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1. 发明授权

US08801187B1 Methods to reduce variance in OCT analysis of the macula 有权
标题翻译：减少黄斑OCT分析方法的方法
公开(公告)号：US08801187B1
公开(公告)日：2014-08-12
申请号：US13250699
申请日：2011-09-30
申请人： Robert W. Knighton , Matthew J. Everett , Mary K. Durbin , Jonathan D. Oakley
发明人： Robert W. Knighton , Matthew J. Everett , Mary K. Durbin , Jonathan D. Oakley
IPC分类号： A61B3/12 , G06F17/00 , A61B3/10
CPC分类号： A61B3/102 , A61B3/0025 , G06T7/0012 , G06T7/12 , G06T7/162 , G06T7/60 , G06T2207/10101 , G06T2207/30041
摘要： Methods for analyzing optical coherence tomography (OCT) images of the macula to reduce variance and improve disease diagnosis are presented. One embodiment of the invention is directed towards selecting analysis locations and data segmentation techniques to take advantage of structural homogeneities. Another embodiment is directed towards reducing the variance in a collection of normative data by transforming the individual members of the database to correspond to a Standard Macula. Variations in foveal size are corrected by radial transformation. Variations in layer thickness are corrected by axial shifting. Diagnosis is performed by comparing OCT images from a patient to the improved normative database.
摘要翻译：提出了分析黄斑的光学相干断层扫描（OCT）图像以减少变异并改善疾病诊断的方法。本发明的一个实施例涉及选择分析位置和数据分割技术以利用结构均匀性。另一个实施例旨在通过将数据库的各个成员变换为对应于标准黄疸来减少规范数据集合中的差异。通过径向变换校正中心凹大小的变化。通过轴向移动来校正层厚度的变化。通过比较患者的OCT图像和改进的规范数据库来进行诊断。

2. 发明授权

US08641193B2 Spectral contrast for glaucoma imaging 有权
标题翻译：青光眼成像的光谱对比
公开(公告)号：US08641193B2
公开(公告)日：2014-02-04
申请号：US13133016
申请日：2009-12-03
申请人： Shuliang Jiao , Xiangrun Huang , Robert W. Knighton
发明人： Shuliang Jiao , Xiangrun Huang , Robert W. Knighton
IPC分类号： A61B3/14 , A61K31/74
CPC分类号： A61B3/102
摘要： A system for analyzing and detecting early stage damage to the retina related to glaucoma. The reflectance of different wavelengths of light by the retinal nerve fiber layer are compared. Changes in relative reflectance values indicate damage to the retinal nerve fibers and indicate early glaucomatous optical neuropathy.
摘要翻译：用于分析和检测与青光眼相关的视网膜早期损伤的系统。比较不同波长的光的视网膜神经纤维层的反射率。相对反射率值的变化表示损伤视网膜神经纤维，并指示早期青光眼性光学神经病变。

3. 发明授权

US07659990B2 Enhanced optical coherence tomography for anatomical mapping 有权
标题翻译：用于解剖图的增强光学相干断层扫描
公开(公告)号：US07659990B2
公开(公告)日：2010-02-09
申请号：US12322607
申请日：2009-02-04
申请人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
发明人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
IPC分类号： G01B9/02
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/02089 , G01B9/02091
摘要： A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.
摘要翻译：一种利用光学相干断层扫描的解剖学映射的系统，方法和装置。在本发明中，可以从从眼睛反射的光的扫描中获取三维眼底强度图像。作为示例，扫描可以包括光谱域扫描。可以实时获取眼底强度图像。可以减少3维数据集以产生解剖学映射，例如水肿测绘和厚度映射。可选地，可以从眼睛的扫描产生部分眼底强度图像，以生成眼睛的视网膜结构的面部视图，而不需要对3D数据集进行全部分割。有利地，本发明的系统，方法和装置可以提供关于黄斑水肿和其他病变的空间位置和程度的定量三维信息。这种三维信息可用于确定治疗的需要，监测治疗的有效性，并确定可能表明需要再次治疗的流体的返回。

