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1. 发明申请

US20110273667A1 ENHANCED OPTICAL COHERENCE TOMOGRAPHY FOR ANATOMICAL MAPPING 有权
标题翻译：用于解剖图的增强光学相干坐标测量
公开(公告)号：US20110273667A1
公开(公告)日：2011-11-10
申请号：US13043401
申请日：2011-03-08
申请人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
发明人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
IPC分类号： A61B3/14 , A61B3/12
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/02089 , G01B9/02091
摘要： A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.
摘要翻译：一种利用光学相干断层扫描的解剖学映射的系统，方法和装置。在本发明中，可以从从眼睛反射的光的扫描中获取三维眼底强度图像。作为示例，扫描可以包括光谱域扫描。可以实时获取眼底强度图像。可以减少3维数据集以产生解剖学映射，例如水肿测绘和厚度映射。可选地，可以从眼睛的扫描产生部分眼底强度图像，以生成眼睛的视网膜结构的面部视图，而不需要对3D数据集进行全部分割。有利地，本发明的系统，方法和装置可以提供关于黄斑水肿和其他病变的空间位置和程度的定量三维信息。这种三维信息可用于确定治疗的需要，监测治疗的有效性，并确定可能表明需要再次治疗的流体的返回。

2. 发明授权

US07659990B2 Enhanced optical coherence tomography for anatomical mapping 有权
标题翻译：用于解剖图的增强光学相干断层扫描
公开(公告)号：US07659990B2
公开(公告)日：2010-02-09
申请号：US12322607
申请日：2009-02-04
申请人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
发明人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
IPC分类号： G01B9/02
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/02089 , G01B9/02091
摘要： A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.
摘要翻译：一种利用光学相干断层扫描的解剖学映射的系统，方法和装置。在本发明中，可以从从眼睛反射的光的扫描中获取三维眼底强度图像。作为示例，扫描可以包括光谱域扫描。可以实时获取眼底强度图像。可以减少3维数据集以产生解剖学映射，例如水肿测绘和厚度映射。可选地，可以从眼睛的扫描产生部分眼底强度图像，以生成眼睛的视网膜结构的面部视图，而不需要对3D数据集进行全部分割。有利地，本发明的系统，方法和装置可以提供关于黄斑水肿和其他病变的空间位置和程度的定量三维信息。这种三维信息可用于确定治疗的需要，监测治疗的有效性，并确定可能表明需要再次治疗的流体的返回。

3. 发明申请

US20100208201A1 ENHANCED OPTICAL COHERENCE TOMOGRAPHY FOR ANATOMICAL MAPPING 有权
标题翻译：用于解剖图的增强光学相干坐标测量
公开(公告)号：US20100208201A1
公开(公告)日：2010-08-19
申请号：US12644526
申请日：2009-12-22
申请人： Robert W. KNIGHTON , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
发明人： Robert W. KNIGHTON , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
IPC分类号： A61B3/14
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/02089 , G01B9/02091
摘要： A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.
摘要翻译：一种利用光学相干断层扫描的解剖学映射的系统，方法和装置。在本发明中，可以从从眼睛反射的光的扫描中获取三维眼底强度图像。作为示例，扫描可以包括光谱域扫描。可以实时获取眼底强度图像。可以减少3维数据集以产生解剖学映射，例如水肿测绘和厚度映射。可选地，可以从眼睛的扫描产生部分眼底强度图像，以生成眼睛的视网膜结构的面部视图，而不需要对3D数据集进行全部分割。有利地，本发明的系统，方法和装置可以提供关于黄斑水肿和其他病变的空间位置和程度的定量三维信息。这种三维信息可用于确定治疗的需要，监测治疗的有效性，并确定可能表明需要再次治疗的流体的返回。

4. 发明授权

US07301644B2 Enhanced optical coherence tomography for anatomical mapping 有权
标题翻译：用于解剖图的增强光学相干断层扫描
公开(公告)号：US07301644B2
公开(公告)日：2007-11-27
申请号：US11219992
申请日：2005-09-06
申请人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
发明人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
IPC分类号： G01B9/02
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/02089 , G01B9/02091
摘要： A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.
摘要翻译：一种利用光学相干断层扫描的解剖学映射的系统，方法和装置。在本发明中，可以从从眼睛反射的光的扫描中获取三维眼底强度图像。作为示例，扫描可以包括光谱域扫描。可以实时获取眼底强度图像。可以减少3维数据集以产生解剖学映射，例如水肿测绘和厚度映射。可选地，可以从眼睛的扫描产生部分眼底强度图像，以生成眼睛的视网膜结构的面部视图，而不需要对3D数据集进行全部分割。有利地，本发明的系统，方法和装置可以提供关于黄斑水肿和其他病变的空间位置和程度的定量三维信息。这种三维信息可用于确定治疗的需要，监测治疗的有效性，并确定可能表明需要再次治疗的流体的返回。

