与磁响应材料结合，由重力沉淀。

9. 发明申请

US20090197329A1 APPARATUS AND METHOD FOR SEPARATING BIOLOGICAL PARTICLES USING DIFFERENCE BETWEEN GRAVITY AND MAGNETIC FORCE 有权
标题翻译：使用重力与磁力之间的差异分离生物颗粒的装置和方法
公开(公告)号：US20090197329A1
公开(公告)日：2009-08-06
申请号：US12160242
申请日：2007-01-11
申请人： Kang Sun Lee , Ji Yoon Kang , Sung Shin Ryu , In Hye Lee , Choong Kim , Su Kyoung Chae , Jin Woo Lee
发明人： Kang Sun Lee , Ji Yoon Kang , Sung Shin Ryu , In Hye Lee , Choong Kim , Su Kyoung Chae , Jin Woo Lee
IPC分类号： C12N5/06 , B03C1/00
CPC分类号： B03C1/288 , B03C1/30
摘要： Disclosed is an apparatus and method for injecting liquid-drops of particle mixture liquid including a mixture of biological particles, affecting magnetic field, and having only positive particles, which are combined with magnetic responsive material, separated by magnetic force, and having negative particles, which are not combined with magnetic responsive material, precipitated by gravity.
摘要翻译：本发明涉及一种装置和方法，用于将包括影响磁场的生物颗粒的混合物的粒子混合液体的液滴注入，并且仅具有正磁性颗粒，其与通过磁力分离并具有负性颗粒的磁响应材料组合，其不与磁响应材料结合，由重力沉淀。

10. 发明申请

US20060286666A1 Methods and apparatuses for culturing stem cell using biomaterial shell 审中-公开
标题翻译：使用生物材料壳培养干细胞的方法和装置
公开(公告)号：US20060286666A1
公开(公告)日：2006-12-21
申请号：US11155532
申请日：2005-06-17
申请人： Ji Kang , Choong Kim , Jin Lee , Su Chae , Dae Na , Byeong Ju
发明人： Ji Kang , Choong Kim , Jin Lee , Su Chae , Dae Na , Byeong Ju
IPC分类号： C12N5/06 , C12N5/08 , C12M3/00
CPC分类号： C12N5/0068 , C12N5/0606 , C12N2533/10
摘要： Disclosed are methods and apparatuses for culturing stem cell using biomaterial shell, e.g. fertilized zebrafish chorions, which may induce formation of embryonic bodies, cell proliferation, and cell differentiation to other types effectively inside the chorions without adding any inducing agents or cell differentiation stimulants. There is provided an apparatus for culturing stem cell using biomaterial shell comprising: a microwell layer having a plurality of microwells; a microhole layer having a plurality of microholes, the microhole layer being located under the microwell layer, diameter of the microholes being smaller than diameter of the microwells and diameter of the biomaterial shell; and a flow-channel layer having a plurality of flow-channels for supplying cell medium to the microholes, the flow-channel layer being located under the microhole layer, and wherein the stem cell is encapsulated by the biomaterial shell in the microwell.
摘要翻译：公开了使用生物材料壳培养干细胞的方法和装置，例如，受精的斑马鱼绒毛，其可以在没有添加任何诱导剂或细胞分化兴奋剂的情况下诱导胚胎体的形成，细胞增殖和细胞分化成其他类型。提供了一种使用生物材料壳培养干细胞的装置，包括：具有多个微孔的微孔层; 具有多个微孔的微孔层，所述微孔层位于所述微孔层下方，所述微孔的直径小于所述微孔的直径和所述生物材料壳的直径; 以及流通道层，其具有用于向微孔提供细胞培养基的多个流动通道，所述流动通道层位于所述微孔层下方，并且其中所述干细胞被所述生物材料壳包封在所述微孔中。

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