4. 发明申请

US20110273667A1 ENHANCED OPTICAL COHERENCE TOMOGRAPHY FOR ANATOMICAL MAPPING 有权
标题翻译：用于解剖图的增强光学相干坐标测量
公开(公告)号：US20110273667A1
公开(公告)日：2011-11-10
申请号：US13043401
申请日：2011-03-08
申请人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
发明人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
IPC分类号： A61B3/14 , A61B3/12
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/02089 , G01B9/02091
摘要： A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.
摘要翻译：一种利用光学相干断层扫描的解剖学映射的系统，方法和装置。在本发明中，可以从从眼睛反射的光的扫描中获取三维眼底强度图像。作为示例，扫描可以包括光谱域扫描。可以实时获取眼底强度图像。可以减少3维数据集以产生解剖学映射，例如水肿测绘和厚度映射。可选地，可以从眼睛的扫描产生部分眼底强度图像，以生成眼睛的视网膜结构的面部视图，而不需要对3D数据集进行全部分割。有利地，本发明的系统，方法和装置可以提供关于黄斑水肿和其他病变的空间位置和程度的定量三维信息。这种三维信息可用于确定治疗的需要，监测治疗的有效性，并确定可能表明需要再次治疗的流体的返回。

5. 发明申请

US20110228223A1 SPECTRAL CONTRAST FOR GLAUCOMA IMAGING 有权
标题翻译： GLAUCOMA成像的光谱对比
公开(公告)号：US20110228223A1
公开(公告)日：2011-09-22
申请号：US13133016
申请日：2009-12-03
申请人： Shuliang Jiao , Xiangrun Huang , Robert W. Knighton
发明人： Shuliang Jiao , Xiangrun Huang , Robert W. Knighton
IPC分类号： A61B3/12 , A61B3/10 , A61B3/14
CPC分类号： A61B3/102
摘要： A system for analyzing and detecting early stage damage to the retina related to glaucoma. The reflectance of different wavelengths of light by the retinal nerve fiber layer are compared. Changes in relative reflectance values indicate damage to the retinal nerve fibers and indicate early glaucomatous optical neuropathy.
摘要翻译：用于分析和检测与青光眼相关的视网膜早期损伤的系统。比较不同波长的光的视网膜神经纤维层的反射率。相对反射率值的变化表示损伤视网膜神经纤维，并指示早期青光眼性光学神经病变。

6. 发明授权

US08319974B2 Enhanced optical coherence tomography for anatomical mapping 有权
标题翻译：用于解剖图的增强光学相干断层扫描
公开(公告)号：US08319974B2
公开(公告)日：2012-11-27
申请号：US13043401
申请日：2011-03-08
申请人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
发明人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
IPC分类号： G01B9/02
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/02089 , G01B9/02091
摘要： A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.
摘要翻译：一种利用光学相干断层扫描的解剖学映射的系统，方法和装置。在本发明中，可以从从眼睛反射的光的扫描中获取三维眼底强度图像。作为示例，扫描可以包括光谱域扫描。可以实时获取眼底强度图像。可以减少3维数据集以产生解剖学映射，例如水肿测绘和厚度映射。可选地，可以从眼睛的扫描产生部分眼底强度图像，以生成眼睛的视网膜结构的面部视图，而不需要对3D数据集进行全部分割。有利地，本发明的系统，方法和装置可以提供关于黄斑水肿和其他病变的空间位置和程度的定量三维信息。这种三维信息可用于确定治疗的需要，监测治疗的有效性，并确定可能表明需要再次治疗的流体的返回。