5. 发明授权

US08319974B2 Enhanced optical coherence tomography for anatomical mapping 有权
标题翻译：用于解剖图的增强光学相干断层扫描
公开(公告)号：US08319974B2
公开(公告)日：2012-11-27
申请号：US13043401
申请日：2011-03-08
申请人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
发明人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
IPC分类号： G01B9/02
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/02089 , G01B9/02091
摘要： A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.
摘要翻译：一种利用光学相干断层扫描的解剖学映射的系统，方法和装置。在本发明中，可以从从眼睛反射的光的扫描中获取三维眼底强度图像。作为示例，扫描可以包括光谱域扫描。可以实时获取眼底强度图像。可以减少3维数据集以产生解剖学映射，例如水肿测绘和厚度映射。可选地，可以从眼睛的扫描产生部分眼底强度图像，以生成眼睛的视网膜结构的面部视图，而不需要对3D数据集进行全部分割。有利地，本发明的系统，方法和装置可以提供关于黄斑水肿和其他病变的空间位置和程度的定量三维信息。这种三维信息可用于确定治疗的需要，监测治疗的有效性，并确定可能表明需要再次治疗的流体的返回。

6. 发明授权

US07924429B2 Enhanced optical coherence tomography for anatomical mapping 有权
标题翻译：用于解剖图的增强光学相干断层扫描
公开(公告)号：US07924429B2
公开(公告)日：2011-04-12
申请号：US12644526
申请日：2009-12-22
申请人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
发明人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
IPC分类号： G01B9/02
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/02089 , G01B9/02091
摘要： A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.
摘要翻译：一种利用光学相干断层扫描的解剖学映射的系统，方法和装置。在本发明中，可以从从眼睛反射的光的扫描中获取三维眼底强度图像。作为示例，扫描可以包括光谱域扫描。可以实时获取眼底强度图像。可以减少3维数据集以产生解剖学映射，例如水肿测绘和厚度映射。可选地，可以从眼睛的扫描产生部分眼底强度图像，以生成眼睛的视网膜结构的面部视图，而不需要对3D数据集进行全部分割。有利地，本发明的系统，方法和装置可以提供关于黄斑水肿和其他病变的空间位置和程度的定量三维信息。这种三维信息可用于确定治疗的需要，监测治疗的有效性，并确定可能表明需要再次治疗的流体的返回。

7. 发明申请

US20090180123A1 Enhanced optical coherence tomography for anatomical mapping 有权
标题翻译：用于解剖图的增强光学相干断层扫描
公开(公告)号：US20090180123A1
公开(公告)日：2009-07-16
申请号：US12322607
申请日：2009-02-04
申请人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
发明人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/02089 , G01B9/02091
摘要： A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.
摘要翻译：一种利用光学相干断层扫描的解剖学映射的系统，方法和装置。在本发明中，可以从从眼睛反射的光的扫描中获取三维眼底强度图像。作为示例，扫描可以包括光谱域扫描。可以实时获取眼底强度图像。可以减少3维数据集以产生解剖学映射，例如水肿测绘和厚度映射。可选地，可以从眼睛的扫描产生部分眼底强度图像，以生成眼睛的视网膜结构的面部视图，而不需要对3D数据集进行全部分割。有利地，本发明的系统，方法和装置可以提供关于黄斑水肿和其他病变的空间位置和程度的定量三维信息。这种三维信息可用于确定治疗的需要，监测治疗的有效性，并确定可能表明需要再次治疗的流体的返回。

8. 发明授权

US07505142B2 Enhanced optical coherence tomography for anatomical mapping 有权
公开(公告)号：US07505142B2
公开(公告)日：2009-03-17
申请号：US11975239
申请日：2007-10-18
申请人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
发明人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
IPC分类号： G01B9/02
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/02089 , G01B9/02091
摘要： A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.

9. 发明授权

US5459570A Method and apparatus for performing optical measurements 失效
标题翻译：用于执行光学测量的方法和装置
公开(公告)号：US5459570A
公开(公告)日：1995-10-17
申请号：US33194
申请日：1993-03-16
申请人： Eric A. Swanson , David Huang , James G. Fujimoto , Carmen A. Puliafito , Charles P. Lin , Joseph S. Schuman
发明人： Eric A. Swanson , David Huang , James G. Fujimoto , Carmen A. Puliafito , Charles P. Lin , Joseph S. Schuman
IPC分类号： A61B1/00 , A61B3/10 , A61B3/12 , A61B5/00 , A61B5/103 , A61B10/00 , G01B9/02 , G01B11/00 , G01B11/06 , G01B11/24 , G01J1/00 , G01N21/17 , G01N21/47 , G02B5/18 , G02B27/44 , G11B7/00 , H01S5/14 , G01D9/02
CPC分类号： G02B26/0875 , A61B1/00096 , A61B1/00172 , A61B1/00183 , A61B3/102 , A61B5/0064 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/6852 , B82Y15/00 , G01B11/00 , G01B11/2441 , G01B9/02002 , G01B9/0201 , G01B9/02019 , G01B9/02027 , G01B9/02063 , G01B9/02087 , G01B9/0209 , G01J1/00 , G01N21/4795 , G02B26/103 , G02B5/1828 , A61B2562/0242 , A61B5/441 , G01B2290/45 , G01B2290/65 , G01B2290/70 , G11B2007/0013 , H01S5/141
摘要： A method and apparatus for performing various optical measurements is provided utilizing an optical coherence domain refrectometer (OCDR). A short coherence optical radiation source applies optical radiation through like optical paths to a sample and an optical reflector. The optical reflector is movable in accordance with a predetermined velocity profile to permit interferometric scanning of the sample, the resulting output having a Doppler shift frequency modulation. This output may be demodulated and detected to obtain desired measurements and other information. Additional information may be obtained by applying radiation from two or more sources at different wavelengths to the sample and reflector and by separately demodulating the resulting outputs before processing. Birefringent information may be obtained by polarizing the optical radiation used, by suitably modifying the polarization in the sample and reference paths and by dividing the output into orthogonal polarization outputs which are separately demodulated before processing.
摘要翻译：使用光学相干域反射计（OCDR）提供用于执行各种光学测量的方法和装置。短相干光辐射源通过相同的光路将光辐射施加到样品和光反射器。光学反射器可以根据预定的速度分布移动以允许样本的干涉扫描，所得到的输出具有多普勒频移调制。该输出可以被解调和检测以获得期望的测量和其他信息。可以通过将不同波长的两个或更多个源的辐射施加到样品和反射器并且在处理之前单独解调所得到的输出来获得附加信息。双折射信息可以通过对所采用的光辐射进行极化，通过适当地修改样本和参考路径中的极化，并将输出划分为在处理之前被单独解调的正交偏振输出。

10. 发明授权

US5321501A Method and apparatus for optical imaging with means for controlling the longitudinal range of the sample 失效
标题翻译：用于光学成像的方法和装置，其具有用于控制样品的纵向范围的装置
公开(公告)号：US5321501A
公开(公告)日：1994-06-14
申请号：US875670
申请日：1992-04-29
申请人： Eric A. Swanson , David Huang , James G. Fujimoto , Carmen A. Puliafito , Charles P. Lin , Joel S. Schuman
发明人： Eric A. Swanson , David Huang , James G. Fujimoto , Carmen A. Puliafito , Charles P. Lin , Joel S. Schuman
IPC分类号： A61B1/00 , A61B3/10 , A61B3/12 , A61B5/00 , A61B5/103 , A61B10/00 , G01B9/02 , G01B11/00 , G01B11/06 , G01B11/24 , G01J1/00 , G01N21/17 , G01N21/47 , G02B5/18 , G02B27/44 , G11B7/00 , H01S5/14
CPC分类号： G02B26/0875 , A61B1/00096 , A61B1/00172 , A61B1/00183 , A61B3/102 , A61B5/0064 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/6852 , B82Y15/00 , G01B11/00 , G01B11/2441 , G01B9/02002 , G01B9/0201 , G01B9/02019 , G01B9/02027 , G01B9/02063 , G01B9/02087 , G01B9/0209 , G01J1/00 , G01N21/4795 , G02B26/103 , G02B5/1828 , A61B2562/0242 , A61B5/441 , G01B2290/45 , G01B2290/65 , G01B2290/70 , G11B2007/0013 , H01S5/141
摘要： A method and apparatus for performing optical imaging on a sample wherein longitudinal scanning or positioning in the sample is provided by either varying relative optical path lengths for an optical path leading to the sample and to a reference reflector, or by varying an optical characteristic of the output from an optical source applied to the apparatus. Transverse scanning in one or two dimensions is provided on the sample by providing controlled relative movement between the sample and a probe module in such direction and/or by steering optical radiation in the probe module to a selected transverse position. The probe module may be an external module or may be an endoscope or angioscope utilized for scanning internal channels. Multiple optical paths may be provided for parallel scanning and focus may be enhanced by varying the focal point in the sample in synchronism with longitudinal scanning of the sample.
摘要翻译：或者通过对通过样品和参考反射体的光路改变相对光程长度，或者通过改变样品的光学特性来改变样品中的纵向扫描或定位来提供样品的光学成像的方法和装置从施加到该装置的光源输出。通过在样品和探针模块之间以这种方向提供受控的相对运动和/或通过将探针模块中的光学辐射转向到选定的横向位置，在样品上提供一维或二维的横向扫描。探针模块可以是外部模块，也可以是用于扫描内部通道的内窥镜或血管造影仪。可以提供用于并行扫描的多个光路，并且可以通过与样品的纵向扫描同步地改变样品中的焦点来增强焦点。

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