7. 发明授权

US07924429B2 Enhanced optical coherence tomography for anatomical mapping 有权
标题翻译：用于解剖图的增强光学相干断层扫描
公开(公告)号：US07924429B2
公开(公告)日：2011-04-12
申请号：US12644526
申请日：2009-12-22
申请人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
发明人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
IPC分类号： G01B9/02
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/02089 , G01B9/02091
摘要： A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.
摘要翻译：一种利用光学相干断层扫描的解剖学映射的系统，方法和装置。在本发明中，可以从从眼睛反射的光的扫描中获取三维眼底强度图像。作为示例，扫描可以包括光谱域扫描。可以实时获取眼底强度图像。可以减少3维数据集以产生解剖学映射，例如水肿测绘和厚度映射。可选地，可以从眼睛的扫描产生部分眼底强度图像，以生成眼睛的视网膜结构的面部视图，而不需要对3D数据集进行全部分割。有利地，本发明的系统，方法和装置可以提供关于黄斑水肿和其他病变的空间位置和程度的定量三维信息。这种三维信息可用于确定治疗的需要，监测治疗的有效性，并确定可能表明需要再次治疗的流体的返回。

8. 发明申请

US20090180123A1 Enhanced optical coherence tomography for anatomical mapping 有权
标题翻译：用于解剖图的增强光学相干断层扫描
公开(公告)号：US20090180123A1
公开(公告)日：2009-07-16
申请号：US12322607
申请日：2009-02-04
申请人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
发明人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/02089 , G01B9/02091
摘要： A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.
摘要翻译：一种利用光学相干断层扫描的解剖学映射的系统，方法和装置。在本发明中，可以从从眼睛反射的光的扫描中获取三维眼底强度图像。作为示例，扫描可以包括光谱域扫描。可以实时获取眼底强度图像。可以减少3维数据集以产生解剖学映射，例如水肿测绘和厚度映射。可选地，可以从眼睛的扫描产生部分眼底强度图像，以生成眼睛的视网膜结构的面部视图，而不需要对3D数据集进行全部分割。有利地，本发明的系统，方法和装置可以提供关于黄斑水肿和其他病变的空间位置和程度的定量三维信息。这种三维信息可用于确定治疗的需要，监测治疗的有效性，并确定可能表明需要再次治疗的流体的返回。

9. 发明授权

US07505142B2 Enhanced optical coherence tomography for anatomical mapping 有权
公开(公告)号：US07505142B2
公开(公告)日：2009-03-17
申请号：US11975239
申请日：2007-10-18
申请人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
发明人： Robert W. Knighton , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
IPC分类号： G01B9/02
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/02089 , G01B9/02091
摘要： A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.

10. 发明申请

US20100208201A1 ENHANCED OPTICAL COHERENCE TOMOGRAPHY FOR ANATOMICAL MAPPING 有权
标题翻译：用于解剖图的增强光学相干坐标测量
公开(公告)号：US20100208201A1
公开(公告)日：2010-08-19
申请号：US12644526
申请日：2009-12-22
申请人： Robert W. KNIGHTON , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
发明人： Robert W. KNIGHTON , Shuliang Jiao , Giovanni Gregori , Carmen A. Puliafito
IPC分类号： A61B3/14
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/02089 , G01B9/02091
摘要： A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.
摘要翻译：一种利用光学相干断层扫描的解剖学映射的系统，方法和装置。在本发明中，可以从从眼睛反射的光的扫描中获取三维眼底强度图像。作为示例，扫描可以包括光谱域扫描。可以实时获取眼底强度图像。可以减少3维数据集以产生解剖学映射，例如水肿测绘和厚度映射。可选地，可以从眼睛的扫描产生部分眼底强度图像，以生成眼睛的视网膜结构的面部视图，而不需要对3D数据集进行全部分割。有利地，本发明的系统，方法和装置可以提供关于黄斑水肿和其他病变的空间位置和程度的定量三维信息。这种三维信息可用于确定治疗的需要，监测治疗的有效性，并确定可能表明需要再次治疗的流体的返回。

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